He manaʻolana hou no nā maʻi Alzheimer? E kamaʻilio kākou e pili ana i kēia lāʻau lapaʻau hou (Donanemab).

Inā loaʻa kekahi o kou ʻohana, ʻo kou makuahine aloha paha, kou makuakāne, a kupuna wahine paha, i ka maʻi Alzheimer, ua ʻike mākou i kona ʻeha. He mea kaumaha loa ka ʻike ʻana i ka nalo mālie ʻana o ka hoʻomanaʻo o kāu mea aloha. Eia naʻe, i waenakonu o kēia kūlana paʻakikī, ke kamaʻilio nei mākou e pili ana i kahi nūhou e lawe mai ana i kahi manaʻolana iki. ʻAʻole kēia he lāʻau lapaʻau piha no ka maʻi, akā hiki ke lilo i mea nui i mua.

He aha kēia nūhou hou?

I kēia mau lā aku nei, ua ʻae like kahi papa kūkākūkā o ka US Food and Drug Administration (FDA) i kahi lāʻau lapaʻau hou no Alzheimer's. ʻO ka inoa o ka lāʻau lapaʻau ʻo donanemab . Paipai ʻia no nā poʻe maʻi i nā pae mua o ka maʻi. ʻO ka ʻae ʻia ʻana o kēia papa kūkākūkā, ʻo ia hoʻi, he nui ka manawa e hāʻawi koke ai ka FDA i ka ʻae piha i kēia lāʻau lapaʻau. He mea nui maoli kēia, no ka mea, ʻo ka hiki ʻana mai o kahi lāʻau lapaʻau hou no kahi maʻi koʻikoʻi e like me Alzheimer's, he manaʻolana nui ia.

Pehea ka hana a Donanemab?

ʻAe, e nānā kākou pehea e hana ai kēia lāʻau. He mea paʻakikī iki kēia, akā e wehewehe maʻalahi wau. ʻO Donanemab kahi ʻano lāʻau i kapa ʻia he monoclonal antibody . I ka ʻōlelo maʻalahi, he protein kūikawā ia i hana ʻia ma ka lab e hoʻouka i kahi pahuhopu kikoʻī me ka hoʻohana ʻana i nā ʻāpana o kā mākou ʻōnaehana pale ponoʻī. He aha ka pahuhopu o kēia lāʻau? ʻO nā plaques amyloid ia, i manaʻo ʻia he kumu nui o ka maʻi Alzheimer. E like me ka hōʻiliʻili ʻana o ka ʻōpala i loko o kā mākou mau paipu wai, hōʻiliʻili kēia mau plaques ma waena o nā cell nerve i loko o ka lolo a hoʻopilikia i kā lākou hana. ʻO ka hana a Donanemab, ʻo ia ke ʻike i kēia mau plaques a kōkua i ka wehe ʻana iā lākou.

Pehea ka maikaʻi o kēia lāʻau lapaʻau?

Wahi a nā hopena o nā hoʻokolohua lapaʻau i paʻi ʻia i ka makahiki i hala, hiki i kēia lāʻau lapaʻau ke hoʻolohi i ka wikiwiki o ka hoʻonui ʻia ʻana o ka maʻi i loko o kekahi mau mahina.Ua hiki nō. Ana ʻia kēia ma o nā hoʻokolohua e ana i nā hiki noʻonoʻo o nā maʻi (e laʻa, ka hoʻomanaʻo, ka hoʻoponopono pilikia) a pehea lākou e hana maikaʻi ai i nā hana o ke ola o kēlā me kēia lā (e laʻa, ka hoʻokele kaʻa, ka hoʻokele kālā). Kāhea kekahi poʻe loea i kēia mau hopena he mau hopena haʻahaʻa a "maʻamau". ʻO ia hoʻi, ʻaʻole hiki iā ʻoe ke manaʻo i kahi ʻokoʻa nui mai kēia. Akā he mea maikaʻi nō hoʻi ka hiki ke hoʻolohi ʻia ka maʻi i loko o kekahi mau mahina wale nō, ma mua o ka ʻoi aku ka ʻino me ka ʻole o ka lāʻau lapaʻau. No ke ʻano o ka hāʻawi ʻana i ka lāʻau lapaʻau, hāʻawi ʻia ka lāʻau lapaʻau i nā maʻi i kēlā me kēia mahina ma o kahi vein (infusion). ʻO ka poʻe i komo i nā hoʻokolohua ua hāʻawi ʻia kēia lāʻau lapaʻau no kahi o hoʻokahi makahiki a me ka hapa.

Aia nā pono a me nā pilikia koʻikoʻi.

E like me nā lāʻau ikaika a pau, loaʻa iā donanemab nā pono a me nā hopena ʻaoʻao koʻikoʻi a me nā pilikia. He mea nui e hoʻomaopopo i nā ʻaoʻao ʻelua ma mua o ka hoʻoholo ʻana. Me kēia mau noʻonoʻo āpau, ua hoʻoholo hope ka papa aʻoaʻo FDA ʻoi aku ka nui o nā pono o kēia lāʻau lapaʻau ma mua o kona mau pilikia.ʻO ia hoʻi, inā hāʻawi ʻia i nā maʻi kūpono, ma lalo o ka nānā pono ʻana, ʻoi aku ka nui o nā pono.

ʻO kēia wale nō anei ka lāʻau lapaʻau hou i loaʻa?

ʻAʻole. Aia kekahi lāʻau lapaʻau ʻē aʻe e hana like ana. Ua kapa ʻia ʻo lecanemab . Hana pū kēlā lāʻau lapaʻau ma ke kuhikuhi ʻana i nā platelets e hōʻiliʻili ana i loko o ka lolo. Ua loaʻa iā ia ka ʻae ʻia e ka FDA i Iulai 2023. ʻO Donanemab kekahi ʻanuʻu i kēlā huakaʻi. Loaʻa i nā hui alakaʻi o ka honua no Alzheimer's nā manaʻolana kiʻekiʻe no nā lāʻau lapaʻau hou e like me kēia. ʻŌlelo lākou, "ʻO ka nui o nā lāʻau lapaʻau i ʻae ʻia e like me kēia e puka mai ana, ʻoi aku ka nui o ka manawa kūpono o nā maʻi e kūpono no lākou. Ke holomua nei ka holomua ma ke ʻano o ka lāʻau lapaʻau." I kēia manawa, miliona mau kānaka a puni ka honua e ʻeha nei i ka maʻi Alzheimer. ʻAʻohe ala e pale loa ai a hoʻōla paha i kēia maʻi. No laila, ʻo nā lāʻau lapaʻau e like me donanemab he mau hanana koʻikoʻi loa ia i kēlā huakaʻi lōʻihi. ʻO ka maʻi o Alzheimer, donanemab, maʻi lolo, nalowale o ka hoʻomanaʻo, dementia, nā lāʻau lapaʻau hou, monoclonal antibody