Ua ʻike anei ʻoe e pili ana i kēia lāʻau lapaʻau no ka nausea a me ka luaʻi? (Serotonin Antagonist) E kamaʻilio kākou!

Ua loaʻa anei iā ʻoe ka nausea nui a me ka luaʻi ma hope o ke ʻoki kino a i ʻole i ka wā o kekahi hana nui ʻē aʻe? A i ʻole ua loaʻa iā ʻoe ka maʻi kakahiaka hiki ʻole ke hoʻomanawanui i ka wā hāpai? Hiki ke lilo i mea ʻoluʻolu ʻole a hiki ke hoʻolilo i ko mākou ola i mea ʻeha. Eia nō naʻe, aia kahi papa lāʻau lapaʻau kūpono loa a nā kauka e hoʻohana ai e kāohi i kēia ʻano nausea a me ka luaʻi. ʻO ia ka mea a mākou e kamaʻilio ai i kēia lā.

I ka ʻōlelo maʻalahi, he aha kēia mea kū'ē i ka serotonin?

ʻO kēia ka inoa i hāʻawi ʻia i kahi papa o nā lāʻau lapaʻau. I ka ʻōlelo maʻalahi, ʻo ia nā lāʻau lapaʻau i hāʻawi ʻia e pale a mālama i ka nausea a me ka luaʻi. Ma nā ʻōlelo lapaʻau, ua kapa ʻia kēia mau mea he 'antiemetics'. ʻOiai inā ʻaʻole i haʻi pololei kāu kauka i kēia inoa, ua kuhikuhi ʻia paha ʻoe i kahi lāʻau lapaʻau ma kēia papa.

Aia kekahi mau inoa ʻē aʻe i hoʻohana ʻia no kēia papa o nā lāʻau lapaʻau:

• Nā mea kū'ē i ka serotonin-receptor
• Nā mea kū'ē i ka mea loaʻa 5HT3
• Nā mea pale serotonin

ʻOiai paha he mea paʻakikī iki kēia mau inoa, ua like ke ʻano o lākou a pau. ʻO ia hoʻi, ke ālai nei kēia mau lāʻau lapaʻau i ka hana o kahi kemika i loko o ko kākou kino i kapa ʻia ʻo serotonin . E nānā kākou iā ia me nā kikoʻī hou aku.

Aia kekahi mau ʻano lāʻau lapaʻau ma kēia māhele i hoʻohana nui ʻia ma Sri Lanka a puni ka honua:

• ʻO Ondansetron - ʻO kēia ka mea i ʻike nui ʻia. Aia ia ma lalo o ka inoa inoa ʻo Zofran®.
• Granisetron - loaʻa ma lalo o ka inoa inoa ʻo Kytril®.
• Palonosetron - loaʻa ma lalo o ka inoa inoa ʻo Aloxi®.
• ʻO Dolasetron - ʻOiai ua kapa mua ʻia ʻo Anzemet®, ua hoʻopau ʻia ka hoʻohana ʻana ma nā ʻāina e like me ʻAmelika Hui Pū ʻIa.

Loaʻa kēia lāʻau lapaʻau ma ke ʻano pila a me ka inikini.

He aha maoli ka hoʻohana ʻia ʻana o kēia lāʻau lapaʻau?

Ua ʻae mua ʻia kēia mau lāʻau lapaʻau e pale i ka nausea a me ka luaʻi ʻana i kekahi mau kūlana.

• Nā lāʻau lapaʻau no ke kanesa (Chemotherapy): He mea nui kēia no ka kaohi ʻana i ka nausea nui a ka poʻe he nui e ʻike ai i ka wā o ka chemotherapy.
• Lapaʻau radiation: Hiki i ka lāʻau radiation no ka maʻi kanesa ke hoʻoulu i ka luaʻi.
• Ma hope o ka Anesthesia: Nui ka poʻe e ʻike i ka luaʻi a me ka nausea ke hoʻi hou lākou i ka ʻike ma hope o ka hana ʻana i ka anesthesia no ke ʻoki kino. Hāʻawi ʻia kēia lāʻau lapaʻau e pale aku i kēia.

Ua kuhikuhi ʻia kēia e nā kauka e like me ke kūpono no nā pākeke a me nā keiki.

Eia nā hiʻohiʻona o ka hoʻohana ʻana i kēia lāʻau lapaʻau ma waho o ka lepili:

• Ke mālama ʻana (ʻaʻole wale ka pale ʻana) i ka nausea a me ka luaʻi ma hope o ke ʻoki ʻana.
• No ka kāohi ʻana i ka nausea nui a me ka luaʻi ʻana (ka maʻi kakahiaka) i ka wā hāpai i paʻakikī ke kaohi me nā lāʻau lapaʻau ʻē aʻe.

Pehea e hana ai kēia lāʻau lapaʻau i loko o ko mākou kino?

No ka hoʻomaopopo ʻana i kēia, e hoʻomaopopo mua kākou i ke ʻano o ka 'serotonin'.

He neurotransmitter ʻo Serotonin i loko o ko kākou kino. Ua like ia me kahi 'ʻelele'. Hoʻomalu kēia ʻelele i nā mea he nui, me ko kākou ʻano, ka hiamoe, a me ka ʻai ʻana. Loaʻa ka 90% o ka serotonin i loko o ko kākou kino i loko o nā pūnaewele o kā kākou ʻōnaehana ʻai (nā ʻōpū).

E noʻonoʻo, ke loaʻa iā mākou kahi mea e like me ka chemotherapy, ua hōʻino ʻia nā cell i loko o ko mākou ʻōpū. A laila, hoʻokuʻu koke kēlā mau cell i ka nui o ka serotonin i loko o ke kahe koko. Hoʻouna kēia serotonin keu i kahi leka i ka lolo e ʻōlelo ana, "Ua hewa kekahi mea ma aneʻi!" ʻO kēlā leka ka mea e hoʻohauʻoli ai iā mākou.

I mea e hiki ai i kēia mau leka serotonin ke hōʻea i ka lolo, pono lākou e nakinaki i nā 'mea loaʻa' kikoʻī i loko o ko kākou ʻōpū a me ka lolo. Ua like kēia me nā 'puka kī' e komo ai kahi kī. ʻO Serotonin ke kī, a ʻo ka mea loaʻa ka puka kī. Ke hoʻokomo pono ʻia ke kī, wehe ʻia ka puka (ʻo ia hoʻi, hoʻouna ʻia ka leka nausea).

Hana ka lāʻau lapaʻau 'Serotonin Antagonist' ma ke komo ʻana i kēia mau puka kī (nā mea loaʻa 5-HT3) a ke ālai nei iā lākou. Ua like ia me ke kau ʻana i kahi kī hoʻopunipuni i loko o ka puka kī. A laila, ʻaʻole hiki i ke kī maoli (serotonin) ke komo. ʻAʻole hele ka leka i ka lolo. ʻO ka hopena? Pau ka nausea a me ka luaʻi.

Nā hopena ʻaoʻao a me nā pilikia o nā lāʻau lapaʻau

Ma ke ʻano laulā, palekana loa kēia lāʻau lapaʻau. Eia nō naʻe, e like me nā lāʻau lapaʻau āpau, loaʻa iā ia kekahi mau hopena ʻaoʻao a me kekahi mau mea e makaʻala ai.

Nā hopena ʻaoʻao maʻamau

• ʻEha poʻo
• Luhi
• Ka paʻa ʻana o ka ʻōpū

ʻAʻole maʻamau kēia mau mea he mea koʻikoʻi, akā inā hoʻopilikia lākou iā ʻoe, e kamaʻilio me kāu kauka.

Nā pilikia e makaʻala nui ʻia

He mea hou aʻe e pili ana i ka Serotonin Syndrome

He kūlana koʻikoʻi kēia hiki ke hoʻoweliweli i ke ola. E makaʻala pono i nā hōʻailona ma lalo nei. Inā ʻike ʻoe i kekahi a ʻoi aku paha o kēia mau mea, e hele koke i ka ʻOihana Pilikia o ka haukapila (ETU).

• Hoʻomaha ʻole, hopohopo
• Ka luaʻi a me ka luaʻi
• Ka maʻi pākī
• Ka hoʻonui ʻia ʻana o nā haumāna o nā maka
• Nā haʻalulu kino
• ʻŌwiliwili ʻana o nā ʻiʻo, ʻoʻoleʻa
• Ke hou nei, ke anu nei
• Ka huikau, ka nalowale o ka ʻike
• Nā palpitations o ka puʻuwai
• Ke koko kiʻekiʻe
• Ka mahana o ke kino kiʻekiʻe (ma luna o 101.3°F / 38.5°C)
• Nā hopu ʻana
• Nalowale o ka ʻike

Āhea wau e ʻike hou ai i ke kauka?

Inā ʻoe e lawe ana i kēia lāʻau lapaʻau no ka manawa lōʻihi, he mea nui e mālama mau i ka launa pū ʻana me kāu kauka. E kamaʻilio me kāu kauka i nā kūlana aʻe:

• Inā hoʻomaka nā hopena ʻaoʻao e hoʻopilikia iā ʻoe.
• Inā ʻaʻole hoʻomaikaʻi a i ʻole e ʻoi aku ka ʻino o kou nausea a me ka luaʻi.
• Inā ʻoe e noʻonoʻo ana e hoʻōki i ka lāʻau lapaʻau (mai hoʻōki i ka lawe ʻana i ka lāʻau lapaʻau me ka ʻole o ke noi ʻana i kāu kauka).

He ʻike ʻoluʻolu ʻole ka luaʻi. Akā ʻo ka nūhou maikaʻi, aia nā lāʻau lapaʻau kūpono loa i loaʻa i kēia lā e kāohi i ia mau kūlana. Inā loaʻa iā ʻoe kēia pilikia, e kamaʻilio me kāu kauka e pili ana i ia mea a loaʻa iā ʻoe ka lāʻau lapaʻau kūpono loa iā ʻoe.