Ke hana nei ʻoe i nā hunaola koko he nui loa i loko o kou kino? E aʻo kākou e pili ana i kēia mau Myeloproliferative Neoplasms (MPN)!

Ua noʻonoʻo paha ʻoe i ka mea e hiki mai ana inā nui nā hunaola koko i loko o kou kino e hana ana i kou iwi iwi? Pēlā ke ʻano o nā neoplasms myeloproliferative, a i ʻole MPN no ka pōkole. He maʻi ʻaʻai koko kakaikahi kēia, akā he mea hoʻoweliweli i ke ola hiki ke make inā ʻaʻole mālama pono ʻia. E kamaʻilio kākou e pili ana i ia mea ma ke ʻano maʻalahi e hiki ai iā ʻoe ke hoʻomaopopo.

He aha kēia myeloproliferative neoplasm (MPN)?

I ka ʻōlelo maʻalahi, ʻo nā myeloproliferative neoplasms (MPNs) nā kūlana e hana ai kou iwi iwi (kahi ʻiʻo palupalu i loaʻa i loko o kou mau iwi) i nā hunaola koko ʻulaʻula, nā hunaola koko keʻokeʻo, a i ʻole nā ​​platelets (nā hunaola e kōkua i kou ʻūlū koko). E noʻonoʻo e like me kahi hale hana e hana ana i nā huahana he nui loa. Hana ʻia kēia ke hele hewa kekahi mea i ke kaʻina hana o ka hana ʻana i nā hunaola koko.

Hoʻomohala pinepine kēia mau kūlana MPN me ka lohi loa . No laila, ʻaʻole paha e loaʻa i kekahi poʻe nā hōʻailona no nā makahiki. ʻO ia ke kumu i kapa ʻia ai lākou he "chronic" a i ʻole nā ​​​​neoplasms myeloproliferative lōʻihi. Eia nō naʻe, i nā hihia kakaikahi, hiki i kēia mau kūlana MPN ke ulu i kahi mea ʻoi aku ka koʻikoʻi.

Akā, mai hopohopo, aia nā lāʻau lapaʻau maikaʻi e kāohi i nā hōʻailona o kēia ʻano a pale iā ia mai ka lilo ʻana i mea koʻikoʻi.

He aha nā ʻano MPN i loaʻa?

Aia kekahi mau ʻano o ka MPN. Hoʻopilikia kēlā me kēia ʻano i ke ʻano o nā hunaola koko a kou iwi iwi e hana nui ai. I kekahi manawa hiki ke hana ʻia nā hunaola koko ʻulaʻula wale nō, a i kekahi manawa hiki ke hana ʻia nā hunaola koko keʻokeʻo a i ʻole nā ​​platelets wale nō. I kekahi mau ʻano o ka MPN, hiki ke hana ʻia ka hui pū ʻana o kēia mau ʻano hunaola me ka nui. ʻO kekahi kumu ʻē aʻe, ʻo ia ka hana ʻokoʻa o kēia mau hunaola keu mai nā hunaola koko olakino.

ʻO wai ka mea i hoʻopilikia nui ʻia e kēia kūlana?

ʻO ʻelua o nā kumu nui e hoʻopilikia i ka hanana ʻana o MPN kou makahiki a me ke kāne .

• Makahiki: ʻOiai hiki ke loaʻa ka MPN i nā kānaka o nā makahiki āpau, ʻike pinepine ʻia ia i nā kānaka he 50, 60, a ʻoi paha .
• Kāne: No ka laʻana, ʻoi aku ka maʻamau o ka polycythemia vera, kahi ʻano MPN, i nā kāne. ʻOi aku ka maʻamau o ka thrombocythemia koʻikoʻi i nā wahine. Hiki i nā ʻano MPN ʻē aʻe ke hoʻopilikia like i nā kāne ʻelua.

Pehea ka hopena o ka MPN i kou kino?

Loaʻa kēia mau maʻi e pili ana i ke koko i ka wā e hana ai kou iwi iwi i kahi ʻano koko ma mua o ka mea e pono ai kou kino. No laila, ʻo ka hopena o kēia ma kou kino e pili ana i ke ʻano o ke koko e hana nui ʻia nei . No ka laʻana, hiki i kekahi ʻano MPN ke hoʻonui i kou pilikia o ka loaʻa ʻana o ka hōʻeha puʻuwai a i ʻole ka hahau. Hiki i kekahi ʻano ke hana i ka anemia.

I mea e maopopo ai i kēia mau kūlana kakaikahi, he mea kōkua ka loaʻa ʻana o kahi ʻike iki i ke ʻano o ka hana ʻia ʻana o kou iwi iwi a me nā hunaola koko. Hoʻomaka kā mākou mau hunaola koko a pau ma ke ʻano he mau hunaola kumu i loko o kou iwi iwi. ʻO kēia iwi iwi ka ʻiʻo palupalu a huʻahuʻa i loko o kou mau iwi. Hiki i nā hunaola kumu e ulu ana mai ia mea ke lilo i mau hunaola kumu myeloid a i ʻole nā ​​hunaola kumu lymphoid.

• ʻO nā pūnaewele kumu lymphoid nā ʻano o nā pūnaewele koko keʻokeʻo e hakakā ana i nā maʻi.
• Hiki i nā pūnaewele kumu Myeloid ke hoʻoulu i nā hunaola koko ʻulaʻula (nāna e lawe i ka oxygen ma ke kino holoʻokoʻa), nā ʻano ʻē aʻe o nā hunaola koko keʻokeʻo, a me nā platelets (nāna e kōkua i ka hoʻōki ʻana i ke kahe koko ke hana ʻia).

E like me nā ʻāpana ʻē aʻe a pau, hana kēia mau ʻāpana kumu e like me nā kuhikuhi i hāʻawi ʻia iā lākou e nā genes. ʻO ka maʻamau, māhele a hoʻonui kēia mau ʻāpana kumu e like me ka mea e pono ai i loko o kou iwi iwi e hana i nā ʻāpana hou. Eia nō naʻe, inā he mutation i loko o kēia mau genes, ʻo ia hoʻi, inā loli nā genes, hoʻouna kēlā mau genes i nā kuhikuhi hewa i nā ʻāpana kumu e hoʻomau i ka māhele ʻana a me ka hoʻonui ʻana. I ka hopena, hōʻiliʻili kēia mau ʻāpana koko keu i loko o ka iwi iwi a i ʻole i loko o nā kīʻaha koko, e ālai ana i ke kahe koko. Ke ālai ʻia kēia kahe koko, hiki ke loaʻa nā pilikia olakino koʻikoʻi.

He aha nā ʻano MPN maʻamau?

ʻEkolu mau ʻano maʻamau o MPN: polycythemia vera, thrombocythemia koʻikoʻi, a me ka myelofibrosis mua.

ʻO ka Polycythemia Vera

ʻO kēia ke ʻano maʻamau o ka MPN . Hana ʻia ia i ka wā e hana ai kou iwi iwi i nā hunaola koko ʻulaʻula he nui loa . Hoʻomānoanoa kēia i kou koko a lohi. ʻO ka poʻe me ka polycythemia vera he nui ka pilikia o ka paʻa ʻana o ke koko. Hiki i kēia mau paʻa ke hoʻoulu i nā hōʻeha puʻuwai a me nā hahau. He mea kākaʻikahi loa, hiki i kēia kūlana ke ulu i loko o kahi maʻi koko koʻikoʻi i kapa ʻia ʻo ka leukemia acute.

ʻO ka Myelofibrosis

ʻO kēia ke ʻano MPN ʻoi loa ka ikaika . I ka myelofibrosis, hana kou iwi iwi i nā hunaola kumu ʻē. Lilo kēia mau hunaola i ka mumū a hana i nā ʻiʻo ʻeha i loko o ka iwi iwi. I ka hala ʻana o ka manawa, piha ka iwi iwi me kēia ʻiʻo ʻeha. A laila, ʻaʻole hiki i ka iwi iwi ke hana hou i nā hunaola koko ʻulaʻula e lawe i ka oxygen a puni ke kino. Hiki i kēia ke kumu iā ʻoe e loaʻa ai ka anemia. Loaʻa iā ʻoe ka hana platelet haʻahaʻa. Hiki i kekahi poʻe me ka myelofibrosis ke loaʻa pū kekahi leukemia myeloid acute (AML).

ʻO ka Thrombocythemia koʻikoʻi

ʻO ka thrombocythemia koʻikoʻi kahi kūlana kahi e hana ai kou iwi iwi i nā platelets he nui.Ke hana nei. ʻO ka maʻamau, ke pohā kahi kīʻaha koko, hui pū nā platelets e hana i kahi clot a hoʻōki i ke kahe ʻana o ke koko. Akā ma kēia kūlana, hana ʻia nā platelets i loko o ka iwi iwi me ke kumu ʻole. Hiki i kēia mau platelets keu ke hana i nā clots koko a hoʻonui i ka pilikia o nā hōʻeha puʻuwai a me nā hahau. E like me nā MPN ʻē aʻe, ulu mālie nā hōʻailona. ʻIke ʻia ka hapa nui o ka poʻe me kēia kūlana ke hōʻike kahi hoʻāʻo koko maʻamau i nā pae platelet kiʻekiʻe. I kekahi poʻe, hiki i ke kūlana ke holomua i ka leukemia.

Aia kekahi mau ʻano ʻē aʻe o MPN?

ʻAe, aia kekahi mau ʻano MPN ʻē aʻe. ʻO kekahi o lākou:

• ʻO ka leukemia eosinophilic mau loa (CEL): He kūlana kēia kahi e nui ai ka hana ʻana o kahi ʻano keʻokeʻo koko i kapa ʻia ʻo eosinophil. Hoʻomohala pinepine ia i loko o ka spleen. I kekahi manawa, hiki ke holomua i ka leukemia myeloid acute (AML). Ua kapa ʻia hoʻi kēia he hypereosinophilic syndrome.
• ʻO ka leukemia myelogenous mau loa (CML): He ʻano kēia o nā keena koko keʻokeʻo i kapa ʻia ʻo granulocytes e hana nui ana. Hōʻiliʻili kēia mau keena a hoʻopaʻakikī i ka iwi iwi e hana i nā keena koko ʻē aʻe e pono ai.
• ʻO ka maʻi leukemia neutrophilic mau loa (CNL): Ma kēia, hana ʻia ke ʻano o ke koko keʻokeʻo i kapa ʻia ʻo neutrophils me ka nui.
• ʻO ka neoplasm myeloproliferative, unclassifiable (MPN-U): He ʻano MPN kēia i kūpono ʻole i kekahi o nā ʻano ʻē aʻe. Hiki iā ia ke hana i ka hana nui ʻana o nā ʻano ʻāpana koko like ʻole, e like me nā ʻāpana koko keʻokeʻo, nā ʻāpana koko ʻulaʻula, a i ʻole nā ​​platelets.

He aha nā hōʻailona o ka MPN?

I nā pae mua, ʻaʻole paha ʻoe e ʻike i kekahi mau hōʻailona . I ka holomua ʻana o ke kūlana, e ʻike paha ʻoe i nā hōʻailona o ka spleen pehu (splenomegaly). Aia ka spleen ma kou ʻaoʻao hema ma lalo o kou mau iwi ʻaoʻao. Hiki ke manaʻo ʻia he piha, ʻoʻoleʻa, a ʻoluʻolu ʻole. ʻOiai he mea maʻamau kēia pehu ʻana o ka spleen i nā ʻano MPN he nui, ʻaʻole ia he mea maʻamau i ka thrombocythemia koʻikoʻi.

ʻOkoʻa nā hōʻailona ʻē aʻe ma muli o ke ʻano o MPN .

ʻO ka maʻi leukemia eosinophilic mau loa (CEL)

• ʻO ka hōʻailona maʻamau ka ʻulaʻula o ka ʻili .
• E luhi paha ʻoe a me ke kuni.
• ʻO nā hōʻailona ʻē aʻe e pili ana i nā ʻāpana o kou kino i hoʻopilikia ʻia e kāu mau kiʻekiʻe eosinophil.

ʻO ka maʻi leukemia myelogenous mau loa (CML) a me ka maʻi leukemia neutrophilic mau loa (CNL)

• ʻEha iwi
• Nā hou o ka pō
• Kuni a me ka luhi
• ʻEha maʻalahi
• Ka nalowale o ka makemake a me ka pohō kaumaha

ʻO ka thrombocythemia koʻikoʻi

• ʻEha maʻalahi
• Ke kahe koko mai ka ihu, ka waha, a i ʻole nā ​​ʻāʻī me ke kumu ʻole
• Ke kahe ʻana o ke koko mai ka ʻōpū a i ʻole nā ​​​​​​naʻau
• Koko i loko o ka mimi

ʻO ka Polycythemia vera

• ʻEha poʻo
• Pōʻino
• Luhi
• ʻIke pōwehiwehi a ʻike pālua paha

ʻO ka myelofibrosis mua

• Hiki ke ʻike ʻia nā hōʻailona o ka anemia (luhi, nāwaliwali, pōkole o ka hanu).
• Nā hiʻohiʻona ʻē aʻe:
• ʻIli keʻokeʻo
• Nā hou o ka pō
• kuni
• ʻIli ʻāʻī
• ʻAi nui a i ʻole ka manaʻo piha koke ma hope o ka ʻai ʻana (māʻona mua)
• Ka emi ʻana o ke kaumaha
• ʻEha iwi

He aha ke kumu o ka MPN?

ʻO nā maʻi MPN āpau he mau maʻi genetic i loaʻa . ʻO ke ʻano kēia, ʻaʻole lākou i hoʻoilina ʻia mai kou mau mākua mai. Hana ʻia lākou i ka wā e loaʻa ai nā mutations a i ʻole nā ​​​​loli i loko o nā genes e kaohi ana i ka ulu ʻana o nā cell, e hoʻoulu ai i nā cell koko e ulu hewa.

Ua hana nā kānaka noiʻi lapaʻau i nā ʻike e pili ana i nā hoʻololi genetic e hoʻoulu ai i ka MPN:

• Nā hoʻololi ʻana o Janus kinase (JAK): ʻO nā kūlana e like me ka polycythemia vera, ka myelofibrosis mua, a me ka thrombocythemia koʻikoʻi e hana pinepine ʻia e nā hoʻololi ʻana i loko o kahi gene i kapa ʻia ʻo Janus kinase 2 (JAK2) . Hiki i kēia hoʻololi ʻana ke hoʻokaʻawale i nā cell me ke kāohi ʻole ʻia.
• Nā hoʻololi ʻana i ka gene MPL a i ʻole ka gene CALR: ʻO ka poʻe me ka thrombocythemia koʻikoʻi a me ka myelofibrosis mua he pinepine nā hoʻololi ʻana i kā lākou gene MPL a i ʻole ka gene CALR.
• Nā hewa chromosome: Loaʻa i ka poʻe me ka leukemia myelogenous mau loa (CML) kahi hewa kikoʻī i kā lākou chromosomes (ke ʻano i loaʻa nā genes). I ka CML, hoʻololi kahi ʻāpana o kekahi chromosome me kekahi chromosome ʻē aʻe, e hana ana i kahi "chromosome Philadelphia."

ʻOiai ʻaʻole wehewehe pono kēia mau ʻike i ke kumu o nā loli genetic, kōkua lākou i nā kauka e ʻike i nā maʻi a hoʻomohala i nā lāʻau lapaʻau e pili ana i kēia mau mutations genetic.

He aha nā kumu pilikia no ka MPN?

ʻO ka moʻolelo ʻohana o ka maʻi (ʻoiai he mau maʻi i loaʻa kēia, hiki i kekahi mau ʻohana ke hōʻike i kahi predisposition), ka makahiki, a me ke kāne ke hoʻonui i ka pilikia o ka hoʻomohala ʻana i ka MPN.

Ua ʻike pū nā kānaka noiʻi i nā pilina ma waena o ka MPN a me ka ʻike ʻana i kekahi mau mea ʻawaʻawa a me ka radiation . Hōʻike kekahi mau noiʻi he nui ka pilikia o ka poʻe i hōʻike ʻia i nā pae kiʻekiʻe o ka radiation a me kekahi mau mea ʻawaʻawa, e like me ka benzene, i ka hoʻomohala ʻana i nā MPN, e like me ka polycythemia vera, ka myelofibrosis mua, a me ka leukemia myelogenous maʻi.

Pehea e ʻike ʻia ai ka MPN?

E nīnau kāu kauka e pili ana i kāu mau hōʻailona a me ka mōʻaukala olakino. A laila, e hana lākou i kahi hoʻokolokolo kino e nānā i nā hōʻailona o MPN. E hoʻāʻo lākou i kou koko a me ka iwi iwi e ʻike i ka maʻi.

• Helu koko piha (CBC):Ana kēia i nā pae o kāu mau ʻano cell koko āpau. I ka thrombocythemia koʻikoʻi, nānā ʻia nā pae platelet. I ka polycythemia vera, nānā ʻia ka hemoglobin (kahi protein i loaʻa i loko o nā cell koko ʻulaʻula), a me nā pae cell koko keʻokeʻo a me nā platelet.
• ʻO ka paʻi koko peripheral (PBS): Hiki i kēia hoʻāʻo ke nānā i nā ʻano ʻē i loko o nā hunaola koko, hiki ke hāʻawi i nā hōʻailona e pili ana i kahi maʻi.
• Nā hoʻāʻo kemika koko: Hiki i kēia ke ana i nā pae o nā kemika like ʻole (e like me nā protein, nā enzyme, a me ka glucose) i loko o kou koko. Hiki i kēia mau helu ke hāʻawi i nā hōʻailona e pili ana i ke ʻano o ka hana ʻana o kāu mau kino, hiki ke hoʻāla i ka kānalua no kahi MPN.
• ʻO ka biopsy iwi iwi: Hiki i kāu kauka ke hana i kahi ʻimi ʻana i ka iwi iwi a i ʻole ka biopsy iwi iwi. Pili kēia i ka lawe ʻana i kahi laʻana o kou iwi iwi a nānā iā ia no nā hunaola koko. A laila nānā nā kauka lapaʻau i nā hunaola koko a me nā ʻiʻo ma lalo o kahi microscope e ʻimi i nā ʻokoʻa ma waena o nā hunaola maʻamau a me nā hunaola ʻē. E ʻimi pū lākou i nā hunaola kumu ʻē. E ʻimi pū lākou i nā loli chromosomal a me nā ʻano ʻē aʻe o ka genetic e hōʻike paha i kahi ʻano MPN.
• Ka hoʻāʻo ʻana i ka genetics: Hiki i nā kauka ke kālailai i kāu mau hunaola koko e ʻike ai inā he mau loli i loko o nā genes e hoʻopilikia ai i ka hana ʻana o nā hunaola koko.

Hiki ke ho'ōla loa ʻia ka MPN? He aha nā lāʻau lapaʻau?

ʻO ke ʻano lapaʻau wale nō i loaʻa i kēia mau maʻi, ʻo ia ka hoʻoili ʻana i nā cell stem allogeneic . ʻO ka mea pōʻino, ʻaʻole hiki i ka nui o ka poʻe ke hana i kēia hoʻoili ʻana i nā cell stem no ka mea he hana paʻakikī a koi kino hoʻi.

E kuhikuhi kāu kauka i nā lāʻau lapaʻau e mālama i kou kūlana, e hoʻemi i ka helu o kāu mau cell koko, e hōʻoluʻolu i nā hōʻailona, ​​​​a pale i nā pilikia. Hiki i kekahi mau lāʻau lapaʻau ke hoʻokuʻu i ka maʻi. ʻOkoʻa nā lāʻau lapaʻau no MPN ma muli o ke ʻano:

• ʻO ka maʻi leukemia eosinophilic mau loa (CEL): Hiki i kāu kauka ke hoʻohana i ka chemotherapy, corticosteroids, a i ʻole immunotherapy e hoʻohaʻahaʻa i kāu mau pae eosinophil.
• ʻO ka maʻi leukemia myelogenous mau loa (CML): ʻO ka lāʻau lapaʻau i hoʻohana pinepine ʻia, ʻo ia ka lāʻau lapaʻau i kuhikuhi ʻia, kahi e hoʻōki ai i nā cell mai ka hoʻonui ʻole ʻia. ʻO nā lāʻau lapaʻau ʻē aʻe e pili ana i ka chemotherapy, immunotherapy, radiation therapy, a me nā hoʻoili cell stem.
• ʻO ka maʻi leukemia neutrophilic mau loa (CNL): Hiki i ka lāʻau lapaʻau ke komo pū me ka chemotherapy, immunotherapy, a me nā hoʻoili cell stem.
• ʻO ka thrombocythemia koʻikoʻi:Inā ʻaʻohe ou hōʻailona, ​​​​hiki i kāu kauka ke hoʻoholo e nānā pono i kou kūlana ma kahi o ke kuhikuhi ʻana i ka lāʻau lapaʻau. Inā loaʻa iā ʻoe nā hōʻailona, ​​​​pono paha ʻoe e lawe i kahi lāʻau lapaʻau e pale ai i nā cell mai ka hoʻonui ʻana ma waho o ke kaohi. Pono paha ʻoe e lawe i ka lāʻau lapaʻau e hōʻemi i ka pilikia o nā ʻōpū koko a i ʻole e pale i kou iwi iwi mai ka hana ʻana i nā platelets he nui.
• Polycythemia vera: ʻO Phlebotomy ka lāʻau lapaʻau maʻamau no ka polycythemia vera. Ma kēia kaʻina hana, e wehe mau kāu kauka i kahi koko liʻiliʻi (e like me ka hoʻoili koko) e hōʻemi i ka nui o kou koko a wehe i nā hunaola koko ʻulaʻula keu. Inā loaʻa iā ʻoe nā hōʻailona, ​​​​hiki ke hāʻawi ʻia iā ʻoe ka lāʻau lapaʻau i kuhikuhi ʻia e hoʻōki i nā hunaola mai ka hoʻonui ʻana ma waho o ke kaohi. Hiki ke hāʻawi ʻia iā ʻoe nā lāʻau lapaʻau e hōʻemi i ka pilikia o nā ʻōpū koko (e like me ka aspirin) a i ʻole nā ​​​​lāʻau lapaʻau e hōʻemi i ka helu o nā hunaola koko ʻulaʻula.
• ʻO ka myelofibrosis mua: Inā ʻaʻohe ou hōʻailona, ​​​​hiki i kāu kauka ke hoʻoholo e nānā pono i kou kūlana. Aia nā ʻano hana like ʻole a i ʻole nā ​​​​lāʻau lapaʻau e hiki ke hoʻohana ʻia e mālama i ka anemia. No ka laʻana, inā ʻaʻole lawa ka hana ʻana o kou iwi iwi i nā hunaola koko ʻulaʻula, pono paha ʻoe i kahi hoʻoili koko. Pono paha ʻoe e lawe i nā lāʻau lapaʻau e hoʻoulu ai i ka iwi iwi e hana i nā hunaola koko hou aʻe. ʻO nā lāʻau lapaʻau ʻē aʻe e pili ana i ka lāʻau lapaʻau i kuhikuhi ʻia, chemotherapy, immunotherapy, radiation therapy, a me ka hoʻoili ʻana o nā cell stem.

ʻEhia ka lōʻihi e hiki ai i kekahi me MPN ke ola?

ʻOkoʻa loa kēia mai kēlā kanaka a kēia kanaka . Nui nā kumu e hoʻopilikia i kēia, me ke ʻano o ka MPN, pehea ka wā mua o ka ʻike ʻia ʻana o ka maʻi, a pehea kou pane maikaʻi ʻana i ka lāʻau lapaʻau. Me ka nānā pono ʻana a me ka lāʻau lapaʻau, ola ka poʻe he nui no nā makahiki he nui . ʻAʻohe prognosis hoʻokahi a i ʻole ka hopena i manaʻo ʻia no kēia mau kūlana. Ma ke ʻano laulā, ʻo ka hapa nui o ka poʻe i ʻike ʻia me ka MPN e ola mau ana ma hope o ʻelima mau makahiki.

ʻO nā helu ola no nā ʻano MPN kikoʻī penei:

• ʻO ka leukemia myelogenous mau loa (CML): Ua piʻi nui ka nui o ke ola e pili ana me CML ma muli o ka holomua o nā lāʻau lapaʻau hou i kuhikuhi ʻia. ʻO ka nui o ke ola ʻelima makahiki no CML he 90%.
• ʻO ka maʻi leukemia neutrophilic mau loa (CNL) a me ka polycythemia vera: Me ka mālama maikaʻi ʻana, ola ka hapa nui o ka poʻe ma ka awelika o 20 mau makahiki ma hope o ka hōʻoia ʻana.
• ʻO ka thrombocythemia koʻikoʻi: He nui ka poʻe e ola ana no nā makahiki he nui ke lawe lākou i nā lāʻau lapaʻau e pale ai i nā pilikia e hoʻoweliweli i ke ola e like me nā ʻōpū koko.
• ʻO ka myelofibrosis mua: ʻO ka hapa nui o ka poʻe me ka myelofibrosis mua e ola ana i ʻelima a ʻumi mau makahiki ma hope o ka hōʻoia ʻana.

Inā loaʻa iā ʻoe kēia maʻi, e nīnau i kāu kauka e pili ana i kāu wānana. ʻO lākou ka poʻe i ʻike i nā mea āpau e pili ana i ka wānana. A ʻo ka mea nui loa, ʻike lākou iā ʻoe, kou mau makahiki, a me kou olakino holoʻokoʻa, a me nā mea pilikia e pili ana i ka wānana.

He make anei kēia mau maʻi?

ʻAʻole kēia he mau maʻi make iā lākou iho , akā hiki i kekahi ʻano MPN ke hoʻoulu i nā pilikia e hoʻoweliweli i ke ola e like me ka hōʻeha puʻuwai a me nā hahau.

He aha nā nīnau e pono iaʻu e nīnau aku i kaʻu kauka?

He maʻi paʻakikī ka MPN. Nui nā koho lapaʻau, a i kekahi manawa nā hopena ʻaoʻao. Eia kekahi, nui nā pilikia e hiki ke kū mai ma muli o kou kūlana. He mea nui e ʻike i nā hōʻailona āu e makaʻala ai. E kamaʻilio me kāu kauka e hoʻomaopopo i kāu hōʻailona a hoʻoholo i nā hoʻoholo e pili ana i ka lāʻau.

ʻO kekahi mau nīnau hiki iā ʻoe ke nīnau:

• He aha ka pahuhopu o ka mālama ʻana (e hōʻoluʻolu i ka maʻi, e hōʻemi i nā hōʻailona, ​​​​e pale i nā pilikia, a pēlā aku)?
• He aha kaʻu mau koho lapaʻau?
• He aha nā hopena ʻaoʻao e hiki ke loaʻa mai ka lāʻau lapaʻau?
• Pehea ka lōʻihi e pono ai iaʻu e mālama ʻia no koʻu maʻi?
• ʻEhia mau manawa e pono ai iaʻu e hana i nā hoʻokolohua (kiʻi a i ʻole ka hana koko) e nānā i koʻu kūlana?
• He aha nā hōʻailona e kōkua iaʻu e ʻike inā e maikaʻi aʻe ana paha koʻu kūlana?
• He aha nā hōʻailona e hōʻike mai iaʻu i kahi pilikia?
• He aha nā pilikia e pono ai ka mālama olakino ulia pōpilikia?
• He aha ka wānana i manaʻo ʻia no koʻu kūlana?
• He aha nā hoʻololi o ke ʻano o ka nohona āu e ʻōlelo nei e mālama i koʻu kūlana a me nā hopena ʻaoʻao o ka lāʻau lapaʻau?

Pehea wau e mālama ai iaʻu iho? (Kekahi mau mea nui nou)

Hiki i ka noho ʻana me MPN ke lilo i mea huikau i kekahi manawa. Ke holo pono nei paha ʻoe a ʻaʻole ʻoe e manaʻo i kekahi pilikia, akā e noʻonoʻo paha ʻoe inā he mea hiki iaʻu ke hana e pale aku i nā hōʻailona. Inā ʻoe e loaʻa ana i ka lāʻau lapaʻau, pono paha ʻoe i ke kōkua i ka hoʻokele ʻana i nā hopena ʻaoʻao o ka lāʻau lapaʻau a me nā hōʻailona. Eia nō naʻe, pono ʻoe e noho me kēia maʻi no nā makahiki he nui e hiki mai ana. Eia kekahi mau manaʻo e kōkua paha iā ʻoe:

• E hoʻomaopopo i kou kūlana olakino: He nui nā hōʻailona MPN e like me nā kūlana ʻē aʻe, ʻaʻole koʻikoʻi. Hiki i kekahi mau hōʻailona ke lilo i mau hōʻailona o nā pilikia olakino koʻikoʻi. Hiki ke paʻakikī ke haʻi i ka ʻokoʻa, a manaʻo paha ʻoe e nele ana ʻoe i nā hōʻailona koʻikoʻi. E noi i kāu kauka e wehewehe pehea e pili ai kēia kūlana iā ʻoe. ʻO ka ʻike i ka mea e manaʻo ai e hiki ke kōkua iā ʻoe e hilinaʻi hou aku i kou kūlana.
• E hoʻokele i kou kaumaha: Hiki ke kaumaha ka noho ʻana me kahi maʻi lōʻihi. Inā ʻoe e hopohopo nei no kou kūlana, e kamaʻilio me kāu kauka e pili ana i ia mea. Hiki iā lākou ke wehewehe i ka mea hiki iā lākou ke hana e kōkua iā ʻoe i kēia manawa a me ka mea hiki iā lākou ke hana e kōkua iā ʻoe i ka wā e hiki mai ana.
• E ʻai i ka meaʻai olakino kaulike:Hiki i ka ʻai pono ʻana ke kōkua iā ʻoe e mālama i kou kūlana. E kamaʻilio me kahi meaʻai meaʻai inā makemake ʻoe i ke kōkua i ka hoʻomohala ʻana i nā ʻano ʻai olakino.
• E hoʻoikaika kino: He ala maikaʻi loa ka hoʻoikaika kino e hoʻokele ai i ke kaumaha.
• E huli i ke kākoʻo: He maʻi laha ʻole ka MPN. Hiki i nā hui kākoʻo ke lilo i ala maikaʻi loa e hoʻopili ai a kamaʻilio me ka poʻe i ʻike i kāu mea e hele nei.

E hoʻomanaʻo, ʻoiai me ke ʻano e like me kēia, hiki iā ʻoe ke ola i kahi ola maikaʻi ma ka makaʻala a me ka hahai ʻana i nā ʻōlelo aʻoaʻo lapaʻau.

Āhea wau e ʻike ai i ke kauka?

Inā loaʻa iā ʻoe ka MPN akā asymptomatic, a i ʻole e ʻike i nā loli i kou kino e hōʻike ana i nā hōʻailona, ​​e ʻike koke i kāu kauka.

He mea pohihihi iki ka MPN. Ua ʻike nā kānaka noiʻi ua pili ka MPN me ka ulu ʻana o nā ʻāpana koko maʻamau ʻole. Ua ʻike pū lākou he mau maʻi genetic lākou, akā ʻaʻole i ʻike ʻia ke kumu pololei no nā hoʻololi genetic e hoʻokumu ai i ka MPN . No ka mea he mau maʻi kakaikahi kēia, ʻaʻole ʻike ka nui o ka poʻe i ke ʻano o ka noho ʻana me MPN. Akā ke aʻo nei nā kauka a me nā mea noiʻi e pili ana i ka MPN, ʻoi aku hoʻi e pili ana i nā ala ʻoi aku ka maikaʻi e hoʻokele ai i nā hōʻailona a hōʻemi i ka pilikia o nā pilikia olakino koʻikoʻi. No laila, mai haʻalele i ka manaʻolana .

ʻO ka neoplasm myeloproliferative, MPN, ka maʻi ʻaʻai koko, ka iwi ʻiʻo, nā hunaola koko ʻulaʻula, nā hunaola koko keʻokeʻo, nā platelets, nā hōʻailona, ​​​​​​ka lāʻau lapaʻau