Ke piʻi nei kou koko me ke kumu ʻole? E aʻo hou kākou e pili ana i ka Factor V Leiden Thrombophilia!

ʻAʻole like ko kākou mau kino a pau, ʻeā? I kekahi manawa, he mau ʻokoʻa liʻiliʻi paha ko kākou mau kino a kākou i ʻike ʻole ai. I kēia lā, e kamaʻilio kākou e pili ana i kekahi ʻano maʻi hoʻoilina, ka mea e hoʻoulu ai i ko kākou koko e paʻa nui loa, ʻo ia hoʻi, ʻoi aku ka nui o ka paʻa ʻana me ke kumu ʻole. Ua kapa ʻia kēia ʻo Factor V Leiden Thrombophilia .

No laila he aha ka Factor V Leiden?

I ka ʻōlelo maʻalahi, he maʻi koko hoʻoilina kēia. ʻO ia hoʻi, ua hānau ʻia ʻoe me kahi loli i loko o kāu mau genes. ʻOi aku ka maʻalahi o kēia loli i kou koko e koko ma mua o ka maʻamau. Hoʻokomo kēia iā ʻoe i kahi pilikia kiʻekiʻe o ka loaʻa ʻana o nā kūlana e like me:

• ʻO ka Thrombosis Vein Deep (DVT): ʻO kēia ka wā e hana ʻia ai nā ʻōpū koko i loko o nā aʻa koko hohonu o kou kino, ʻoi aku hoʻi i kou mau wāwae a i ʻole nā ​​​​lima. Eia nō naʻe, hiki iā lākou ke hana i kekahi manawa i loko o nā aʻa koko ma nā wahi e like me ke akepaʻa, nā puʻupaʻa, ka lolo, a me nā maka.
• ʻO ka Pulmonary Embolism (PE) : He mea weliweli iki kēia. ʻO ka mea e hana ʻia ma ʻaneʻi, ʻo ia kekahi o nā ʻūpē koko i ʻōlelo ʻia ma luna, a i ʻole kahi ʻūpē koko i hana ʻia ma kahi ʻē, e haki ana, e hele ana ma ke kahe koko, a paʻa i loko o kekahi o kou mau māmā.

Akā eia ka mea, ʻoiai inā loaʻa iā ʻoe kēia maʻi, ʻaʻole ia he manaʻo e loaʻa maoli iā ʻoe kahi DVT a i ʻole PE . ʻO ka ʻoiaʻiʻo, ma kahi o ʻeiwa o ka ʻumi o ka poʻe me kēia maʻi, ʻaʻole loa lākou e loaʻa i kahi ʻōpū koko maʻamau i ko lākou ola. Eia nō naʻe, he mea nui e hoʻomaopopo he ʻoi aku kou pilikia ma mua o nā poʻe ʻē aʻe.

ʻOkoʻa ka nui o kēia maʻi 'Factor V Leiden' ma waena o nā hui lāhui like ʻole. ʻIke pinepine ʻia ia ma waena o ka poʻe keʻokeʻo ma ʻAmelika Hui Pū ʻIa a me ʻEulopa.

• Ma kahi o 5 o 100 mau kānaka o ka hanauna ʻEulopa.
• Ma kahi o 2 o 100 mau kānaka no ka ʻohana Hispanika.
• Ma kahi o 1 i loko o 100 poʻe he ʻeleʻele a he ʻōiwi ʻAmelika paha.
• Ma waena o nā kānaka o ka lāhui ʻAsia, ʻoi aku ka liʻiliʻi ma mua o 1 i loko o 100.

Eia nō naʻe, ua ʻike ʻia ma kahi o hoʻokahi o kēlā me kēia ʻelima poʻe me nā ʻūpā koko i loko o ko lākou mau aa koko he ʻano gene `Factor V Leiden`. Ua kapa ʻia kēia ʻo ``Factor V Leiden.'' ʻO ka leka V ke kū nei no ka helu Roma no ʻelima.

He aha nā hōʻailona o kēia maʻi?

Eia kekahi mea e hoʻomanaʻo ai: ʻO kēia hoʻololi ʻana o ka genetic wale nō ʻaʻole ia e hoʻoulu i kekahi mau hōʻailona . Hiki iā ʻoe ke loaʻa iā ia no ke koena o kou ola me ka ʻike ʻole. Eia nō naʻe, e like me ka mea i ʻōlelo ʻia ma mua, ʻike wale ʻia nā hōʻailona inā hana ʻia kahi ʻūpā koko.

He mea nui: Inā manaʻo ʻoe he mau hōʻailona kou o ka `DVT` a i ʻole `PE`, e kelepona koke i ka 911 a i ʻole kāu helu ulia pōpilikia kūloko . A i ʻole, e hele koke i ka keʻena ulia pōpilikia o ka haukapila kokoke loa me kekahi. ʻAʻole kēia he mea e hoʻopaneʻe ai.

ʻO nā hōʻailona o ka thrombosis vein hohonu (DVT) hiki ke komo pū me:

• Ka pehu ʻana o ka wāwae a i ʻole ka lima, ka wela ke pā, a me ka loli ʻana o ke kala o ka ʻili (e huli ana paha i ka ʻulaʻula a i ʻole ka polū).
• ʻEha ka manaʻo i ka pā ʻana i kēlā wāwae a lima paha, ʻeha i ke kaomi ʻana .
• ʻOi aku ka nui o nā aʻa koko ma lalo o ka ʻili ma mua o ka maʻamau a ʻike ʻia ma ka ʻili .
• Inā hoʻokumu ʻia nā ʻōpū koko i loko o nā aa koko i loko o ka ʻōpū, hiki iā ʻoe ke ʻeha i ka ʻōpū a i ʻole ka ʻeha ma ka ʻōpū lalo .
• Inā hoʻokumu ʻia nā ʻūpā koko i loko o ka lolo, hiki iā lākou ke hana i nā ʻeha poʻo koʻikoʻi a me/a i ʻole nā ​​hopu ʻana .

ʻO nā hōʻailona o ka embolism pulmonary (PE) e komo pū paha:

• Ka paʻakikī koke o ka hanu ʻana .
• ʻEhaʻeha nui ma ka umauma i ka wā e hanu hohonu ai, e ʻū ana, a i ʻole e ʻūhā ana.
• ʻŪhū, i kekahi manawa me kahi koko liʻiliʻi e puka mai ana me ka huʻa .
• Ke kani ʻana o ka hanu ʻana i ka wā e hanu ana.
• Ka puʻuwai wikiwiki loa (tachycardia) .
• Ka manaʻo hopohopo a me ka hoʻomaha ʻole .
• Ke poniuniu nei, me he mea lā e nalowale ana kou ʻike (kākaʻikahi paha, hiki paha iā ʻoe ke nalowale ka ʻike) .

He aha ke kumu o ka Factor V Leiden?

ʻO ke kumu nui o kēia, he ʻano ʻokoʻa o ka gene . Aia kahi protein i loko o ko kākou kino e kōkua ana i ke kāpili ʻana o ke koko, ua kapa ʻia ʻo 'Coagulation factor V' . I mea e pololei ai, kōkua ia i ka hoʻōki ʻana i ke kahe ʻana o ke koko ke loaʻa kahi ʻeha. No laila, ua kauoha ʻia ko kākou kino e hana i kēia protein e kahi gene i kapa ʻia ʻo 'F5' .

ʻO ka maʻamau, loaʻa iā kākou āpau ʻelua kope maʻamau o kēia gene 'F5'. Eia nō naʻe, inā loaʻa iā ʻoe hoʻokahi a ʻoi aku paha kope ʻē aʻe o kēia gene, ua ʻōlelo ʻia he ʻano 'Factor V Leiden' ʻoe (i kekahi manawa i kapa ʻia he 'mutation'). ʻO ka inoa ʻo 'Leiden' mai ke kūlanakauhale ʻo Leiden ma Netherlands kahi i ʻike ai nā kānaka noiʻi i kēia ʻano gene.

ʻO kēia ʻano gene `Factor V Leiden` ke kumu o kahi loli liʻiliʻi i ke ʻano o ka protein `factor V` i hana ʻia i loko o ko kākou kino. Ma muli o kēia loli, ua kūʻē kēia protein `factor V` i hoʻololi ʻia i ka hana a ʻelua mau protein koʻikoʻi ʻē aʻe e kāohi ana i ke kāpili ʻana o ke koko , ʻo Protein C (`Protein C`) a me Protein S (`Protein S`) . I ka ʻōlelo maʻalahi, ʻaʻole hiki i kēlā mau protein e kāohi ana ke hoʻōki iā ia. A laila, lilo ka protein `factor V` i ʻoi aku ka hana ma mua o ka mea e pono ai, a hoʻomaka ke koko e kāpili pono ʻole, ʻoiai inā ʻaʻole pono.

He mea kēia e laha aku ana mai kekahi ʻohana a i kekahi ʻohana?

ʻAe, ʻoiaʻiʻo nō. Hiki iā ʻoe ke hoʻoilina i kēia maʻi mai kou makuahine a i ʻole kou makuakāne, a i ʻole nā ​​mea ʻelua. Hoʻoilina ʻia ʻo Factor V Leiden ma ke ʻano hoʻoilina autosomal dominant.ʻO ia hoʻi, inā loaʻa iā ʻoe kēia ʻano gene maʻamau ʻole mai kekahi o kou mau mākua, hiki iā ʻoe ke hoʻoilina i kēia ʻano.

Hoʻoilina ka hapa nui o nā kānaka (me Factor V Leiden) i hoʻokahi kope ʻē aʻe o ka gene. Ua kapa ʻia kēia he heterozygous . He mea kākaʻikahi loa, hiki iā ʻoe ke hoʻoilina i nā kope ʻē aʻe ʻelua o ka gene mai kou makuahine a me kou makuakāne. Ua kapa ʻia kēia he homozygous .

He aha nā kumu ʻē aʻe e hoʻonui ai i ka pilikia o nā ʻūpā koko?

ʻOi aku ka nui o ka hoʻomohala ʻana o ke koko i kahi kanaka me Factor V Leiden inā:

• Inā ua hoʻoilina ʻoe i nā kope ʻelua o ka gene 'F5' ʻano ʻē e like me ka mea i ʻōlelo ʻia ma mua (inā he 'homozygous' ʻoe) .
• Inā he moʻolelo ko kou mau hoahānau koko (e like me ka makuahine, ka makuakāne, nā kaikaina) o DVT a i ʻole PE .
• Inā he mau pilikia ʻē aʻe kou e pili ana i ke koko .
• Inā ʻoe e hana ʻia ana i ke ʻoki kino (ʻoi aku hoʻi ma hope o ke ʻoki kino nui, no ka mea, e noho ana ʻoe ma kahi hoʻokahi no ka manawa lōʻihi).
• Inā hāpai ʻoe (i kēia manawa, hiki i nā loli hormonal a me ka pēpē ke hoʻokau i ke kaomi ma nā aʻa koko).
• Inā ʻoe e lawe ana i kekahi mau ʻano pila hoʻomalu hānau (loaʻa ka estrogen) a i ʻole ka lāʻau hoʻololi hormone .

Inā loaʻa iā ʻoe kekahi o kēia mau mea pilikia, he mea nui loa e kamaʻilio me kāu kauka a aʻo e pili ana i ka pilikia o nā ʻūpā koko a me nā hana palekana hiki iā ʻoe ke hana.

He aha nā pilikia e hiki ke hana ma muli o kēia ʻano?

Inā loaʻa iā ʻoe ka Factor V Leiden Thrombophilia, hiki iā ʻoe ke ʻike i kēia mau mea:

• Ke ulu nei i kahi `DVT` a i ʻole `PE` ma mua o 50 mau makahiki .
• ʻOi aku ma mua o hoʻokahi manawa, ʻo ia hoʻi nā hanana pinepine o `DVT` a i ʻole `PE`.
• Hoʻokumu ʻia nā ʻūpā koko i loko o nā aa koko e hana maʻamau ana i nā ʻūpā koko liʻiliʻi , no ka laʻana, i loko o nā aa koko o ke akepaʻa, ka lolo, a me nā puʻupaʻa.
• ʻO DVT a i ʻole PE i ka wā hāpai a ma hope paha o ka hānau keiki ʻana .
• Hiki ke hana ʻia ka DVT a i ʻole PE i loko o kahi manawa pōkole ma hope o ka hoʻomaka ʻana i nā pila hoʻomalu hānau .

Pehea e ʻike ai nā kauka i kēia maʻi?

Hiki i nā kauka ke ʻike inā loaʻa iā ʻoe kēia maʻi ma o nā hoʻāʻo koko . Hiki i kēia ke komo pū me ka hoʻāʻo genetic . Hiki i kāu kauka ke kuhikuhi i ka hoʻāʻo ʻana no kēia maʻi, ʻoiai:

• Inā ua loaʻa iā ʻoe kahi DVT a i ʻole PE ma mua , ʻoiai inā i hana ʻia i ka wā ʻōpio ma mua o ka mea i manaʻo ʻia.
• Inā loaʻa i kekahi a ʻoi aku paha o kou mau hoahānau koko kahi moʻolelo o nā ʻōpū koko .

Pehea e mālama ʻia ai ʻo Factor V Leiden?

He maʻi no ke ola holoʻokoʻa ka Factor V LeidenʻO ia hoʻi, ʻaʻohe lāʻau lapaʻau kūikawā a lāʻau lapaʻau paha no kēia ʻano gene. Akā, hana nā lāʻau lapaʻau e hoʻoheheʻe i nā ʻōpū koko e kū nei a hōʻemi i ka pilikia o nā ʻōpū koko e hiki mai ana . Hiki i kāu kauka ke ʻōlelo i nā lāʻau lapaʻau e like me:

• Nā lāʻau lapaʻau anticoagulant (ʻike ʻia hoʻi he mau mea hoʻokahe koko) : Kōkua kēia i ka hoʻoheheʻe ʻana i nā ʻōpū koko e kū nei a pale i ka hoʻokumu ʻana o nā ʻōpū koko hou.
• Nā kāmaʻa hoʻopaʻa : He mau kāmaʻa paʻa kūikawā kēia i hoʻokomo ʻia ma nā wāwae e hoʻomaikaʻi i ke kahe koko a hōʻemi i ka pilikia o nā ʻūpā koko.
• Ke kau ʻana o ka kānana Vena cava : He mea liʻiliʻi kēia i kau ʻia i loko o kahi aa koko nui e pale aku i nā ʻūpē koko mai ka hele ʻana i nā māmā. ʻAʻole pono nā kānaka a pau.
• Wehe ʻana i nā ʻōpū koko : I kekahi mau hihia, pono paha ke ʻoki ʻana e wehe i nā ʻōpū koko nui.

ʻO ka lōʻihi o kou lawe ʻana i ka lāʻau hoʻokahe koko e pili ana i kou pilikia o ka loaʻa ʻana o kahi ʻūpā koko ʻē aʻe. Pono kekahi poʻe e lawe i kēia lāʻau no kekahi mau mahina wale nō. Pono paha kekahi e lawe iā ia no ka manawa lōʻihi, a hiki i ke koena o ko lākou ola. E wehewehe kāu kauka i ka hoʻolālā lapaʻau kūpono loa iā ʻoe.

Āhea ʻoe e ʻike ai i ke kauka?

Inā ʻike ʻoe he maʻi kou, he mea nui e launa mau me ke kauka.

• E hele i kahi hoʻokolohua lapaʻau ma ka liʻiliʻi i hoʻokahi manawa i ka makahiki .
• Inā loaʻa iā ʻoe kahi DVT a i ʻole PE a ke loaʻa nei ka lāʻau lapaʻau, pono ʻoe e ʻike i kāu kauka no nā manawa hoʻopaʻa maʻamau e ʻike ai pehea e hele nei ka lāʻau lapaʻau.
• Inā ʻoe e lawe ana i kahi lāʻau hoʻokahe koko e like me Warfarin , pono ʻoe e hana i kahi hoʻāʻo koko (Prothrombin time test - PT/INR test) i nā manawa maʻamau e nānā ai inā hana pono ka lāʻau lapaʻau a pololei ka dosage.

Eia kekahi, he mea nui e kamaʻilio me ke kauka i nā hihia e like me kēia:

• Ma mua o ka hoʻohana ʻana i ka kaohi hānau (ʻoi aku hoʻi ka poʻe i loaʻa ka estrogen).
• Ma mua o ka hoʻomaka ʻana i ka lāʻau hoʻololi hormone .
• Inā ʻoe e hoʻolālā e hāpai, ma mua o kēlā .

He aha ka ʻōlelo a kēia e pili ana i ka manaʻolana ola?

No ka hapa nui o nā kānaka, ʻaʻole pili ka loaʻa ʻana o Factor V Leiden i ko lākou ola maʻamau . ʻOiai inā loaʻa iā ʻoe kahi ʻūpā koko, inā loaʻa iā ʻoe ka lāʻau lapaʻau koke a kūpono, hiki iā ʻoe ke pale i nā hopena koʻikoʻi . Inā he mau hopohopo kāu e pili ana i kou manaʻolana ola a i ʻole nā ​​​​pilikia e hiki mai ana, e kamaʻilio me kāu kauka e pili ana iā lākou.

He aha kā mākou e pale aku ai inā loaʻa iā mākou ʻo Factor V Leiden?

E hāʻawi kāu kauka iā ʻoe i ka ʻōlelo aʻoaʻo e pili ana i kou kūlana pilikino, akā ma ke ʻano laulā, ʻoi aku ka maikaʻi o ka pale ʻana i kēia mau mea:

• Ka puhipaka, ka vaping, a me ka hoʻohana ʻana i nā huahana paka ʻē aʻe .
• Ke noho ʻana ma ke kūlana like no ka manawa lōʻihi (e.g., ka hana ʻana ma ke keʻena, ka holo ʻana ma kahi kaʻa a kaʻaahi paha, a i ʻole ka lele ʻana no nā hola). Inā hiki, e ala a hele wāwae ma ka liʻiliʻi hoʻokahi manawa i ka hola.
• E pale i ka inu nui ʻana i ka waiʻona , ʻoiai hoʻi i nā mokulele lōʻihi.
• ʻO nā lāʻau hoʻomalu hānau a me ka lāʻau hoʻololi hormone i loaʻa ka estrogen (pono ʻoe e kamaʻilio me kāu kauka ma mua o ka hoʻohana ʻana i kēia mau mea).

He mea like anei ka hemahema o ka Factor V a me ka Factor V Leiden?

ʻAe, mai huikau i nā mea ʻelua. He ʻelua mau kūlana genetic ʻokoʻa loa kēia. Eia nō naʻe, pili kēia mau kūlana ʻelua me nā ʻokoʻa o ka gene 'F5'.

Ma ka Factor V Leiden Thrombophilia, ʻo kahi loli hoʻoilina ke kumu e maʻalahi ai ke koko e pipili.

Eia nō naʻe, ma ke ʻano i kapa ʻia ʻo 'Factor V deficiency' , pale kahi hoʻololi genetic i kou koko mai ke kāpili pono ʻana i ka wā e pono ai. ʻO ke ʻano kēia ua pilikia ʻoe i ke kahe koko. ʻO ka 'Factor V deficiency' kahi maʻi kahe koko kakaikahi loa (ma kahi o hoʻokahi i loko o ka miliona). Hiki iā ia ke hana i nā mea e like me ke kahe pinepine ʻana o ka ihu, ke kahe nui ʻana o ke koko i ka wā o ka menstruation, a me ke kahe mau ʻana o ke koko ma hope o ke ʻoki kino.

ʻO ka mea hope loa, nā mea e hoʻomanaʻo ai

No laila, inā ʻike ʻoe ua loaʻa iā ʻoe a i ʻole kekahi āu i ʻike ai ka Factor V Leiden Thrombophilia, mai hopohopo koke. E hoʻomanaʻo, hiki i ka hapa nui o ka poʻe me kēia maʻi ke ola i kahi ola olakino me ka ʻole o ka hoʻomohala ʻana i nā ʻōpū koko .

Eia nō naʻe, inā loaʻa iā ʻoe kahi ʻūpā koko, aia nā lāʻau lapaʻau kūpono i loaʻa . ʻO ka mea nui loa, ʻo ia ka hahai pono ʻana i nā ʻōlelo a kāu kauka, e kiʻi i nā hoʻokolohua a me ka lāʻau lapaʻau āu e pono ai, a e ola i kahi ola maʻamau a hauʻoli me ke kūlana, e hoʻokele pono ana ma mua o ka lilo ʻana i pilikia.

ʻO Factor V Leiden, Thrombophilia, ke koko ʻana, DVT, PE, maʻi hoʻoilina, nā ʻōpala koko, maʻi hoʻoilina