Makemake ʻoe e aʻo e pili ana i ka lāʻau Taxane no ka maʻi ʻaʻai umauma? Mai makaʻu, e kamaʻilio kākou!

I ka wā i haʻi aku ai kāu kauka iā ʻoe ua loaʻa iā ʻoe ka maʻi ʻaʻai umauma, ua ʻike anei ʻoe i ka inoa ʻo 'Taxane' i ʻōlelo ʻia ma kāu hoʻolālā lapaʻau? Ua hopohopo iki paha ʻoe i kou lohe ʻana i kēia inoa. He mea maʻamau ka noʻonoʻo ʻana i nā mea ke lohe ʻoe i ka huaʻōlelo 'chemotherapy' me kēia inoa. Akā, mai hopohopo. He lāʻau lapaʻau maikaʻi loa ʻo Taxane i hoʻohana ʻia i ka mālama ʻana i ka maʻi ʻaʻai umauma no nā makahiki he 40 a ʻoi. E kamaʻilio kākou e pili ana i ia mea ma ke ʻano maʻalahi hiki iā ʻoe ke hoʻomaopopo.

He aha kēia mau taxanes? Pehea lākou e hana ai?

I ka ʻōlelo maʻalahi, ʻo nā taxanes kahi ʻano chemotherapy e pale ai i nā hunaola kanesa mai ka māhele ʻana, hoʻonui ʻana, a me ka laha ʻana ma ke kino holoʻokoʻa.

E noʻonoʻo wale, e like me nā ʻōnaehana olakino i loko o ko kākou kino, hoʻonui nā ʻōnaehana maʻi kanesa ma ka māhele ʻana. Kōkua ʻia kēia kaʻina hana o ka māhele ʻana o nā ʻōnaehana e kahi ʻōnaehana o nā ʻōmole liʻiliʻi (microtubules) i loko o kā lākou mau ʻōnaehana. ʻO ka papa taxane o nā lāʻau lapaʻau, a ʻoi aku ka pololei o nā "antimicrotubule agents", e hele pololei i kēlā ʻōnaehana ʻōnaehana ʻōnaehana a kuhikuhi iā ia. Hoʻopilikia kēia mau lāʻau lapaʻau i ka hana o kēlā ʻōnaehana ʻōnaehana ʻōnaehana a hoʻopau iā ia. A laila ʻaʻole hiki i nā ʻōnaehana ʻōnaehana ʻōnaehana ke māhele, a make kēlā mau ʻōnaehana. ʻO kēia ke kumu nui o kēia lāʻau lapaʻau.

He mea pono paha kēia lāʻau lapaʻau i kāu hoʻolālā lapaʻau, ʻoiai inā he ʻano maʻi ʻaʻai umauma "(HER2-positive)" kou.

Hoʻohana ʻia nā lāʻau Taxane (no ka laʻana, `(Docetaxel)` a me `(Paclitaxel)`) i nā ʻano ʻelua:

1. Ka maʻi ʻaʻai umauma mua: Hāʻawi ʻia kēia lāʻau lapaʻau ma mua o ke ʻoki ʻana e hoʻēmi a hoʻemi i ka puʻupuʻu. Hāʻawi ʻia nō hoʻi ma hope o ke ʻoki ʻana e pale aku i ka hoʻi hou ʻana mai o ke kanesa.

2. Ka maʻi ʻaʻai umauma metastatic: Hoʻohana ʻia kēia lāʻau lapaʻau e kāohi i ka maʻi ʻaʻai i laha i nā ʻāpana ʻē aʻe o ke kino.

Pehea e hāʻawi ʻia ai nā lāʻau Taxane?

I kēia manawa, hāʻawi ʻia nā lāʻau Taxane ma ke ʻano intravenous (IV) , ʻo ia hoʻi, hāʻawi ʻia lākou ma ke ʻano he wai saline i loko o kahi aa. Hana ʻia kēia ma kahi haukapila a i ʻole ke keʻena maʻi kanesa.

I kekahi manawa hāʻawi wale ʻia nā taxanes (monotherapy). I kekahi manawa, hāʻawi ʻia lākou me ka hui pū ʻana me nā lāʻau chemotherapy ʻē aʻe e ʻoi aku ka maikaʻi o ka lāʻau. No ka laʻana, hāʻawi pū ʻia lākou me nā lāʻau e like me Capecitabine, Carboplatin, a me Cyclophosphamide.

He aha kāu e manaʻo ai i ka wā e loaʻa ai ka lāʻau lapaʻau?

Ke hoʻoholo kāu kauka e hoʻomaka i ka mālama ʻana i ka taxane, e hana lākou i kahi papa hana lapaʻau kūikawā nou. Hoʻokomo pū kēia i ka pinepine o kou pono e hele mai i ka haukapila a me ka lōʻihi o ka manawa e loaʻa ai ka lāʻau lapaʻau.

• Helu o nā lāʻau lapaʻau: ʻOkoʻa kēia mai kēlā kanaka a kēia kanaka. Aia ia i ke ʻano o ka lāʻau lapaʻau i hāʻawi ʻia iā ʻoe (`(Docetaxel)` a i ʻole `(Paclitaxel)`), ka nui o ka lāʻau lapaʻau, a pehea e pane ai kou kino iā ia.
• Eia kekahi laʻana, hāʻawi pinepine ʻia ʻo `(Docetaxel)` i hoʻokahi manawa i kēlā me kēia 3 pule . ʻO kēlā me kēia mahele lāʻau e lawe ʻia ma kahi o hoʻokahi hola.
• Hāʻawi pinepine ʻia ʻo Paclitaxel. Malia paha i hoʻokahi manawa i kēlā me kēia ʻelua pule . Hiki ke hala ma kahi o ʻelua hola. Aia kekahi mau hihia kahi e hāʻawi ʻia ai kahi mahele haʻahaʻa i hoʻokahi manawa i ka pule no kekahi poʻe.
• Ka nui o ka lāʻau lapaʻau: ʻO ka nui o ka lāʻau lapaʻau i hāʻawi ʻia iā ʻoe ma muli o kekahi mau kumu, me ke ʻano a me ke kahua o kou maʻi ʻaʻai, kou kaumaha a me ke kiʻekiʻe, a me nā lāʻau lapaʻau ʻē aʻe i hāʻawi ʻia iā ʻoe.
• Ka lōʻihi o ka lāʻau lapaʻau: Pili nō hoʻi kēia i ka holomua o ka lāʻau lapaʻau a inā he mau hopena ʻino kou. ʻO ka maʻamau, ʻekolu a ʻeono mau pōʻaiapuni o ka lāʻau lapaʻau e hāʻawi ʻia no ka maʻi ʻaʻai i laha ʻole. ʻO ka maʻi ʻaʻai i laha paha e koi aku i ka lāʻau lōʻihi.

Akā e hoʻomanaʻo, inā loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi a i ʻole ʻaʻole hiki ke ʻae i ka lāʻau lapaʻau, hiki i kāu kauka ke hoʻololi iā ʻoe i kahi lāʻau lapaʻau ʻē aʻe.

Hoʻopilikia anei ʻo Taxanes i nā hopena ʻaoʻao?

ʻAe. Minamina, e like me nā lāʻau chemotherapy āpau, hiki i nā taxanes ke hana i nā hopena ʻaoʻao. ʻO kēia no ka mea ʻaʻole wale kēia mau lāʻau e hoʻopilikia i nā cell cancer, akā i nā cell olakino hoʻi e māhele wikiwiki ana. Eia nō naʻe, i ka hapanui o nā hihia, he liʻiliʻi a ʻae ʻia nā hopena ʻaoʻao o nā taxanes i hoʻohālikelike ʻia me nā lāʻau chemotherapy ʻē aʻe.

Hiki i kēia mau hopena ʻaoʻao ke ʻano mai ka liʻiliʻi a i ka koʻikoʻi e pono ai ke mālama ʻia i ka haukapila. E nānā kākou i kēia mau hopena ʻaoʻao.

ʻO ka hapa nui o ka manawa, e nalowale ana kēia mau hopena ʻaoʻao i loko o kekahi mau pule a i ʻole mau mahina ma hope o ka hoʻōki ʻana o ka lāʻau lapaʻau. Eia nō naʻe, aia kekahi mau hihia kahi i koʻikoʻi ai ka neuropathy a ʻaʻole e nalowale loa no kekahi poʻe.

Pehea ka maikaʻi o kēia lāʻau lapaʻau?

He lāʻau lapaʻau kūpono loa ʻo Taxane, ʻo ia ke kumu i hoʻohana ʻia ai no ka manawa lōʻihi.

No ke kahua mua o ka maʻi kanesa:

Ua ʻike ʻia e ka noiʻi ʻana ʻo ka hāʻawi ʻana i nā taxanes i nā wahine me ke kanesa umauma mua i hana ʻia i ke ʻoki ʻana e hoʻonui i ko lākou helu ola a hoʻemi i ka pilikia o ka hoʻi hou ʻana mai o ke kanesa.

No ka maʻi ʻaʻai umauma metastatic:

I nā hihia i pālahalaha ai ke kanesa, ʻaʻole hiki i ka taxane therapy ke ho'ōla i ke kanesa, akā hiki iā ia ke kōkua nui i ka kaohi ʻana i ka holomua o ka maʻi a hoʻolōʻihi i ke ola.

ʻOiai ʻo kēia lāʻau lapaʻau ka mea i hoʻohana pinepine ʻia no nā maʻi kanesa HER2-positive, hiki ke hoʻohana ʻia no kahi ʻano maʻi kanesa paʻakikī ke mālama ʻia i kapa ʻia ʻo Triple-Negative Breast Cancer (TNBC).

Aia kekahi mau manawa i holo pono ʻole ai ka lāʻau Taxane?

ʻAe, i kekahi manawa hiki. ʻAʻole pane like nā maʻi kanesa āpau i nā taxanes. ʻAʻole paha e pane kekahi mau maʻi kanesa i kēia lāʻau mai ka hoʻomaka ʻana. I kekahi manawa, ma hope o ka hana ʻana o ka lāʻau no kekahi manawa, ua maʻa ke kanesa i ka lāʻau a hoʻomohala i ke kūʻē. A laila pau ka hana ʻana o ka lāʻau.

He mea maʻamau kēia kūlana i nā maʻi ʻaʻai "triple-negative". ʻAʻole maopopo i nā kānaka ʻepekema ke kumu o kēia.

I kēia manawa, hiki i kāu kauka ke hoʻololi i ka hui pū ʻana o ka lāʻau lapaʻau a hoʻololi paha iā ʻoe i kahi ʻano lapaʻau ʻokoʻa loa.