Ua lohe paha ʻoe i ka inoa ʻo 'Monoclonal Antibody'? Ua lohe paha ʻoe i kēia inoa i hoʻohana ʻia ma ke ʻano he lāʻau lapaʻau no ke kanesa, a i ʻole no nā maʻi e like me Covid-19. ʻOiai he ʻōlelo ʻano ʻē a nui hoʻi ia, he ʻano lāʻau lapaʻau kēia i hana i kahi kipi kupaianaha i kā mākou lāʻau lapaʻau. Mai hopohopo, ʻaʻole paʻakikī kēia e hoʻomaopopo. I kēia lā, e kamaʻilio wale kākou e pili ana i ke ʻano o kēia mau mea, pehea lākou e hana ai, a me nā maʻi i hoʻohana ʻia ai.
I ka ʻōlelo maʻalahi, he aha nā antibodies monoclonal?
No ka hoʻomaopopo ʻana i kēia, e aʻo mua kākou e pili ana i kahi mea i loko o ko kākou kino: ʻo 'Antibodies'.
E noʻonoʻo he ʻāina ko kākou kino. A laila ʻo kā kākou ʻōnaehana pale kino ka pūʻali koa o ia ʻāina. Ua kapa ʻia nā koa kūikawā o kēia pūʻali koa ʻo 'Antibodies'. Ke komo mai kahi ʻenemi mai waho mai, ʻo ia hoʻi, kahi mea e like me ka germ a i ʻole kahi cell cancer (i ka lāʻau lapaʻau e kapa mākou i kēia mau antigens ) i loko o ke kino, hele kēia mau koa e hopu i kēlā ʻenemi a hōʻailona i nā cell ʻē aʻe e luku iā ia.
I kēia manawa, ʻo nā 'monoclonal antibodies' kahi ʻano kūikawā o ka antibody a mākou e hana ai i loko o kahi keʻena hoʻokolohua. Ua like kēia me nā kope o nā antibodies i loaʻa iā mākou i loko o ko mākou kino.
- ʻO ke ʻano o "Mono" ʻo ia hoʻi "hoʻokahi".
- ʻO ke ʻano o "Clonal" ʻo ia hoʻi "clone".
ʻO ia hoʻi, ua like lākou me nā 'kope' he nui o ka antibody like. Hana ʻia lākou e hoʻouka i hoʻokahi ʻenemi kikoʻī (antigen). No ka laʻana, hana ʻia nā antibodies e hoʻouka wale i kahi protein kikoʻī ma luna o ka ʻili o kahi cell cancer. Ua ʻike paha ʻoe i nā inoa o kēia mau lāʻau i pau i ka "mab" (e.g. Trastuzumab, Rituximab).
I ka ʻōlelo maʻalahi, ʻo nā antibodies monoclonal he 'missiles' i hoʻolālā ʻia i loko o kahi keʻena hoʻokolohua e luku i kahi ʻenemi kikoʻī a ʻaʻole loa e haʻalele i kā lākou pahuhopu.
He aha nā ʻano maʻi i mālama ʻia me kēia mau mea?
Ke hoʻohana ʻia nei kēia ʻenehana i kēia manawa e mālama i nā ʻano maʻi like ʻole. Mai ka wā i ʻāpono ʻia ai ka lāʻau antibody monoclonal mua i ka makahiki 1986, ua hoʻomohala ʻia nā ʻano lāʻau like ʻole.
| Māhele maʻi | Ka wehewehe a me nā laʻana |
|---|---|
| Ka maʻi ʻaʻai | No ka hoʻopaʻa ʻana a me ka luku ʻana i nā hunaola maʻi e like me ke kanesa o ka umauma, lymphoma, a me ka leukemia. |
| Nā maʻi Autoimmune | No ka hoʻomalu ʻana i ka overactivity o ka ʻōnaehana pale ma nā kūlana e like me ka rheumatoid arthritis a me ka maʻi o Crohn. |
| Nā maʻi | No ka pale ʻana a me ke kaua ʻana i nā maʻi e like me ke COVID-19. |
| Hōʻole ʻia ke kāpili ʻana o nā kino | I mea e pale ai i ke kino mai ka hōʻole ʻana i kahi ʻōkana, e like me ka puʻupaʻa, ma hope o ka hoʻoili ʻia ʻana. |
| Nā maʻi ʻē aʻe | Hoʻohana ʻia nō hoʻi ia no ka osteoporosis, migraines, cholesterol kiʻekiʻe, kekahi mau maʻi maka, a me nā maʻi o ka ʻōnaehana nerve. |
Pehea e hāʻawi ʻia ai kēia lāʻau lapaʻau?
Hoʻokomo pinepine ʻia kēia lāʻau lapaʻau ma ke ʻano he wai saline i loko o kahi aʻa (intravenous - IV) . Ua kapa ʻia hoʻi kēia he 'infusion'. E hoʻokomo ʻia paha ʻoe i kahi haukapila a i ʻole ke keʻena lapaʻau 'infusion center' no hoʻokahi lā a hāʻawi ʻia kēia lāʻau no kekahi mau hola.
- Lapaʻau mua: Inā ʻo kēia kou manawa mua e hana ai i kēia lapaʻau, makemake paha ʻoe e noi i kahi lālā o ka ʻohana e hele pū me ʻoe. ʻO kēia no ka mea e nānā pono ana nā limahana lapaʻau iā ʻoe e wehewehe i ka lāʻau a e nānā i nā hopena alerika.
- ʻIniki subcutaneous: I kekahi manawa, hāʻawi ʻia kēia lāʻau lapaʻau ma ke ʻano he iniki ma lalo o ka ʻili (subcutaneous) . I kēia hihia, e hōʻike kāu kauka a kahu maʻi paha iā ʻoe pehea e iniki ai iā ʻoe iho. Hāʻawi pinepine ʻia kēia mau mea ma ka ʻōpū a i ʻole ka ʻūhā.
Nā ʻano hana lapaʻau
Hoʻohana ʻia kēia mau antibodies ma nā ʻano like ʻole:
1. Nā Antibodies Monoclonal ʻōlohelohe: He lāʻau lapaʻau kū hoʻokahi kēia. Hele pololei lākou a hoʻopili i nā mea e like me nā hunaola kanesa, e hoʻōki ana i ko lākou ulu ʻana a i ʻole e hōʻailona ana i ka ʻōnaehana pale e luku iā lākou.
2. Nā Antibodies Monoclonal i hoʻohui ʻia:Ua like kēia me kahi 'parcel'. Hoʻopili ʻia kahi lāʻau chemotherapy a i ʻole kahi ʻāpana radioactive i ka antibody a hoʻouna ʻia. Loaʻa i ka antibody ke keena kanesa pololei a 'lawe' i kēia 'parcel' ma laila. ʻAʻole nui ka pōʻino o kēia i nā keena olakino.
3. Nā Antibodies Monoclonal Bispecific: Hiki i kēia ke hoʻouka i ʻelua mau pahuhopu i ka manawa hoʻokahi. Ua like ia me ka loaʻa ʻana o ʻelua mau lima e hana ana i ʻelua mau hana. No ka laʻana, ʻoiai e hopu ana i kahi cell kanesa me kekahi lima, hopu ka lima ʻē aʻe i kahi cell immune, e hoʻohui ana i nā mea ʻelua a kōkua i ka luku ʻana i ka cell kanesa.
He aha nā pōmaikaʻi a me nā pilikia o kēia lāʻau lapaʻau?
Nā Pōmaikaʻi
- He kikoʻī ka pahuhopu: ʻO nā lāʻau lapaʻau kuʻuna e like me ka chemotherapy e hōʻino i nā ʻāpana āpau e māhele wikiwiki ana (nā ʻāpana maʻi kanesa a me nā ʻāpana lauoho olakino a me ka ʻili). Akā no ka mea e hoʻouka pololei kēia mau mea i nā ʻāpana e pili ana i ka maʻi, ua liʻiliʻi nā hopena ʻaoʻao.
- ʻOi aku ka maikaʻi: Ua kūleʻa loa kēia i ka ho'ōla ʻana i kekahi mau maʻi, ʻoi aku hoʻi nā maʻi kanesa.
- Kūlana like: No ka mea, hana ʻia ia ma kahi keʻena hoʻokolohua, like ka maikaʻi o kēlā me kēia pūʻulu lāʻau lapaʻau.
Nā Pōʻino
E like me nā lāʻau lapaʻau āpau, hiki i kēia lāʻau lapaʻau ke loaʻa kekahi mau pilikia. Akā, mai hopohopo, e aʻo aku kāu kauka iā ʻoe e pili ana i kēia mau mea āpau a mālama pono iā ʻoe.
- Nā Hana Hoʻokomo: ʻO kēia nā hana maʻamau e kū mai ana i ka wā a ma hope koke iho paha o ka hoʻokomo ʻana. Hiki i kēia ke komo pū me nā ʻeha kino, ke kuni, ke anu, ka paʻakikī o ka hanu ʻana, ka hou ʻana, a me nā loli o ke koko. Hiki ke hoʻomalu ʻia kēia mau mea ma ka hoʻolohi ʻana i ka wikiwiki o ka hoʻokomo ʻana.
- Nā hopena koʻikoʻi (kākaʻikahi): Kākaʻikahi loa, akā hiki ke loaʻa nā hopena koʻikoʻi.
- Anaphylaxis ʻĀkiaki: He hopena maʻi ʻaleka koʻikoʻi e hiki koke mai ana.
- ʻO ka Cytokine Release Syndrome (CRS): Hiki i ka ʻōnaehana pale ke lilo i overactive a hōʻino i nā kino.
- Maʻi Serum: He hoʻouka ʻana o ka ʻōnaehana pale o ke kino i ka lāʻau lapaʻau.
No ka mea hiki ke hana ʻia nā mea e like me kēia, ua makaʻala loa nā kauka a me nā kahu maʻi iā ʻoe, ʻoiai ke mālama ʻia nei ʻoe no ka manawa mua.
Makemake ʻoe e kamaʻilio me ke kauka?
ʻAe, ʻoiaʻiʻo nō. Inā he mau nīnau kāu e pili ana i kēia lāʻau lapaʻau, a inā makemake ʻoe e ʻike inā kūpono kēia lāʻau lapaʻau iā ʻoe, e kamaʻilio ākea me kāu kauka. E hāʻawi ʻo ia iā ʻoe i ka ʻōlelo aʻoaʻo maikaʻi loa e pili ana i kou kūlana olakino a me ke kūlana olakino.
Mea nui: Inā loaʻa iā ʻoe kahi hopena i manaʻo ʻole ʻia ma hope o ka mālama ʻana, ʻoi aku hoʻiInā pilikia ʻoe i ka hanu ʻana, ʻeha ka umauma, ʻeha nui, paʻakikī i ka ʻōlelo ʻana, a i ʻole nā loli o ka ʻike, e kāhea koke aku i kāu kauka, a i ʻole e hele i ka Emergency Department (ETU) o ka haukapila kokoke loa.
Leka Lawe-Home
- ʻO nā antibodies monoclonal kahi ʻano protein kūikawā i hana ʻia i loko o kahi keʻena hana e hana e like me nā ʻāpana o kā mākou ʻōnaehana pale ponoʻī.
- He mau hana hou a holomua kēia i hoʻohana ʻia no ka mālama ʻana i nā ʻano maʻi like ʻole, me ke kanesa, ka ʻāʻī, a me COVID-19.
- Ma muli o ka hana ʻana o kēia lāʻau lapaʻau ma ka pahuhopu, hiki ke emi mai nā hopena ʻaoʻao ma mua o nā lāʻau lapaʻau kuʻuna.
- Hiki ke loaʻa nā hopena e like me ke kuni a me ka ʻulaʻula ke hāʻawi ʻia ka lāʻau lapaʻau. Eia nō naʻe, he kakaikahi loa nā hopena ʻaoʻao koʻikoʻi.
- E kūkākūkā mau me kāu kauka inā kūpono kēia lāʻau lapaʻau iā ʻoe a he aha kona mau pono a me nā pōʻino.
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