E aʻo kākou e pili ana i nā lāʻau lapaʻau e kuhikuhi ana a hoʻōki i ka ulu ʻana o nā hunaola kanesa (Tyrosine Kinase Inhibitors)

Ke lohe kākou i ka huaʻōlelo kanesa, nui ka poʻe o kākou e makaʻu a kaumaha. He mea maʻamau kēlā. Akā me ka holomua o ka ʻepekema lapaʻau, ua hiki mai nā lāʻau lapaʻau hou i ke ao nei e kōkua iā kākou e kāohi i ka kanesa a ola i kahi ola maikaʻi aʻe. I kēia lā, e kamaʻilio kākou e pili ana i kahi papa kūikawā o nā lāʻau lapaʻau e kuhikuhi ana a hoʻōki i ka ulu ʻana o nā hunaola kanesa. Ua kapa ʻia kēia mau mea he Tyrosine Kinase Inhibitors, a i ʻole TKIs no ka pōkole.

I ka ʻōlelo maʻalahi, he aha nā Tyrosine Kinase Inhibitors (TKIs)?

He ʻano lāʻau lapaʻau kēia i kapa ʻia ʻo "nā lāʻau lapaʻau i kuhikuhi ʻia." E noʻonoʻo i kēia ʻano: ʻo ka lāʻau lapaʻau maʻamau (chemotherapy) ua like ia me ka pōkā i hoʻokuʻu ʻia i ke kaua. Hiki iā ia ke pepehi i nā koa ʻenemi (nā ʻāpana kanesa) a me ko kākou poʻe hala ʻole (nā ʻāpana olakino). Akā ʻo kēia lāʻau lapaʻau i kuhikuhi ʻia i kapa ʻia ʻo TKI ua like ia me ka sniper. Nānā pololei ia i ka pahuhopu a hōʻino wale i nā ʻāpana kanesa. He liʻiliʻi loa ka hōʻino ʻana i nā ʻāpana olakino.

Hana kēia mau lāʻau lapaʻau ma ke kāohi ʻana i nā enzymes i loko o nā hunaola kanesa e kōkua iā lākou e ulu a māhele koke. ʻAʻole paha e ho'ōla loa kēia mau lāʻau lapaʻau i ke kanesa, akā hiki iā lākou ke kōkua i ka kaohi ʻana i ke kanesa a hoʻokomo iā ia i loko o ke kala ʻana no ka manawa lōʻihi , a i ʻole hiki iā lākou ke kōkua iā ʻoe e ola lōʻihi a olakino me ke kanesa.

Pehea e hana ai kēia lāʻau lapaʻau i loko o ke kino?

I mea e hoʻomaopopo ai i kēia, e nānā kākou pehea e kāohi ʻia ai nā ʻāpana o ko kākou kino. E noʻonoʻo i ka māhele ʻana o kā kākou mau ʻāpana e like me ke hoʻā ʻana i ke kukui.

1. Nā kumu ulu: Ua like kēia me ka manamana lima e hoʻohuli ai i ke kuapo kukui. ʻO lākou ka mea e hāʻawi i nā cell i ka hōʻailona e "māhele i kēia manawa."

2. Tyrosine kinases: ʻO kēia nā kuapo kukui. Ke hoʻā ʻoe iā lākou me kou manamana lima, huli lākou i ka 'On', a hoʻomaka nā cell e māhele. Ke pau ka pono, huli hou lākou i ka 'Off'.

I loko o nā pūnaewele olakino, hana pono kēia kuapo. Hoʻohuli ia i ka 'On' ke pono, a hoʻohuli i ka 'Off' ke pau ka hana.

Akā i loko o kekahi mau hunaola kanesa, ʻoi aku hoʻi i kahi ʻano kanesa koko i kapa ʻia ʻo Chronic Myeloid Leukemia (CML) , ua haki kēia kuapo i kapa ʻia ʻo 'Tyrosine kinase'. Aia mau ia 'On'. ʻO ia hoʻi, ke loaʻa mau nei i nā hunaola ka hōʻailona e "māhelehele, māhelehele, māhelehele." No laila, māhelehele kēia mau hunaola kanesa me ke kāohi ʻole ʻia, e hoʻopiha ana i ka iwi iwi a hoʻōki i ka hana ʻana o nā hunaola koko olakino.

ʻO ia ka manawa e hoʻomaka ai nā lāʻau TKI. ʻO ka hana a kēia mau lāʻau, ʻo ia ke kinai ikaika i kēlā kuapo i haki a hoʻā mau ʻia. A laila nalowale nā ​​​​​​pūnaewele kanesa i ka hōʻailona e māhelehele, a oki ko lākou ulu ʻana. Maopopo iā ʻoe ke ʻano kikoʻī o kēlā kaʻina hana?

He aha nā ʻano maʻi kanesa e hoʻohana ʻia ai nā lāʻau TKI?

Hoʻohana ʻia kēia mau lāʻau lapaʻau no nā ʻano maʻi kanesa he nui. E nānā i ka papa ma lalo.

Aia kekahi mau hopena ʻaoʻao i kēia mau lāʻau lapaʻau?

ʻAe. E like me nā lāʻau lapaʻau āpau, hiki i kēia ke loaʻa nā hopena ʻaoʻao. Akā ʻokoʻa loa kēia mai kēlā kanaka a kēia kanaka a ma muli o ke ʻano o ka lāʻau lapaʻau āu e lawe ai. Hiki i kekahi poʻe ke ʻike i ka ʻeha iki wale nō, aʻo kekahi poʻe e ʻike paha i nā mea ʻoi aku ka koʻikoʻi.

ʻO kekahi o nā hopena ʻaoʻao i ʻike pinepine ʻia:

• Luhi a me ka māluhiluhi: He mea maʻamau loa kēia.
• Ka maʻi kahe: Ka neʻe ʻana o ka ʻōpū.
• Nā pilikia ʻili: Nā ʻōhūhū ʻili, maloʻo, maneʻo, a pēlā aku. I nā hihia kakaikahi , hiki ke loaʻa nā maʻi ʻili koʻikoʻi e like me ka Stevens-Johnson syndrome .
• Ka luaʻi a me ka luaʻi
• Ke koko kiʻekiʻe (hypertension)
• Proteinuria
• Ka emi ʻana o ke kaumaha a i ʻole ka loaʻa ʻana o ke kaumaha

He mea nui: Ma mua o kou hoʻomaka ʻana i kēia lāʻau lapaʻau, e kūkākūkā pono kāu kauka i nā hopena ʻaoʻao o ka lāʻau lapaʻau āu e loaʻa ai. He mea nui loa e hoʻomaopopo koke i kāu kauka inā loaʻa iā ʻoe kekahi mau hōʻailona hou a i ʻole ka ʻoluʻolu ʻole i ka wā o ka lāʻau lapaʻau.

He aha kā mākou e hana ai e maʻalahi ai ka mālama ʻana?

He huakaʻi paʻakikī ka mālama ʻana i ka maʻi kanesa, ma ke kino a me ka noʻonoʻo. Aia kekahi mau mea hiki iā ʻoe ke hana e maʻalahi iki ai kēia huakaʻi.

• ʻO ka mea maikaʻi loa no ka luhi, ʻo ia ka hoʻomaha: Inā manaʻo ʻoe ua luhi, e hoʻomaopopo he mea maʻamau ia. E hoʻomaha nui e like me ka hiki. He mea maikaʻi nō hoʻi ke hiamoe pōkole i ke ao.
• E makaʻala i kāu ʻai: Hoʻemi ke kaumaha o kekahi poʻe ma muli o ka nalowale o ka makemake e ʻai. Hiki i kekahi ke piʻi ke kaumaha. Inā manaʻo ʻoe pēlā, e ʻimi i ke kōkua mai kahi mea lapaʻau meaʻai . A laila hiki iā lākou ke hana i kahi hoʻolālā ʻai e kūpono i kou kūlana.
• E hoʻolālā i kou lā: Hiki i ka lāʻau lapaʻau ke hoʻololi nui i kou ola o kēlā me kēia lā. E ho'āʻo e hoʻonohonoho i nā mea ma ke kaha ʻana i nā manawa a kāu kauka a me nā manawa lāʻau lapaʻau ma kahi kalena.
• E aʻo e pili ana i ka Mālama Palliative: He mea kēia a ka poʻe he nui i ʻike ʻole ai, akā he mea nui loa ia. ʻO ka mālama palliative kahi ʻano mālama kūikawā, ma waho aʻe o ka mālama ʻana i ka maʻi kanesa, kōkua iā ʻoe e ola ʻoluʻolu me kou maʻi ma o ka kaohi ʻana i nā hōʻailona e like me ka ʻeha, ka nausea, ka luhi, a me nā hopena ʻaoʻao o ka mālama ʻana. E nīnau i kāu kauka e pili ana i kēia.

I ka hala ʻana o ka manawa, hiki i kekahi mau hunaola kanesa ke kūʻē i kēia mau lāʻau TKI a hoʻōki i ka pane ʻana i ka lāʻau. Ua kapa ʻia kēia ʻo 'drug resistance'. I kēlā mau manawa, hiki i kāu kauka ke hoʻololi iā ʻoe i kahi lāʻau TKI ʻē aʻe a i ʻole kahi ʻano lāʻau ʻē aʻe. No laila, he mea nui loa ia e mālama mau i ka launa pū ʻana me kāu kauka i ka wā o ka lāʻau.