He mana kupaianaha i loko o ko kākou kino! ʻO nā mea āpau e pono ai ʻoe e ʻike e pili ana i ka endothelium!

Ua noʻonoʻo paha ʻoe i nā mea liʻiliʻi i loko o ko kākou kino, ʻoiai hoʻi i loko o ko kākou mau kīʻaha koko, e hana ana no ko kākou olakino? ʻĀ, i kēia lā e kamaʻilio kākou e pili ana i kahi mea nui loa, akā ʻaʻole paha mākou e kamaʻilio nui. ʻO ia ka endothelium . ʻOiai ke kani ʻepekema iki nei ka inoa, he maʻalahi loa ia. E kamaʻilio kākou e pili ana i ia mea me nā kikoʻī, a e maopopo iā ʻoe kona waiwai.

He aha ka endothelium? E hoʻomaopopo maʻalahi kākou.

I ka ʻōlelo maʻalahi, ʻo kou endothelium he papa lahilahi loa o nā cell e uhi ana i loko o kou mau kīʻaha koko a me nā kīʻaha lymphatic . Ua like ia me kahi membrane liʻiliʻi e uhi ana i loko o kahi paipu wai. Kāhea mākou i kēia mau cell he mau cell endothelial . Aia ma hea lākou?

• I loko o kou mau aʻa .
• I loko o kou mau aa koko .
• I loko o kou mau capillaries .
• A i loko nō hoʻi o nā capillaries lymph .

E noʻonoʻo, ʻo ka endothelium ka mea e hoʻopili ai i kou koko i ke koena o kou kino, e ʻae ana i ka ʻike a me nā meaʻai e kahe ma waena o lākou. No laila, he mea nui ka endothelium i kēlā me kēia ʻōkana a me nā ʻiʻo i loko o kou kino. ʻAʻole wale ka endothelium he uhi. Ua like ia me kahi mea hana paʻahana. Hana maikaʻi ia i ka mālama ʻana i ke kahe maikaʻi o kou koko a me ka mālama ʻana i kahi kūlana paʻa. ʻO ia ke kumu e manaʻo ai nā kānaka ʻepekema he ʻōkana endocrine ka endothelium. ʻOiaʻiʻo, e kahaha ʻoe i ka ʻike ʻana ʻo ia kekahi o nā ʻōkana nui loa i loko o kou kino! Inā loaʻa kekahi mea i kēia mau cell endothelial liʻiliʻi, hiki iā ia ke loaʻa ka hopena nui i ke kino. No ka mea, hana kēia mau cell i kahi hana maikaʻi i ka mālama ʻana iā mākou i ke olakino a me ka ikaika. No laila, he mea nui loa ka ʻike e pili ana i kēia endothelium a me kāna hana. A laila hiki iā mākou ke hoʻāʻo i ka mea maikaʻi loa e pale aku i kēia mai ka hana ʻana.

Aia kekahi mau ʻano o ka endothelium?

ʻAe, ʻelua ʻano nui a mākou e kamaʻilio nei. Hana ʻia nā mea ʻelua me nā cell endothelial, akā aia kekahi mau ʻokoʻa iki ma muli o ko lākou wahi.

• ʻO ka endothelium vascular: ʻO kēia ka uhi i loko o kou mau kīʻaha koko. I ka ʻōlelo maʻalahi, ʻo ka endothelium ka mea e kōkua ai i ke kahe ʻana o ke koko.
• ʻO ka endothelium lymphatic:Aia kēia i loko o kāu ʻōnaehana lymphatic. Ua like nā kīʻaha lymphatic me kahi pūnaewele o nā paipu liʻiliʻi. Hoʻopau lākou i ke kahe keu (ka mea a mākou e kapa nei he lymph) e hōʻiliʻili ana i loko o nā ʻiʻo. No laila, kōkua ka endothelium o kēia mau kīʻaha lymphatic i ka neʻe ʻana o ka lymph.

He mea nui kēia mau mea ʻelua no kou olakino cardiovascular .

He aha ke ʻano o ka hana nui a kēia endothelium liʻiliʻi?

ʻOkoʻa ka hana ʻana o nā pūnaewele endothelial ma muli o ko lākou wahi i loko o ke kino. E nānā kākou i nā hana nui o ka endothelium o ke kīʻaha koko.

Ka hoʻohaiki ʻana (Vasoconstriction) a me ka hoʻonui ʻana (Vasodilation) o nā kīʻaha koko

Ke loaʻa iā ʻoe nā cell endothelial olakino, kōkua lākou e mālama i kou mau kīʻaha koko ākea (wehe) i hiki i ke koko ke kahe ma o lākou me ka ʻole o ke keʻakeʻa. Pane pū lākou i nā mea hoʻonāukiuki mai loko a i waho. No ka laʻana, ʻo ke kaomi o ke koko ma nā paia o kou mau kīʻaha koko, nā loli i kou pae kaumaha, a me nā lāʻau lapaʻau āu e lawe ai hiki ke hoʻopilikia i kēia. Pane pū lākou i nā loli o ka mahana. E noʻonoʻo e pili ana i ia mea, i ke anuanu , ʻūlū nā kīʻaha koko i loko o kou mau lālā. ʻAe kēia i ke koko hou aku e kahe i kou mau kino koʻikoʻi, e hoʻomehana iā lākou. I ke anuanu , hoʻonui lākou, e ʻae ana i ke koko e kaʻa maikaʻi a hoʻomaʻalili i kou kino. Ke hoʻoikaika kino ʻoe , hoʻonui nā kīʻaha koko i loko o kou mau ʻiʻo, e hāʻawi ana iā lākou i ke koko a me ka oxygen e pono ai lākou. No laila, ʻaʻohe mea āu e hana ai, kōkua ka endothelium e hōʻoia i kēlā me kēia ʻano a me nā ʻiʻo i loko o kou kino e loaʻa ka nui kūpono o ke koko.

Hoʻomalu i ka neʻe ʻana o nā wai mai ke koko i loko o nā ʻiʻo

Ke olakino, ua ʻano permeable ka endothelium. ʻO ia hoʻi, ʻae ia i nā wai e hele ma o kona mau cell i loko o nā ʻiʻo. Eia naʻe, hana pū ia ma ke ʻano he pale maikaʻi. Pale ia i nā mea makemake ʻole ʻia e like me nā toxins mai ke komo ʻana i ke koko. Eia naʻe, i kekahi mau kūlana maʻi, e like me ka maʻi / sepsis , lilo ka endothelium i mea permeable iki. ʻAe kēia i nā cell e hakakā nei i ka maʻi e komo i loko o nā ʻiʻo a kōkua iā lākou e ho'ōla.

Kāohi i ke kāpili ʻana o ke koko pono ʻole (Kāohi i ka Thrombosis )

ʻO ka Thrombosis kahi kūlana e hoʻokumu ʻia ai nā ʻōpū koko a ālai i ke kahe koko, hiki ke alakaʻi i nā pilikia koʻikoʻi. Hoʻopuka kāu endothelium i nā kemika i kapa ʻia ʻo nitric oxide a me prostacyclin . Mālama kēia i kou koko i lahilahi a pale iā ia mai ka clotting. I kekahi mau kūlana maʻi, ʻaʻole i hana pono ʻia kēia mau mea. Hoʻonui kēia i ka pilikia o nā ʻōpū koko.

Ma hea i loko o ko kākou kino kēia endothelium? Pehea kona nui?

Ua pālahalaha ʻia kou endothelium ma kou kino holoʻokoʻa! E noʻonoʻo, ʻo kou endothelium kīʻaha koko wale nōʻO ka lōʻihi o nā kīʻaha koko ma kahi o 60,000 mile . Inā ʻoe e noi i kekahi e hōʻike iā ʻoe i kahi o kou puʻuwai, e kuhikuhi lākou i kou umauma. Inā ʻoe e noi i kekahi e hōʻike iā ʻoe i kahi o kou lolo, e kuhikuhi lākou i kou poʻo. Akā inā ʻoe e noi i kekahi e hōʻike iā ʻoe i ka endothelium, e kuhikuhi lākou i kekahi ʻāpana o kou kino! ʻO ia ka mea e kūikawā ai ka endothelium. Hoʻopili nā pūnaewele endothelial i loko o kou mau kīʻaha koko. ʻO lākou nā pūnaewele e pili pono ana i kou koko. Hoʻopili ʻia lākou i kahi lamina basal . ʻO ka endothelium a me kēia lamina basal e hana pū ana i ka papa o loko o ka paia o ke kīʻaha koko, ʻo ia ka tunica intima . ʻO kēia tunica intima ka mea e hiki ai i ke koko ke kahe mālie. Pehea ka nui o ka endothelium? ʻO ia kekahi o nā ʻōkana nui loa i loko o kou kino. Ma ke ʻano o ka ʻili, ua uhi ʻia ke kino o ke kanaka maʻamau e ia, e uhi ana ma waena o 3,000 a me 6,000 mika kuea . A, aia ma mua o 1 trillion mau pūnaewele endothelial ! Hana ʻia kēia mau mea me ka ʻiʻo epithelial . Pehea ka liʻiliʻi o nā pūnaewele endothelial? Hiki ke ʻike ʻia kēia mau pūnaewele me kahi microscope wale nō. ʻO ko lākou nui awelika:

• Ma kahi o 30 a 50 micrometers (microns) ka lōʻihi.
• Ma kahi o 10 a 30 micrometers ka laulā.
• Ma kahi o 0.1 a 10 micrometers ka mānoanoa.

No ka noʻonoʻo ʻana i ka nui o kēia cell, e noʻonoʻo i kou lauoho ponoʻī. ʻO ke anawaena o ka lauoho hoʻokahi ma kahi o 100 micrometers. No laila, ʻoiai ma kona lōʻihi loa (50 micrometers), ʻo kahi cell endothelial he hapalua wale nō ke anawaena o ka lauoho! ʻO ia ke kumu e hiki ai iā mākou ke loaʻa ma mua o hoʻokahi trillion o kēia mau cell kūikawā i loko o ko mākou kino.

He aha ka ʻokoʻa ma waena o ka Endothelium a me ka Epithelium?

He mau ʻiʻo uhi kēia mau mea ʻelua, akā he ʻokoʻa iki.

• Loaʻa ka endothelium i loko o nā kahawai i loko loa o ke kino a ʻaʻohe pilina me ke kaiapuni o waho. Eia kekahi laʻana, nā kīʻaha koko a me nā kīʻaha lymphatic.
• Loaʻa ka Epithelium ma nā ala e pili ana me ke kaiapuni o waho. Eia kekahi laʻana, kou ʻōnaehana hoʻoheheʻe a me ka ʻōnaehana hanu .

Ua kūikawā nā mea ʻelua no kā lākou mau hana. ʻOi aku ka palekana o ka epithelium, e hana ana ma ke ʻano he pale i ka honua waho. Ua kūikawā ʻia ka endothelium e hoʻolako i ke kino me ke koko a me nā mea ʻē aʻe.

He aha inā ua hōʻino ʻia ka endothelium? He kūlana kēlā i kapa ʻia ʻo ka endothelial dysfunction!

ʻO ka hana ʻino ʻana o ka endothelial ka wā hiki ʻole i kāu endothelium ke hana pono i kāna hana maʻamau. Hana ʻia kēia ke hōʻino kekahi mea i kāu mau cell endothelial. Hiki ke hana ʻia kēia hōʻino e nā ʻano maʻi like ʻole a me nā ʻano nohona.

He aha paha ke kumu o kēia?

• Nā maʻi e like me COVID-19 .
• Hoʻonui ʻia ke kiʻekiʻe o ke kō koko (hyperglycemia) .
• Ke koko kiʻekiʻe (hypertension) .
• Hoʻonui ʻia ka nui o ka cholesterol i loko o ke koko (Hyperlipidemia) .
• Ka nele i ka hana kino.
• Ka puhipaka a me ka hoʻohana ʻana i ka paka .
• Nā maʻi ʻino e like me ka sepsis .

ʻO ka mea ʻino loa e hana ʻia ke hōʻino ʻia ka endothelium ʻo ia ka atherosclerosis.

ʻO Atherosclerosis ka hōʻiliʻili mālie ʻana o ka plaque i loko o kou mau aʻa i ka hala ʻana o ka manawa. Ua ʻike nā kānaka ʻepekema ʻo ka pae mua o ka atherosclerosis ka hōʻino ʻana i ka endothelium. ʻO ka maʻamau, hana ʻia kēia e nā pae kiʻekiʻe o ka LDL (cholesterol maikaʻi ʻole) i loko o ke koko, ka puhipaka, a i ʻole ke koko kiʻekiʻe lōʻihi. Ke hōʻino ʻia kou endothelium, hoʻomaka ka ʻōnaehana pale o kou kino. Hoʻouna ia i kahi ʻano o nā cell koko keʻokeʻo i kapa ʻia ʻo monocytes i ka paia o ke aʻa i hōʻino ʻia. Hōʻuluʻulu kēia mau monocytes ma laila a hana i ka mumū i loko o ke aʻa. A laila, hana ʻia kekahi mau loli cellular, a laila alakaʻi i ka hoʻokumu ʻana o kahi mea i kapa ʻia ʻo "fatty streak." ʻO ia kahi e hoʻomaka ai ka plaque e hana. I ka hala ʻana o ka manawa, ulu kēia plaque a hoʻohaiki i kou aʻa. Hoʻemi kēia i ke kahe koko. ʻAʻole wale ia, akā hoʻonui pū kēia plaque i ka pilikia o nā clots koko. ʻO ia ke kumu e ʻoi aku ka nui o ka pilikia o ka poʻe me ka endothelium i hōʻino ʻia i ka loaʻa ʻana o kēia mau maʻi.

A laila he aha nā maʻi ʻē aʻe e hiki mai ana ma muli o kēia pōʻino?

• Maʻi ʻAʻa Coronary
• Maʻi hohola
• ʻO ka Ischemia Myocardial (hoʻemi ʻia ke kahe koko i ka ʻiʻo o ka puʻuwai)
• Maʻi ʻAʻai Peripheral
• Nā kūlana e like me ka hahau ʻana
• ʻO ka Thrombosis ( ʻūpū koko)

Hiki i ka hōʻino ʻana o ka Endothelial ke hoʻonui i ka pilikia o:

• Ka maʻi ʻaʻai
• Nā maʻi lele
• Ke kū'ē ʻana o ka insulin
• Maʻi puʻupaʻa

No laila pehea mākou e mālama ai i kēia endothelium makamae i ke olakino?

Hiki iā ʻoe ke kōkua i ka mālama ʻana i nā cell endothelial olakino ma ka hōʻemi ʻana i ka nui o nā radical manuahi i loko o kou kino. He mau ʻātoma paʻa ʻole nā ​​​​radicals manuahi. Hoʻopōʻino lākou i nā ʻātoma olakino i loko o ke kino. Nā AntioxidantsʻO nā antioxidants he mau mea e pale ai i kou kino (ʻoi aku ka endothelium) mai nā radical manuahi. No laila, he mea nui loa ka ʻai ʻana i nā meaʻai waiwai i nā antioxidants. ʻO nā meaʻai e like me kēia he waiwai i nā antioxidants:

• Laiki ʻeleʻele (laiki ʻōniʻoniʻo)
• Nā hua citrus e like me nā lemona a me nā ʻalani a me ko lākou wai
• Nā mea kanu ʻōmaʻomaʻo ʻeleʻele (e like me ka spinach, kale)
• ʻOatmeal
• Nā pepa bele ʻulaʻula a me melemele (chili iʻa)
• ʻUala
• Nā tōmato a me ka wai tōmato
• Nā hua palaoa piha

Hiki iā ʻoe ke nīnau i kāu kauka i ka mea hiki iā ʻoe ke hana e hoʻohui i nā antioxidants hou aʻe i kāu papaʻai. Hiki i kāu kauka ke kuhikuhi iā ʻoe i kahi meaʻai meaʻai. Hiki iā lākou ke kōkua iā ʻoe e hana i nā hoʻololi liʻiliʻi e maʻalahi ke hoʻomaka. No ka laʻana, hiki iā lākou ke paipai i ka hahai ʻana i ka papaʻai Mediterranean, kahi i ʻike ʻia e kōkua i kou puʻuwai a me nā kīʻaha koko e noho olakino.

He aha nā mea e hoʻonui ai i nā radical manuahi? Pehea e hiki ai iā kākou ke pale aku iā kākou iho mai iā lākou?

Hiki i kekahi mau kūlana olakino, nā ʻano nohona, a me nā mea ʻawahia ke hoʻonui i ka nui o nā radical manuahi i loko o kou kino. Eia kekahi mau mea e makaʻala ai:

• Ka haumia o ka ea.
• Kekahi mau lāʻau lapaʻau, nā pesticides, a me nā mea hoʻomaʻemaʻe hale hana.
• Ka ʻai nui ʻana i ke kō.
• ʻAʻole lawa ka hiamoe.
• Ka momona nui .
• Uahi mai nā huahana paka.

E kamaʻilio me kāu kauka e pili ana i ke ʻano o ke kaua ʻana i kēia mau radical manuahi a pale i kou kino mai ko lākou hopena ʻino. He mea nui hoʻi e loaʻa nā nānā makahiki a lawe i kāu mau lāʻau lapaʻau i kuhikuhi ʻia i ka manawa kūpono. E kamaʻilio me kāu kauka e pili ana i kahi papahana hoʻoikaika kino kūpono nou e noho olakino. Kōkua kēia mau mea i kou puʻuwai a me ka ʻōnaehana circulatory e hana pono. A kōkua lākou e mālama i kou endothelium olakino.

E hoʻomanaʻo, he mau mea pilikia ko kēlā me kēia kanaka e hiki ke hōʻino i ka endothelium i kekahi manawa o ko lākou ola. Eia nō naʻe, hiki iā ʻoe ke hōʻemi i kēia mau pilikia ma ka lawe ʻana i kahi nohona olakino a me ka mālama ʻana i kou mau kūlana olakino.

ʻO ka mea hope loa, nā mea nui e hoʻomanaʻo (Leka Lawe-Home)

No laila, hiki iā ʻoe ke ʻike i kēia manawa ʻo ka endothelium a mākou i kamaʻilio ai i kēia lā he ʻāpana kupaianaha a koʻikoʻi loa ia o ko mākou kino. Ua like ia me kekahi e noho ana i loko o ko mākou mau kīʻaha koko, e lawelawe mālie ana i ke olakino o ko mākou kino holoʻokoʻa.

• ʻO ka endothelium kahi papa o nā pūnaewele e uhi ana i loko o nā kīʻaha koko a me nā kīʻaha lymph.
• Hana kēia i nā hana koʻikoʻi he nui, e like me ke kaohi ʻana i ke kahe o ke koko, ka pale ʻana i ke kāpili ʻana o ke koko, a me ke kōkua ʻana i nā ʻiʻo e hoʻololi i nā mea.
• Inā ua hōʻino ʻia ka endothelium (endothelial dysfunction), hiki ke ulu mai nā maʻi koʻikoʻi e like me ka maʻi puʻuwai a me ka hahau.
• Hiki iā mākou ke pale i kēia endothelium makamae ma ka hahai ʻana i ka ʻai maikaʻi, ka hoʻoikaika kino, ka pale ʻana i ka puhipaka, a me ka hoʻohana ʻana i nā ʻano olakino ʻē aʻe.

E kamaʻilio me kāu kauka e pili ana i ke olakino o kou endothelium, a ma o ia mea, ke olakino o kou kino holoʻokoʻa. He kōkua nui ia i kou ola olakino!