Koj tus kws kho mob puas tau qhia koj txog ib hom tshuaj hu ua SERMs lossis SERDs rau kev kho mob qog noj ntshav hauv lub mis? Tsis txhob txhawj, cov npe no yuav zoo li nyuaj me ntsis. Hnub no, peb yuav tham ua lus yooj yim txog lawv yog dab tsi, lawv ua haujlwm li cas, thiab koj yuav tsum paub dab tsi txog lawv. Cov no yog ob hom tshuaj tseem ceeb heev uas tuaj yeem pab peb tawm tsam mob qog noj ntshav hauv lub mis .
SERMs yog dab tsi? Lawv ua haujlwm li cas?
Hais yooj yim xwb, SERMs (Selective Estrogen Receptor Modulators) yog ib hom tshuaj uas tiv thaiv kev loj hlob ntawm cov hlwb mob qog noj ntshav hauv lub mis. Txawm li cas los xij, lawv tsuas yog ua haujlwm rau ib hom mob qog noj ntshav tshwj xeeb xwb. Ntawd yog hom mob qog noj ntshav hu ua Estrogen Receptor-Positive . Tsuas yog 75% ntawm cov mob qog noj ntshav hauv lub mis uas pom hauv peb lub tebchaws yog hom no.
Xav txog seb, cov hlwb qog noj ntshav no muaj cov "antennas" me me ntawm lawv qhov chaw. Hauv kev kho mob, peb hu cov receptors no. Thaum cov tshuaj hormone estrogen hauv peb lub cev txuas rau cov antennas no, cov hlwb qog noj ntshav tau txais lub teeb liab kom "faib thiab loj hlob ntxiv."
Nov yog qhov SERMs ua:
Lawv mus thaiv cov antennas, uas yog, cov receptors. Ces cov tshuaj estrogen tsis muaj qhov twg los txuas nws tus kheej. Vim tias nws tsis tau txais lub teeb liab, kev loj hlob ntawm cov cell mob qog noj ntshav nres lossis feem ntau raug tswj.
Qhov tseem ceeb yog, nws hu ua 'xaiv' rau ib qho laj thawj. Txawm hais tias cov tshuaj no thaiv kev ua haujlwm ntawm estrogen hauv lub mis, lawv tso cai rau cov tshuaj hormones ua haujlwm zoo hauv lwm qhov ntawm lub cev, xws li pob txha thiab lub tsev menyuam. Qhov ntawd yog qhov ua rau lawv tshwj xeeb.
Hom SERMs thiab lawv siv
Muaj ntau hom SERMs tseem ceeb uas tau pom zoo rau mob qog noj ntshav hauv lub mis .
| Lub npe ntawm cov tshuaj | Cov ntaub ntawv siv tseem ceeb |
|---|---|
| Tamoxifen |
|
| Toremifene | |
| Raloxifene |
Yog li ntawd, SERDs yog dab tsi?
Cov tshuaj SERDs (Selective Estrogen Receptor Downregulators) yog ib hom tshuaj uas ua haujlwm muaj zog dua li cov tshuaj SERMs. Ib yam li cov tshuaj SERMs, lawv kuj thaiv cov tshuaj estrogen receptors. Tab sis ntxiv rau, cov tshuaj SERDs txo cov receptors (downregulate) thiab hloov cov haujlwm ntawm cov receptors seem, ua rau lawv tsis muaj txiaj ntsig zoo.
Tam sim no muaj ob hom SERD uas tau pom zoo:
- Fulvestrant
- Elacestrant
Cov no feem ntau yog muab rau cov mob qog nqaij hlav mis uas mob hnyav heev, uas yog cov tshuaj hormone receptor-positive thiab HER2-negative . HER2-negative txhais tau hais tias cov qog nqaij hlav mis tsis muaj cov protein hu ua HER2 nyob rau ntawm lawv qhov chaw uas pab lawv loj hlob.
Yuav siv cov tshuaj no li cas?
- SERMs: Feem ntau ntawm cov no tuaj ua cov tshuaj ntsiav . Koj tus kws kho mob yuav qhia koj kom noj 20mg txog 40mg ib hnub. Yog tias koj noj cov tshuaj no los tiv thaiv kab mob qog noj ntshav kom tsis txhob rov qab los, feem ntau koj yuav tsum tau noj lawv txuas ntxiv mus rau 5 txog 10 xyoo.
- SERDs: Piv txwv li, Fulvestrant los ua cov tshuaj txhaj.Ob. Ob koob tshuaj no muab rau hauv cov leeg nqaij ntawm lub pob tw. Lawv muab peb zaug thaum lub hlis thawj zaug ntawm kev kho mob thiab tom qab ntawd ib hlis ib zaug tom qab ntawd.
Cov SERMs thiab SERDs muab rau hauv cov xwm txheej twg?
Muaj ntau qhov xwm txheej uas koj tus kws kho mob yuav sau ntawv rau cov kev kho mob no.
| Lub cib fim | Kev piav qhia |
|---|---|
| Ua ntej phais (Neoadjuvant Therapy) | Yog tias koj lub qog loj, cov tshuaj no tuaj yeem muab tau ua ntej phais kom nws me thiab ua kom yooj yim dua rau tshem tawm. |
| Tom qab phais (Kev Kho Mob Adjuvant) | Kev kho mob no yog muab los rhuav tshem cov hlwb qog me me uas tseem tshuav tom qab phais thiab tiv thaiv kom tsis txhob rov qab los dua. |
| Rau Mob Cancer Theem Kawg | Yog tias tus mob qog noj ntshav tau kis mus rau lwm qhov ntawm lub cev sab nraum lub mis, cov tshuaj no tuaj yeem pab tswj lossis qeeb nws txoj kev loj hlob. |
| Rau Kev Tiv Thaiv | Txawm tias koj tsis tau muaj mob qog noj ntshav hauv lub mis los xij, yog tias koj qhov kev pheej hmoo ntawm kev mob nws siab dua li qhov nruab nrab vim muaj cov yam xws li noob caj noob ces, SERMs yuav raug sau tseg kom txo qhov kev pheej hmoo ntawd. |
Cov kev mob tshwm sim thiab kev pheej hmoo ntawm cov kev kho mob no yog dab tsi?
Ib yam li lwm yam tshuaj, cov no tuaj yeem muaj cov kev mob tshwm sim. Tab sis tsis yog txhua tus neeg tau txais lawv. Nws yog ib qho tseem ceeb kom paub txog cov kev mob tshwm sim uas yuav tshwm sim.
Cov kev mob tshwm sim ntawm SERMs
Cov kev mob tshwm sim feem ntau pom zoo ib yam li cov uas tau ntsib thaum lub sijhawm tsis muaj menyuam.
- Kub hnyiab
- Qhov chaw mos qhuav, tso zis tawm, lossis los ntshav me ntsis
- Kev hws hmo ntuj
- Xeev siab
- Kev hloov pauv ntawm lub siab
Cov kev mob tshwm sim tsawg tab sis loj heev:
- Kev pheej hmoo ntawm mob qog noj ntshav hauv tsev menyuam nce me ntsis
- Cov ntshav txhaws hauv ob txhais ceg (Deep Vein Thrombosis, lossis DVT) lossis cov ntshav txhaws hauv lub ntsws (Pulmonary Embolism)
- Kab mob qhov muag
- Cov pob txha nyias nyias rau cov poj niam ua ntej lub hnub nyoog tas
Cov kev mob tshwm sim ntawm SERDs
- Mob ib ntus ntawm qhov chaw txhaj tshuaj
- Xeev siab
- Mob pob txha, mob nqaij, lossis mob pob qij txha
- Mob taub hau
- Kev ua haujlwm hnyav
- Kub hnyiab
Tseem ceeb heev: SERDs tuaj yeem txo cov platelets, uas pab cov ntshav txhaws. Qhov no tuaj yeem ua rau muaj kev pheej hmoo ntawm kev los ntshav me ntsis. Tsis tas li ntawd, ob qho tshuaj no yeej tsis pom zoo kom siv thaum cev xeeb tub lossis yog tias koj tab tom sim cev xeeb tub . Nws yog ib qho tseem ceeb uas yuav tsum siv hom tshuaj tiv thaiv kev yug me nyuam uas tsis yog hormonal thaum noj cov tshuaj no thiab tsawg kawg yog ib xyoos tom qab tso tseg kev kho mob.
Yog koj tus kws kho mob pom zoo kom siv txoj kev kho no, nrog nws tham txog qhov ntawd. Tsis txhob ntshai nug cov lus nug xws li, "Cov tshuaj no yuav muab cov txiaj ntsig dab tsi rau kuv?", "Kuv yuav xav tau cov kev mob tshwm sim dab tsi?", thiab "Kuv yuav tsum noj cov tshuaj no ntev npaum li cas?"
Cov Lus Qhia Txog Kev Coj Mus Tsev
- SERMs thiab SERDs yog cov kev kho mob zoo heev rau mob qog noj ntshav hauv lub mis uas muaj estrogen receptor-positive. Lawv thaiv qhov ua haujlwm ntawm cov tshuaj hormone estrogen, uas yog qhov tseem ceeb rau kev loj hlob ntawm cov hlwb qog noj ntshav.
- Tsis yog txhua yam tshuaj no haum rau txhua tus. Tsuas yog koj tus kws kho mob thiaj li txiav txim tau txoj kev kho mob zoo tshaj plaws rau koj raws li hom mob qog noj ntshav, koj lub hnub nyoog, thiab koj txoj kev noj qab haus huv.
- Tej zaum yuav muaj tej yam tsis zoo tshwm sim, tab sis feem ntau ntawm lawv yeej tswj tau. Tham nrog koj tus kws kho mob txog tej yam tsis xis nyob uas koj ntsib, txawm tias me me li cas los xij.
- Nws yog ib qho tseem ceeb heev uas yuav tsum tsis txhob cev xeeb tub thaum noj cov tshuaj no. Nco ntsoov nrog koj tus kws kho mob tham txog cov kev tswj kom tsis txhob muaj menyuam.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus