Ua ʻike mākou i ka paʻakikī o ke kaua ʻana i ka maʻi ʻaʻai umauma. Akā me ka holomua o ka ʻepekema lapaʻau, hoʻohui mau ʻia nā manaʻolana hou. I kēia lā ke kamaʻilio nei mākou e pili ana i kahi lāʻau i lawe mai i kēlā manaʻolana hou, kahi lāʻau e kuhikuhi pono ana a mālama i nā hunaola kanesa. ʻO Truqap ka inoa o kēia lāʻau.
He aha ʻo Truqap? He ʻokoʻa anei ia mai ka lāʻau lapaʻau maʻamau?
He lāʻau lapaʻau i kuhikuhi ʻia ʻo Truqap (capivasertib) no ka maʻi ʻaʻai umauma. I kēia manawa ke noʻonoʻo nei paha ʻoe, "He aha kēia lāʻau lapaʻau i kuhikuhi ʻia?"
I ka ʻōlelo maʻalahi, e noʻonoʻo i kahi māla me ka nui o nā nāhelehele. ʻO ka chemotherapy maʻamau e like me ka pīpī ʻana i ka māla holoʻokoʻa me ka herbicide. A laila, me nā nāhelehele, hiki ke luku ʻia nā mea kanu maikaʻi a olakino. ʻO ke ʻano kēia, hiki i ka chemotherapy ke pepehi i nā hunaola kanesa, akā hiki nō hoʻi ke hōʻino i nā hunaola olakino i loko o ko mākou kino.
Akā, ua like ka lāʻau lapaʻau i kuhikuhi ʻia me ka loaʻa ʻana o kahi mauʻu a pīpī wale nō. Hoʻomaopopo ia i nā protein kikoʻī e kōkua i nā hunaola kanesa e ulu koke, a kāohi iā lākou mai ka hana ʻana pēlā. ʻO ke ʻano kēia, ʻoi aku ka liʻiliʻi o ka hōʻino ʻana i nā hunaola olakino.
ʻO Truqap kekahi o ia ʻano lāʻau lapaʻau i kuhikuhi ʻia. Ua ʻāpono ka US FDA i ka lāʻau lapaʻau i ka makahiki 2023, no ke kanesa umauma holomua i loaʻa ka hormone-positive (HR-positive) a he mau loli genetic. Hāʻawi pinepine ʻia ka lāʻau lapaʻau me kahi lāʻau lapaʻau hormone ʻē aʻe i kapa ʻia ʻo fulvestrant.
Pehea ka hana a Truqap ma ke kino?
ʻO kekahi mau maʻi me ka maʻi ʻaʻai umauma e hilinaʻi ana i ka hormone (HR-positive) he mau mutations i loko o nā genes i kapa ʻia ʻo PIK3CA, AKT1, a i ʻole PTEN . ʻO nā mutations i loko o ka gene AKT1, ma ke ʻano kūikawā, hiki ke kōkua i nā hunaola kanesa e ulu a māhelehele koke.
ʻO ka hana a Truqap , ʻo ia ke ālai i ka hana o kahi protein i kapa ʻia ʻo AKT . Ua like ia me ke kinai ʻana i kahi kuapo e hoʻolalelale ana i ka ulu ʻana o nā hunaola kanesa.
ʻAʻole wale ia. Hilinaʻi nā hunaola kanesa e hilinaʻi ana i ka hormone i nā hormones e like me ka estrogen i loko o ko kākou koko e ulu ai. ʻO ia ke kumu i hāʻawi ʻia ai ʻo Truqap me ka hui pū ʻana me kahi lāʻau hormone i kapa ʻia ʻo fulvestrant.
- Truqap: Hoʻopaʻa i ka protein AKT e hoʻonui ai i ka ulu ʻana o nā hunaola kanesa.
- Fulvestrant: Kāohi i ka hormone estrogen mai ka hiki ʻana i nā hunaola kanesa.
ʻO ka hoʻouka ʻana mai nā ʻaoʻao ʻelua ma kēia ʻano e kōkua nui i ke kāohi ʻana i ka ulu ʻana o nā hunaola maʻi ʻaʻai.
Pehea e ʻike ai inā kūpono kēia lāʻau lapaʻau iaʻu?
Hiki ke kūpono ka lāʻau lapaʻau ʻo Truqap iā ʻoe i nā hihia aʻe:
- Kou maʻi kanesaInā ua holomua, a ua pālahalaha paha i nā ʻāpana ʻē aʻe o ke kino (metastatic) .
- Inā ua hōʻoia nā hoʻokolohua kikoʻī ua loaʻa i kāu mau hunaola kanesa nā loli genetic i ʻōlelo ʻia ma luna (PIK3CA, AKT1, PTEN) .
- Inā ua loaʻa mua iā ʻoe ka lāʻau lapaʻau hormone, a ua hoʻi mai ke kanesa i ka wā a ma hope paha o kēlā lāʻau lapaʻau.
ʻO ka mea nui loa, na kāu kauka maʻi kanesa e hoʻoholo inā kūpono kēia lāʻau lapaʻau iā ʻoe. E nānā ʻo ia i nā loli genetic i loko o kou maʻi kanesa a nānā hou i kāu mōʻaukala lapaʻau piha e hana i ka hoʻoholo hope loa.
He aha nā hopena ʻaoʻao o Truqap? Pehea e hiki ai ke mālama ʻia?
E like me nā lāʻau lapaʻau āpau, hiki iā Truqap ke hana i nā hopena ʻaoʻao. Hiki i kekahi o lākou ke koʻikoʻi. No laila he mea nui e makaʻala i kēia mau mea.
Aia ma lalo iho nā hopena ʻaoʻao nui a me nā mea e hana ai inā loaʻa.
| Ka hopena ʻaoʻao | He aha e hana ai |
|---|---|
| Ke kō koko kiʻekiʻe | Inā ʻike ʻoe i nā hōʻailona e like me ka makewai ʻole, ka mimi pinepine ʻana, a i ʻole ka pohō kaumaha ʻoiai ʻo ka ʻai nui ʻana, e haʻi koke i kāu kauka . E hoʻāʻo mau ʻo ia i kāu kō koko a hana i nā mea e pono ai e kaohi i kāu pae kō. |
| Ka maʻi pākī | E haʻi koke aku i kāu kauka ke hoʻomaka ʻoe e loaʻa i ka maʻi diarrhea. E inu i nā wai he nui, e like me ka wai a me ka wai huaʻai, e pale aku i ka maloʻo ʻana o ka wai. Na kāu kauka e kuhikuhi i ka lāʻau kūpono nāu. |
| Nā hopena ʻili | Inā ʻike ʻoe i nā ʻeha ʻili hou, ka hoʻonui ʻia ʻana o nā ʻeha e kū nei, ka ʻulaʻula o ka ʻili, ke kuni, nā pehu ma nā lehelehe/maka/waha, nā pehu ʻili a i ʻole ka ʻili ʻiliE hoʻomaopopo koke i kāu kauka. Na ia e hoʻoholo inā e hoʻomau i ka lawe ʻana i ka lāʻau lapaʻau a i ʻole e hoʻololi i ka nui. |
Ma waho aʻe o kēia mau mea, hiki iā ʻoe ke ʻike i ka nausea, ka luaʻi ʻana, ka luhi, nā ʻeha waha, a me nā loli i kekahi mau hopena o nā hoʻāʻo koko.
ʻO ka mea nui loa: Mai ho'ōki i ka lawe ʻana i kāu lāʻau lapaʻau a hoʻololi paha i ka nui me ka ʻole o ke aʻo ʻana a kāu kauka. Inā loaʻa iā ʻoe kekahi mau hōʻailona e hoʻopilikia nei iā ʻoe, e kamaʻilio me lākou e pili ana iā lākou.
Ke launa pū nei ʻo Truqap me nā lāʻau lapaʻau a meaʻai paha?
ʻAe, he mea nui loa kēia. Hiki iā Truqap ke launa pū me kekahi mau lāʻau lapaʻau a me nā meaʻai ʻē aʻe. No laila, pono ʻoe e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau āpau āu e lawe nei (me nā lāʻau lapaʻau no nā kūlana ʻē aʻe, nā huaora, a me nā huahana lāʻau).
ʻO kēia no ka mea hoʻohana ko mākou kino i kahi enzyme i kapa ʻia ʻo CYP3A e wāwahi i kēia lāʻau a wehe iā ia mai ke kino. Hiki i kekahi mau lāʻau lapaʻau a me nā meaʻai ke hoʻololi i ke ʻano o ka hana ʻana o kēia enzyme CYP3A.
- Nā mea pale CYP3A: Ke kāohi nei kēia i ka hana o ka enzyme CYP3A. Hiki i kēia ke hoʻolilo iā Truqap e noho lōʻihi i loko o ke kino a hoʻonui i ka pilikia o nā hopena ʻaoʻao. Hāʻule kekahi mau antibiotics a me nā antifungals i loko o kēia māhele. Ma ke ʻano kūikawā, pono ʻoe e pale i ka inu ʻana i ka wai grapefruit a i ʻole ka wai grapefruit i ka wā e lawe ana iā Truqap.
- Nā mea hoʻoulu CYP3A: Hana kēia ma ka hoʻonui ʻana i ka hana o ka enzyme CYP3A. Hiki i kēia ke hoʻoneʻe koke iā Truqap mai ke kino, e hōʻemi ana i kona pono . Hāʻule kekahi mau antibiotics (e like me ka rifampicin) a me kekahi mau lāʻau lapaʻau no ka HIV i loko o kēia māhele.
No laila, ma mua o ka hoʻomaka ʻana i kekahi lāʻau lapaʻau hou, e kamaʻilio pono me kāu oncologist e pili ana i ia mea.
Pehea ʻoe e ʻike ai inā e hana ana ka lāʻau lapaʻau?
E nānā mau ana kāu kauka i kou kūlana. E hana ʻo ia i nā hoʻokolohua e like me nā hoʻokolohua koko, nā scan CT, a me nā scan MRI e loiloi i ka maikaʻi o ka hana a ka lāʻau. ʻO kāu wale nō e hana ai, ʻo ia ke lawe i ka lāʻau e like me ka ʻōlelo a kāu kauka iā ʻoe.
Leka Lawe-Home
- He lāʻau lapaʻau i kuhikuhi ʻia ʻo Truqap (capivasertib) no ka maʻi ʻaʻai umauma. Kuhikuhi pono ia i nā hunaola kanesa, no laila e hōʻemi ana i ka hōʻino ʻana i nā hunaola olakino.
- He kūpono kēia lāʻau lapaʻau no nā maʻi ʻaʻai e hilinaʻi ana i ka hormone (HR-positive), huhū, a he mau loli hoʻoilina kikoʻī (PIK3CA, AKT1, a i ʻole PTEN).
- I ka wā e loaʻa ai nā hopena ʻaoʻao e like me ke kiʻekiʻe o ke kō koko, ka maʻi pākī, a me nā hopena ʻili, e hōʻike koke i nā hōʻailona ʻē i kāu kauka.
- Mai ho'ōki i ka lawe ʻana i ka lāʻau lapaʻau a hoʻololi paha i ka nui me ka ʻole o ke aʻo ʻana a kāu kauka.
- He mea nui e hoʻomaopopo i kāu kauka e pili ana i nā lāʻau lapaʻau ʻē aʻe a me nā mea hoʻopihapiha meaʻai āu e lawe nei.
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