Kab mob Castleman yog dab tsi? Cia peb tham txog nws yooj yim!

Koj puas tau pom tias koj muaj cov pob me me no ntawm koj lub caj dab lossis caj npab? Qee zaum lawv tshwm sim thaum koj mob khaub thuas lossis mob ntsws. Tab sis, qhov no tsis yog hais txog qee yam yooj yim li ntawd. Qhov no yog ib qho mob tsis tshua muaj tab sis tseem ceeb uas yuav tsum paub txog. Peb hu ua Kab Mob Castleman .

Hais yooj yim xwb, Kab mob Castleman yog ib yam mob uas peb lub cev tiv thaiv kab mob ua haujlwm ntau dhau . Xav txog seb, thaum ib tug kab mob uas ua rau muaj mob nkag mus rau hauv peb lub cev, peb lub cev tiv thaiv kab mob tawm tsam nws zoo li ib tug tub rog mus ua rog. Thaum tus kab mob kho tau zoo, tus tub rog ntawd rov qab ntsiag to dua. Tab sis rau ib tug neeg uas muaj Kab Mob Castleman, lub cev tiv thaiv kab mob no yeej ib txwm 'ua haujlwm'. Qhov no ua rau mob o ntev hauv lub cev, uas tuaj yeem ua rau peb cov kabmob puas tsuaj.

Lub sijhawm no, peb cov qog ntshav - cov pob me me ntawd yog qhov peb hu lawv - ua haujlwm zoo li lub lim dej. Tag nrho cov kab mob thiab cov hlwb tiv thaiv kab mob raug lim los ntawm lawv. Yog li, vim tias lub cev tiv thaiv kab mob ua haujlwm tas li, cov qog ntshav no kuj ua haujlwm dhau sijhawm. Tom qab ntawd cov hlwb hauv lawv loj hlob ntau dhau, thiab cov qog ntshav o. Tsis yog qhov o no xwb, tab sis hauv Castleman Kab Mob, muaj kev hloov pauv hauv cov ntaub so ntswg ntawm cov qog ntshav no.

Qhov no yog ib yam kab mob tsis tshua muaj . Piv txwv li, hauv Tebchaws Meskas, tsuas muaj 4,300 txog 5,200 tus neeg mob tshiab raug kuaj pom txhua xyoo. Yog li cov kws kho mob tseem tab tom kawm ntau yam txog qhov no. Txawm li cas los xij, yog tias koj raug kuaj pom tias muaj tus kab mob no, koj yuav tau txais kev kho mob tshwj xeeb uas tshwj xeeb rau koj.

Cov hom kab mob Castleman tseem ceeb yog dab tsi?

Muaj ob hom kab mob no tseem ceeb.

Kab mob Castleman Unicentric (UCD)

Kab mob Castleman Unicentric (UCD) yog thaum tsuas yog ib lossis ob peb lub qog ntshav hauv ib cheeb tsam ntawm koj lub cev loj hlob tuaj . Xav txog koj lub caj dab, lossis koj lub qhov tsoob xwb. Kwv yees li peb feem plaub ntawm cov neeg mob Castleman poob rau hauv pawg no.

Kab mob Castleman ntau lub chaw (MCD)

Kab mob Castleman ntau lub hlwb (MCD) yog ib yam mob uas cov qog ntshav o ntau qhov chaw ntawm lub cev, tsis yog ib qho xwb. Yog xav kom meej meej, cov kws kho mob faib hom MCD no ua:

• MCD uas cuam tshuam nrog POEMS: POEMS yog ib qho mob ntshav tsis tshua muaj. Qee zaum, POEMS tuaj yeem tshwm sim nrog MCD.
• HHV-8-associated MCD: Hom kab mob no yog tshwm sim los ntawm kev kis tus kab mob hu ua Human Herpes Virus-8 (HHV-8) . Yog tias koj muaj tus kab mob HIV lossis koj lub cev tiv thaiv kab mob tsis zoo, koj yuav muaj feem ntau dua los mob hom MCD no.
• MCD uas tsis paub ua rau muaj (Idiopathic MCD - iMCD):Qhov no yog hom MCD uas feem ntau pom. 'Idiopathic' txhais tau tias tsis paub meej tias yog vim li cas.

Tam sim no qhov tsis paub meej no iMCD kuj muaj peb ntu me:

• iMCD cuam tshuam nrog TAFRO syndrome: Qee zaum iMCD tuaj yeem nrog los ntawm ib qho mob hu ua TAFRO syndrome. Lub npe TAFRO yog los ntawm cov tsiaj ntawv thawj zaug ntawm nws cov tsos mob. Cov no yog: Thrombocytopenia (cov ntshav platelets qis), Anasarca (lub cev o nrog dej), Kub taub hau , Renal (raum) ua haujlwm tsis zoo, thiab Organomegaly (lub po lossis siab loj hlob).
• iMCD nrog Idiopathic Plasmacytic Lymphadenopathy (iMCD-IPL): Hauv hom kab mob no, cov ntshav platelets yuav siab dua. Koj cov qe ntshav dawb kuj tseem yuav tsim cov tshuaj tiv thaiv kab mob ntau dhau.
• iMCD tsis tau teev tseg lwm yam (iMCD-NOS): Qhov ua rau muaj hom no, hu ua iMCD-NOS, kuj tsis paub meej, thiab nws tsis muaj feem cuam tshuam nrog TAFRO.

Cov tsos mob ntawm tus kab mob Castleman yog dab tsi?

Cov tsos mob ntawm tus kab mob Castleman sib txawv nyob ntawm hom kab mob uas koj muaj. Feem ntau, yog tias koj muaj tus kab mob Castleman unicentric (UCD), koj yuav tsis muaj cov tsos mob loj. Cov qog ntshav o tuaj yeem yog tib qho cim uas koj pom. Txawm li cas los xij, qee zaum cov tsos mob tuaj yeem tshwm sim yog tias cov qog ntshav o nias rau lwm lub cev ze.

Txawm li cas los xij, yog tias koj muaj MCD, cov tsos mob yuav pom tseeb dua. Ntxiv nrog rau cov qog ntshav o, koj yuav pom cov tsos mob xws li:

• Ua npaws
• Qaug zog (qhov no tuaj yeem yog ib qho cim ntawm anemia)
• Tawm hws thaum hmo ntuj
• Xeev siab thiab ntuav
• Kev poob phaus tsis muaj laj thawj
• O ntawm koj txhais taw, pob luj taws, lossis plab
• Lub qhov ntswg loj (splenomegaly) lossis lub siab loj (hepatomegaly)
• Kev tsis muaj zog ntawm tes thiab taw (peripheral neuropathy)

Dab tsi ua rau muaj tus kab mob Castleman?

Qhov ua rau muaj tus kab mob Castleman uas muaj tus kab mob unicentric (UCD) tseem tsis tau paub meej, tab sis kev kis tus kab mob hu ua HHV-8 tau pom tias yog ib qho tseem ceeb hauv kev loj hlob ntawm tus kab mob Castleman uas muaj ntau tus kab mob (MCD).

Cov kws tshawb fawb tseem tab tom tshawb nrhiav lwm yam ua rau UCD thiab iMCD. Piv txwv li, lawv tab tom tshawb nrhiav cov kab mob uas tsis yog HHV-8, kev hloov pauv ntawm cov noob caj noob ces , thiab cov lus teb ntawm lub cev tiv thaiv kab mob .

Leej twg muaj feem yuav mob no tshaj?

Tseem tsis tau txheeb xyuas cov yam tshwj xeeb uas ua rau muaj UCD lossis iMCD. Txawm li cas los xij, yog tias koj muaj tus kab mob HIV lossis lwm yam mob uas ua rau koj lub cev tiv thaiv kab mob tsis muaj zog, koj muaj feem yuav mob HHV-8-associated MCD ntau dua.

Kab mob Castleman tuaj yeem tshwm sim rau txhua lub hnub nyoog, tab sis feem ntau nws raug kuaj pom rau cov neeg hnub nyoog ntawm 30 thiab 60 xyoo .

Cov teeb meem uas yuav tshwm sim ntawm tus kab mob Castleman yog dab tsi?

Kab mob Castleman ua rau koj muaj feem yuav mob qog noj ntshav, tshwj xeeb yog lymphoma .

Tsis tas li ntawd xwb, txawm hais tias tsis tshua muaj neeg mob UCD los, cov neeg uas muaj UCD muaj feem yuav mob hnyav hu ua Paraneoplastic Pemphigus (PNP) . MCD kuj ua rau koj muaj feem yuav mob uas ua rau koj cov kab mob puas tsuaj. Qhov kev puas tsuaj no tuaj yeem ua rau koj tuag taus yog tias tsis kho kom zoo.

Tsis txhob txhawj, koj tus kws kho mob yuav saib xyuas koj tus mob tas li thiab pab koj tiv thaiv cov teeb meem no thaum twg ua tau.

Cov kws kho mob kuaj mob Castleman li cas?

Cov tsos mob ntawm tus kab mob Castleman zoo ib yam li lwm yam kab mob uas tshwm sim, xws li mob khaub thuas lossis mob khaub thuas. Yog li koj tus kws kho mob yuav txiav txim siab ua ntej seb puas muaj cov mob ntawd. Tom qab ntawd, lawv yuav ua qhov kev kuaj mob los kuaj mob Castleman thiab txiav txim siab hom kab mob.

Cov kev kuaj thiab cov txheej txheem yuav suav nrog:

• Kev kuaj mob hauv chav kuaj: Koj tus kws kho mob yuav kuaj koj cov qe ntshav kom paub txog qhov tsis zoo thiab lwm yam cim qhia me me ntawm tus kab mob Castleman. Lawv kuj tseem yuav xaj kom kuaj HIV . Yog tias koj muaj MCD cuam tshuam nrog HHV-8, koj qhov kev kuaj HIV yuav zoo.
• Kev kuaj duab: Kev kuaj xws li CT scans thiab PET scans tuaj yeem pab nrhiav cov qog ntshav hauv koj lub cev, nrog rau kev kuaj xyuas lwm yam cim ntawm tus kab mob Castleman, xws li lub siab lossis tus po loj dua.
• Kev kuaj mob qog ntshav hauv cov qog ntshav: Tib txoj kev los paub tseeb tias koj puas muaj tus kab mob Castleman yog kev kuaj mob qog ntshav. Qhov no suav nrog kev rho ib daim nqaij me me los ntawm cov qog ntshav thiab kuaj nws hauv qab lub tshuab kuaj mob me me. Qhov no yuav txiav txim siab seb puas muaj cov cim qhia ntawm tus kab mob.

Yuav kho tus kab mob Castleman li cas?

Kev kho mob rau tus kab mob Castleman sib txawv nyob ntawm hom koj muaj.

Kev Kho Mob Unicentric Castleman Disease (UCD)

Txoj kev kho mob tseem ceeb rau UCD yog phais tshem cov qog ntshav uas raug mob. Qee zaum koj yuav xav tau kev kho mob hluav taws xob lossis kev kho mob tiv thaiv kab mob ua ntej phais. Cov kev kho mob no ua rau cov qog ntshav hauv cov qog ntshav me me, ua rau lawv yooj yim dua rau kev tshem tawm.

Tab sis yog tias cov kws phais tsis tuaj yeem tshem tawm cov qog ntshav uas raug mob, thiab koj tsis muaj tsos mob, koj tus kws kho mob yuav saib xyuas nws es tsis kho nws. Yog tias koj muaj tsos mob thiab tsis tuaj yeem phais, lawv yuav pom zoo kom kho MCD.

Kev kho mob ntawm ntau lub chaw Castleman kab mob (MCD)

MCD nyuaj kho dua li UCD me ntsis. Vim tias nws kis thoob plaws lub cev, feem ntau tsis siv phais lossis kho mob hluav taws xob. Hloov chaw, kev kho mob nyob ntawm seb koj puas muaj tus kab mob HHV-8 thiab tus kab mob hnyav npaum li cas.

Koj tus kws kho mob yuav siv cov kev kho mob xws li:

• Corticosteroids: Cov tshuaj no pab txo qhov o thiab muab kev pab los ntawm cov tsos mob.
• Cov tshuaj kho mob qog noj ntshav: Cov tshuaj kho mob qog noj ntshav tswj cov qe ntshav hauv koj lub cev lymphatic loj hlob ntau dhau. Rituximab yog ib hom tshuaj uas feem ntau sau rau HHV-8-cuam tshuam MCD.
• Kev Kho Mob Tiv Thaiv Kab Mob: Kev kho mob no suav nrog kev siv cov khoom xws li monoclonal antibodies . Cov no pab ua kom koj lub cev tiv thaiv kab mob tsis txhob ntxhov siab. Siltuximab (Sylvant®) yog tib txoj kev kho mob uas tau pom zoo los ntawm US Food and Drug Administration (FDA) rau iMCD.
• Cov tshuaj tua kab mob: Yog tias koj muaj MCD cuam tshuam nrog HHV-8, koj yuav xav tau cov tshuaj tua kab mob los kho HIV lossis kev kis kab mob HHV-8.

Kuv yuav tsum mus ntsib kws kho mob thaum twg?

Yog koj pom ib lub pob lossis loj hlob hauv koj lub caj dab, qhov chaw mos, lossis qhov chaw mos, mus ntsib kws kho mob tam sim ntawd . Tsis tas li ntawd, yog tias koj muaj lwm cov tsos mob ntawm tus kab mob Castleman uas tau hais los saum toj no uas tsis zoo dua tom qab ob peb lub lis piam, qhia rau koj tus kws kho mob txog lawv thiab.

Koj muaj peev xwm nyob nrog tus kab mob no tau ntev npaum li cas?

Rau feem ntau cov neeg uas muaj UCD, qhov kev kwv yees, lossis qhov kev cia siab, yog qhov zoo heev. Kev tshem tawm cov qog ntshav uas cuam tshuam tuaj yeem kho tus kab mob. Nrog kev kho mob, UCD feem ntau tsis cuam tshuam rau lub neej ntev.

Tiam sis qhov kev xav ntawm cov neeg uas muaj MCD nyob ntawm seb lawv muaj hom MCD thiab qhov mob hnyav npaum li cas. Rau qee tus neeg, cov tsos mob tuaj yeem tshwm sim sai sai thiab ua rau muaj kev phom sij rau lub neej. Rau lwm tus, cov tsos mob tuaj yeem kav ntev. Nruab nrab ntawm 65% thiab 75% ntawm cov neeg uas kuaj pom tias muaj MCD tseem muaj sia nyob tom qab tsib xyoos . Nrog rau kev kho mob tshiab, muaj kev cia siab tias qhov xwm txheej no yuav zoo dua.

Tsis muaj lus teb yooj yim thaum nws los txog rau tus kab mob Castleman. Koj qhov kev paub yuav nyob ntawm hom kab mob Castleman uas koj muaj. Cov mob ntxiv, xws li HIV, lossis cov mob cuam tshuam, xws li TAFRO thiab POEMS, kuj tuaj yeem cuam tshuam rau koj qhov kev paub. Qee zaum, kev phais thiab kev soj ntsuam ze yuav yog txhua yam uas xav tau. Lossis, koj yuav xav tau ntau yam kev kho mob thoob plaws hauv koj lub neej kom tiv thaiv cov teeb meem. Nug koj tus kws kho mob seb koj qhov kev kuaj mob yuav cuam tshuam li cas rau koj txoj kev kho mob thiab koj txoj kev xav.

Yog li ntawd, tej yam tseem ceeb tshaj plaws uas peb yuav tsum nco ntsoov ntawm qhov no yog dab tsi?

• Kab mob Castleman yog ib qho kab mob tsis tshua muaj tab sis muaj peev xwm ua rau muaj teeb meem loj heev uas peb lub cev tiv thaiv kab mob ua haujlwm ntau dhau.
• Muaj ob hom tseem ceeb: UCD thiab MCD. Hauv UCD, cov qog ntshav hauv lub cev o tuaj rau hauv ib qho chaw, thaum nyob hauv MCD, lawv o tuaj rau ntau qhov chaw.
• Cov tsos mob sib txawv. Tej zaum yuav tsis muaj tsos mob li, tsuas yog ib lub pob o xwb. Los yog tej zaum yuav muaj cov tsos mob xws li kub taub hau, qaug zog, thiab poob phaus.
• Cov ua rau mob tsis yog ib txwm meej, tab sis tus kab mob HHV-8 tau txuas nrog MCD. Cov neeg uas muaj HIV muaj feem yuav mob ntau dua.
• Kev kuaj pom thaum ntxov thiab kev kho mob kom zoo feem ntau tuaj yeem ua rau muaj txiaj ntsig zoo. Yog li ntawd, yog tias koj pom ib lub pob txawv txawv, o, lossis lwm yam tsos mob txawv txawv ntawm koj lub cev, nrhiav kev pab kho mob tam sim ntawd. Qhov tseem ceeb tshaj plaws yog kom paub txog thiab tsis txhob ntshai.

Kab mob Castleman, Cov qog ntshav hauv lub cev, Kab mob Lymphadenopathy, Lub cev tiv thaiv kab mob, UCD, MCD, HHV-8, Cov tsos mob, Kev kho mob