He aha kēia mau lāʻau hou no ka maʻi o Alzheimer? (NMDA Receptor Antagonists) E kamaʻilio kākou.

Loaʻa i kāu mea aloha, ʻo kou makuahine paha, kou makuakāne, kupuna wahine a kupuna kāne paha, ka maʻi ʻo Alzheimer? Ua ʻike mākou a pau i ke kaumaha a me ke kōkua ʻole e hele mai me ka nalowale mālie ʻana o ka hoʻomanaʻo a me ka poina ʻana i nā helehelena maʻamau. ʻO ka maʻi ʻo Alzheimer kahi maʻi e hiki ai ke alakaʻi i ka nalowale o ka hoʻomanaʻo, ka hōʻino ʻana o ka lolo a me ka make. ʻOiai ʻaʻohe lāʻau lapaʻau no kēia maʻi, aia nā lāʻau lapaʻau e hiki ke hoʻolohi iā ia a hāʻawi i kahi hōʻoluʻolu i ka mea maʻi. I kēia lā e kamaʻilio mākou e pili ana i kekahi papa kūikawā o nā lāʻau lapaʻau. ʻO ia hoʻi ʻo NMDA Receptor Antagonists . ʻOiai he paʻakikī iki ka inoa, e hoʻomaopopo maʻalahi kākou.

He moʻolelo kemika liʻiliʻi e hana ana i loko o ka lolo

He wahi kupaianaha ko kākou lolo. Loaʻa iā ia nā piliona o nā hunaola nerve, a i ʻole nā ​​'neurons'. Hoʻoponopono kēia mau hunaola i ka ʻike, hoʻomanaʻo i ka ʻike, a haʻi i nā ʻāpana ʻē aʻe o ke kino i ka mea e hana ai ma ka hoʻouna ʻana i nā hōʻailona uila a me nā kemika i kekahi i kekahi.

Kāhea mākou i nā ʻelele e lawe ana i kēia mau hōʻailona kemika he 'neurotransmitters'. ʻO kekahi o kēlā mau ʻelele he 'glutamate' .

E noʻonoʻo wale i ka glutamate ma ke ʻano he waʻa e lawe ana i kahi leka mai kekahi cell nerve i kekahi. Pono kēia waʻa i kahi uapo kūikawā e hele ai i kekahi cell a uapo. ʻO kēlā uapo ka mea a mākou e kapa nei ʻo ka NMDA receptor (`N-methyl-D-aspartate` receptor. Ke hoʻopili ka waʻa i kapa ʻia ʻo glutamate i kēia awa NMDA, hoʻouna ia i kahi mea nui ʻē aʻe i kapa ʻia ʻo `calcium` i loko o ke kelepona. ʻO kēia calcium ka mea e hoʻopau ai i kēlā leka a kōkua iā mākou e aʻo a hoʻomanaʻo i kekahi mea. He hana maʻamau kēia i loko o ka lolo olakino.

No laila he aha ka mea e hana ai i ka maʻi o Alzheimer?

I loko o nā pūnaewele lolo o kekahi me ka maʻi Alzheimer , hoʻomaka ka nui o ka glutamate e hana ʻia . ʻO ka mea e hana ʻia, ʻo ia ka nui o ka calcium e kahe ana i loko o kēlā mau pūnaewele nerve. E noʻonoʻo i ka mea e hana ʻia inā ʻoe e hoʻopiha i kahi pahu wai me ka nui o ka wai? Piha ia. Pēlā nō, i ka wā e hōʻiliʻili nui ai ka calcium i loko o nā pūnaewele, hoʻomaka ka hōʻino ʻia o kēlā mau pūnaewele. ʻO kēia pōʻino ka mea e hoʻonui mālie ai i nā hōʻailona o Alzheimer.

Eia ke kōkua ʻana o nā NMDA Receptor Antagonists

Hana ka papa o nā lāʻau i kapa ʻia ʻo NMDA receptor antagonists ma ka hōʻemi ʻana i ka helu o nā wahi e hiki ai i kēlā mau waʻa glutamate keu ke kau ma ka NMDA receptor. ʻO ia hoʻi, ke ālai nei ka lāʻau i kekahi o nā awa. Akā ʻo ka mea nui loa, ʻo ia ka ʻae ʻana o kēia mau lāʻau i nā leka koʻikoʻi e kahe . ʻO ia hoʻi, ke kāohi wale nei lākou i ke kahe luku o ka calcium me ka ʻole o ka hoʻopilikia nui ʻana i ka hana maʻamau o ka lolo. Hoʻemi kēia i ka hōʻino ʻana i nā hunaola nerve a kāohi i ka wikiwiki o ka maʻi.

ʻO ka mea hoʻouka kaua NMDA nui i ʻae ʻia i kēia manawa no ka mālama ʻana i ka maʻi Alzheimer ʻo ia ka memantine (inoa inoa ʻo `Namenda XR`). Hoʻomaʻamaʻa pinepine ʻia e nā kauka no nā pae waena a koʻikoʻi o ka maʻi. I kekahi manawa, hāʻawi ʻia ka memantine me ka hui pū ʻana me nā `cholinesterase inhibitors` i ʻōlelo mua ʻia, kahi e hoʻonui ai i nā pae acetylcholine. Hiki i kēia ke alakaʻi i nā hopena maikaʻi aʻe i kekahi mau maʻi.

Akā e hoʻomanaʻo, ʻaʻole like ka hana o kēia mau lāʻau lapaʻau no nā kānaka a pau.

E makaʻala hoʻi kākou i nā hopena ʻaoʻao.

E like me nā lāʻau lapaʻau āpau, hiki i kēia ke loaʻa nā hopena ʻaoʻao liʻiliʻi.

• ʻO ka dizziness ka hōʻailona maʻamau.
• Eia kekahi, hiki ke loaʻa nā mea e like me ka ʻeha poʻo a me ka constipation .
• He mea kākaʻikahi loa, aia kahi hiki ke huikau i loko o ka lolo .

Inā ʻike ʻoe a i ʻole kāu maʻi i kekahi o kēia mau mea, pono ʻoe e hoʻomaopopo koke i kāu kauka . ʻAʻole maikaʻi ka hoʻōki ʻana i ka lawe ʻana i ka lāʻau lapaʻau a hoʻololi paha i ka nui o ka lāʻau ma kāu iho.

Nā lāʻau lapaʻau ʻē aʻe i loko o kēia ʻohana a me kā lākou hoʻohana

Aia kekahi mau lāʻau ʻē aʻe i loko o kēia ʻohana i kapa ʻia ʻo NMDA receptor antagonists. ʻIke mākou i kekahi o lākou i ke ola o kēlā me kēia lā. ʻOi aku ka weliweli o kekahi, a ua hoʻohana hewa ʻia e like me nā lāʻau lapaʻau. Ke noiʻi nei nā kānaka ʻepekema i nā pono o kēia papa o nā lāʻau lapaʻau no nā maʻi neurological ʻē aʻe, e like me ka maʻi Parkinson a me ALS (amyotrophic lateral sclerosis).

E aʻo hou kākou e pili ana i ia mea mai ka papa ma lalo nei.