Cia peb paub txog Neuroleptic Malignant Syndrome, ib qho mob txaus ntshai uas tshwm sim los ntawm cov tshuaj neuroleptic!

Tej zaum koj lossis ib tug neeg uas koj paub yuav noj ib hom tshuaj hu ua neuroleptic, uas yog siv los kho qee yam mob hlwb. Txawm hais tias cov tshuaj no tuaj yeem pab tau ntau tus neeg, tab sis muaj qee kis tsis tshua muaj uas cov tshuaj no tuaj yeem ua rau muaj kev phom sij, txawm tias muaj kev phom sij rau lub neej. Qhov ntawd yog qhov peb hu ua Neuroleptic Malignant Syndrome (NMS). Nws yog lub npe nyuaj, tab sis nws tseem ceeb heev kom paub txog nws.

Kab mob Neuroleptic Malignant Syndrome (NMS) yog dab tsi? Cia peb nkag siab yooj yim!

Hais yooj yim xwb, tus mob neuroleptic malignant syndrome (NMS) yog ib qho tsis tshua muaj thiab muaj peev xwm ua rau tuag taus rau ib pawg tshuaj hu ua neuroleptics (tseem hu ua antipsychotic medications). Cov tshuaj no yog siv los tswj thiab kho cov tsos mob ntawm ntau yam mob hlwb.

Muaj ntau yam tsos mob tseem ceeb uas pom tau hauv tus mob 'NMS' no:

• Muaj kub taub hau heev (hyperthermia).
• Cov leeg nqaij hauv lub cev yuav nruj thiab mob (yog qhov no txuas ntxiv mus, cov leeg nqaij yuav tawg).
• Kev hloov pauv ntawm lub hlwb (xws li kev tsis meej pem, kev nco tsis zoo).
• Kev ua haujlwm tsis zoo ntawm lub paj hlwb autonomic lossis dysautonomia.

Peb lub paj hlwb autonomic zoo li lub cev autonomous hauv peb lub cev. Nws tswj cov khoom xws li ntshav siab thiab kev ua pa. Thaum nws ua haujlwm tsis zoo, ntshav siab tuaj yeem nce thiab nqis, ua rau hws ntau dhau (hyperhidrosis thib ob), thiab ua rau qaub ncaug ntau dhau.

NMS yog ib qho xwm txheej ceev uas ua rau tuag taus, yuav tsum tau kho mob tam sim ntawd. Yog li ntawd, yog tias koj muaj cov tsos mob no, qhov zoo tshaj plaws uas yuav tsum ua yog mus rau tsev kho mob tam sim ntawd.

Cov tshuaj neuroleptic no yog dab tsi?

Cov tshuaj kho mob neuroleptic, lossis cov tshuaj tiv thaiv kev puas siab puas ntsws, tuaj yeem muab faib ua ob pawg tseem ceeb.

1. Cov tshuaj tiv thaiv kev puas siab puas ntsws tiam thawj lossis "ib txwm".

2. Cov tshuaj tiv thaiv kev puas siab puas ntsws tiam ob lossis "tsis zoo li qub".

Cov kws kho mob tau sau ntawv kom siv cov tshuaj antipsychotics tiam thawj thiab tiam ob no rau ntau yam mob hlwb thiab mob paj hlwb. Nov yog ob peb yam piv txwv:

• Cov teeb meem kev coj cwj pwm uas tshwm sim hauv kev puas hlwb.
• Kev puas siab puas ntsws bipolar.
• Kev nyuaj siab.
• Kev noj zaub mov tsis zoo.
• Kev ntxhov siab dav dav.
• Kev ntxhov siab ntawm cov neeg laus.
• Tsis tsaug zog.
• Kev puas siab puas ntsws obsessive-compulsive (OCD).
• Kev muaj teeb meem ntawm tus cwj pwm.
• Kev ntxhov siab tom qab raug mob (PTSD).
Kev puas siab puas ntsws schizoaffective . Kab mob schizophrenia thiab cov kab mob cuam tshuam.

Cov tshuaj twg ua rau muaj tus mob neuroleptic malignant syndrome (NMS)?

Muaj ntau hom tshuaj uas ua rau muaj 'NMS'. Cia peb saib seb lawv yog dab tsi.

Cov tshuaj neuroleptic (antipsychotic) ib txwm muaj:

• Bromperidol
• Chlorpromazine (Chlorpromazine) tshuaj
• Clopenthixol
• Fluphenazine (Fluphenazine)
• Haloperidol (Haloperidol)
• Loxapine
• Promazine
• Thioridazine (Thioridazine)
• Thiothixene
• Trifluoperazine (Trifluoperazine)

Cov tshuaj kho mob hlwb tsis zoo (antipsychotic):

• Amisulpride
• Aripiprazole
• Clozapine
• Olanzapine
• Quetiapine
• Risperidone
• Ziprasidone
• Zotepine

Qee cov tshuaj antiemetic:

• Domperidone
• Droperidol `(Droperidol`)
• Metoclopramide
• Prochlorperazine '(Prochlorperazine)'
• Promethazine

Cov tshuaj dopaminergic (Parkinson's) (los ntawm kev tsum tsis txhob noj cov no tam sim ntawd):

• Amantadine
• Cov tshuaj dopamine agonists
• Levodopa
• Tolcapone

Tsis txhob ntshai daim ntawv teev npe no. Tsis yog txhua tus neeg uas noj cov tshuaj no yuav muaj tus kab mob NMS. Qhov no yog ib qho mob tsis tshua muaj . Tab sis yog tias koj noj cov tshuaj no, nws yog ib qho tseem ceeb uas yuav tsum paub txog qhov no.

Qhov txawv ntawm NMS thiab malignant hyperthermia yog dab tsi?

Tej zaum koj kuj tau hnov ​​​​​​txog ib qho mob hu ua malignant hyperthermia. Nws kuj yog ib qho tsis tshua muaj, hnyav heev. Tab sis nws yog tshwm sim los ntawm cov tshuaj loog dav dav thiab cov tshuaj so cov leeg .

Nws kuj tseem ua rau cov leeg nqaij tawv, txo qis reflexia (hyporeflexia), thiab hloov pauv ntawm daim tawv nqaij (xiav, liab). Cov tsos mob no zoo ib yam li NMS. Txawm li cas los xij, cov kws kho mob tuaj yeem paub qhov txawv ntawm ob qho no los ntawm kev saib tus neeg mob keeb kwm kho mob. Ntawd yog, seb lawv puas tau txais tshuaj loog lossis noj tshuaj neuroleptic.

Qhov txawv ntawm NMS thiab Serotonin Syndrome yog dab tsi?

Serotonin syndrome yog lwm yam mob uas ua rau neeg tsis meej pem. Nws yog tshwm sim los ntawm cov tshuaj uas koom nrog pawg serotonergic, xws li qee cov tshuaj antidepressants, amphetamines, antihistamines, thiab cov tshuaj tswj kev xav. Hais yooj yim xwb, nws tshwm sim thaum muaj ntau dhau ntawm cov tshuaj lom neeg hauv lub cev hu ua serotonin.

Cov tsos mob ntawm tus kab mob serotonin muaj xws li cov leeg nqaij tawv, hyperreflexia, raws plab, tawm hws, cov leeg nqaij ntswj (myoclonus), thiab kev hloov pauv ntawm lub hlwb. Txawm li cas los xij , kub taub hau thiab cov leeg nqaij tawv feem ntau tsis tshua pom muaj hauv tus kab mob serotonin dua li hauv NMS.

Koj tus kws kho mob yuav paub qhov txawv ntawm ob yam mob no los ntawm kev mloog koj cov tsos mob thiab cov tshuaj uas koj noj.

Leej twg thiaj li muaj tus mob neuroleptic malignant syndrome (NMS)?

NMS tuaj yeem tshwm sim rau txhua tus neeg uas noj tshuaj neuroleptic (antipsychotic).

Txawm hais tias nws xav tias kwv yees li ob feem peb ntawm cov neeg mob NMS tshwm sim hauv thawj lub lim tiam ntawm kev pib siv tshuaj neuroleptic, nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias qhov mob no tuaj yeem tshwm sim txhua lub sijhawm thaum kho mob.

Tus mob 'NMS' no feem ntau tshwm sim li cas?

Qhov tseeb, tus mob neuroleptic malignant syndrome (NMS) yog ib qho mob tsis tshua muaj. Nws tshwm sim ntawm 0.01% thiab 3.2% ntawm cov neeg noj tshuaj neuroleptic.

Txawm li cas los xij, qhov xov xwm zoo yog tias tus naj npawb ntawm cov ntawv ceeb toom ntawm NMS tab tom txo qis vim yog kev qhia txog cov tshuaj tshiab uas muaj kev pheej hmoo qis dua ntawm kev ua rau NMS, thiab kev paub ntawm cov kws kho mob thiab cov neeg mob txog qhov mob no.

Cov tsos mob ntawm tus mob neuroleptic malignant syndrome (NMS) yog dab tsi?

Cov tsos mob ntawm 'NMS' feem ntau pib tshwm sim hauv ib mus rau peb hnub . Cov tsos mob tseem ceeb yog:

• Kub taub hau heev (102 txog 104 degrees Fahrenheit - 38.9 txog 40 degrees Celsius).
• Lub plawv dhia tsis sib xws (arrhythmia).
• Lub plawv dhia ceev zuj zus (tachycardia).
• Ua pa ceev dua (tachypnea).
• Cov leeg nqaij tawv/mob nqaij tawv '(mob nqaij tawv tawv)'.
• Kev hloov pauv ntawm lub hlwb (xws li kev tsis meej pem, kev ntxhov siab, tsis nco qab).
• Ntshav siab los yog ntshav qis.
• Tawm hws ntau dhau.

Yog koj muaj ib lossis ntau yam ntawm cov tsos mob no, tshwj xeeb tshaj yog tias koj noj tshuaj neuroleptic, thov hu rau 911 lossis mus rau tsev kho mob ze tshaj plaws tam sim ntawd. Qhov no yog xwm txheej ceev hauv kev kho mob.

Cov tshuaj neuroleptic ua rau muaj 'NMS' li cas?

Mob 'NMS' yog tshwm sim los ntawm tshuaj neuroleptic (antipsychotic).Nws tuaj yeem tshwm sim nrog ib koob tshuaj xwb, nrog rau kev nce ntxiv ntawm cov tshuaj, lossis nrog kev siv tib koob tshuaj. Txawm hais tias NMS feem ntau yog txuam nrog thawj tiam tshuaj tiv thaiv kev puas siab puas ntsws, nws kuj tuaj yeem tshwm sim, rau qhov tsawg dua, nrog rau kev tshem tawm sai sai ntawm tiam tshuaj tiv thaiv kev puas siab puas ntsws thib ob, qee cov tshuaj tiv thaiv kev ntuav, thiab cov tshuaj dopaminergic siv rau Parkinson tus kab mob.

Cov kws tshawb fawb tseem tab tom sim nrhiav seb yog dab tsi ua rau muaj NMS. Lub tswv yim tam sim no yog tias nws yog los ntawm kev sib tawm tsam ntawm dopamine D2 receptor . Dopamine yog ib qho neurotransmitter hauv peb lub hlwb. Nws yog ib yam tshuaj uas nqa cov lus ntawm cov cell. Cov tshuaj Neuroleptic ua haujlwm los ntawm kev thaiv tus neeg xa dopamine no kom tsis txhob nkag mus rau hauv cov cell los ntawm cov receptors tshwj xeeb.

Thaum cov dopamine receptors hauv koj lub hypothalamus thiab/lossis cov hlab ntsha qaum raug thaiv, cov leeg nqaij nruj zuj zus. Tsis tas li ntawd, kev cuam tshuam ntawm dopamine receptors hauv hypothalamus yog qhov ua rau kub taub hau thiab kev hloov pauv loj hauv cov ntshav siab uas pom hauv NMS.

Yuav kuaj mob li cas yog tias muaj tus mob neuroleptic malignant syndrome (NMS)?

Rau cov kws kho mob kom kuaj mob NMS, koj yuav tsum muaj tag nrho cov tsos mob lossis tej yam mob hauv qab no :

• Koj tab tom noj tshuaj neuroleptic lossis koj cia li tsum tsis noj tshuaj dopaminergic lawm.
• Koj cov leeg nqaij nruj heev (qhov no tuaj yeem ua rau cov leeg nqaij tawg).
• Koj kub taub hau heev.
• Muaj kev hloov pauv hauv koj lub siab lub ntsws.

Ntxiv rau, yuav tsum muaj tsawg kawg yog ob yam ntawm cov yam ntxwv hauv qab no :

• Kev tawm hws ntau dhau los yog tsis tshua muaj.
• Nyuaj nqos.
• Tsis muaj peev xwm tswj tau cov zis lossis quav (incontinence).
• Lub plawv dhia ceev zuj zus (tachycardia).
• Tam sim ntawd tsis tuaj yeem tham tau.
• Kev hloov pauv ntawm cov ntshav siab ntau ntxiv lossis ntau zaus.
• Kev nce ntxiv ntawm cov qe ntshav dawb (leukocytosis).
• Cov theem ntawm creatine phosphokinase (CPK) nce ntxiv vim yog kev tawg ntawm cov leeg nqaij.
• Cov kev xav qeeb lossis tsawg dua (hyporeflexia).

Yuav ua li cas thiaj kuaj tau 'NMS'?

Yog koj tus kws kho mob xav tias koj muaj NMS, lawv yuav xaj kom kuaj xws li:

• Muaj kev sib xyaw ua ke ntawm cov txheej txheem metabolic.
• Kev kuaj zis.
• Kev kuaj roj ntshav hauv cov hlab ntsha lossis cov leeg ntshav.
• Kev kuaj ntshav ntawm Creatine phosphokinase (CPK).

Yuav kho tus mob neuroleptic malignant syndrome (NMS) li cas?

NMS yog ib qho mob ceev heev. Yog li ntawd, nws yog ib qho tseem ceeb uas yuav tsum kuaj mob thiab pib kho sai sai. Yog tias koj muaj NMS, koj yuav tsum tau mus pw hauv tsev kho mob.Koj yuav tsum tau txais kev kho mob hauv chav saib xyuas mob hnyav (ICU).

Hauv txhua rooj plaub ntawm 'NMS', cov kws kho mob yuav tsum tsis txhob noj tshuaj neuroleptic (antipsychotic) uas ua rau muaj 'NMS' tam sim ntawd. Tsis tas li ntawd, lawv yuav kho cov tsos mob ntawm 'NMS' thiab ua cov kauj ruam los tiv thaiv cov teeb meem uas yuav tshwm sim. Cov kev kho mob no suav nrog:

• Tswj kom lub plawv thiab txoj kev ua pa ruaj khov siv tshuab ua pa, tshuaj tiv thaiv kev dhia tsis xwm yeem, thiab/lossis cov tshuab pacemakers.
• Tswj kom cov electrolyte sib npaug hauv lub cev los ntawm kev muab cov kua dej rau hauv cov hlab ntsha (IV fluids).
• Txo qhov kub ntawm lub cev siv cov pam txias, dej khov, thiab/lossis cov hnab dej khov.
• Yog tias ntshav siab, tswj nws nrog tshuaj.
• Kev muab cov tshuaj xws li heparin los tiv thaiv cov ntshav txhaws.
• Kev muab cov tshuaj uas tuaj yeem kho lub cev cov dopamine qis.
• Muab cov tshuaj ua kom cov leeg nqaij lossis cov pob txha so.

Cov yam ua rau muaj kev pheej hmoo ntawm 'NMS' yog dab tsi?

Muaj ntau yam ua rau muaj kev pheej hmoo ntawm kev mob neuroleptic malignant syndrome (NMS):

• Pib siv tshuaj neuroleptic (antipsychotic) tshiab los yog nce qhov ntau npaum li cas.
• Siv ntau tshaj ib yam tshuaj neuroleptic lossis siv cov tshuaj lithium.
• Kev tsum tsis txhob siv tshuaj dopaminergic rau tus kab mob Parkinson tam sim ntawd.

Yuav siv sijhawm ntev npaum li cas los rov zoo los ntawm 'NMS'? (Kev kwv yees)

Yog tias NMS raug kuaj pom thaum ntxov thiab kho sai thiab kom raug, feem ntau cov neeg yuav zoo li qub hauv ob lub lis piam mus rau 14 hnub.

Txawm li cas los xij, yog tias kev kho mob qeeb, cov teeb meem loj tuaj yeem tshwm sim uas cuam tshuam rau cov leeg nqaij, raum, lub plawv, thiab/lossis lub ntsws.

Yog tsis kho sai sai, NMS tuaj yeem ua rau tuag taus. Tus nqi tuag rau NMS yog li ntawm 5% txog 20%. Txawm li cas los xij, kev paub ntau ntxiv txog NMS thiab kev siv cov tshuaj tiv thaiv kev puas siab puas ntsws tshiab tau txo tus nqi tuag no hauv ob peb xyoos dhau los.

Muaj ntau tus neeg, nyob rau hauv kev taw qhia ntawm tus kws kho mob, muaj peev xwm rov pib dua cov tshuaj neuroleptic (antipsychotic) tau zoo.

Cov teeb meem ntawm tus kab mob neuroleptic malignant syndrome (NMS) yog dab tsi?

Tu siab kawg li, tej teeb meem ntawm NMS yog ib qho uas tshwm sim ntau thiab hnyav heev. Qee qhov teeb meem yog tshwm sim los ntawm cov tsos mob ntawm NMS thiab kev ua haujlwm tsis zoo ntawm lub paj hlwb, thaum lwm qhov, tshwj xeeb tshaj yog kev kis kab mob, tuaj yeem tshwm sim los ntawm kev nyob hauv chav kho mob hnyav (ICU) ntev.

Qee qhov teeb meem ntawm NMS yog:

• Rhabdomyolysis (kev tawg ntawm cov leeg nqaij - qhov no yog qhov teeb meem feem ntau).
• Kev qhuav dej.
• Mob raum tsis ua haujlwm sai.
• Ua tsis taus pa sai heev.
• Cov mob qaug dab peg / qaug dab peg .
• Kev mob plawv nres.
• Kev txhaws ntshav thoob plaws lub cev (Kev txhaws ntshav hauv cov hlab ntsha uas nthuav tawm).
• Mob siab ua haujlwm tsis zoo.
• Mob ntsws o.
• Sepsis (cov kab mob nkag mus rau hauv cov ntshav).
• Kev kis kab mob ntawm txoj hlab zis (UTI).
• Mob ntsws embolism.

Vim tias cov teeb meem no hnyav heev thiab ua rau tuag taus, nws yog ib qho tseem ceeb heev uas yuav tsum hu rau 911 tam sim ntawd thiab mus rau tsev kho mob ze tshaj plaws kom tau kev kho mob yog tias koj muaj cov tsos mob ntawm NMS. Dua li no, NMS yog qhov xwm txheej ceev uas ua rau tuag taus thiab tej zaum yuav xav tau kev kho mob hauv Chav Saib Xyuas Mob Hnyav (ICU).

Kuv yuav tsum mus ntsib kuv tus kws kho mob thaum twg?

Yog tias koj noj ib lossis ntau yam tshuaj neuroleptics (antipsychotics), antiemetics, thiab/lossis dopaminergic (Parkinson's), nws yog ib qho tseem ceeb uas yuav tsum mus ntsib koj tus kws kho mob tsis tu ncua kom paub tseeb tias lawv ua haujlwm zoo rau koj. Tsis tas li ntawd, nug koj tus kws kho mob txog cov kev phiv ntawm cov tshuaj uas koj noj thiab cov tsos mob uas koj yuav tsum paub txog.

Kuv puas yuav tsum mus rau Chav Kho Mob Thaum Muaj Xwm Ceev (ETU) yog tias kuv muaj cov tsos mob ntawm 'NMS'?

Yog tias koj muaj cov tsos mob ntawm tus kab mob neuroleptic malignant syndrome (NMS), xws li kub taub hau heev thiab cov leeg nqaij tawv, nws yog ib qho tseem ceeb uas yuav tsum hu rau 911 lossis mus rau tsev kho mob ze tshaj plaws tam sim ntawd. NMS xav tau kev kho mob tam sim ntawd. Yog tias tsis kho sai thiab kom raug, nws tuaj yeem ua rau tuag taus.

Kab mob Neuroleptic malignant syndrome (NMS) yog ib yam mob loj heev uas yuav ua rau tuag taus. Yog li ntawd, yog tias koj muaj cov tsos mob, nws yog ib qho tseem ceeb uas yuav tsum nrhiav kev kho mob sai li sai tau. NMS yooj yim dua rau kev kho yog tias nws raug ntes thaum ntxov. Txawm hais tias NMS tsis tshua muaj, yog tias koj noj tshuaj neuroleptic (antipsychotic), nrog koj tus kws kho mob lossis kws muag tshuaj tham txog cov kev mob tshwm sim thiab cov tsos mob uas yuav tsum tau saib xyuas. Lawv nyob ntawd los pab koj.

Cov ntsiab lus tseem ceeb tshaj plaws uas peb tau kawm los ntawm tsab xov xwm no (Cov Lus Qhia Coj Mus Tsev)

Zoo, yog li cia peb rov qab qhia koj txog qee yam tseem ceeb tshaj plaws uas yuav tsum nco ntsoov los ntawm qhov peb tau tham txog hauv 'NMS' no:

• NMS yog ib qho mob tsis tshua muaj, tab sis muaj peev xwm ua rau tuag taus los ntawm cov tshuaj neuroleptic.
• Kub taub hau heev, mob nqaij, thiab tsis meej pem yog cov tsos mob tseem ceeb.
• Yog koj pom ib qho ntawm cov tsos mob no, nrhiav kev pab kho mob tam sim ntawd. Tsis txhob ncua sijhawm.
• Yog koj noj tshuaj neuroleptic, nrog koj tus kws kho mob tham txog cov tshuaj thiab nws cov kev mob tshwm sim. Tsis txhob ntshai nug cov lus nug.
• NMS tuaj yeem kho tau tag nrho yog tias kuaj pom thiab kho thaum ntxov.

Peb vam tias koj tau txais cov ntaub ntawv no lawm. Nyob zoo!

` Neuroleptic Malignant Syndrome, NMS, tshuaj kho mob puas siab puas ntsws, cov kev mob tshwm sim, kub taub hau heev, cov leeg nqaij nruj