Ke luhi mau nei ʻoe no ka mea he haʻahaʻa kou koko? E kamaʻilio kākou e pili ana i ka Erythropoietin!

Ke luhi nei ʻoe i kekahi manawa a make ke ola? ʻO kekahi kumu o kēia, ʻo ia ka emi ʻana o ka nui o nā hunaola koko ʻulaʻula i loko o ke kino. Loaʻa i ko mākou kino kahi hormone koʻikoʻi e kōkua ana i ka hana ʻana o kēia mau hunaola koko ʻulaʻula. ʻO ia ka hormone a mākou e kamaʻilio ai i kēia lā. ʻO kona inoa ʻo Erythropoietin, a i ʻole EPO no ka pōkole.

He aha ka Erythropoietin?

I ka ʻōlelo maʻalahi, ʻo ka Erythropoietin kahi hormone i hana nui ʻia e ko kākou mau puʻupaʻa. ʻAe, ua lohe pololei ʻoe, ke noʻonoʻo kākou i nā puʻupaʻa, manaʻo wale kākou i ka hana ʻana o ka mimi, akā ʻoi aku ka nui o ka hana a nā puʻupaʻa i loko o ko kākou kino. ʻO kekahi hana koʻikoʻi, ʻo ia ka hana ʻana i kēia hormone (EPO). Kōkua kēia hormone (EPO) i ka mālama ʻana i kahi helu olakino o nā hunaola koko ʻulaʻula, ʻo ia hoʻi, nā erythrocytes, i loko o ko kākou kino.

I kekahi manawa, hoʻohana nā kauka i kahi ʻano synthetic o ka erythropoietin e mālama i ka anemia , ʻoiai i nā kūlana e like me ka maʻi puʻupaʻa mau. Eia kekahi, hoʻohana hewa kekahi mau mea pāʻani i kēia lāʻau lapaʻau e hoʻomaikaʻi i kā lākou hana. No ka mea, hoʻonui ka EPO i ka nui o ka oxygen e hiki aku i ko lākou mau ʻiʻo. He kū ʻole anei kēlā i ke kānāwai? ʻAe?

ʻO nā inoa ʻē aʻe no kēia erythropoietin e komo pū me ka erythropoietin, hematopoietin, a me ka hemopoietin. Eia naʻe, ua like ke ʻano o lākou a pau.

He aha ka lawelawe a ka erythropoietin (EPO) e hāʻawi ai i ko mākou kino?

ʻAe, e nānā kākou i ka hana a EPO. ʻO ka hana nui a EPO ke kōkua i ka hana ʻana i nā hunaola koko ʻulaʻula. ʻO kēia mau hunaola koko ʻulaʻula ka mea e lawe i ka oxygen i nā ʻiʻo i loko o ko kākou kino. Hoʻololi ʻia ka oxygen i ikehu, a laila hoʻokuʻu ʻia ke kalapona ʻokikene mai ko kākou mau ʻiʻo. Ke hanu ʻoe i waho, kōkua kēia mau hunaola koko ʻulaʻula like i ka wehe ʻana i kēlā kalapona ʻokikene.

ʻO kēia ka mea maʻamau e hana ʻia: Ke ʻike kahi ʻano cell kūikawā i loko o ko kākou mau puʻupaʻa ua haʻahaʻa ka pae oxygen i loko o ko kākou koko, hoʻonui lākou i kā lākou hana ʻana o (EPO). A laila haʻi aku kēia hormone (EPO) i ka ʻāpana huʻahuʻa o ko kākou mau iwi, ka iwi iwi, e hana i nā hunaola koko ʻulaʻula hou aʻe. E noʻonoʻo e like me ke kauoha ʻana i kahi hale hana.

Ke ʻike nā pūnaewele i loko o nā puʻupaʻa ua lawa ka oxygen i loko o ke koko, hoʻemi lākou i ka hana ʻana o ka erythropoietin. He hana paʻakikī loa kēia, akā he hana i kāohi maikaʻi ʻia.

Eia nō naʻe, hiki i kekahi mau kūlana olakino ke hoʻopilikia i ka nui o ka EPO i hana ʻia e nā puʻupaʻa. Hiki iā lākou ke hana nui a ʻaʻole paha e hana lawa. Hiki i kēia ke hana i nā pilikia me ka nui a i ʻole ka liʻiliʻi o nā hunaola koko ʻulaʻula.

He aha ka mea e hana ai inā piʻi aʻe ka pae o ka erythropoietin (EPO)?

Inā piʻi pono ʻole nā ​​pae EPO, ʻo ia hoʻi, inā ʻoi aku ka nui o ka EPO o ke kino ma mua o ka mea e pono ai, hiki ke piʻi pū ka nui o nā hunaola koko ʻulaʻula me ke kumu ʻole. Kāhea mākou i kēia polycythemia. Ua like ia me ke kaʻa ma ke alanui, i ka wā e nui loa ai nā hunaola koko ʻulaʻula, hiki ke keakea ʻia ke kahe o ke koko.

He aha nā kumu no ia piʻi ʻana o nā pae EPO?

Aia kekahi mau kumu e kiʻekiʻe loa ai nā pae EPO.

• ʻO ka lōʻihi o ka hoʻopili ʻana i nā pae oxygen haʻahaʻa: Hiki ke hana kēia i ka poʻe puhipaka a noho paha ma nā wahi mauna, kahi kiʻekiʻe ma luna o ka ʻilikai. ʻO kēia no ka mea ʻoi aku ka liʻiliʻi o ka oxygen i ka ea i kou piʻi ʻana. Eia nō naʻe, he mea maʻamau no kekahi e noho ana ma kahi mauna ke loaʻa nā pae kiʻekiʻe o ka EPO, ʻo ia ke ala no ke kino e hoʻomaʻamaʻa ai.
• ʻAʻole i hoʻokumu ʻia ka anemia e ka maʻi puʻupaʻa: I kekahi manawa, ʻaʻole i hoʻokumu ʻia ka anemia e ka pilikia puʻupaʻa. Eia nō naʻe, ke ʻike nā puʻupaʻa ua haʻahaʻa ke kino i nā hunaola koko ʻulaʻula, hana lākou i ka EPO hou aʻe e kōkua i ka hana ʻana i nā hunaola koko ʻulaʻula. He piʻi maʻamau a pono hoʻi kēia o ka EPO.
• Nā maʻi ʻaʻai laha ʻole: He mea kākaʻikahi loa, hiki i kekahi ʻano maʻi ʻaʻai ke hana i nā puʻupaʻa e hana i ka nui o ka EPO me ka pono ʻole.

He aha nā kumu o ka haʻahaʻa o ka erythropoietin (EPO)?

ʻO ke kumu nui a me ke kumu maʻamau o nā pae EPO haʻahaʻa, ʻo ia ka maʻi puʻupaʻa mau loa ( CKD ). Ke hōʻino ʻia nā puʻupaʻa, ʻaʻole hiki iā lākou ke hana i ka EPO lawa. ʻO kēia ke kumu o nā pae EPO haʻahaʻa. Hiki i kēia kūlana, me nā pae EPO haʻahaʻa, ke alakaʻi i ka anemia. Hiki iā ʻoe ke ʻike i ka nui o nā pilikia e hiki mai ana inā ʻaʻole hana pono nā puʻupaʻa, ʻeā?

Eia kekahi, hiki i kahi maʻi i kapa ʻia ʻo Polycythemia Vera ke kumu i nā pae EPO haʻahaʻa. He ʻano maʻi koko kēia. I loko o kēia, ʻo ka hoʻololi ʻana o ka genetic ke kumu o ko mākou iwi iwi e hana i nā hunaola koko ʻulaʻula he nui loa. A laila, ʻike nā puʻupaʻa he nui loa nā hunaola koko ʻulaʻula i loko o ke kino, a hoʻemi lākou i kā lākou hana ʻana o EPO.

Pehea e mālama ʻia ai nā pae erythropoietin haʻahaʻa (EPO)?

Inā haʻahaʻa kou pae EPO, ʻo ka mea mua e hana ai i ka wā e mālama ai iā ia, ʻo ia ke ʻimi i ke kumu kumu a mālama iā ia.

ʻO ke ala nui e mālama pololei ai i ka anemia i hoʻokumu ʻia e nā pae EPO haʻahaʻa, ʻo ia ka hoʻokomo ʻana i ka erythropoietin recombinant. Ua kapa ʻia kēia mau mea he erythropoietin-stimulating agents a i ʻole ESAs. ʻO kēia nā hormone EPO kūlohelohe a me kahi ʻano synthetic, a i ʻole i hana ʻia ma ka lab, o EPO. Hoʻopili nā kauka, a kope paha, i ka gene EPO a hāʻawi iā ʻoe ma ke ʻano he pana e hoʻoulu ai i ka hana ʻana o nā hunaola koko ʻulaʻula hou aʻe.

Hoʻohana nui ʻia kēia mau lāʻau pale (ESA) no ka mālama ʻana i nā maʻi puʻupaʻa mau loa.E mālama i ka anemia i hoʻokumu ʻia e ka hāʻule mau ʻana o nā puʻupaʻa. Hāʻawi ʻia nō hoʻi i nā poʻe me kekahi mau ʻano maʻi kanesa kakaʻikahi.

Eia nō naʻe, hiki i kēia mau lāʻau pale (ESA) ke hana i kekahi mau hopena ʻaoʻao. ʻAʻole loaʻa i nā kānaka a pau, akā hiki i kekahi poʻe ke:

• Ke koko kiʻekiʻe
• kuni
• Pōʻino
• Ka luaʻi
• ʻEha ma kahi i hoʻokomo ʻia

Ma mua o ka hoʻomaka ʻana i kēia ʻano lāʻau lapaʻau, he mea nui loa ia e kūkākūkā i kēia mau mea a pau me kāu kauka a nīnau i kāu mau nīnau.

Pehea e ana ai nā kauka i nā pae erythropoietin (EPO)?

Hiki i kāu kauka ke ana i kāu mau pae EPO me kahi hoʻāʻo koko. Hiki i kēia hoʻāʻo koko ke kōkua i ka hoʻoholo ʻana inā he mau loli i loko o kāu mau hunaola koko, e like me ka polycythemia, anemia, a i ʻole nā ​​kūlana ʻē aʻe o ka iwi iwi, ke hoʻopilikia nei i ka hana ʻana o EPO.

Eia nā mea āu e hana ai i ka wā e lawe ai i ke koko:

1. ʻO ka mea mua, e hoʻomaʻemaʻe i ka ʻili a puni ke aʻa koko ma kou lima me kahi mea e like me ka iodine a i ʻole ka isopropyl alcohol.

2. A laila, me ka hoʻohana ʻana i kahi nila lahilahi (ʻo ka maʻamau he 21 anana, ʻoi aku ka liʻiliʻi ma mua o kahi pou apo pepeiao maʻamau), lawe ʻia kahi koko liʻiliʻi mai kahi aʻa koko ma kou lima.

3. A laila hoʻouna ʻia ke koko i kahi keʻena hoʻokolohua no ka nānā ʻana.

Ke pau ka hoʻāʻo ʻana o ka lab i kāu hāpana koko, e kāhea aku kāu kauka iā ʻoe e kūkākūkā i nā hopena o ka hoʻāʻo a pane i nā nīnau āu e loaʻa ai. I kekahi manawa, ʻoiai inā aia kāu mau pae EPO i loko o ka pae maʻamau, pono paha ʻoe i nā lāʻau lapaʻau ʻē aʻe. E hoʻoholo ʻia kēia e kāu kauka.

He aha ka pae maʻamau o ka erythropoietin (EPO)?

Ana nā kauka i ka EPO ma nā milliunits no ka milliliter (mU/mL). Hiki i ka pae EPO o ke kanaka olakino ke piʻi mai 4 a 26 mU/mL.

Akā e hoʻomanaʻo, hiki ke ʻokoʻa iki kāu mau hopena hoʻāʻo (EPO) ma muli o kekahi mau kumu. Eia kekahi laʻana:

• kou mau makahiki
• Kou moekolohe pili kino
• Kou kūlana olakino holoʻokoʻa

No laila, ʻo kāu kauka ka mea nāna e kālailai pololei i kāu mau hopena a haʻi iā ʻoe inā olakino kāu mau pae (EPO) a ʻaʻole paha. Mai nānā wale i nā helu a lele i nā hopena, ʻae?

He aha nā ala e hoʻonui ai i nā pae erythropoietin (EPO) ma ke ʻano kūlohelohe?

Inā loaʻa iā ʻoe ka maʻi puʻupaʻa mau loa (CKD), a inā he anemia kou me nā pae EPO haʻahaʻa, hiki i kekahi mau hoʻololi i ka ʻai a me ke ʻano o ka nohona ke kōkua i ka hoʻonui iki ʻana i kāu mau pae EPO. Eia nō naʻe, pono e hana ʻia kēia mau mea me ka ʻōlelo aʻoaʻo lapaʻau wale nō.

• Hoʻoikaika Kino: Ua hōʻike ʻia e ka noiʻi ke hoʻoikaika kino mau ʻoe, ma kahi ikaika kūpono (hoʻoikaika kino ikaika), hoʻohana kou kino i ka oxygen hou aku. A laila haʻi aku kou lolo i kou kino e hana i ka EPO hou aku. ʻO nā hiʻohiʻona o kēia ʻano hoʻoikaika kino he paikikala, holo wikiwiki, a me ka ʻauʻau ʻana.
• Hao meaʻai: ʻO ka hao kahi ʻāpana nui o ka hemoglobin. Kōkua kēia hemoglobin i ka lawe ʻana i ka oxygen i nā hunaola o ko kākou kino. ʻO nā meaʻai waiwai i ka hao e komo pū me ka ʻiʻo ʻulaʻula, nā yolks hua manu, ke akepaʻa, ka tofu, a me nā meaʻai i hoʻonui ʻia me ka hao (e.g., kekahi mau cereals, berena, a me ka pasta).

Akā, ʻaʻole paha e nui ka ʻokoʻa o kēia mau mea wale nō, ʻoiai inā koʻikoʻi ke kūlana kumu. No laila, he mea nui e hahai i ka ʻōlelo aʻo a kāu kauka.

Nā mea āu e hoʻomanaʻo ai mai kēia mau mea a pau (Leka Lawe-Home)

He hormone koʻikoʻi loa ka Erythropoietin e haʻi ana i ko kākou iwi iwi e "hana i nā hunaola koko ʻulaʻula hou aʻe." Eia nō naʻe, i kekahi manawa hana pono ʻole ko kākou kino i nā hunaola koko ʻulaʻula he nui, a ʻaʻole paha i lawa. Hiki i kēia mau mea ʻelua ke hoʻopilikia i ke olakino.

Inā ʻoe e luhi mau ana a palaualelo, mai hoʻowahāwahā iā ia. Hiki iā ʻoe ke ʻike i ke kauka a nānā i kou mau pae koko (EPO). A laila hiki i ke kauka ke ʻōlelo i ka lāʻau kūpono loa nāu. E hoʻomanaʻo, he mea nui loa ke kaulike o kēia mau hormones no ke ola olakino.