Ke ʻike ʻia ʻoe a i ʻole kekahi mea kokoke iā ʻoe me ka maʻi ʻaʻai umauma, he mea maʻamau ka manaʻo kaumaha a huikau i ka wā e kūkākūkā ana i nā koho lapaʻau. Hiki ke paʻakikī loa ka hoʻomanaʻo ʻana i nā inoa o nā lāʻau lapaʻau hou ke kamaʻilio nā kauka e pili ana iā lākou. I kēia lā, e kamaʻilio mākou e pili ana i kekahi lāʻau lapaʻau, ʻo abemaciclib. E kamaʻilio maʻalahi a maopopo kākou e pili ana i ke ʻano o kēia lāʻau lapaʻau, pehea e hana ai, a me nā mea e makaʻala ai i ka wā e lawe ai.
He aha ke ʻano lāʻau lapaʻau ʻo Verzenio a pehea e hana ai?
I ka ʻōlelo maʻalahi, ʻo Verzenio kahi ʻano lāʻau lapaʻau e hoʻōki i ka ulu ʻana o nā hunaola kanesa. Ma ke ʻano lapaʻau, no kahi papa o nā lāʻau lapaʻau i kapa ʻia ʻo "kinase inhibitors".
I kēia manawa, e noʻonoʻo i loko o nā pūnaewele o ko kākou kino he mau ʻelele liʻiliʻi e hoʻouna ana i nā leka kekahi i kekahi. ʻO kēia hoʻololi ʻana o nā leka ka mea e hoʻoholo ai inā e māhele a ulu paha kahi pūnaewele. Kāhea mākou i kēia mau ʻelele he mau enzymes. I loko o ke kanesa, lilo kekahi o kēia mau ʻelele i mea hana nui a hoʻomau i ka hoʻouna ʻana i ka leka hewa i nā pūnaewele kanesa, e haʻi ana iā lākou e "māhele koke, ulu koke."
Hoʻopaʻa ʻo Verzenio i ʻelua mau ʻelele kūikawā i kapa ʻia ʻo `cyclin-dependent kinases 4 a me 6`, a i ʻole CDK4 a me CDK6 no ka pōkole. ʻO kēia mau mea ʻelua e kōkua nui i nā hunaola kanesa e ulu a māhele. Hana pololei ʻo Verzenio i kēia ma ka "ālai ʻana" i ka hana a kēia mau ʻelele ʻelua. Hoʻōki ia i kēlā leka mai ka hele ʻana i ke hunaola kanesa. A laila nalowale nā hunaola kanesa i ka hōʻailona e ulu a māhele. ʻO kēia ke kumu e oki ai ka ulu ʻana o nā hunaola kanesa a i ʻole e emi ka nui o ka puʻupuʻu.
He aha ke ʻano o ka maʻi ʻaʻai umauma i hāʻawi ʻia ai ʻo Verzenio?
ʻAʻole ʻo Verzenio kahi lāʻau lapaʻau no nā maʻi ʻaʻai umauma āpau. Hoʻohana kūikawā ʻia ia no nā maʻi ʻaʻai me nā ʻano kikoʻī.
ʻo lākou:
- ʻO ka Hormone Receptor (HR)-positive: ʻO ia hoʻi, hoʻohana kēia mau hunaola kanesa i nā hormones, e like me ka estrogen, e ulu. ʻO ia hoʻi, ʻo nā hormones ka "meaʻai" no kēia mau kanesa.
- HER2-maikaʻi ʻole: Eia kekahi, ʻaʻole kēia ʻano maʻi kanesa e hana i kahi protein i kapa ʻia ʻo `HER2` ma kona ʻili.
Hoʻohana pinepine ʻia ʻo Verzenio no ka poʻe me kēia mau ʻano ʻelua, ka poʻe i loaʻa i ka maʻi ʻaʻai umauma mua , a me ka poʻe i loaʻa i ka pilikia nui o ka hoʻi hou ʻana mai o ke kanesa ma hope o ka mālama ʻana. ʻO ke ʻano o "ka wā mua" ʻaʻole i laha ka maʻi kanesa ma waho o ka umauma a i ʻole nā kikowaena lymph kokoke.
ʻO ka mea nui loa, ʻaʻole ʻo Verzenio he lāʻau kū hoʻokahi. Hāʻawi ʻia ia me ka hui pū ʻana me ka lāʻau lapaʻau hormone ma hope o ka pau ʻana o ka mālama mua e like me ke ʻoki ʻana a me ka chemotherapy.
Pehea e pono ai iaʻu ke hoʻohana i kēia lāʻau lapaʻau?
He pila ʻo Verzenio āu e ale ai. E makaʻala i kēia mau mea i ka wā e hoʻohana ai.
- Ka nui o ka lāʻau: ʻO ka maʻamau, ua ʻōlelo ʻia e lawe i ʻelua manawa i ka lā.
- Manawa o ka lā: E ho'āʻo e lawe i kāu lāʻau lapaʻau i ka manawa like i kēlā me kēia lā, ʻoi aku ka maikaʻi i ke kakahiaka a me ke ahiahi. E kōkua kēia i ka mālama ʻana i nā pae like o ka lāʻau lapaʻau i loko o kou kino.
- ʻO ka lawe ʻana me ka meaʻai: Hiki ke lawe ʻia kēia pila me ka meaʻai a me ka ʻole. ʻAʻohe pilikia no ia mea.
- Pehea e ale ai: He mea nui loa kēia! Pono e ale holoʻokoʻa ʻia ka papa. Mai kuʻi, nau, a uhaʻi paha i ka papa. Inā he mau papa haki a nahā paha kāu, mai hoʻohana iā lākou a haʻi i kāu kauka.
- Inā ʻoe e luaʻi: Inā ʻoe e luaʻi ma hope koke o ka lawe ʻana i ka lāʻau lapaʻau, e hōʻalo i kēlā mahele lāʻau . Mai lawe i kahi pila ʻē aʻe. E lawe i kāu mahele lāʻau aʻe i ka manawa i hoʻonohonoho ʻia.
ʻO ka lāʻau lapaʻau ʻo Verzenio no ka maʻi ʻaʻai umauma mua e hāʻawi pinepine ʻia a hiki i 2 mau makahiki. ʻO ke ʻano kēia e hoʻōki ʻia ka lāʻau lapaʻau inā hoʻi mai ke kanesa, inā loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi, a i ʻole inā ua pau ka manawa 2 makahiki. Inā loaʻa iā ʻoe kekahi mau hopena ʻaoʻao, hiki i kāu kauka ke hoʻohaʻahaʻa i kāu mahele lāʻau a hoʻōki paha i ka lawe ʻana i ka lāʻau no kekahi manawa a laila hoʻomaka hou.
Pehea ka maikaʻi o Verzenio?
Ua hōʻoia ʻia ka holomua o Verzenio ma o nā hoʻokolohua lapaʻau nui. ʻO ka mea nui loa o kēia mau mea ʻo ia ka hoʻokolohua lapaʻau i kapa ʻia ʻo `monarchE`.
Ma kēia noiʻi, ua hoʻohana ʻia he 5,637 mau maʻi me nā ʻano maʻi ʻaʻai umauma i ʻōlelo ʻia ma luna. Ua māhele ʻia lākou i ʻelua mau pūʻulu.
1. Ua hāʻawi ʻia kekahi hui i ka lāʻau lapaʻau hormone me Verzenio .
2. Ua hāʻawi wale ʻia ka lāʻau lapaʻau hormone i ka hui ʻē aʻe.
A laila ua hahai lākou i kēia poʻe no ʻehā mau makahiki. Ua nānā lākou i ka nui o ka poʻe i ola me ka ʻole o ka hoʻi hou ʻana mai o ke kanesa, ka loaʻa ʻana o kahi kanesa hou, a i ʻole ka make ʻana. Ua kapa ʻia kēia ana he invasive disease-free survival (IDFS).
Eia nā hopena ma hope o 4 mau makahiki:
- ʻO ka IDFS o ka poʻe i loaʻa ka lāʻau lapaʻau hormone me Verzenio he 85.5% .
- ʻO ka IDFS o ka poʻe i loaʻa ka lāʻau lapaʻau hormone wale nō he 78.6% .
Hōʻike maopopo kēia i ka hoʻohui ʻana iā Verzenio i hōʻemi nui i ka pilikia o ka hoʻi hou ʻana o ka maʻi kanesa ma kahi o 6.9%.He holomua nui kēia i ka mālama ʻana i ka maʻi kanesa i ke kahua mua.
Pehea e nānā ʻia ai ʻoe i ka wā o ka mālama ʻana?
Hoʻomaka ka hana ʻana o Verzenio i loko o kou kino mai ka lā āu e hoʻomaka ai e lawe. E hana kāu kauka i nā mea like ʻole e nānā i kāu holomua lapaʻau.
- Nā Scan: ʻO ka maʻamau, ma kahi o 6 mau pule ma hope o ka hoʻomaka ʻana o ka lāʻau lapaʻau, e loaʻa iā ʻoe kahi scan e ʻike ai pehea e pane ai ke kanesa i ka lāʻau lapaʻau. Eia nō naʻe, hiki ke hoʻoponopono ʻia kēia manawa e kāu kauka ma muli o kou kūlana.
- Nā Hoʻāʻo Koko: He mea nui loa kēia. Hiki iā Verzenio ke hoʻemi i ka nui o nā hunaola koko keʻokeʻo i loko o ke kino i kekahi manawa. Ua kapa ʻia kēia ʻano he "neutropenia." Ua like nā hunaola koko keʻokeʻo me nā koa i loko o ko kākou kino, e pale ana iā kākou mai nā maʻi. Inā haʻahaʻa lākou, hiki ke loaʻa nā maʻi koʻikoʻi. No laila, e hana kāu kauka i nā hoʻāʻo koko maʻamau e nānā i nā pae o nā hunaola koko keʻokeʻo, nā neutrophils, a me nā platelets. E hōʻoia kēia he palekana ka hoʻomau ʻana i ka lawe ʻana i ka lāʻau.
Pehea e mālama ai i nā hopena ʻaoʻao?
He mea maʻamau ka loaʻa ʻana o nā hopena ʻaoʻao me ka mālama ʻana i ka maʻi kanesa. ʻO ka mea nui loa, ʻaʻole e hopohopo a e hōʻike koke i nā hopena ʻaoʻao i kāu kauka . Hiki iā lākou ke hoʻoholo inā he koʻikoʻi lākou a hāʻawi iā ʻoe i ka ʻōlelo aʻoaʻo e pono ai.
Eia nā hopena ʻaoʻao maʻamau a pehea e hana ai me lākou.
| Nā hopena ʻaoʻao maʻamau | Pehea e hoʻokele ai |
|---|---|
| Ka maʻi pākī | He mea maʻamau loa kēia. E nīnau i kāu kauka a mālama i kahi lāʻau lapaʻau (e like me Loperamide) no ka maʻi diarrhea. E pale i nā meaʻai ʻala a me ka ʻaila. E inu i ka nui o nā wai a me nā wai. E haʻi koke i kāu kauka inā loaʻa iā ʻoe ka maʻi diarrhea koʻikoʻi. |
| Ka luaʻi a me ka luaʻi | Ma kahi o ka ʻai ʻana i kahi ʻai nui i ka manawa hoʻokahi, e ʻai i nā ʻai liʻiliʻi i nā manawa he nui i ka lā. Hiki i nā mea e like me ke kī kinikini a me nā kuki ke kōkua. Inā pono, e kuhikuhi kāu kauka i ka lāʻau lapaʻau no ka luaʻi ʻana. |
| Luhi | E hoʻomaha nui e like me ka hiki. Hiki i ka hoʻoikaika kino māmā (e laʻa me ka hele wāwae) ke hāʻawi iā ʻoe i ka ikehu i kekahi manawa. E ʻai i nā meaʻai momona. |
| Ka nalowale o ka makemake | ʻOiai inā paʻakikī ke ʻai, e hoʻāʻo i nā mea e like me ka sopa, ka wai huaʻai, a me nā mea inu momona e loaʻa ai ka ikehu. |
Eia kekahi, e aʻo aku kāu kauka iā ʻoe e pili ana i nā hōʻailona o nā hopena ʻino koʻikoʻi, e like me nā pilikia o ka māmā (kuke, paʻakikī i ka hanu ʻana) a i ʻole nā ʻū koko (pehu ʻana, ʻeha ma nā wāwae). Inā ʻike ʻoe i kekahi o kēia mau mea, he mea nui e ʻimi koke i ke aʻo lapaʻau.
He aha kaʻu e pale aku ai i ka wā e lawe ana iā Verzenio?
I ka wā e lawe ai iā Verzenio, hiki ke loaʻa nā pilina me kekahi mau meaʻai a me nā lāʻau lapaʻau ʻē aʻe. Hiki i kēia ke hoʻololi i ke ʻano o ka hana ʻana o ka lāʻau lapaʻau a hoʻonui paha i nā hopena ʻaoʻao.
| He aha e pale aku ai | Kumu |
|---|---|
| ʻAlapalapala | Mai ʻai i ka ʻōpae jumbo a i ʻole ka inu ʻana i ka wai ʻōpae jumbo. Hiki i nā mea hoʻohui i loko o ka ʻōpae jumbo ke pale i ke kino mai ka wāwahi ʻana (metabolizing) iā Verzenio. Hiki i kēia ke alakaʻi i nā pae kiʻekiʻe pono ʻole o ka lāʻau lapaʻau i loko o ke kino, e hoʻonui ana i ka pilikia o nā hopena ʻaoʻao. |
| ʻO ka lāʻau lapaʻau Ketoconazole | He lāʻau lapaʻau kēia no nā maʻi fungal. Hoʻoulu pū kēia i ka mea like me nā pōpō jumbo. Hiki iā ia ke hoʻonui weliweli i ka pae o Verzenio i loko o ke kino. |
No laila, ma mua o kou hoʻomaka ʻana iā Verzenio, e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau āpau āu e lawe nei (me nā huaora, nā lāʻau lapaʻau lāʻau, a me nā mea hoʻohui) . Eia kekahi, e haʻi i kāu kauka inā loaʻa iā ʻoe kekahi mau maʻi olakino ʻē aʻe, e like me ka maʻi akepaʻa. A laila hiki i kāu kauka ke hoʻoholo i ka lāʻau palekana loa nāu.
Leka Lawe-Home
- ʻO Verzenio kahi lāʻau lapaʻau i hāʻawi ʻia me ka hui pū ʻana me ka lāʻau lapaʻau hormone no kahi ʻano kikoʻī o ka maʻi ʻaʻai umauma mua i kapa ʻia ʻo HR-positive, HER2-negative .
- Pale kēia i nā hōʻailona e hoʻoulu ai i nā hunaola kanesa e ulu a māhelehele, e kaohi ana i ke kanesa.
- Mai kuʻi a nau paha i ka pila. E ale holoʻokoʻa.
- Hiki ke loaʻa nā hopena ʻaoʻao e like me ka maʻi pākī, ka nausea, a me ka luhi i ka wā o ka mālama ʻana, no laila e hoʻomaopopo koke i kāu kauka e pili ana i kekahi ʻehaʻeha.
- E pale i ka ʻai ʻana i ka pomelo i ka wā o ka mālama ʻana.
- He mea nui e hoʻomaopopo i kāu kauka e pili ana i nā lāʻau lapaʻau ʻē aʻe āu e lawe nei a me nā pilikia olakino ʻē aʻe āu e loaʻa ai.
- No ka hōʻoia ʻana i ka palekana, e hōʻoia e loaʻa nā hoʻāʻo koko i kauoha ʻia e kāu kauka i ka manawa kūpono.
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