Puas muaj teeb meem nrog cov qe ntshav dawb hauv koj lub cev? Cia peb tham txog Lymphoproliferative Disorders (LPDs)!

Koj puas tau hnov ​​​​tias muaj cov tub rog me me hauv peb lub cev uas tiv thaiv peb ntawm kab mob? Cov tub rog ntawd hu ua cov qe ntshav dawb. Ntawm cov qe ntshav dawb no, muaj ib hom tshwj xeeb hu ua lymphocytes . Lawv txoj haujlwm tseem ceeb yog ua kom peb lub cev tiv thaiv kab mob muaj zog los ntawm kev tawm tsam cov yeeb ncuab xws li cov kab mob thiab cov kab mob uas nkag mus rau hauv peb lub cev, thiab txawm tias rhuav tshem cov qe ntshav qog. Txawm li cas los xij, qee zaum cov lymphocytes no tsis ua haujlwm zoo, lossis lawv pib loj hlob ntau dhau. Thaum ntawd peb hu ua ib pawg kab mob hu ua Lymphoproliferative Disorders (LPDs) . Qhov no yog ib qho mob tsis tshua muaj. Cia peb tham txog qhov no kom meej ntxiv, puas yog?

Cov Kab Mob Lymphoproliferative Disorders (LPDs) yog dab tsi? Puas muaj hom kab mob?

Hais yooj yim xwb, LPDs yog ib pawg kab mob uas tshwm sim thaum peb cov qe ntshav dawb, hu ua lymphocytes, tsis ua haujlwm zoo lossis loj hlob tsis tuaj yeem tswj tau. Cov no tuaj yeem muab faib ua ob pawg tseem ceeb.

1. LPDs (Kev Mob Hlwb Tiv Thaiv Kab Mob) uas cuam tshuam nrog lub cev tiv thaiv kab mob

Cov hom LPD no cuam tshuam txoj kev uas peb lub cev tiv thaiv kab mob teb rau cov neeg txawv teb chaws tuaj. Cov neeg uas muaj cov mob no muaj feem yuav mob qog noj ntshav xws li lymphoma .

• X-linked lymphoproliferative disorder (XLP): Yog tias ib tug neeg uas muaj tus mob no kis tus kab mob Epstein-Barr , nws tuaj yeem hloov mus ua lymphoma.
• Kab mob lymphoproliferative syndrome (ALPS): Qhov no yog thaum muaj cov lymphocytes ntau heev sib sau ua ke rau hauv cov chaw xws li peb cov qog ntshav, lub qhov ntswg, thiab lub siab, ua rau cov kabmob ntawd o. Zoo li peb cov cell tsuas yog sib sau ua ke rau hauv cov chaw uas tsis tswj tau.
• Cov kab mob lymphoproliferative tom qab hloov hlwb (PTLD): Qhov no yog ib qho mob tsis tshua muaj tab sis loj heev. Nws tuaj yeem tshwm sim tom qab hloov hlwb (piv txwv li, raum, siab) lossis hloov hlwb allogeneic stem cell . Qhov no muaj tseeb tshwj xeeb yog tias koj lossis tus neeg uas pub lub hlwb lossis hlwb stem cell tau kis tus kab mob Epstein-Barr, uas cuam tshuam rau B-cell.

2. Mob qog ntshav Lymphoid

Cov no yog cov kab mob loj uas peb feem ntau hnov ​​txog, xws li Leukemia thiab Lymphoma . Qhov tshwm sim ntawm no yog tias cov qe ntshav dawb hauv peb cov pob txha thiab cov ntshav, uas yog B-cells, T-cells thiab Natural killer cells (NK cells), raug puas tsuaj.Kev hloov pauv, cov qe ntshav tsis zoo uas loj hlob tsis tau tswj. Cov qe ntshav tsis zoo no ua rau cov qe ntshav noj qab nyob zoo tsis muaj zog. Txawm hais tias qee zaum cov no kho tau los xij, lawv yog cov kab mob loj uas tuaj yeem ua rau tuag taus.

Cov mob qog nqaij hlav uas cuam tshuam nrog B-cell

Qee hom lymphomas uas tsis yog Hodgkin uas poob rau hauv pawg no yog:

• Diffuse loj B-cell lymphoma
• Cov kab mob follicular lymphoma
• Mantle cell lymphoma

Kuj tseem muaj hom kab mob B-cell leukemia:

• Mob leukemia lymphocytic ntev (CLL): Ntawm no, cov B-cell ib txwm muaj nyob rau hauv cov pob txha pob txha ntau dhau, ua rau cov qe ntshav thiab cov platelets noj qab nyob zoo tsis muaj zog.
• B-cell prolymphocytic leukemia: Ntawm no ib yam nkaus, cov B-cell tsis zoo sib sau ua ke hauv cov pob txha pob txha, ua rau cov cell noj qab haus huv tsis muaj zog.
• Kab mob ntshav dawb uas muaj plaub hau: Raws li lub npe qhia, cov qe ntshav dawb uas tsis zoo no tau muab lub npe rau vim lawv zoo li cov plaub hau thaum saib hauv lub tshuab tsom iav. Lawv kuj tsim nyob rau hauv cov pob txha thiab loj hlob ntau dhau.

Cov mob qog nqaij hlav uas cuam tshuam nrog T-cell

Cov kab mob ntsig txog T-cell feem ntau muab faib ua ob pawg:

• Cov kab mob T-cell lymphomas uas kis thoob plaws lub cev: Cov no tuaj yeem cuam tshuam rau koj cov qog ntshav, tus po, pob txha, ntshav, thiab lwm yam hauv lub cev.
• Cov kab mob Cutaneous T-cell lymphomas: Cov no feem ntau cuam tshuam rau daim tawv nqaij, tab sis qee zaum tuaj yeem cuam tshuam rau cov qog ntshav, cov ntshav, cov pob txha, thiab cov kabmob sab hauv.

Muaj ntau hom kab mob T-cell lymphomas uas kis thoob plaws lub cev. Qee hom uas pom ntau tshaj plaws yog:

• Peripheral T-cell lymphoma, tsis tau teev tseg lwm yam (PTCL NOS)
• Angioimmunoblastic T-cell lymphoma (AITL)
• Anaplastic large cell lymphoma

Kuj tseem muaj ntau hom tsis tshua muaj:

• Kab mob Hepatosplenic T-cell lymphoma (HSTCL)
• Kab mob Enteropathy-associated T-cell lymphoma (EATL)

Qee cov kab mob T-cell lymphomas uas tshwm sim hauv lub cev kuj hu ua chronic T-cell leukemias . Piv txwv li:

• T-cell prolymphocytic leukemia (T-PLL)
• T-cell large granular lymphocytic leukemia (T-LGL)

Muaj ob hom kab mob cutaneous T-cell lymphoma tseem ceeb:

• Mycosis fungoides
• Kab mob Sézary

Cov kab mob ntsig txog NK-cell

Cov no tsis tshua muaj thiab cuam tshuam rau NK hlwb.

• Extranodal NK T-cell lymphoma hom ntswg
• Kab mob NK-cell leukemia uas muaj zog heev (AKNL)
• NK-cell loj granular lymphocytic leukemia (NK-LGL)

Tam sim no koj tuaj yeem pom tias muaj pes tsawg yam mob sib txawv uas raug them rau hauv LPDs. Koj tsis tas yuav mus tob txog txhua yam, tab sis nws yog ib qho tseem ceeb kom paub tias qhov mob no muaj nyob.

Cov tsos mob ntawm LPD yog dab tsi? Koj paub lawv li cas?

Cov tsos mob ntawm cov LPD no tuaj yeem sib txawv heev, nyob ntawm hom LPD uas koj muaj. Tab sis muaj qee cov tsos mob uas koj yuav pom. Cia peb saib seb lawv yog dab tsi:

• Tawm hws ntau dhau thaum hmo ntuj: Tsis yog tawm hws xwb, tab sis tawm hws ntau heev ua rau daim ntaub pua chaw ntub.
• Cov qog ntshav hauv lub cev, daim siab, lossis tus po: Yog tias koj pom cov qog hauv qhov chaw xws li caj dab, qhov chaw mos, lossis qhov chaw mos, lossis yog tias koj muaj qhov o ntawm koj lub plab tsis zoo li qub, koj yuav tsum txhawj xeeb.
• Los ntshav thiab mob nqaij txawv txawv lossis ntau dhau: Yog tias koj los ntshav ntau txawm tias yog los ntawm kev raug mob me me, lossis yog tias koj tsuas muaj mob nqaij xiav rau ntawm koj lub cev.
• Qaug zog ntau zaus: Xav tias nkees txawm tias koj pw tsaug zog npaum li cas los xij.
• Kub taub hau tas li: Yog tias koj kub taub hau tas li yam tsis muaj laj thawj.
• Cov kab mob sib kis ntau zaus: Vim yog koj lub cev tiv thaiv kab mob tsis zoo, koj yuav muaj mob xws li mob khaub thuas thiab mob ntsws.
• Anorexia: Kev xav tsis xav noj mov.
• Kev poob phaus yam tsis muaj laj thawj: Yog tias koj poob phaus sai sai yam tsis tau noj zaub mov lossis tawm dag zog, qhov ntawd kuj yog ib qho cim qhia tias yuav tsum tau saib xyuas.

Tseem Ceeb: Tsis txhob ntshai yog tias koj muaj ib lossis ob qho ntawm cov tsos mob no. Lawv kuj tuaj yeem tshwm sim los ntawm lwm yam, cov laj thawj yooj yim dua. Txawm li cas los xij, yog tias cov tsos mob no tseem muaj, nws yog ib lub tswv yim zoo kom mus ntsib kws kho mob kom tau txais lus qhia.

Cov ua rau muaj LPDs yog dab tsi?

Nws nyuaj rau txheeb xyuas ib qho ua rau feem ntau ntawm LPDs, tab sis ntau yam tseem ceeb tuaj yeem pab txhawb.

• Kev kis kab mob: Qee hom LPD tuaj yeem tshwm sim los ntawm kev kis kab mob xws li tus kab mob Epstein-Barr lossis cov kab mob H. pylori . Xav txog, cov kab mob me me no nkag mus rau hauv peb lub cev tab tom cuam tshuam peb lub cev.
• Qee cov kab mob autoimmune: Rheumatoid mob caj dab, lupusCov neeg uas muaj tej yam kab mob muaj feem yuav mob tau tej hom mob LPD (piv txwv li, mob qog nqaij hlav ntawm thaj tsam ntug). Qhov no yog thaum peb lub cev tiv thaiv kab mob tawm tsam peb cov hlwb.
• Tshuaj: Qee cov tshuaj uas tiv thaiv kab mob (piv txwv li, cov tshuaj uas tau muab los tiv thaiv lub cev tiv thaiv kab mob tom qab hloov pauv lub cev) tuaj yeem ua rau muaj mob xws li hepatosplenic T-cell lymphoma.
• Qee qhov kev hloov pauv caj ces: Tsis tshua muaj, koj tuaj yeem tau txais kev hloov pauv caj ces uas ua rau hom LPD no. Piv txwv li, cov neeg uas muaj X-linked lymphoproliferative disorder (XLP) muaj kev hloov pauv hauv ob lub caj ces. Qhov no ua rau lawv muaj feem ntau dua los muaj kev teb hnyav rau tus kab mob Epstein-Barr thiab tsim lymphoma. Kev hloov pauv caj ces uas cuam tshuam rau kev loj hlob ntawm cov qe ntshav dawb kuj txuas nrog lymphoma thiab leukemia.

Cov kws kho mob kuaj mob LPD li cas? (Kev kuaj mob)

Vim muaj ntau hom LPD, thaum kuaj mob, cov kws kho mob yuav tsum xub nrhiav seb hom LPD twg ua rau koj cov tsos mob.

Yuav ua li no, tus kws kho mob yuav xav txog koj cov tsos mob, xws li cov qog ntshav o, cov cim qhia tias koj lub siab lossis tus po loj dua li qub, thiab nug txog koj keeb kwm kev kho mob yav dhau los thiab seb puas muaj leej twg hauv koj tsev neeg tau muaj cov mob zoo sib xws.

Tom qab ntawd nws muaj peev xwm ua cov kev ntsuam xyuas zoo li no:

• Kev kuaj mob: Kev kuaj mob pob txha yuav ua tau los nrhiav cov cim ntawm cov mob qog ntshav xws li mob leukemia lossis lymphoma. Qhov no suav nrog kev coj me me ntawm cov pob txha thiab kuaj nws. Qee zaum ib daim me me ntawm cov qog ntshav o kuj tseem yuav raug coj mus.
• Kev kuaj ntshav: Kev suav cov ntshav tag nrho (CBC) , Kev ntsuas metabolic panel (CMP) , Kev kuaj Epstein-Barr antibody, kev kuaj mob hepatitis, kev kuaj HIV, kev kuaj Lactate dehydrogenase (LDH) , thiab lwm yam. Cov no tuaj yeem qhia koj ntau yam txog kev hloov pauv hauv cov qe ntshav, kev kis kab mob, thiab kev ua haujlwm ntawm lub siab thiab lub raum.
• Kev kuaj duab: Kev kuaj xws li kev ntsuas computer tomography (CT) thiab positron emission tomography (PET) tuaj yeem ua tau. Cov no tuaj yeem saib cov khoom xws li cov kabmob hauv lub cev, cov mob ntawm cov qog ntshav, thiab seb cov qog nqaij hlav puas tau kis mus rau lwm qhov. Nws zoo li thaij duab sab hauv ntawm lub cev.
• Kev kuaj hauv chav kuaj: Cov kev kuaj tshwj xeeb xws li flow cytometry tuaj yeem pab txheeb xyuas hom LPD tshwj xeeb.

Yuav kho cov LPD li cas?

Kev kho mob rau LPDs nyob ntawm seb koj muaj hom LPD twg. Tsis yog txhua tus neeg muaj kev kho mob zoo ib yam. Piv txwv li, yog tias koj muaj mob leukemia lossis lymphoma, koj yuav muaj kev kho mob zoo li no:

• Kev kho mob qog noj ntshav: Cov tshuaj uas muab los tua cov hlwb qog noj ntshav.
• Kev Kho Mob Tiv Thaiv Kab Mob: Kev kho mob uas ua rau koj lub cev tiv thaiv kab mob ua haujlwm kom tawm tsam cov hlwb qog noj ntshav.
• Kev Kho Mob Hluav Taws Xob: Tua cov hlwb qog noj ntshav siv cov hluav taws xob muaj zog heev.
• Kev hloov hlwb pob txha: Kev hloov cov hlwb pob txha noj qab haus huv los hloov cov hlwb pob txha uas puas lawm.
• Kev kho mob uas tsom mus rau: Cov tshuaj uas tsom mus rau cov molecules tshwj xeeb uas pab cov hlwb qog noj ntshav loj hlob thiab muaj sia nyob.

Nco ntsoov, koj tus kws kho mob yuav txiav txim siab seb yuav kho koj li cas. Nws paub koj tus mob zoo tshaj plaws.

Tus neeg uas muaj tus kab mob LPD no zoo li cas? Puas kho tau?

Qhov no yog ib lo lus nug nyuaj me ntsis los teb vim tias muaj ntau hom LPDs, thiab ntau yam xws li koj txoj kev noj qab haus huv, hnub nyoog, thiab theem ntawm tus kab mob tuaj yeem cuam tshuam rau qhov tshwm sim.

Qee hom LPDs tuaj yeem kho tau tag nrho. Piv txwv li, chemo-immunotherapy tuaj yeem kho tau qee hom lymphoma, xws li large B-cell lymphoma thiab Burkitt lymphoma. Ib tug neeg uas muaj X-linked lymphoproliferative disorder (XLP) tuaj yeem kho tau los ntawm kev hloov noob hlwb.

Tiam sis qee zaum, kev kho mob tuaj yeem ua rau qee cov lymphomas ploj mus , txhais tau tias cov tsos mob ploj mus thiab kev kuaj mob tsis tuaj yeem pom tus kab mob lawm. Tiam sis tus kab mob tsis tau kho tag nrho. Qee cov LPD tuaj yeem rov qab los ntau lub hlis lossis ntau xyoo tom qab kev kho mob xaus.

Yog koj muaj LPD, tej zaum koj yuav xav paub seb nws puas kho tau thiab koj yuav nyob tau ntev npaum li cas. Qhov chaw zoo tshaj plaws kom tau cov ntaub ntawv txog qhov no yog los ntawm koj tus kws kho mob. Nws paub koj thiab koj tus mob zoo tshaj plaws. Yog li ntawd, tsis txhob ntshai nug nws txog tej lus nug uas koj muaj.

Kuv yuav saib xyuas kuv tus kheej li cas? (Kev saib xyuas tus kheej)

Cov mob LPD yog cov mob hnyav heev. Txawm hais tias kev kho mob tuaj yeem txo cov tsos mob thiab ua rau koj zoo, koj tseem yuav ntsib teeb meem thaum kho mob. Nov yog qee cov lus qhia uas yuav pab tau koj:

• Nug txog kev kho mob palliative: Ib tug neeg uas muaj LPD tej zaum yuav xav tau kev pab tswj cov tsos mob thiab cov kev mob tshwm sim ntawm kev kho mob. Kev kho mob palliative yog ib hom kev kho mob tshwj xeeb uas pab txhim kho tus neeg lub neej zoo dua thiab txo qhov mob thiab lwm yam kev tsis xis nyob, es tsis txhob sim kho tus kab mob. Koj pab neeg kho mob palliative tuaj yeem muab cov lus qhia zoo rau koj.
• Noj mov kom zoo: Tej zaum koj yuav tsis xav noj mov thaum koj mob lossis tab tom kho mob. Yog tias koj noj, nrog tus kws noj zaub mov tham. Nws yuav qhia koj txog cov khoom noj thiab dej haus uas zoo rau koj.
• Ua kom koj lub cev tawm dag zog me ntsis: Kev tawm dag zog me me tuaj yeem pab txo qhov kev ntxhov siab uas los nrog kev mob hnyav. Tab sis nco ntsoov tham nrog kws kho mob ua ntej pib ua ib qho kev tawm dag zog tshiab.
• Tiv thaiv koj tus kheej ntawm kev kis kab mob: Koj lub cev tiv thaiv kab mob tuaj yeem qaug zog los ntawm kev mob lossis kev kho mob. Yog li nug koj tus kws kho mob txog cov hau kev los tiv thaiv kev kis kab mob viral. Tsis txhob mus rau qhov chaw muaj neeg coob coob thiab ntxuav koj txhais tes ntau zaus yog qhov tseem ceeb.

Kuv yuav tsum mus ntsib kws kho mob thaum twg?

Yog tias koj tab tom kho mob rau LPD, nug koj tus kws kho mob seb cov cim qhia tias koj tus mob hnyav zuj zus (piv txwv li, kub taub hau tas li) kom koj paub thaum twg yuav tsum tiv tauj nws.

Thaum tus kws kho mob siv lo lus kho mob "lymphoproliferation" lossis "lymphoproliferative disorders (LPDs)," lawv tab tom tham txog ib pawg kab mob uas muaj cov qe ntshav dawb tshwj xeeb uas tuaj yeem cuam tshuam rau koj lub cev tiv thaiv kab mob lossis ua mob qog noj ntshav.

Yog koj muaj ib yam mob zoo li no, tej zaum koj yuav xav paub txog koj tus mob ntau dua li cov lus siv kho mob. Tab sis thaum koj mob, kev paub yog lub hwj chim. Hauv qhov no, kev paub lub ntsiab lus tom qab lub npe tuaj yeem pab koj nkag siab zoo dua txog yam uas tshwm sim hauv koj lub cev.

Piv txwv li, cov kab mob LPD muaj cov tsos mob thiab kev kho mob zoo sib xws. Tab sis lawv tsis zoo ib yam. Tsis tas li ntawd, koj qhov kev paub yuav txawv ntawm lwm tus neeg. Yog tias koj tus kws kho mob siv lo lus "lymphoproliferative disorder (LPD), nug kom paub meej ntxiv txog koj tus mob tshwj xeeb. Lawv yuav zoo siab teb koj cov lus nug.

Thaum kawg, cov lus coj mus tsev:

Cov Kab Mob Lymphoproliferative (LPDs) yog ib pawg ntawm cov mob nyuaj, uas muaj peev xwm loj heev uas tshwm sim los ntawm kev ua haujlwm tsis zoo ntawm cov lymphocytes, peb lub cev tiv thaiv kab mob.

• Ceev faj txog cov tsos mob: Tsis txhob tub nkeeg yog tias koj kub taub hau tas li, qaug zog heev, poob phaus, lossis o ntawm cov qog ntshav.
• Nws yog ib qho tseem ceeb uas yuav tsum nrhiav kev pab tswv yim los ntawm kws kho mob: Yog tias koj tsis paub meej, mus ntsib kws kho mob sai li sai tau kom kuaj xyuas koj tus kheej. Yog koj pom tus kab mob sai sai, ces koj yuav muaj feem ntau dua uas kev kho mob yuav ua tiav.
• Tsis yog txhua tus LPD zoo ib yam: muaj ntau hom sib txawv, thiab txhua tus muaj kev kho mob sib txawv. Koj tus kws kho mob yuav txiav txim siab seb kev kho mob twg zoo tshaj plaws rau koj.
• Koj tsis nyob ib leeg: Thaum ntsib teeb meem zoo li no, kev txhawb nqa ntawm tsev neeg, cov phooj ywg, thiab cov neeg ua haujlwm kho mob yog qhov tseem ceeb heev.

Qhov tseem ceeb tshaj plaws yog tsis txhob ntshai, nyob ruaj khov, thiab ua raws li cov lus qhia ntawm cov kws kho mob. Yog tias koj kho mob zoo thiab muaj lub siab zoo, koj yuav kov yeej tau qhov teeb meem no.

Cov kab mob lymphoproliferative, LPDs, cov qe ntshav dawb, cov lymphocytes, lub cev tiv thaiv kab mob, mob qog noj ntshav, leukemia, lymphoma