He aha ʻo Aldosterone? E ʻike kākou pehea e pili ai i kou koko koko!

Ua lohe paha ʻoe iā Aldosterone? Ua ʻōlelo paha kāu kauka iā ia, a ua lohe paha ʻoe i ka inoa i ke kamaʻilio ʻana e pili ana i kou koko . He hormone liʻiliʻi akā koʻikoʻi loa ia i loko o ko mākou kino. Kōkua ia i ka hoʻoponopono ʻana i nā pae o ka sodium a me ka potassium i loko o ko mākou kino a mālama i ko mākou koko. No laila, e kamaʻilio kākou e pili ana iā Aldosterone i kēia lā ma ke ʻano maʻalahi e hiki ai iā ʻoe ke hoʻomaopopo, ʻae?

He aha ka aldosterone? No hea mai ia?

I ka ʻōlelo maʻalahi, ʻo Aldosterone kahi hormone i hana ʻia e kou mau kelepa adrenal . ʻIke anei ʻoe i ke ʻano o kēia mau kelepa adrenal? He ʻelua mau kelepa liʻiliʻi, ʻano triangular e like me nā pāpale liʻiliʻi ma luna o kou mau puʻupaʻa. He ʻāpana lākou o kā mākou ʻōnaehana endocrine . Hoʻopuka kēia mau kelepa i nā hormones he nui i mea nui i ko mākou kino.

Ua like nā hormones me nā ʻelele kemika e hoʻonohonoho i ka hana o ko kākou kino. Hele lākou ma ke kahe koko a haʻi i nā ʻōkana, nā ʻiʻo, a me nā ʻiʻo ʻē aʻe i ka mea e hana ai a me ka manawa e hana ai.

I kēia manawa, ʻo kēia hormone , ʻo Aldosterone, ke hoʻokele nei i nā pae o ka sodium a me ka potassium i loko o kou koko. Ua kapa ʻia kēia mau sodium a me ka potassium he electrolytes . ʻO kēia nā mea e kōkua ai i ka mālama ʻana i nā wai o ke kino i ke kaulike a kōkua i nā aʻalolo a me nā ʻiʻo e hana pono. Eia kekahi, hoʻomalu ʻo Aldosterone i ka nui o ka wai i hoʻopili hou ʻia e nā puʻupaʻa. Hoʻonui kēia i ka nui o ke koko a hoʻopilikia i ke koko.

No laila, inā haʻahaʻa a kiʻekiʻe paha kāu pae aldosterone, hiki iā ia ke hoʻopilikia i kou olakino.

He aha ka lawelawe a ka aldosterone e hāʻawi ai i ko mākou kino?

ʻO ka hana nui a Aldosterone ke kōkua i ka hoʻoponopono ʻana i kou koko. He kōkua ia i kēia hana koʻikoʻi ma kekahi mau ʻano:

• Hoʻouna ʻo Aldosterone i nā hōʻailona i nā kino e like me kou mau puʻupaʻa a me kou kolona e hoʻonui i ka nui o ka sodium i hoʻohui ʻia i kou koko a i ʻole e hoʻonui i ka nui o ka potassium i hoʻokuʻu ʻia i loko o kou mimi.
• Ke piʻi aʻe ka nui o ka sodium ma kēia ʻano, hoʻomaka ke kino e mālama i ka wai, kahi e hoʻonui ai i ka nui o ke koko.

He mea nui kēia mau mea a pau, i ka wā e haʻahaʻa ai ke koko, e hoʻihoʻi iā ia i kahi pae olakino.

Ma ke ʻano ʻē, kōkua pū ʻo aldosterone i ka mālama ʻana i ka pH (ʻo ia hoʻi ke kaulike acid-base) a me nā pae electrolyte o kou koko.

Pehea e kāohi ʻia ai nā pae aldosterone? E nānā pono kākou!

ʻO Aldosterone kekahi ʻāpana o kahi pūnaewele paʻakikī o nā hormones, nā enzymes, nā protein, a me nā hopena i kapa ʻia ʻo Renin-Angiotensin-Aldosterone System (RAAS) . ʻO ia ke kuleana nui no ka kaohi ʻana i ke koko.

E noʻonoʻo i kēia ma ke ʻano he kaʻina hana pae-ma-ka-pae:

1. ʻO ka mea mua, ke hāʻule kou koko , hoʻokuʻu ʻia kahi enzyme i kapa ʻia ʻo renin i loko o kou koko mai kou mau puʻupaʻa.

2. Hele kēia renin a wāwahi i kahi protein i kapa ʻia ʻo angiotensinogen , i hana ʻia i loko o kou ake. ʻO kekahi o nā ʻāpana ʻo angiotensin I. ʻAʻole hana kēia i kēlā manawa, ʻo ia hoʻi, ʻaʻohe ona hopena nui.

3. A laila, hele mai ka Angiotensin-Converting Enzyme (ACE) mai kou mau māmā a wāwahi i kēia Angiotensin I i mau ʻāpana hou aʻe. ʻO kekahi o kēlā mau ʻāpana ka hormone hana i kapa ʻia ʻo Angiotensin II .

4. ʻO kēia kahi e hana ai ʻo Angiotensin II i ka hana koʻikoʻi:

• ʻO kekahi, ʻo ia ka hoʻonui ʻana i ke koko ma o ka hoʻoulu ʻana i nā paia ʻiʻo o nā kīʻaha koko liʻiliʻi (arterioles).
• ʻO kekahi, ʻo ia ke "hōʻailona" i kāu mau kelepa adrenal e hoʻokuʻu i ka aldosterone.
• Ke haʻi aku nei hoʻi ia i kāu kelepa pituitary e hoʻokuʻu i ka Antidiuretic Hormone (ADH) , i ʻike ʻia hoʻi ʻo Vasopressin .

5. No laila, hana pū ʻo Aldosterone lāua ʻo ADH e haʻi i nā puʻupaʻa e mālama i ka sodium i loko o ke kino. Hoʻoulu ʻo Aldosterone i nā puʻupaʻa e hoʻokuʻu i ka potassium i loko o ka mimi. Ke piʻi aʻe nā pae sodium i loko o ke koko, paʻa ka wai i loko o ke kino. Hoʻonui kēia i ka nui o ke koko a me ke koko.

Penei ka hoʻopau ʻia ʻana o ka ʻōnaehana Renin-Angiotensin-Aldosterone. Maopopo iā ʻoe kēlā kaʻina hana?

Hiki ke hoʻāla ʻia kēia ʻōnaehana e nā hormones ʻē aʻe e like me corticosteroids , estrogen, a me nā hormones thyroid .

Inā he pilikia me kekahi ʻāpana o kēia ʻōnaehana, hiki iā ia ke hoʻopilikia i kou koko a me nā pae sodium a me ka potassium. Eia nō naʻe, he mea nui e hoʻomanaʻo he nui nā mea ʻē aʻe e hiki ke hoʻopilikia i kou koko, e like me ke kolesterol kiʻekiʻe, nā genetics, a me kekahi mau lāʻau lapaʻau.

Pehea e nānā ai i nā pae aldosterone?

ʻO ka hoʻāʻo nui a nā kauka e hoʻohana ai e nānā i nā pilikia e pili ana i ka aldosterone ʻo ia ka Aldosterone: Renin Ratio Test . Ma muli o ka pili loa o ka renin a me ka aldosterone, hiki i kēia hoʻāʻo ke hoʻoholo inā he pilikia wale nō ka pilikia me ka hana a me ka hana aldosterone, a i ʻole he pilikia me ka ʻōnaehana renin-angiotensin ponoʻī.

No kēia hoʻāʻo Aldosterone: Renin Ratio, lawe pinepine ʻia kahi hāpana koko mai kahi aa koko ma kou lima.

Hiki i nā kauka ke ana i ka nui o ka aldosterone i loko o kou koko a/a i ʻole ka mimi.

I kekahi manawa, e kauoha paha kāu kauka i kahi hoʻāʻo hoʻokomo catheter e lawe i kahi hāpana koko mai kahi aʻa koko i loko o kou puʻupaʻa (no ka renin) a i ʻole kahi aʻa koko i loko o kou kelepa adrenal (no ka aldosterone). He hoʻāʻo kēia i hana ʻia ma kahi haukapila e kahi radiologist i aʻo kūikawā ʻia.

He aha nā pae maʻamau o ka aldosterone?

Hiki ke ʻokoʻa iki nā waiwai maʻamau no nā pae aldosterone mai kekahi keʻena hoʻokolohua a i kekahi. No laila, e hōʻoia e nānā i ka pae maʻamau ma kāu hōʻike keʻena hoʻokolohua, a i ʻole e nīnau i kāu kauka inā he mau nīnau kāu e pili ana i kāu mau hopena.

ʻOkoʻa ka pae maʻamau no nā pae aldosterone i loko o ke koko me ka makahiki. Ma keʻano laulā, penei nā pae maʻamau:

• No nā pēpē 1 a 12 mahina: 5.8 - 110.0 nanograms no ka deciliter (ng/dL)
• No nā keiki 1 a 5 mau makahiki: < 36.0 ng/dL
• No nā keiki 6 a 9 mau makahiki: < 24.0 ng/dL
• No nā keiki 10 a 11 mau makahiki: < 15.0 ng/dL
• No nā keiki 12 a 14 mau makahiki: < 22.0 ng/dL
• No nā ʻōpio 15 a 17 mau makahiki: 3.0 - 32.0 ng/dL
• Nā pākeke 18 a 99 mau makahiki: 3.1 - 35.4 ng/dL

I ka nānā ʻana i nā pae aldosterone i loko o kahi hoʻāʻo mimi 24-hola, ʻo ka pae maʻamau ma waena o 3 - 25 micrograms i kēlā me kēia 24 hola (3 - 25 mcg/24 hola).

He aha ka mea e hana ai inā piʻi aʻe ka pae o ka aldosterone?

Ke kiʻekiʻe aʻe nā pae aldosterone ma mua o ka maʻamau, kapa mākou ia he hyperaldosteronism .

ʻO ke kumu nui o kēia, ʻo ia ka Aldosteronism mua , i ʻike ʻia hoʻi ʻo Conn's syndrome . Hoʻokumu ʻia kēia ʻano e kahi puʻupuʻu ʻaʻole cancerous (benign) e ulu pinepine ana i loko o kekahi o kāu mau kelepa adrenal.ʻO kēia ke kumu o ka hana ʻana o ka gland i ka aldosterone ma mua o ka mea e pono ai. Ke piʻi aʻe nā pae aldosterone, piʻi aʻe nā pae sodium ( hypernatremia ) a emi iho nā pae potassium ( hypokalemia ). Hiki i kēia ke hana i kahi electrolyte imbalance.

Nā hōʻailona o ke kiʻekiʻe o ka aldosterone

I ke ʻano o ka aldosteronism mua, ʻo ia hoʻi, ke kiʻekiʻe ka pae aldosterone, nā hōʻailona e like me:

• Ke koko kiʻekiʻe (Hypertension)
• ʻEha poʻo
• Ka nāwaliwali o nā ʻiʻo , ʻoiai inā haʻahaʻa loa nā pae potassium
• Ka makewai nui a me ka mimi pinepine

Inā loaʻa iā ʻoe kēia mau hōʻailona, ​​​​he mea nui loa e ʻimi koke i ke kōkua lapaʻau.

He aha ka mea e hana ai inā e emi iho ka pae o ka aldosterone?

Ke haʻahaʻa nā pae aldosterone ma mua o ka maʻamau, kapa mākou ia he hypoaldosteronism . He hemahema kēia o ka aldosterone, a i ʻole kona hana ʻole. Ke haʻahaʻa nā pae aldosterone, emi nā pae sodium ( hyponatremia ), piʻi nā pae potassium ( hyperkalemia ), a hana ke kino i ka nui o ka waikawa ( metabolic acidosis ).

Aia kekahi mau kumu no ka hypoaldosteronism:

• ʻO ka maʻi ʻo Addison: He ʻano laha ʻole kēia. Ua kapa ʻia hoʻi ʻo ia ʻo ka Primary Adrenal Insufficiency . He maʻi autoimmune ia. ʻO ke ʻano kēia, hoʻouka kāu ʻōnaehana pale ponoʻī i ka ʻaoʻao waho (cortex) o nā kelepa adrenal. Hana ʻia nā hormones aldosterone a me cortisol ma laila. ʻO kēia ke kumu o ka emi ʻana o nā pae o nā hormones ʻelua.
• ʻO Congenital Adrenal Hyperplasia (CAH): He hui kēia o nā maʻi genetic e hoʻopilikia ana i nā kelepa adrenal. Hānau ʻia ka poʻe me CAH me nā hemahema i kekahi mau enzymes e pono ai e hana i nā hormones i hana ʻia e nā kelepa adrenal.
• Kekahi mau kūlana olakino: Hiki i ka poʻe me ka maʻi diabetes mellitus, ka maʻi puʻupaʻa, ka lāʻau make kēpau, a i ʻole nā ​​​​​​kūlana olakino koʻikoʻi ke hoʻomohala i ka hypoaldosteronism.
• ʻO kekahi mau lāʻau lapaʻau: Nā lāʻau anti-inflammatory non-steroidal (NSAIDs) , HeparinHiki ke hana ʻia kēia kūlana e nā lāʻau lapaʻau i hāʻawi ʻia e mālama i nā maʻi puʻuwai.

Nā hōʻailona o ka aldosterone haʻahaʻa

Ma keʻano laulā, hiki i nā pae aldosterone haʻahaʻa (Hypoaldosteronism) ke hana i nā hōʻailona e like me:

• Ke koko haʻahaʻa (Hypotension)
• Nāwaliwali o nā ʻiʻo
• Ka luaʻi
• Nā palpitations o ka puʻuwai
• Nā hewa o ka puʻuwai (Arrhythmia)

Ma muli o ke kumu o kou hypoaldosteronism, loaʻa paha iā ʻoe nā hōʻailona hou aʻe. No ka laʻana, ma ka maʻi ʻo Addison, hiki i nā pae cortisol haʻahaʻa ke hoʻololi i ka ʻili (e like me nā kiko ʻeleʻele a me nā ʻili ʻili) a me nā pae kō koko haʻahaʻa ( hypoglycemia ).

Inā loaʻa iā ʻoe kekahi o kēia mau hōʻailona, ​​e ʻike koke i kāu kauka.

ʻO ka mea hope loa, nā mea e hoʻomanaʻo ai (Leka Lawe-Home)

He hormone koʻikoʻi ʻo Aldosterone no ka kaohi ʻana i ke koko. Inā pilikia ʻoe i ka mālama ʻana i ke koko olakino a loaʻa iā ʻoe nā loli i kou pae potassium koko, he manaʻo maikaʻi e kamaʻilio me kāu kauka e pili ana i nā ʻano hana hoʻokele koko ʻē aʻe a me nā hoʻokolohua hou aʻe. A laila hiki iā ia ke kauoha i nā hoʻokolohua e ʻike inā ma muli o nā pae aldosterone maʻamau ʻole kāu mau hōʻailona.

Manaʻolana wau he mea pono kēia ʻike iā ʻoe! E ola kino!

ʻAldosterone , Aldosterone, Hormone, Kaomi Koko, Nā Kelepona Adrenal, Sodium, Potassium