Ua pilikia anei kou ʻike ma muli o ka maʻi diabetes? E kamaʻilio kākou e pili ana i ka lāʻau lapaʻau ʻo Vabysmo (Faricimab)

Inā loaʻa iā ʻoe ka maʻi diabetes, ʻike paha ʻoe i ka hala ʻana o ka manawa, hiki ke hoʻopilikia i kou mau maka. ʻO ka ʻike maka pohihihi, nā mea lana, a me ka makapō kala nā hōʻailona maʻamau o kēia ʻano. Ua lohe paha ʻoe i nā inikini maka ma ke ʻano he lāʻau lapaʻau no kēia ʻano. Hiki i kēia mau inikini ke hoʻomaikaʻi i ka ʻike a hoʻōki i ka hōʻino hou ʻana i kou mau maka. I kēia lā, e kamaʻilio mākou e pili ana i kekahi lāʻau lapaʻau hou, kahi mea e kōkua nui iā ʻoe.

Pehea ka hana a kēia lāʻau Vabysmo no nā maka?

I ka ʻōlelo maʻalahi, ke loaʻa i kahi kanaka me ka maʻi diabetes ke kiʻekiʻe o ke kō koko no ka manawa lōʻihi, hoʻomaka ka hōʻino ʻia ʻana o nā kīʻaha koko palupalu i loko o ka maka. Hana ʻia kēia hōʻino ma ka retina, ka papa o ka maka e hana i nā kiʻi. Kāhea mākou i kēia ʻano he diabetic retinopathy .

Hoʻokahe mālie kēia mau kīʻaha koko i hōʻino ʻia i ke koko a me ka wai i loko o ka retina. I ka wā e ʻoi aʻe ai ke kūlana, hoʻāʻo ka maka e hana i nā kīʻaha koko hou e pani i nā mea i hōʻino ʻia. Akā, ua nāwaliwali loa kēia mau kīʻaha koko hou, a ʻoi aku ka nui o ka wai e kahe ana.

No laila he aha ka macular edema?

Aia kekahi wahi kūikawā ma ka retina i kapa ʻia ʻo ka macula . ʻO kēia ka mea e kōkua iā mākou e ʻike i nā mea i mua o ko mākou mau maka, ʻo ia hoʻi, ko mākou ʻike pololei, me ka maopopo. E like me ka mea i ʻōlelo ʻia ma mua, i ka wā e kahe ai ke wai mai nā kīʻaha koko, hoʻomaka kēia macula e pehu. Kāhea mākou i kēia he edema macular diabetic .

ʻO kēia ka manawa e pōwehiwehi ai ka ʻike, ʻike pālua ʻia ka ʻike, ʻike ʻia nā kiko ʻeleʻele, a ʻike ʻia nā kala me ka palalulu. Hiki i kekahi poʻe ke nalowale loa ko lākou ʻike.

He aha ka mea kūikawā e pili ana iā Vabysmo?

ʻO ka pahuhopu nui o ka mālama ʻana i kēia kūlana, ʻo ia ke kāohi i ka hōʻino ʻana i ka retina. Aia kekahi mau ʻano lāʻau lapaʻau i hoʻokomo ʻia i loko o ka maka no kēia. Hana ka hapa nui o kēia mau lāʻau lapaʻau ma ke kāohi ʻana i kahi protein i kapa ʻia ʻo VEGF . I ka ʻōlelo maʻalahi, ʻo VEGF kahi mea nui e kōkua ai i kēlā mau kīʻaha koko hou i makemake ʻole ʻia a nāwaliwali hoʻi e hana. No laila, ke ālai ʻia ʻo VEGF, ua kāohi ʻia ke kūkulu ʻia ʻana o nā kīʻaha koko hou.

ʻO Faricimab ka mea hana nui i loko o Vabysmo. ʻO kēia lāʻau lapaʻau, e like me nā lāʻau lapaʻau ʻē aʻe, ke ālai nei i ka VEGF. Akā ma waho aʻe o kēlā, hana kēia lāʻau lapaʻau i kahi mea ʻē aʻe. ʻO ia hoʻi, ke ālai nei ia i kahi protein ʻē aʻe i kapa ʻia ʻo Ang-2 (angiopoietin-2) . Ke hoʻonui ʻia kēia protein Ang-2 i loko o ka maka, lilo nā kīʻaha koko i mea paʻa ʻole a kahe hou aku ka wai.

He aha ka mea i hōʻike ʻia e ka noiʻi ʻana e pili ana i kēia lāʻau lapaʻau?

Ua mālama ʻia ʻelua mau hoʻokolohua lapaʻau nui e hoʻoholo ai i ka palekana a me ka pono o Vabysmo, e pili ana i kahi heluna nui o ka poʻe me ka maʻi diabetes a me ka macular degeneration mai nā ʻāina a me nā lāhui like ʻole a puni ka honua.

Ma kēia mau hoʻokolohua, ua hoʻohālikelike ʻia ʻo Vabysmo me kahi lāʻau i loaʻa mua i kapa ʻia ʻo Aflibercept (Eylea) , ka mea e ālai wale ana i ka VEGF. ʻAʻole ʻike ka poʻe i komo i ka hoʻokolohua i ka lāʻau a lākou e loaʻa nei. Ua loaʻa i nā kānaka a pau kekahi mau inikini, akā ua emi iho ka nui o nā inikini i loaʻa i kekahi poʻe ma mua o nā poʻe ʻē aʻe.

He aha nā hopena o ka noiʻi?

He mea hoʻoikaika maoli nā hopena.

Ka hoʻomaikaʻi ʻana i ka ʻike maka

Ma hope o hoʻokahi makahiki o ka lāʻau lapaʻau, ua hoʻomaikaʻi nui ʻia ka ʻike o ka poʻe i lawe iā Vabysmo lāua ʻo Aflibercept ma mua o ka wā i hoʻomaka ai ke aʻo ʻana. ʻO ke ʻano kēia ua like ka maikaʻi o nā lāʻau ʻelua i ka hoʻomaikaʻi ʻana i ka ʻike .

Ka nui o nā inikini i koi ʻia (ʻo ia ka mea nui loa!)

ʻO kēia kahi i ʻike ʻia ai ka ʻokoʻa nui loa.

I nā mahina mua o ka noiʻi, ua hoʻopili ʻia nā kānaka a pau i hoʻokahi manawa i ka mahina, akā ua hoʻololi ʻia ka papa hana hoʻopili.

• Ua hoʻomau ka poʻe i loaʻa iā Aflibercept i ka loaʻa ʻana o ka lāʻau pale i kēlā me kēia 8 pule (ʻo ia hoʻi, i kēlā me kēia 2 mahina) ma hope o nā mahina 5 mua.
• Ua mālama ʻia ka poʻe i loaʻa iā Vabysmo e like me kahi "papa kuhikuhi dosis pilikino," ʻo ia hoʻi, ua loiloi ʻia ke kūlana o ka maka o kēlā me kēia kanaka a ua hāʻawi ʻia ka lāʻau pale i kēlā me kēia 4, 8, 12, a i ʻole 16 pule, e like me ke kūpono.

Ua hōʻike ʻia nā hopena he ʻoi aku ma mua o 70% o ka poʻe i loaʻa iā Vabysmo he pana wale nō i pono i kēlā me kēia 12-16 pule (ʻo ia hoʻi, i kēlā me kēia 3-4 mahina) . Eia kekahi, ʻaʻohe ʻokoʻa i ka hoʻomaikaʻi ʻana o ka maka ma waena o ka poʻe i loaʻa i ka lāʻau i kēlā me kēia 3-4 mahina a me ka poʻe i loaʻa i ka lāʻau i kēlā me kēia 2 mahina.

E hoʻomau anei ka hana a ka lāʻau lapaʻau ma hope o ka makahiki mua?

ʻAe. Ua mālama ʻia kēia noiʻi ma luna o ʻelua mau makahiki. ʻO ka mea a lākou i ʻike ai, ma hope o ʻelua mau makahiki, ma kahi o 78% o ka poʻe i lawe iā Vabysmo e pono ai ka lāʻau lapaʻau i kēlā me kēia 3-4 mahina . A ua mau ko lākou ʻike e like me ia i ka makahiki mua.

Ma muli o ka holomua ʻana o ka pōʻino o ka maka mai ka maʻi diabetes i ka hala ʻana o ka manawa, hōʻike kēia mau hopena e hiki iā Vabysmo lāua ʻo Aflibercept ke kōkua i ka pale ʻana i ka pōʻino lōʻihi o ka maka. Hiki nō hoʻi iā Vabysmo ke hoʻokō i kēia hopena me nā lāʻau lapaʻau liʻiliʻi.

Pehea e loaʻa ai kēia lāʻau lapaʻau?

He wai ʻo Vabysmo. He inikini intravitreal ia i hāʻawi pololei ʻia i loko o ka maka e ke kauka i aʻo ʻia . ʻAʻole hiki iā ʻoe ke hana i kēia ma ka home.

Ke hoʻomaka ʻoe i ka lāʻau lapaʻau, e loaʻa mua iā ʻoe he 4 mau inikini i kēlā me kēia 4 pule . A laila e nānā kāu kauka i kou mau maka a hoʻoholo inā e hoʻomau i nā inikini ma nā manawa 4, 8, 12, a i ʻole 16 pule, ma muli o ke kūlana o kou mau maka. ʻO ka hapa nui o ka poʻe e pono ai nā inikini i kēlā me kēia 3-4 mahina.

I ka wā o ka inikini, e hoʻohana ke kauka i kahi mea liʻiliʻi e paʻa ai kou maka. A laila, e kau lākou i nā kulu i loko o kou maka e hoʻomāʻū iā ia a pale i ka maʻi. A laila, hāʻawi ʻia ka inikini me kahi nila lahilahi loa. ʻAʻole ʻoe e ʻeha i kēia manawa.

Nā hopena ʻaoʻao a pehea e mālama ai iā lākou?

E like me nā lāʻau lapaʻau āpau, hiki i kēia ke loaʻa nā hopena ʻaoʻao liʻiliʻi.

• Nā hopena ʻaoʻao maʻamau: Hiki ke pohihihi kou ʻike no kekahi manawa pōkole ma hope o ka inikini. He mea maʻamau kēia. E pale i ka hoʻokele kaʻa a i ʻole ka hoʻohana ʻana i nā mīkini i kēia manawa. E hoʻi hou kou ʻike i ka maʻamau i ka manawa pōkole.

• Nā hōʻailona koʻikoʻi e makaʻala ai: He mea kākaʻikahi loa, hiki ke loaʻa nā hōʻailona o kekahi mau maʻi koʻikoʻi. Pono ʻoe e makaʻala i kēia mau mea.
• Me he mea lā e lana ana nā kiko ʻeleʻele a i ʻole nā ​​kaha i mua o nā maka.
• Nā ʻālohilohi o ke kukui e like me ka uila .
• Me he mea lā e huki ʻia ana kahi pale i mua o nā maka.
• ʻEha nui o ka maka .

Aia kekahi pilikia me nā lāʻau lapaʻau ʻē aʻe?

ʻAʻohe pilina i ʻike ʻia ma waena o Vabysmo a me nā lāʻau lapaʻau ʻē aʻe i kēia manawa.

Akā, he mea nui loa kēia: E hōʻoia e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau ʻē aʻe āu e lawe nei, me nā lāʻau lapaʻau i kauoha ʻia, nā huaora, nā huahana lāʻau, a me nā lāʻau lapaʻau kuʻuna.