Aia kekahi hewa me ka "mana" o kou kino? E aʻo kākou e pili ana i nā maʻi Mitochondrial!

Ke noʻonoʻo nei paha ʻoe i kekahi manawa no ke aha wau i luhi ai? A i ʻole he pilikia olakino ko kekahi o kou ʻohana, a he paʻakikī ke loaʻa i kahi kumu maopopo no ia mea? I kekahi manawa ʻo ke kumu o kēia he loli i kekahi o nā mea liʻiliʻi loa i loko o ko mākou kino. I kēia lā e kamaʻilio mākou e pili ana i kahi mea paʻakikī iki, akā he mea nui loa e ʻike. ʻO ia nā maʻi Mitochondrial.

He aha kēia mau mitochondria? He "hale mana" o ke kino?

I ka ʻōlelo maʻalahi, ʻo nā mitochondria nā mea kanu mana liʻiliʻi i loko o kēlā me kēia cell i loko o ko kākou kino. Ua like lākou me kahi kikowaena mana e hoʻopuka ana i ka uila e hoʻoikaika i ko kākou mau home. Ma ka hoʻohana ʻana i ka meaʻai a kākou e ʻai ai a me ka oxygen a kākou e hanu ai, hoʻopuka kēia mau mitochondria i 90% o ka ikehu e pono ai ko kākou kino e hana. E noʻonoʻo wale, pono ko kākou lolo i ka ikehu e hana, pono ko kākou naʻau i ka ikehu e kuʻi ai, pono ko kākou mau ʻiʻo i ka ikehu e hana ai. ʻO Mitochondria ke kumu nui o kēlā ikehu. ʻO ia ke kumu i kapa ʻia ai lākou ʻo "powerhouse of the cell."

No laila he aha nā maʻi mitochondrial?

I kēia manawa ua maopopo iā ʻoe ke koʻikoʻi o nā mitochondria. No laila, inā ʻaʻole hana pono kēia mau mea kanu mana i kapa ʻia ʻo mitochondria, a inā ʻaʻole hiki iā lākou ke hana i ka ikehu e like me ka mea e pono ai, ʻo nā maʻi e kū mai ana ua kapa ʻia ʻo nā maʻi mitochondrial. E like me ka haki ʻana o ke kahua mana a pau kā mākou hana me ka ʻole o nā kukui, inā ʻaʻole hana pono nā mitochondria i ka ikehu, ʻaʻole hiki i nā ʻōpū o ko mākou kino ke hana i kā lākou hana.

Hiki i kēia mau maʻi ke hoʻopilikia i kekahi ʻāpana o ke kino. Eia kekahi laʻana:

• I loko o ka lolo
• ʻŌnaehana nerve
• Nā ʻiʻo
• nā puʻupaʻa
• Puʻuwai
• Ake
• Nā maka
• Nā pepeiao
• ʻO ka pancreas

Hiki ke hoʻopilikia ʻia nā pūnaewele ma nā wahi āpau e like me kēia.

Aia kekahi mau ʻano maʻi mitochondrial?

ʻAe, ʻaʻole hoʻokahi maʻi ka maʻi mitochondrial, he nui nā ʻano. He paʻakikī iki kēia mau mea, a ʻo nā kauka ka poʻe nāna e ʻike pololei iā lākou. Akā no kou ʻike ma ke ʻano laulā, eia kekahi o nā ʻano maʻamau:

• ʻO ka encephalopathy mitochondrial, ka acidosis lactic, a me nā hōʻailona like me ka hahau (MELAS syndrome)
• ʻO ka neuropathy optic hereditary Leber (LHON)
• ʻO ka maʻi Leigh
• ʻO ka maʻi Kearns-Sayre (KSS)
• ʻO ka maʻi epilepsy myoclonic a me ka maʻi fiber ʻulaʻula (MERRF)

He mea ʻē paha kēia mau inoa, akā ʻo ia nā inoa i ʻike ʻia ai kēia mau maʻi i ka ʻepekema lapaʻau.

Pehea ka maʻamau o kēia mau maʻi?

Ua manaʻo ʻia aia ma kahi o hoʻokahi i loko o 5,000 mau kānaka e loaʻa i ka maʻi mitochondrial genetic.Akā he mea paʻakikī iki kēia. No ka mea, he ʻokoʻa loa nā hōʻailona o kēia mau maʻi a hoʻopilikia i nā ʻōnaehana kino like ʻole o ke kino, i kekahi manawa hiki ke ʻike ʻia ka maʻi ma hope, a i ʻole hiki ke kuhihewa ʻia he maʻi ʻē aʻe. No laila, ʻoi aku ka nui o ka poʻe me kēia maʻi.

He aha nā hōʻailona o nā maʻi mitochondrial?

He mea nui loa kēia. Hiki ke ʻokoʻa loa nā hōʻailona o nā maʻi mitochondrial mai kēlā kanaka a kēia kanaka. Eia kekahi, ʻokoʻa nā hōʻailona ma muli o ke ʻano a me kahi o nā cell i hoʻopilikia ʻia e ka maʻi. No kekahi poʻe, hiki ke maalea loa nā hōʻailona, ​​​​akā no kekahi poʻe, hiki ke koʻikoʻi loa.

ʻO kekahi o nā hōʻailona maʻamau e ʻike ʻia:

• Ka lohi o ka ulu ʻana (ʻoi aku hoʻi i nā keiki ʻōpio)
• Ka nāwaliwali o nā ʻiʻo, ka ʻeha o nā ʻiʻo, a i ʻole ka emi ʻana o ke kani o nā ʻiʻo
• Nā hemahema o ka ʻike a me/a i ʻole ka lohe
• Nā lohi o ka ulu ʻana a i ʻole nā ​​pilikia ulu noʻonoʻo (e like me nā pilikia aʻo)
• Nā pilikia ʻōpū e like me ka maʻi diarrhea a i ʻole ka constipation
• Ka luaʻi ʻana me ke kumu ʻole
• ʻO ka reflux waikawa a/a i ʻole ka pilikia o ka moni ʻana
• Loaʻa i ka maʻi (nā hopu)
• Nā migraines
• Paʻakikī ka hanu ʻana
• Ka mae ʻana

Hiki i kēia mau hōʻailona ke hoʻomaka i ka wā hānau, a i ʻole hiki ke ʻike ʻia i kēlā me kēia makahiki o ke ola. Hoʻomaopopo pinepine ke kauka i kēia ʻano maʻi ke ʻike ʻia nā hōʻailona ma mua o hoʻokahi ʻōnaehana kino i ka manawa like. ʻO ka mea kupanaha, ʻoiai nā poʻe o ka ʻohana hoʻokahi me ke ʻano like o ka maʻi mitochondrial hiki ke loaʻa nā hōʻailona like ʻole.

No ke aha e kū mai ai kēia mau maʻi mitochondrial?

I ka ʻōlelo maʻalahi, ʻo ke kumu nui o nā maʻi mitochondrial ʻo ia ka hiki ʻole o ka mitochondria i loko o kā mākou mau cell ke hana i ka ikehu lawa. I mea e hiki ai i ka mitochondria ke hana i ka ikehu, pono lākou e loaʻa nā kuhikuhi pololei mai kā mākou 'DNA' (genes). Inā he loli i kēia 'DNA' (kapa nā kauka i kēia he 'mutation'), ʻaʻole loaʻa i ka mitochondria kēlā mau kuhikuhi me ka pololei. A laila ua hoʻopilikia ʻia ka hana ʻana o ka ikehu. Hiki i kēia ke hōʻino i nā cell, a i ʻole hiki i nā cell ke make koke. ʻO kēia ka mea e hoʻopilikia ai i ka hana o kā mākou mau kino a hoʻoulu i nā hōʻailona.

Pehea e loaʻa ai i kekahi ka maʻi mitochondrial?

He hui nā maʻi mitochondrial o nā maʻi genetic. ʻO ia hoʻi, hiki iā kākou ke hoʻoilina iā lākou mai ko kākou mau mākua mai. Hiki ke loaʻa kēia hoʻoilina ma nā ʻano nui ʻelua:

1. Autosomal dominant: ʻO ke ʻano kēia hiki ke loaʻa ka maʻi ʻoiai inā ua hoʻoilina ʻia ka gene i hoʻololi ʻia e hoʻokumu ai i ka maʻi mai hoʻokahi makua wale nō.

2. Autosomal recessive: I kēia hihia, pono e hoʻoilina ʻia ka gene i hoʻopilikia ʻia mai nā mākua ʻelua i mea e hiki ai ke maʻi.

I kekahi manawa, ʻoiai inā ʻaʻohe mea o ka ʻohana i loaʻa i ka maʻi ma mua, hiki i kekahi ke loaʻa i ka maʻi ma muli o kahi loli genetic hou (ua kapa ʻia kēia he 'de novo mutation').

ʻO kekahi mea kūikawā ʻē aʻe,Ua hoʻoilina ʻia kekahi mau maʻi mitochondrial ma o kahi 'DNA' kūikawā i ka mitochondria. ʻAe, ua lohe pololei ʻoe i kēlā. Ma waho aʻe o ka 'DNA' i loko o ka nucleus o kā mākou mau cell, loaʻa pū kekahi i ka mitochondria kā lākou 'DNA' ponoʻī. ʻO nā maʻi mitochondrial i hoʻokumu ʻia e nā loli i loko o kēia 'DNA mitochondrial' ua hoʻoilina wale ʻia mai ka makuahine a i kāna mau keiki.

Hiki i nā pilikia olakino ʻē aʻe ke hoʻopilikia i ka mitochondrial?

ʻAe, ua kapa ʻia ʻo ia he hana ʻino lua o ka mitochondria . ʻO kēia ka manawa ʻaʻole hana pono nā mitochondria ma muli o kekahi maʻi a kūlana paha. ʻO kekahi o nā maʻi e hiki ke hana i kēia:

• ka maʻi o Alzheimer
• ʻO ka dystrophy muscular
• ʻAno 1 diabetes
• ʻO ka sclerosis lehulehu (MS)
• Ka maʻi ʻaʻai

Inā loaʻa iā ʻoe ka maʻi mitochondrial lua, ʻaʻole ia he maʻi mitochondrial genetic.

He aha nā mea pilikia no ka hoʻomohala ʻana i nā maʻi mitochondrial?

Inā loaʻa i kekahi o kou ʻohana kēia maʻi, a inā he maʻi ʻē aʻe kou e hoʻoulu ai i ka hana ʻino lua o ka mitochondrial, ua piʻi aʻe kou pilikia o ka loaʻa ʻana o ka maʻi mitochondrial. Hiki i kēia mau maʻi ke hoʻopilikia i nā pākeke a me nā keiki ʻōpio.

He aha nā pilikia e hiki mai ana o kēia mau maʻi?

Hiki i nā maʻi mitochondrial ke hoʻopilikia i ka hana o ko mākou mau kino, e alakaʻi ana i nā pilikia like ʻole. Eia kekahi laʻana:

• ʻOi aku ka nui o ka pilikia o ka maʻi
• Nā hahau
• Ka hāʻule ʻana o ka pancreas
• Ka hāʻule ʻana o ka parathyroid
• Maʻi diabetes
• Ka hemahema o ke akepaʻa
• ʻO ke cardiomyopathy
• Maʻi puʻupaʻa
• Dementia (ka hōʻino ʻana o ka hoʻomanaʻo a me ka naʻauao)
• Nā kūlana gastrointestinal
• Ka lihilihi ʻana o ka maka (Ptosis)

Hiki i kekahi o kēia mau pilikia ke hoʻoweliweli i ke ola, no laila he mea nui e ʻike i kēia.

Pehea e ʻike ʻia ai ka maʻi mitochondrial?

He hana paʻakikī iki kēia. Hoʻoholo ke kauka i ka maʻi mitochondrial ma hope o kekahi mau hoʻāʻo. Hiki i kēia mau mea ke komo pū me:

• He loiloi piha o kou mōʻaukala olakino a me ka mōʻaukala olakino ʻohana.
• He hoʻokolokolo kino piha.
• He hoʻokolokolo neurological.
• ʻO kahi hoʻokolohua metabolic, e komo pū ana me nā hoʻāʻo koko a me ka mimi. Inā pono, hiki ke hana ʻia kahi hoʻāʻo wai cerebrospinal (ʻike ʻia hoʻi he spinal tap).
• Ka hoʻāʻo ʻana i ka DNA.

Ma muli o kāu mau hōʻailona a me nā ʻāpana o kou kino i hoʻopilikia ʻia, hiki ke hana ʻia nā hoʻokolohua kikoʻī hou aku. Eia kekahi laʻana:

• Inā he mau hōʻailona o nā pilikia o ka ʻōnaehana nerve, hiki ke hana ʻia nā hoʻokolohua MRI (Magnetic Resonance Imaging) a i ʻole MRS (Spectroscopy).
• Hana ʻia kahi hoʻokolohua retinal a i ʻole kahi hoʻokolohua ERG (Electroretinogram) e nānā ai i nā pilikia ʻike.
• Nā hoʻāʻo EKG (Electrocardiogram) a i ʻole Echocardiogram no nā hōʻailona pili i ka puʻuwai.
• He hoʻāʻo `Audiogram` no nā pilikia lohe.
• Hana ʻia kahi hoʻokolohua 'EEG (Electroencephalogram)' e ʻimi ai i nā pilikia e pili ana i ka lolo i ka wā e hoʻokokoke mai ai ke kūpono.

ʻO nā hoʻokolohua holomua hou aʻe paha e komo pū me ka hoʻāʻo biochemical, kahi e nānā ai i nā loli i nā kemika o ke kino e pili ana i ka hana ikehu. I kekahi manawa, lawe paha ke kauka i kahi laʻana liʻiliʻi o kou ʻili a i ʻole nā ​​​​ʻiʻo ʻiʻo (he biopsy) a nānā iā ia ma lalo o kahi microscope.

He paʻakikī ke ʻike i nā maʻi mitochondrial?

ʻAe, hiki i kekahi manawa ke paʻakikī ka ʻike ʻana i nā maʻi mitochondrial. ʻO kēia no ka mea e hoʻopilikia kēia mau maʻi i nā ʻano kino like ʻole a me nā ʻiʻo i loko o ke kino, a he ʻokoʻa loa nā hōʻailona. ʻAʻohe hoʻokolohua lab hoʻokahi e hiki ke haʻi pololei iā ʻoe inā loaʻa iā ʻoe kēia maʻi. ʻO ia ke kumu he mea nui loa ka ʻimi ʻana i kahi hōʻailona mai ke kauka loea i kēia mau maʻi.

Pehea e mālama ʻia ai nā maʻi mitochondrial?

ʻOkoʻa ka mālama ʻana no ka maʻi mitochondrial ma muli o ke ʻano o ka maʻi a me kāu mau hōʻailona. Hiki i ka mālama ʻana ke komo pū me:

• Ke hoʻohana nei i nā lāʻau lapaʻau e hōʻemi i nā hōʻailona. Eia kekahi laʻana, nā lāʻau lapaʻau e pale aku i ka hiki ʻana mai o ke kino.
• Ke lawe nei i nā wikamina a i ʻole nā ​​mea hoʻohui meaʻai. Eia kekahi laʻana: Riboflavin, Coenzyme Q10, Carnitine.
• Nā loli i ka ʻai (meaʻai) a me ka hoʻoikaika kino.
• Hoʻōla kino, hoʻōla hana, a i ʻole ka hoʻōla ʻōlelo.
• Ke komo ʻana i nā mea kōkua e like me nā mea kōkua hoʻolohe.

ʻO ka mea pōʻino, ʻaʻohe lāʻau lapaʻau no ka maʻi mitochondrial i kēia manawa. ʻO ke kumu nui o ka lāʻau lapaʻau ʻana, ʻo ia ka pale ʻana i nā pilikia e hoʻoweliweli ana i ke ola a me ka hoʻomaikaʻi ʻana i ke ʻano o ke ola ma o ka kaohi ʻana i nā hōʻailona. ʻO ka mea e pono ai no kekahi kanaka, ʻaʻole paha e pono no kekahi, ʻoiai me ka maʻi like.

Aia kekahi mau hopena ʻaoʻao o ka lāʻau lapaʻau?

ʻAe, e like me nā lāʻau lapaʻau āpau, aia nā hopena ʻaoʻao. He mea nui e kūkākūkā i kēia mau mea me kāu kauka ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau. E kōkua kēia iā ʻoe e hoʻomaopopo i nā hopena ʻaoʻao kikoʻī o ka lāʻau lapaʻau āu e loaʻa nei a me nā mea e manaʻo ai.

Hiki ke pale ʻia nā maʻi mitochondrial?

ʻAʻohe ala i ʻike ʻia i kēia manawa e pale aku ai i ka maʻi mitochondrial genetic. Eia nō naʻe, inā loaʻa iā ʻoe ka maʻi, hiki iā ʻoe ke pale aku i kekahi o nā mea e hiki ai ke hoʻonui i kou mau hōʻailona. Eia kekahi laʻana:

• ʻIke ʻia i ke anu loa a me/a i ʻole ka wela.
• Ke hōʻalo nei i nā meaʻai.
• ʻAʻole lawa ka hiamoe.
• Kaumaha.

I kekahi manawa, e aʻo aku paha ke kauka iā ʻoe e mālama i kou ikehu. ʻO ia hoʻi, ʻaʻole e hoʻohana i kou ikehu a pau i kahi manawa pōkole.

Pehea ka lōʻihi e hiki ai iā ʻoe ke ola me ka maʻi mitochondrial?

Hiki i kāu kauka ke pane maikaʻi loa i kēia nīnau. Aia kēia i kāu mau hōʻailona, ​​​​nā ʻōpū i hoʻopilikia ʻia, a me kou olakino holoʻokoʻa. Noho kekahi mau keiki a me nā pākeke i kahi ola maʻamau, e like me kekahi me ka maʻi ʻole. No kekahi poʻe, hiki ke loli nui ko lākou olakino i loko o kahi manawa pōkole. No kekahi, hiki ke hoʻāla pinepine ʻia nā hōʻailona i ko lākou ola. ʻOiai ʻaʻohe lāʻau lapaʻau no nā maʻi mitochondrial, ke hoʻomau nei ka noiʻi e ʻike hou aku.

Āhea wau e ʻike ai i ke kauka?

Inā hoʻopilikia kāu mau hōʻailona maʻi mitochondrial i kāu mau hana o kēlā me kēia lā a hiki i kahi hiki ʻole iā ʻoe ke hana maʻamau, e ʻike pono i ke kauka. Inā ʻike ʻoe i nā hōʻailona koʻikoʻi, e like me ka hopu ʻana a i ʻole ka paʻakikī o ka hanu ʻana, e kelepona koke i ka 911 a i ʻole kāu helu ulia pōpilikia kūloko.

He aha nā nīnau e pono iaʻu e nīnau aku i kaʻu kauka?

Hiki iā ʻoe ke nīnau i kāu kauka i nā nīnau penei:

• He aha ke ʻano o ka maʻi mitochondrial i hoʻokumu i koʻu mau hōʻailona?
• He aha ke ʻano o ka lāʻau lapaʻau āu e paipai nei?
• Aia kekahi mau hopena ʻaoʻao o ka lāʻau lapaʻau?
• ʻEhia pinepine e pono ai iaʻu ke lawe i nā wikamina a i ʻole nā ​​mea hoʻohui?
• He aha ke ʻano o ka papaʻai āu e paipai nei?
• Pehea e hiki ai iaʻu ke mālama i koʻu ikehu?
• Aia kekahi mau hui kākoʻo no ka poʻe me nā maʻi mitochondrial?

ʻO ka mea hope loa, nā mea e hoʻomanaʻo ai (Leka Lawe-Home)

ʻO ka ʻike ʻana ua loaʻa iā ʻoe a i ʻole kahi mea aloha ka maʻi mitochondrial hiki ke lilo i hoʻoholo paʻakikī. No ka mea hiki i ka maʻi ke hoʻopilikia i nā ʻōnaehana he nui i loko o ke kino, pono paha ʻoe e hoʻololi i kou nohona. Akā e hoʻomanaʻo, ʻaʻole ʻoe hoʻokahi. Ma waho aʻe o ke kākoʻo o kou ʻohana a me kou mau hoaaloha, hiki i kāu hui mālama ola ke kōkua iā ʻoe e hoʻokele i kēia mau koho hōʻailona a me nā koho lapaʻau.

ʻOiai ʻaʻohe lāʻau lapaʻau no ka maʻi mitochondrial, hiki i ka lāʻau lapaʻau ke kōkua i ka hōʻemi ʻana i nā hōʻailona a hoʻolohi i ka holomua o ka maʻi. ʻO ka mea nui loa, ʻo ia ke noho maikaʻi, e hahai i nā ʻōlelo aʻoaʻo a kāu kauka, a e ola i kou ola piha.

Lana ko mākou manaʻo ua kōkua kēia ʻike iā ʻoe. A hui hou kākou me nā ʻike olakino koʻikoʻi e like me kēia!

ʻO Mitochondria, nā maʻi mitochondrial, nā maʻi genetic, ikehu cellular, hana ikehu, nā hōʻailona, ​​​​lāʻau lapaʻau