He puʻupuʻu manaʻo ʻole i loko o ke kino? E kamaʻilio kākou e pili ana i kēia (Undifferentiated Pleomorphic Sarcoma - UPS)!

Ua manaʻo paha ʻoe i kahi mea e like me ka puʻupuʻu e ulu ana a e nui ana ma kahi o kou kino? I kekahi manawa, me ke kumu ʻole, hiki iā ʻoe ke ʻike i ka pehu a i ʻole ka mae ʻana i ka lima a i ʻole ka wāwae. ʻOiai ʻaʻole mākou e nānā nui i kēia mau mea, aia paha kekahi mea koʻikoʻi i hūnā ʻia ma hope o lākou. I kēia lā, e kamaʻilio mākou e pili ana i kahi ʻano maʻi ʻaʻai kūikawā a ka poʻe he nui i lohe pinepine ʻole ai, akā he mea nui loa ia no kākou āpau e makaʻala. Mai makaʻu, e hoʻomaopopo maʻalahi kākou i kēia.

He aha ka "Undifferentiated Pleomorphic Sarcoma - UPS"?

I ka ʻōlelo maʻalahi, ʻo ka "Undifferentiated Pleomorphic Sarcoma" a i ʻole "UPS" e like me kā mākou e kapa nei no ka pōkole, he ʻano maʻi kanesa i kapa ʻia ʻo ka sarcoma ʻiʻo palupalu . ʻO kēia ka wā e hoʻokumu ʻia ai nā hunaola kanesa i loko o nā ʻiʻo palupalu o ko mākou kino, e like me nā ʻiʻo, nā ʻiʻo momona, a me nā kīʻaha koko.

ʻO ka hapa pinepine, hoʻomaka kēia `(UPS)` i nā ʻiʻo palupalu o kou mau lima a i ʻole nā ​​wāwae . I kekahi manawa hiki ke hana pū ʻia ma ka ʻaoʻao hohonu o ke kua o ka ʻōpū, i kapa ʻia ʻo `retroperitoneum` . Kākaʻikahi loa, hoʻopilikia kēia `(UPS)` i nā iwi. ʻO ka mea kaumaha, he ʻano maʻamau kēia o ka maʻi kanesa ikaika . No laila, ʻoi aku ka nui o ka laha ʻana i nā ʻāpana ʻē aʻe o ke kino, ʻoi aku hoʻi nā māmā a i ʻole nā ​​​​​​kikowaena lymph .

I ka wā ma mua, ua kapa ʻia kēia `(UPS)` he `malignant fibrous histiocytoma` . ʻO ke kumu o kēia, ua manaʻo nā kānaka noiʻi ua kū mai kēia maʻi kanesa mai nā pūnaewele pale kūikawā i kapa ʻia ʻo `histiocytes` . Eia naʻe, ua ʻike ʻia ma hope mai ua hoʻomaka paha ia i loko o nā pūnaewele i kapa ʻia ʻo `mesenchymal cells`, ka mea e hana ana i nā ʻiʻo pili i loko o ko kākou kino.

I kēia manawa, e nānā kākou i ke ʻano o nā huaʻōlelo ʻelua ma kēia inoa.

ʻO ke ʻano o ka "Undifferentiated" ʻo ia hoʻi, ua lilo kēia mau cell kanesa i mea haunaele a hoʻonohonoho pono ʻole ʻia . E like me nā mea pāʻani i hoʻopuehu ʻia a puni me ke kauoha ʻole. Ua lilo lākou i ʻokoʻa loa a ʻōpiopio hoʻi i hiki ʻole ke ʻike pono i nā cell olakino a lākou i hoʻomaka ai a i ʻole ka hana a lākou i manaʻo ai e hana.

ʻO ke ʻano o ka huaʻōlelo "pleomorphic" ʻo ia hoʻi he ʻokoʻa ke ʻano, ka nui, a i ʻole ka nucleus, ke kikowaena hoʻomalu o ke kelepona . E noʻonoʻo e like me kahi ʻāpana lako i hana ʻole ʻia mai ka ʻōmole like, ʻokoʻa kēlā me kēia i ke ʻano a me ka nui. He liʻiliʻi kekahi mau kelepona, he nui kekahi. He poepoe kekahi, he hoʻolōʻihi ʻia kekahi. ʻOiai ka nucleus, nona nā chromosomes i loko o nā kelepona, he ʻokoʻa ia i kēlā me kēia kelepona. ʻO ia ke kumu e ulu wikiwiki ai kēia mau kelepona kanesa me ka ʻole o ka hoʻomalu.

He ʻano maʻi kanesa laha ʻole ka UPS. No ka laʻana, ma ʻAmelika Hui Pū ʻIa, hoʻopilikia kēia maʻi i ka liʻiliʻi ma mua o 5,000 mau kānaka i ka makahiki. Eia nō naʻe, i waena o nā ʻano sarcomas palupalu,Me ka liposarcoma (kahi maʻi ʻaʻai e ulu ana i loko o nā ʻiʻo momona) a me ka leiomyosarcoma (kahi maʻi ʻaʻai e ulu ana i loko o nā ʻiʻo laumania), ʻo (UPS) ke kolu o ke ʻano maʻamau o ka sarcoma ʻiʻo palupalu .

He aha nā hōʻailona o ka `(UPS)`?

Hiki ke ʻokoʻa nā hōʻailona o ka `Undifferentiated Pleomorphic Sarcoma (UPS)` mai kēlā kanaka a kēia kanaka. ʻAʻole paha e ʻike kekahi poʻe i kekahi mau hōʻailona. Eia nō naʻe, aia kekahi mau hōʻailona maʻamau:

• He puʻupuʻu a puʻupuʻu paha e ulu mālie ana: ʻO kēia ka hōʻailona nui. Hiki ke manaʻo ʻia he puʻupuʻu ma nā wahi a pau o ke kino, ʻoi aku hoʻi ma ka lima, ka wāwae, a i ʻole ka ʻōpū.
• He puʻupuʻu ʻeha ʻole e neʻe paha a ʻaʻole paha e neʻe ke hoʻopā ʻia: ʻO ka hapa nui o ka manawa, ʻaʻole kēia mau puʻupuʻu e hōʻeha i nā pae mua. No laila, ʻaʻole paha e nānā nui kekahi poʻe iā lākou.
• ʻO ka maneʻo a i ʻole ka wela ma muli o ke kaomi ʻana o ka puʻupuʻu ma luna o ke aʻalolo: I kekahi manawa, i ka ulu ʻana o kēia puʻupuʻu, hiki iā ia ke kaomi ma luna o ke aʻalolo kokoke. Hiki i kēia ke hana i ka maneʻo i nā lima a i ʻole nā ​​​​wāwae, kahi manaʻo ʻūlū, a i ʻole kahi manaʻo wela.
• Ka pehu ʻana i ka lima a i ʻole ka wāwae: Inā pehu ka lima a i ʻole ka wāwae me ke kumu ʻole, pono e noʻonoʻo ʻia kēlā.

ʻO ka mea nui, ʻaʻole hōʻike mau ka UPS i nā hōʻailona maopopo. ʻAʻohe pinepine lākou ʻeha , a ʻaʻohe loli o ka ʻili ma luna o ka puʻupuʻu (e like me ke kala ʻana o ke kala a i ʻole nā ​​​​ʻeha). Eia kekahi, ʻaʻole ʻike pinepine ʻia nā hōʻailona maʻamau e like me ke kuni, ka pohō kaumaha, a me ka malaise.

He aha nā kumu o ka `(UPS)`?

ʻAʻole maopopo loa i nā loea ke kumu o ka UPS. ʻO ka mea a lākou i ʻike ai, ua hana ʻia ia e nā loli (nā mutations) i loko o ka DNA (ka molekala e loaʻa ana kā mākou ʻike genetic) o nā cell olakino. Eia nō naʻe, ʻaʻole maopopo loa ke kumu o kēlā mau loli i ka DNA.

Nā Kumu Pōpilikia e Hoʻonui ai i ka Pōpilikia o ka Hoʻomohala ʻana i nā UPS

ʻO kahi mea pilikia kekahi mea e hoʻonui ai i ka likelika o ka loaʻa ʻana o kahi maʻi. Aia kekahi mau mea pilikia i ʻike ʻia no `(UPS)`. Akā e hoʻomanaʻo, ʻaʻole nā ​​​​mea āpau i loaʻa i kēia mau mea pilikia e loaʻa iā `(UPS)`, a ʻaʻole hiki ke ʻōlelo ʻia ʻaʻole e loaʻa i ka poʻe i loaʻa ʻole kekahi o kēia mau mea pilikia.

ʻO nā kumu pilikia i ʻike ʻia i kēia manawa:

• ʻO ke kāne: ʻOi aku ka nui o ka loaʻa ʻana o kēia maʻi i nā kāne ma mua o nā wahine, a ʻoi aku ka kiʻekiʻe o ka pilikia i waena o nā kāne keʻokeʻo.
• Ma luna o 50 mau makahiki: Piʻi ka nui o kēia maʻi me ka makahiki.
• Kekahi mau kūlana olakino: No ka laʻana, ʻo ka poʻe me nā maʻi e like me ka neurofibromatosis (kahi kūlana e hoʻokumu ai i nā puʻupuʻu i loko o ka ʻōnaehana nerve) a i ʻole ka maʻi iwi o Paget (kahi maʻi e hoʻoulu ai i ka ulu ʻana o ka iwi maʻamau) e piʻi aʻe ana ka pilikia o ka ulu ʻana (UPS).
• ʻO kekahi mau kūlana genetic:ʻO ka poʻe me nā maʻi genetic kakaikahi e like me ka maʻi Li-Fraumeni e piʻi aʻe ka pilikia o ka hoʻomohala ʻana i nā ʻano maʻi kanesa like ʻole, me (UPS).
• Ka ʻike ʻana i kekahi mau kemika: ʻO ka ʻike lōʻihi ʻana i kekahi mau kemika, e like me ka arsenic a vinyl chloride paha, hiki ke lilo i mea pilikia.
• ʻO ka radiation therapy ma mua i ka wahi i hoʻopilikia ʻia: Inā ua loaʻa iā ʻoe ka radiation therapy i kahi wahi no kahi maʻi ʻē aʻe, aia kahi pilikia liʻiliʻi o ka hoʻomohala ʻana i ka sarcoma (UPS) ma ia wahi ma hope.
• Ka ʻike ʻia ʻana o ka radiation ma ka hana: Inā pono ʻoe e ʻike ʻia i ka radiation ma kekahi mau hana, hiki i kēlā ke lilo i mea pilikia.

He mea kupaianaha ka nui o ka poʻe i loaʻa i ka UPS ʻaʻohe o kēia mau mea pilikia . No laila, inā ʻike ʻoe i kahi mea e like me kahi puʻupuʻu ma kou kino, mai hoʻowahāwahā iā ia ma ka noʻonoʻo ʻana, "ʻAʻohe oʻu mau mea pilikia."

Pehea e ʻike ai nā kauka i ka `(UPS)`?

Ke ʻike ʻoe i ke kauka me kahi puʻupuʻu e like me kēia, e nīnau mua ʻo ia iā ʻoe e pili ana i kou olakino, inā paha ua loaʻa i kekahi o kou ʻohana nā maʻi e like me ke kanesa (mōʻaukala ʻohana), a pēlā aku. A laila e nīnau ʻo ia e pili ana i kāu mau hōʻailona. Pehea ka lōʻihi o kēia puʻupuʻu ma laila? Ke ulu nui nei? He ʻeha anei? Eia kekahi, e hana ʻo ia i kēia mau hoʻokolohua:

1. Hoʻokolokolo kino: E nānā ke kauka i kahi o ka puʻupuʻu, kona nui, a pehea kona manaʻo ke hoʻopā ʻia (paʻakikī a palupalu paha).

2. Nā hoʻāʻo kiʻi: Kōkua kēia mau hoʻāʻo e ʻike i ke ʻano o ka puʻupuʻu i loko a me ka mamao o kona laha ʻana. ʻO ka maʻamau, hiki ke hana ʻia hoʻokahi a ʻoi aku paha mau hoʻāʻo, e like me nā X-ray, nā scan ultrasound, a/a i ʻole nā ​​​​scan MRI .

3. Biopsy: ʻO kēia ka hoʻāʻo koʻikoʻi loa e ʻike pono ai i ka maʻi . Pili kēia i ka lawe ʻana i kahi ʻāpana liʻiliʻi o ka ʻiʻo mai ka puʻupuʻu (malia paha me kahi mea hana liʻiliʻi e like me ke nila) a nānā ʻia ma lalo o kahi microscope e kahi pathologist (he kauka loea i ka ʻike ʻana i nā maʻi). A laila wale nō hiki iā mākou ke ʻōlelo maopopo inā he UPS a i ʻole kekahi maʻi ʻē aʻe.

He aha nā lāʻau lapaʻau no ka `(UPS)`?

ʻO ka lāʻau no ka UPS e pili ana i nā mea e like me ka nui o ka puʻupuʻu a inā ua pālahalaha ke kanesa. ʻO ka lāʻau nui no ka UPS mua, ʻo ia ke ʻoki ʻana e wehe i ka puʻupuʻu . Hana pinepine ʻia kēia me ka radiation therapy . Eia nō naʻe, i kekahi manawa pono paha nā lāʻau lapaʻau kanesa hou aʻe.

ʻoki kino

ʻO ka pahuhopu nui o ke ʻoki kino no UPS, ʻo ia ka wehe loa ʻana i ka puʻupuʻu kanesa.. Hoʻāʻo nā kauka e wehe ʻaʻole wale i ke kanesa, akā, i kahi liʻiliʻi o nā ʻiʻo olakino a puni ia (ua kapa ʻia kēia ʻo "margin") . E like me ka wā e wehe ai mākou i kahi mauʻu i loko o kahi māla, ʻaʻole mākou e wehe wale i ka mea kanu, akā, i kahi papa lepo liʻiliʻi a puni ia. A laila, ʻaʻohe ʻāpana liʻiliʻi o ke aʻa mauʻu i koe. Ma ke ʻano like, ke wehe nā kauka i kēia kanesa, wehe lākou iā ia me kahi liʻiliʻi o nā ʻiʻo olakino a puni ia. A laila wale nō e hiki ai iā mākou ke maopopo ua wehe ʻia nā hunaola kanesa a pau me ka ʻole o nā mea i koe. Inā he mau hunaola kanesa ma ka lihi o ka puʻupuʻu i wehe ʻia, ʻo ia hoʻi, aia paha he nui aku nā hunaola kanesa i koe i loko o ke kino.

Inā aia ka puʻupuʻu ma kou lima a wāwae paha, e hoʻāʻo kāu kauka ʻoki e wehe i ke kanesa a mālama i ka nui o ka hana e like me ka hiki ma kēlā lima a wāwae paha. Eia nō naʻe, i kekahi mau hihia koʻikoʻi, pono paha ke ʻoki ʻia ke kino . No laila, he mea nui e kamaʻilio me kāu kauka oncologist e hoʻoholo i ke koho lapaʻau maikaʻi loa no kou kūlana.

Nā Lapaʻau Kanesa ʻē aʻe

Hiki i nā kauka maʻi ʻoki ke hoʻohana i nā lāʻau lapaʻau hou aʻe ma mua a ma hope paha o ke ʻoki ʻana. ʻOiai ʻaʻole pinepine kēia mau lāʻau lapaʻau e hoʻemi i ka puʻupuʻu, hiki iā lākou ke kōkua i ka palekana no ke ʻoki ʻana e wehe i ka puʻupuʻu, a i ʻole e pepehi i nā hunaola kanesa e koe paha ma hope o ke ʻoki ʻana.

ʻO kēia mau lāʻau lapaʻau hou aʻe:

• Chemotherapy: Ke hāʻawi ʻana i nā lāʻau lapaʻau e pepehi i nā hunaola kanesa.
• Immunotherapy: Hoʻoulu i ka ʻōnaehana pale ponoʻī o ke kino e hakakā i nā hunaola kanesa.
• Lapaʻau radiation: Ke luku ʻana i nā hunaola kanesa me ka hoʻohana ʻana i nā kukuna ikehu kiʻekiʻe.

He kū hoʻokahi kāu hoʻolālā lapaʻau iā ʻoe. He ʻokoʻa paha ia mai ka mea ʻē aʻe. No laila, e kamaʻilio me kāu kauka maʻi ʻaʻai e pili ana i kāu mau koho. E mālama pinepine ʻia ʻoe e kahi hui multidisciplinary . Hiki i kēia hui ke komo pū me kahi kauka lapaʻau, kahi kauka maʻi ʻaʻai radiation, a me kahi kauka maʻi ʻaʻai lapaʻau. ʻOiai he ʻokoʻa ke kuleana o kēlā me kēia loea, hana pū lākou a pau e mālama iā ʻoe. E kōkua lākou iā ʻoe e hoʻoholo i ka mea maikaʻi loa no kou kūlana.

Āhea wau e ʻike ai i ke kauka?

Inā ʻike ʻoe i kahi puʻupuʻu a i ʻole ka ulu ʻana ma kekahi wahi o kou kino e ulu mālie ana , ʻoiai inā hele pū ʻia me nā hōʻailona e like me ka ʻeha, ka pehu ʻana, a i ʻole ka hiki ʻole ke hoʻoneʻe pono i kou lālā , pono ʻoe e ʻike koke i ke kauka .

Inā ua ʻike mua ʻoe he `(UPS)` kāu, ʻo ʻoeInā loaʻa iā ʻoe nā hōʻailona hou, a inā e ʻoi aku ka ʻino o kāu mau hōʻailona, ​​e haʻi koke aku i kāu kauka maʻi kanesa .

He aha nā mea e hiki i kekahi me `(UPS)` ke manaʻo?

ʻOkoʻa ke kūlana ola o kēlā me kēia kanaka. Aia ia i ka nui o ka sarcoma a me ke kahua o ka maʻi . Ma keʻano laulā, ʻo ka nui o ke ola ʻelima makahiki no ke kūlana kiʻekiʻe (UPS) ma kahi o 60% . ʻO ke ʻano kēia ma kahi o 60% o ka poʻe i ʻike ʻia me ka maʻi e ola mau ana ma hope o ʻelima mau makahiki. ʻO ka nui o ke ola ʻana he 10 makahiki ma kahi o 48% .

Akā e hoʻomanaʻo, he mau kuhi wale nō kēia mau helu ola . ʻAʻole lākou e haʻi pololei iā ʻoe i ka lōʻihi o kou ola ʻana a i ʻole ka lāʻau lapaʻau e kūpono loa iā ʻoe. No ka ʻike hou aku e pili ana i nā helu ola a pehea lākou e hoʻopilikia ai iā ʻoe, ʻoi aku ka maikaʻi o ke kamaʻilio ʻana me kāu hui oncology.

Hiki ke ho'ōla loa ʻia ʻo `(UPS)`?

(UPS) hiki ke ho'ōla loa ʻia, ʻoiai inā ʻike mua ʻia . ʻOiai i nā hihia i laha ai ka maʻi, aia nā koho lapaʻau e hiki ke kōkua i ka hoʻomaikaʻi ʻana i kou ola a hoʻolōʻihi i kou ola. E like me nā ʻano maʻi kanesa āpau, ʻo ka ʻike mua ʻana a me ka mālama ʻana i (UPS) ke ala maikaʻi loa e hoʻokō ai i kahi hopena holomua .

Nā mea e noʻonoʻo ai

Ke ʻike ʻia ʻoe he maʻi kanesa, hiki iā ia ke hoʻopilikia i kēlā me kēia ʻano o kou ola. Inā he maʻi kanesa laha ʻole e like me Undifferentiated Pleomorphic Sarcoma (UPS), hiki iā ʻoe ke manaʻo mehameha loa a me he mea lā ʻaʻohe mea e hoʻomaopopo iā ʻoe. I nā manawa e like me kēia, hiki ke kōkua i ka hui pū ʻana me kahi hui kākoʻo kahi e loaʻa ai nā poʻe ʻē aʻe e hele nei i nā ʻike like me ʻoe . ʻO ke kamaʻilio ʻana me lākou e hiki ke kōkua iā ʻoe e hoʻomaopopo i kou mau manaʻo a hoʻokele iā lākou.

Eia kekahi, aia mau kāu hui lapaʻau ma laila e kōkua iā ʻoe . Hiki iā lākou ke kamaʻilio me ʻoe e pili ana i kāu mau koho lapaʻau, kākoʻo iā ʻoe, a hāʻawi iā ʻoe i ka ʻike a me nā kumuwaiwai āu e pono ai e hana i nā hoʻoholo olakino naʻauao. Mai makaʻu e nīnau iā lākou i kāu mau nīnau . E hoʻomanaʻo mau ʻaʻole ʻoe hoʻokahi.

ʻO ka Sarcoma Pleomorphic Undifferentiated, UPS, sarcoma, maʻi ʻaʻai palupalu, maʻi ʻaʻai, puʻupuʻu, nā hōʻailona maʻi ʻaʻai, mālama ʻana i ka maʻi ʻaʻai