Hiki ke hoʻomake ʻia ko kākou mau aʻalolo? E kamaʻilio kākou e pili ana i ka neurotoxicity!

Ke manaʻo nei ʻoe i kekahi manawa ua poniuniu ʻoe me ke kumu ʻole? Ke mae nei kou mau lālā? A i ʻole ke manaʻo nei ʻoe e ʻino ana kou hoʻomanaʻo, a paʻakikī paha ke mālama i kou manaʻo ma kahi hoʻokahi? Malia paha ke kumu o kēia mea he mea a mākou i noʻonoʻo ʻole ai. ʻO ia ka neurotoxicity, a i ʻole e like me kā mākou e kapa nei ma nā ʻōlelo lapaʻau, he ʻano i kapa ʻia ʻo neurotoxicity . E kamaʻilio kākou e pili ana i kēia me nā kikoʻī hou aku i kēia lā, ʻae?

I ka ʻōlelo maʻalahi, he aha ka neurotoxicity?

ʻO ka neurotoxicity ka wā e hōʻino ai nā mea ʻawahia kūlohelohe a i hana ʻia e ke kanaka (i kapa ʻia he neurotoxicants) i ka lewa a mākou e hanu ai, ka wai a mākou e inu ai, ka meaʻai a mākou e ʻai ai, a me kekahi o nā mea a mākou e hoʻohana ai i kā mākou ʻōnaehana nerve. Ua ʻike anei ʻoe he pūnaewele paʻakikī loa kā mākou ʻōnaehana nerve? Hoʻokomo pū ia i ko mākou lolo, ke kaula spinal, a me nā aʻalolo ma loko o ko mākou kino . ʻO kēia nā mea e kaohi ana i nā mea āpau a mākou e noʻonoʻo ai, hana ai, ʻōlelo ai, a me ka manaʻo.

No laila, hiki i kēia mau mea ʻawahia ke hoʻololi i ka hana o ka ʻōnaehana nerve. Hiki i kēia mau loli ke liʻiliʻi i kekahi manawa, a i kekahi manawa koʻikoʻi loa . ʻOiai hiki ke mālama ʻia a ho'ōla ʻia kekahi mau loli, hiki i kekahi ke ola a pau. I nā hihia ʻino loa, hiki i kēia neurotoxicity ke alakaʻi i ka make . E noʻonoʻo i ka weliweli o ia mea!

I kekahi manawa, ʻoiai nā mea i maʻamau ʻole i ka ʻawahia iā mākou, no ka laʻana, kekahi mau lāʻau lapaʻau, hiki ke hana i ka neurotoxicity inā lawe nui ʻia. A i ʻole, aia kekahi mau mea, e like me ke kēpau, hiki ke lilo i mea ʻawahia ʻoiai i nā liʻiliʻi.

Hiki ke loaʻa kēia neurotoxicity i ka wā o ka ulu ʻana o ka fetal , ka ulu ʻana o ke keiki , a i ʻole ka wā makua . Eia nō naʻe, ʻoi aku ka nui o ka pōʻino i hana ʻia e ka ʻike ʻana i kēia mau mea ʻawahia i ka wā o ka fetal a me ka wā kamaliʻi. Eia kekahi, ʻoi aku ka nui o ka poʻe me kekahi mau maʻi, no ka laʻana, ka poʻe me ka jaundice (hyperbilirubinemia) a i ʻole ka poʻe me nā maʻi e like me ka Charcot-Marie-Tooth Disease (CMT), i ka pilikia nui o ka hoʻomohala ʻana i kēia neurotoxicity.

He aha kēia mau mea hoʻomake neuro?

ʻO ka ʻoiaʻiʻo, he mau haneli o nā ʻano o kēia mau mea ʻāʻī aʻalolo. Hiki iā lākou ke ʻano kinoea, wai, a paʻa paha. Hiki i kekahi mau mea ʻawahia ke hana i nā hōʻailona me ka liʻiliʻi loa, a i ʻole ma hope o ka hoʻopili ʻana hoʻokahi. ʻOiai ʻo kekahi e pono ai ka nui o ka nui a me ka hoʻopili lōʻihi e hana i nā hōʻailona.

Eia kekahi mau laʻana:

• Nā metala kaumaha: No ka laʻana, ke kēpau, ka mercury.
• Nā mea kūlohelohe ʻē aʻe: No ka laʻana, carbon monoxide, arsenic, a me trichothecene mycotoxins mai kekahi mau ʻōpala.
• Mea pepehi pepeke:Eia kekahi laʻana, ʻo `(organophosphates)` a me `(chlorpyrifos)`. Hoʻohana ʻia kēia mau mea i kā mākou mahiʻai, ʻeā?
• Nā mea hoʻoheheʻe i loaʻa i nā hale hana a me nā huahana hoʻomaʻemaʻe: No ka laʻana, `(tetrachloroethylene)`.
• Nā mea hana: No ka laʻana `(vinyl chloride)`, `(toluene)`, `(formaldehyde)` a me `(polybrominated diphenyl ethers) (PBDEs)`.
• Nā lāʻau lapaʻau a me ka waiʻona: Waiʻona, Amphetamines, Opioids, Inhalants, a me Cocaine.

Aia kekahi mau kemika e hoʻopilikia i kā mākou ʻōnaehana hormonal, i kapa ʻia ʻo Endocrine-disrupting chemicals (EDCs). ʻO nā laʻana e komo pū me Bisphenol A (BPA) (i loaʻa i loko o kekahi mau plastics), phthalates, a me nā polychlorinated biphenyl compounds (PCBs). Hiki i kēia mau mea ke hoʻoulu i ka neurotoxicity ma ke ʻano ʻole.

ʻO ka pilina ma waena o nā lāʻau lapaʻau a me ka neurotoxicity

Ua ʻike anei ʻoe hiki i kekahi mau lāʻau lapaʻau, no ka laʻana, kekahi mau antibiotics a me kekahi mau antipsychotics, ke hoʻoulu i ka neurotoxicity no nā kumu like ʻole? Akā i ka hapanui o nā hihia, ʻoi aku ka nui o nā pono o kēia mau lāʻau lapaʻau ma mua o nā pilikia o ka neurotoxicity . ʻO ia ke kumu e kuhikuhi pono ai nā kauka iā lākou.

ʻO kekahi mau lāʻau lapaʻau, ʻoiai nā mea i hoʻohana ʻia i nā lāʻau lapaʻau maʻi kanesa, hiki ke hana i ka neurotoxicity.

• Nā lāʻau lapaʻau i loaʻa ka platinum: `(oxaliplatin)`, `(cisplatin)`, `(carboplatin)`
• Nā lāʻau lapaʻau Taxane: `(paclitaxel)`, `(docetaxel)`
• Nā alkaloids Vinca: `(vincristine)`, `(vinblastine)`
• Nā mea hoʻopaʻa proteasome
• Nā analog Thalidomide

ʻAʻole wale ka chemotherapy, akā hiki i ka radiation therapy ke hōʻino i ka ʻōnaehana nerve waena a hoʻoulu i ka neurotoxicity.

Pehea ka maʻamau o kēia ʻano?

ʻO kaʻoiaʻiʻo, he mea paʻakikī i nā kānaka noiʻi ke ʻōlelo pololei i ke ʻano maʻamau o kēia maʻi, no ka nui o nā ʻano o nā mea ʻāʻī a me nā ʻano hōʻailona like ʻole. Eia nō naʻe, ke ʻōlelo nei nā kānaka noiʻi ua laha nui ko mākou ʻike ʻana i kēia mau mea ʻāʻī .

E hāʻawi aku wau iā ʻoe i ʻelua mau laʻana e kōkua iā ʻoe e hoʻomaopopo i ka nui o kēia:

• Ua ʻike ʻia kekahi noiʻi aia ma kahi o 385 miliona mau lāʻau make ulia pōpilikia mai nā pesticides ma ka honua holoʻokoʻa i kēlā me kēia makahiki , e hopena ana ma kahi o 11,000 mau make i kēlā me kēia makahiki.
• Ua manaʻo ʻia hoʻi he hoʻokahi miliona mau kānaka e make ana i kēlā me kēia makahiki mai ka lāʻau make kēpau . Hoʻokahi o nā keiki ʻekolu ma ka honua holoʻokoʻa - ʻo ia hoʻi ma kahi o 800 miliona mau keiki - he kiʻekiʻe ko lākou pae kēpau i loko o ko lākou koko . E noʻonoʻo i ke koʻikoʻi o kēia! Hiki ke loaʻa ke kēpau i loko o ka pena i loko o nā hale kahiko a i loko o kekahi mau mea pāʻani.

He aha nā hōʻailona?

Hiki ke ʻokoʻa loa nā hōʻailona o ka lāʻau make ʻana o nā aʻalolo. Aia ia i ke ʻano o ka toxin i hōʻike ʻia iā ʻoe. Hiki i nā hōʻailona ke ʻano mai ka liʻiliʻi a i ka koʻikoʻi . I kekahi manawa hiki ke ʻike koke ʻia nā hōʻailona ma hope o ka hōʻike ʻana i ka toxin, a hiki paha ke hala i nā pule, nā mahina, a i ʻole nā ​​​​makahiki e ʻike ʻia.

Eia kekahi mau hōʻailona kino:

• Nā pilikia me ke kaulike a me ka hoʻonohonoho ʻana (ʻaʻole hiki ke hele pololei, pilikia i ka hopu ʻana i nā mea)
• Ka maʻi ʻōpū (ʻeha ʻōpū)
• Luhi, luhi
• ʻEha poʻo
• Makemake nui
• Nā kūlana ʻeha e like me ka ʻeha neuropathic
• Nā pilikia ʻiʻo: nāwaliwali, ʻūlū, ʻūlū
• Ka luaʻi a me/a i ʻole ka luaʻi
• Ka mae ʻana o nā lālā
• Nā loli hiamoe: e like me ka insomnia
• Paʻakikī i ka ʻōlelo ʻana, ʻōlelo slurred (dysarthria)
• Nā pilikia ʻike a i ʻole ka nalowale o ka ʻike

I kēia manawa, e nānā kākou i nā hōʻailona noʻonoʻo a me ka noʻonoʻo:

• Nā loli a i ʻole nā ​​pilikia o ka hana
• Ua emi iho nā mana noʻonoʻo, no ka laʻana, ka hemahema o ka noʻonoʻo iki
• Pōʻino a i ʻole ka nalowale o ke kuhikuhi
• Hana ʻole o ka luna hoʻokō: ʻO ke ʻano kēia o ka paʻakikī i ka kaohi ʻana i nā manaʻo a me ka hiki ʻole ke noʻonoʻo.
• ʻOi aku ka wikiwiki o ka huhū ma mua o ka maʻamau, lilo i mea hoʻouka kaua
• Poho hoʻomanaʻo
• Nā loli o ke ʻano

ʻO ka mea nui loa, ʻo ia ke ʻike i ke kauka inā ʻike ʻoe a i ʻole kāu keiki i kekahi mau loli a pilikia paha i ko lākou noʻonoʻo ʻana, ʻano, ʻano, a i ʻole ke olakino kino . Hiki paha kēia ma muli o nā neurotoxicants, akā aia paha kekahi mau kumu ʻē aʻe.

Nā hōʻailona e hōʻike ana i kahi pilikia

I kekahi manawa hiki ke koke a koʻikoʻi loa ka neurotoxicity (acute neurotoxicity). Hiki ke ʻike koke ʻia kēia mau hōʻailona. Inā loaʻa iā ʻoe kekahi o nā hōʻailona ma lalo nei, pono ʻoe e hele koke i ka haukapila. Kāhea iā 911 (1990 ma Sri Lanka) a i ʻole e hele i ka haukapila kokoke loa.

ʻO nā hōʻailona o ka lāʻau make nerve koʻikoʻi e hiki ke komo pū me:

• Nā loli i ka helu o ka puʻuwai
• Ka huikau a i ʻole ka delirium
• Nalowale o ka ʻike
• ʻO ka Psychosis, me nā hallucinations
• Nā hopu ʻana
• Nā loli koʻikoʻi i ka mahana o ke kino (ke kuni kiʻekiʻe loa (hyperthermia) a i ʻole ka mahana kino haʻahaʻa loa (hypothermia))
• Ka hoʻomaka koke ʻana o ka nāwaliwali nui o nā ʻiʻo
• Nā pilikia ʻike koke a i ʻole ka nalowale o ka ʻike
• Paʻakikī ka hanu ʻana

He aha nā kumu o ka lāʻau make ʻana o ke aʻalolo?

I ka ʻōlelo maʻalahi, hana ʻia ka neurotoxicity i ka wā e hōʻino ai, hoʻololi, a pepehi paha nā neurotoxicants i ʻōlelo ʻia ma luna i nā cell i loko o kā mākou ʻōnaehana nerve peripheral a i ʻole waena. ʻO ka hapa pinepine, hoʻopilikia kēia i nā cell nerve, a i ʻole neurons . ʻIke ʻoe, ʻo kēia mau neurons nā mea nui e hoʻouna a hana i nā hōʻailona i loko o ko mākou lolo, spinal cord, a me nā aʻalolo peripheral. ʻAʻole wale nā ​​​​neurons, akā hiki ke hōʻino ʻia nā ʻāpana ʻē aʻe o ka ʻōnaehana nerve, no ka laʻana , ka myelin e uhi ana i nā aʻalolo.

No ka mea he ʻōnaehana paʻakikī loa ko kākou ʻōnaehana nerve, hiki ke hōʻike ʻia ka pōʻino i hana ʻia e ka neurotoxicity ma nā ʻano like ʻole. Eia kekahi mau laʻana:

• Nā loli i nā pae o nā neurotransmitters (no ka laʻana, dopamine), kahi kemika koʻikoʻi i ko kākou lolo, a me kā lākou hōʻailona.
• Ka mumū, a i ʻole ka pehu ʻana, o ka lolo a i ʻole ke kaula kuamoʻo (neuroinflammation).
• Nā loli kūkulu i loko o ka lolo, no ka laʻana, nā loli i ka nui o nā mea hina a me keʻokeʻo i loko o ka lolo.
• Ka hōʻino ʻana i ka ʻupena myelin e hoʻopuni ana i nā aʻalolo peripheral.

Ka hōʻike ʻana i nā mea hana aʻalolo

Aia nā ʻano like ʻole e hiki ai i kēia mau mea ʻāʻī ke komo i loko o ko mākou kino:

• Ma ka hanu ʻana
• Ma o ka meaʻai a mea inu paha (mai nā mea āu e ʻai ai a inu paha)
• Ma ka omo ʻana ma o ka ʻili

Hiki i kēia mau mea ʻawahia ke hoʻopilikia i kahi fetus. Inā komo kēia mau mea ʻawahia i ke kino o ka makuahine i ka wā hāpai, hiki iā lākou ke hele ma ke kahe koko i ka fetus ma o ke kaula umbilical . ʻO ia ke kumu i ʻōlelo ʻole ʻia ai kekahi mau lāʻau lapaʻau i ka wā hāpai, no ka mea hiki iā lākou ke loaʻa nā hopena neurotoxic i ka fetus.

Ke komo kēia mau mea ʻawahia i loko o ko kākou koko, hiki iā lākou ke hele i ke ala pale koko-lolo (BBB) ​​​​e pale ana i ko kākou lolo a hoʻopilikia pololei i nā ʻāpana o ka ʻōnaehana nerve waena. A i ʻole, e like me nā EDC i ʻōlelo ʻia ma mua, hiki iā lākou ke hoʻopilikia pololei i ka lolo ma ka hoʻololi ʻana i nā ʻōnaehana kino ʻē aʻe.

Nui nā wahi e hiki ai iā ʻoe ke pili i kēia mau mea ʻawaʻawa, no ka mea, ua pālahalaha ʻia nā kumu o kēia mau mea ʻawaʻawa ma nā wahi a pau.

• Haumia o ke kaiapuni: ka ʻōpala o ke kaʻa, nā hoʻokuʻu ʻana mai ka mahiʻai, nā hoʻokuʻu ʻana mai nā hale hana.
• Ka haumia kūloko: Ma nā wahi e like me nā paka, nā kula, a i ʻole mai nā ulia kemika ma ia wahi.
• Ka haumia o ka hale: Mai kekahi mau mea hale, nā meaʻai a me nā mea inu. Eia kekahi laʻana, kekahi mau wai hoʻomaʻemaʻe, nā pīpī pepeke, a me nā pena.

He aha nā pilikia e hiki mai ana?

Ua kūkākūkā mua mākou e hiki i kekahi mau neurotoxicants ke hoʻoulu i nā maʻi neurological mau loa . I nā hihia koʻikoʻi, hiki ke make.

ʻO ka ʻike ʻana i kekahi mau neurotoxicants, ʻoiai i ka wā o ka ulu ʻana o ka fetal a me ka wā kamaliʻi, ua ʻike ʻia e pili ana i kekahi o nā kūlana ma lalo nei:

• Ka maʻi hoʻolohe-nele/hyperactivity (ADHD)
• Nā kīnā aʻo
• Kaumaha
• Hopohopo
ʻO ka Schizophrenia-naʻau `(Schizophrenia)`
• Ka maʻi autism spectrum (ASD)

Akā, he mea nui e hoʻomanaʻo he hōʻike wale kēia i kahi pilina ma waena o ka ʻike ʻana i nā neurotoxins a me kēia mau kūlana. ʻAʻole maopopo i nā kānaka noiʻi inā paha ke kumu pololei nei kēia mau mea ʻawahia i kēia mau kūlana. Ke hoʻomau nei lākou i ke aʻo ʻana i nā hopena a me nā pilikia āpau o kēia mau neurotoxins.

Pehea ʻoe e ʻike ai i kēia? (Diagnosis)

No ka mea he mau haneli o nā ʻano o nā mea ʻāʻī aʻalolo a ʻokoʻa loa nā hōʻailona o nā mea ʻāʻī aʻalolo, pono paha kahi hōʻailona i kekahi mau hoʻokolohua a me nā hoʻokolohua. E nīnau mua kāu kauka iā ʻoe e pili ana i kāu mau hōʻailona a me ka mōʻaukala olakino . A laila e hana lākou i nā hoʻokolohua kino a me nā neurological.

Eia kekahi, hiki ke ʻōlelo ʻia nā hoʻokolohua aʻe:

• Loiloi ʻano hana
• Nā hoʻāʻo koko
• Nā hoʻokolohua noʻonoʻo
• ʻElectroencephalogram (EEG)
• He hoʻokolohua maka
• Nā hoʻokolohua kiʻi e like me ka MRI scan lolo
• Ke aʻo ʻana i ke alakaʻi ʻana o nā aʻalolo a me ka electromyography (EMG)
• Ka hoʻāʻo ʻana a me ka loiloi Neuropsychological
• Ka nānā ʻana i ka wai o ka lolo (CSF) (Spinal tap / Lumbar puncture)

I kekahi mau hihia, ʻaʻole hiki i nā kauka ke loaʻa ke kumu kūpono o nā hōʻailona o ka neurotoxicity.

He aha nā lāʻau lapaʻau?

ʻO nā koho lapaʻau e hilinaʻi nui ʻia i kāu mau hōʻailona a me ke ʻano o ka neurotoxin e hoʻoulu ai iā lākou. ʻO ka maʻamau, ʻo ka mālama ʻana e pili ana i ka hoʻopau ʻana a i ʻole ka hōʻemi ʻana i ka ʻike ʻana i ka toxin, a laila mālama a mālama paha i nā hōʻailona .

He aha ka manaʻo? (Wānana)

ʻO ka nānā ʻana no kekahi me ka neurotoxicosis e hilinaʻi ʻia i nā kumu he nui, e like me:

• He aha ke ʻano o ka mea hoʻopili aʻalolo i hōʻike ʻia?
• ʻEhia ka nui o ka hōʻike ʻia ma laila?
• ʻEhia ka lōʻihi o ka hōʻike ʻia ʻana?
• ʻEhia ka nui o ka pōʻino i hana ʻia i ka ʻōnaehana nerve?
• Kou makahiki a me kou olakino holoʻokoʻa

Hiki i ka hopena i kekahi mau mea ʻeha aʻalolo ke make. I kekahi mau hihia, ʻoiai inā he mea hoʻoweliweli ke ola, ʻaʻole paha e hoʻōla piha ka ʻōnaehana aʻalolo. I nā hihia ʻē aʻe, hiki ke hoʻōla piha ʻia ma hope o ka mālama ʻana.

Pehea ʻoe e pale aku ai i kēia? (Kāohi ʻana)

I ka ʻoiaʻiʻo, no ka nui o kēia mau mea hoʻopili aʻalolo i ke ola o kēlā me kēia lā, he mea paʻakikī ke pale loa iā lākou a pau . Eia nō naʻe, aia kekahi mau mea hiki iā ʻoe ke hana e hōʻemi i kou pilikia o ka hōʻike ʻia ʻana:

• E hoʻouka i kahi mea ʻike carbon monoxide i loko o kou home, a hoʻololi i kāna mau pila i hoʻokahi manawa i ka makahiki.
• Mai hoʻohui pū i nā huahana hoʻomaʻemaʻe a i ʻole nā ​​​​kemika o ka hale. ʻO ka hana ʻana pēlā e loaʻa ai nā hopena weliweli, a hiki i ka make.
• E hoʻāʻo ʻia kou home no nā mea ʻawahia ʻino ʻē aʻe, e like me ke kēpau.
• E pani i kou mau puka makani i nā lā me ka maikaʻi ʻole o ka ea (haumia kiʻekiʻe).
• E hōʻalo i ka hoʻohana ʻana i nā lāʻau lapaʻau a me ka waiʻona.
• Inā hāpai ʻoe, e kamaʻilio me kāu kauka e pili ana i ka ʻike ʻana i nā mea aʻalolo a pehea e pili ai i ka ulu ʻana o ka pēpē.

ʻO ka mea nui loa, ʻo ka pale ʻana iā ʻoe iho a me kou ʻohana mai kēia mau mea ʻawaʻawa ʻaʻole ia kou kuleana wale nō. ʻO ke kuleana hui ia o nā aupuni mokuʻāina a me nā aupuni kūloko, nā ʻoihana, a me nā kamaʻāina. Ke hoʻomau nei nā ʻoihana e like me ka National Institute of Environmental Health Services (NIEHS) i ka noiʻi ʻana pehea e pili ai ke kaiapuni a me nā mea ʻawaʻawa i ke olakino kanaka.

ʻO ka mea hope loa, nā mea e hoʻomanaʻo ai

Hiki ke hana ʻia ka neurotoxicity e nā mea like ʻole a hiki ke hana i nā ʻano hōʻailona like ʻole. ʻOiai he paʻakikī ke pale aku i nā neurotoxicants āpau, aia nā mea hiki iā ʻoe ke hana e pale iā ʻoe iho a me kou ʻohana. Inā loaʻa iā ʻoe a i ʻole kāu keiki kekahi mau hōʻailona neurological, a inā he hopohopo kou e pili ana i ka hōʻike ʻana i nā neurotoxicants, e ʻike pono i ke kauka. Eia lākou e kōkua.

ʻO ka neurotoxicity, ʻōnaehana neurological, nā mea ʻawahia, nā hōʻailona, ​​​​​​ke olakino o ka lolo, ka pale ʻana