Aia kekahi moʻolelo ʻohana o ka maʻi kanesa? E aʻo kākou e pili ana i ka Lynch Syndrome

I kekahi manawa ke nīnau nei mākou iā mākou iho, "He moʻolelo ʻohana koʻu no ka maʻi kanesa, no laila ke noʻonoʻo nei au inā paha e loaʻa iaʻu kekahi." ʻO ka ʻoiaʻiʻo, hiki ke hana ʻia kekahi mau ʻano maʻi kanesa e nā mana genetic i hoʻoili ʻia mai kēlā hanauna a i kēia hanauna. No ka laʻana, ʻo Lynch Syndrome kahi maʻi e hoʻonui nui ai i ka pilikia o ka maʻi kanesa, akā ʻaʻole i kamaʻilio nui ʻia. He mea nui loa ka ʻike i kēia. No laila e kamaʻilio wale kākou e pili ana i kēia lā.

I ka ʻōlelo maʻalahi, he aha ka Lynch Syndrome?

ʻO ka Lynch syndrome kahi maʻi genetic i hoʻoili ʻia mai ka makua a i ke keiki, a i ʻole ka hoʻoilina . ʻOi aku ka nui o ka manawa o ke kanaka me kēia maʻi, a i ʻole ka pilikia, e hoʻomohala i kekahi mau ʻano maʻi kanesa ma mua o nā mea ʻē aʻe.

ʻO ke kikoʻī, ʻo ka mea me kēia maʻi he 40% a 80% kiʻekiʻe aʻe ka manawa e loaʻa ai ka maʻi ʻaʻai colorectal i ka piha ʻana o 70 makahiki. Aia kekahi pilikia kiʻekiʻe aʻe o ka loaʻa ʻana o ka maʻi ʻaʻai o ka uterus, nā ovaries, a me ka ʻōpū. ʻO ka mea kūikawā e pili ana i kēia, hiki i ka maʻi ʻaʻai ke ulu ma mua o ka makahiki maʻamau o ka maʻi ʻaʻai, malia paha i nā makahiki 30 a 40 paha.

He aha ke kumu o kēia kūlana?

I mea e hoʻomaopopo ai i kēia, e noʻonoʻo kākou i ko kākou kino no kekahi manawa. Ua hana ʻia ko kākou kino me nā piliona o nā cell. Ke māhele mau nei kēia mau cell a hana i nā cell hou. E noʻonoʻo e like me ka hana kope ʻana me kahi mīkini kope. Ke māhele ʻia nā cell ma kēia ʻano, i kekahi manawa loaʻa nā hewa liʻiliʻi. Akā, ʻo ka mea pōmaikaʻi, aia i loko o ka DNA o ko kākou kino nā 'mismatch repair genes' kūikawā e ʻike ana i kēia mau hewa a hoʻoponopono iā lākou.

He kīnā a hewa paha ko kekahi kanaka me ka maʻi Lynch i kekahi o kēia mau 'gene checker' . A laila, i ka wā e māhele ʻia ai kēlā mau cell, ʻaʻole i hoʻoponopono ʻia nā hewa ʻē aʻe, a hoʻomau ka māhele ʻana o nā cell hemahema, a hoʻomaka nā cell hemahema he nui e hana i loko o ke kino. I ka hala ʻana o ka manawa, lilo kēia mau cell hemahema i maʻi kanesa.

Inā loaʻa kēia maʻi i kou makuahine a makua paha, he 50% ka manawa kūpono e hoʻoilina ai iā ia.

He aha nā hōʻailona e hōʻike ana i ka Lynch Syndrome?

Aia kekahi mau kumu koʻikoʻi e hiki ke hoʻāla i nā hopohopo e pili ana i kēia maʻi. Inā pili kekahi a ʻoi aku paha o kēia mau mea iā ʻoe a i kou ʻohana paha, he mea nui loa ke kamaʻilio me ke kauka.

Pehea e ʻike ai i kēia maʻi?

Inā ua loaʻa iā ʻoe a i ʻole kekahi o kou ʻohana ke kanesa a manaʻo kāu kauka he maʻi Lynch syndrome paha ia, hiki ke hoʻāʻo ʻia kahi hāpana liʻiliʻi o ke kanesa. ʻElua ala nui e hana ai i kēia:

• Hoʻāʻo Immunohistochemistry (IHC): Hoʻāʻo kēia no nā ʻano protein i loaʻa i loko o nā cell cancer. Inā ʻaʻole i loko o kēlā mau cell nā protein i hana ʻia e nā 'checker genes' a mākou i kamaʻilio ai ma mua, he hōʻailona paha ia o ka Lynch syndrome.
• Hoʻāʻo paʻa ʻole o ka Microsatellite (MSI): Nānā pololei kēia i nā hewa i loko o ka DNA o nā hunaola kanesa.

Inā hōʻoia kēia mau hoʻokolohua he Lynch syndrome kou, a inā manaʻo ʻoe ua pilikia ʻoe no ka mea ua loaʻa i kekahi o kou ʻohana ke ʻano, hiki iā ʻoe ke hana i kahi hoʻokolohua genetic ma kahi hāpana koko e ʻike pono ai inā loaʻa iā ʻoe kēia kīnā genetic.

Kākoʻo mai kahi Kākā'ōlelo Genetic

I kēia manawa, e kuhikuhi paha kāu kauka iā ʻoe i kahi kākā'ōlelo genetic. E wehewehe lākou i nā mea he nui iā ʻoe e pili ana i kēia.

• Pehea i hoʻoilina ai ka Lynch syndrome i loko o kahi ʻohana.
• He aha ka manaʻo o nā hopena o kāu hōʻike hoʻāʻo genetic.
• Pehea e pili ai kēia mau hopena i kou pilikia o ka maʻi kanesa.
• ʻO ka hiki ke hoʻoilina kāu mau keiki i kēia gene mai ou aku.
• ʻO kāu mau koho e pale aku ai i ka maʻi kanesa.

Inā loaʻa iā ʻoe ka Lynch syndrome, pehea e mālama ʻia ai?

ʻO ka mea maikaʻi loa e hana ai ke ʻike ʻoe he maʻi kou, ʻo ia ke hele i nā hoʻokolohua maʻamau e nānā i ka maʻi kanesa. A laila, inā ulu ka maʻi kanesa, ʻoi aku ka nui o ka ʻike ʻia ʻana i ka wā mua loa a hoʻōla loa ʻia . No ka laʻana, hiki ke ho'ōla ʻia ka maʻi kanesa colon ma 90% o nā hihia inā ʻike mua ʻia.

Na kāu kauka e hoʻoholo i nā hoʻokolohua āu e pono ai e hana a me ka pinepine o kou pono ʻana iā lākou. ʻO nā hoʻokolohua i ʻōlelo pinepine ʻia penei:

• Nā Colonoscopies: E hoʻomaka ana i ka makahiki 20-25, hiki ke noi ʻia ʻoe e hana i kēia hoʻāʻo i kēlā me kēia makahiki a ʻelua paha. Nānā kēia i nā polyps a i ʻole nā ​​​​hōʻailona o ka maʻi kanesa i loko o ka ʻōpū nui.
• Endoscopy: Hoʻomaka i kou mau makahiki 30, hiki ke hana ʻia kēia i kēlā me kēia 3-5 mau makahiki e nānā i ka ʻōpū a me nā naʻau.
• Nā hoʻāʻo no nā wahine: Ma hope o 30 mau makahiki, hiki ke ʻōlelo ʻia nā hoʻokolohua e like me ka hoʻokolokolo pelvic, ka ultrasound transvaginal, a i ʻole ka biopsy uterine i kēlā me kēia makahiki e nānā i ka uterus a me nā ovaries.

Kamaʻilio kekahi poʻe, ʻoiai nā wāhine i loaʻa nā keiki, me kā lākou kauka e pili ana i ke ʻoki kino pale e hōʻemi i ko lākou pilikia o ka maʻi kanesa. ʻO ke ʻano kēia o ka wehe ʻana i ka colon, uterus, a i ʻole ovaries ma mua o ka ulu ʻana o ke kanesa. He hoʻoholo pilikino loa kēia.

Ke koʻikoʻi o kahi nohona olakino

ʻOiai ke loaʻa ʻana o nā nānā kino maʻamau, ʻo ka noho ʻana i kahi nohona olakino e kōkua pū i ka hōʻemi ʻana i kēia pilikia.

• E ʻai i ka meaʻai momona i nā mea kanu, nā huaʻai, nā legumes, a me nā palaoa holoʻokoʻa.
• E hana i ka hoʻoikaika kino maʻamau .
• E kāohi i kou kaumaha.
• E kaupalena i ka inu ʻana i ka waiʻona.

Ua hōʻike kekahi mau noiʻi e hiki i ka lawe ʻana i ka aspirin haʻahaʻa i kēlā me kēia lā ke hōʻemi i kēia pilikia, akā pono ka noiʻi hou aku ma kēia. No laila , mai hoʻomaka e lawe i ka lāʻau lapaʻau iā ʻoe iho me ka ʻole o ke kūkākūkā ʻana me kāu kauka.