Koj puas paub txog tus mob qog noj ntshav tsawg tsawg no? Cia peb tham txog NUT Carcinoma

Koj puas tau hnov ​​txog NUT Carcinoma? Tej zaum tsis tau. Vim tias nws yog ib hom mob qog noj ntshav uas tsis tshua muaj, tsis tshua muaj, thiab loj hlob sai. Tab sis nws yog ib qho tseem ceeb heev uas yuav tsum paub txog nws, vim tias tus mob no tuaj yeem tshwm sim rau txhua tus neeg. Yog li hnub no peb yuav tham txog nws kom ntxaws me ntsis, zoo li peb tab tom tham nrog ib tug phooj ywg.

NUT Carcinoma yog dab tsi?

Hais yooj yim xwb, NUT Carcinoma yog ib hom mob qog noj ntshav uas loj hlob sai heev thiab hnyav heev . Nws suav hais tias yog hom mob qog noj ntshav squamous cell carcinomas uas hnyav tshaj plaws. Tam sim no koj yuav xav paub tias cov hlwb squamous yog dab tsi. Cov no yog ib hom hlwb uas pom muaj nyob hauv peb daim tawv nqaij. Tsis yog li ntawd xwb, tab sis qee cov kab mob sab hauv ntawm peb lub cev kuj raug npog los ntawm cov hlwb no.

Tus kab mob NUT Carcinoma no yog tshwm sim los ntawm kev hloov pauv ntawm peb cov noob caj noob ces. Yog hais kom meej, nws yog tshwm sim los ntawm qhov tsis zoo hauv ib lub noob hu ua 'NUTm1'. Koj paub, cov noob caj noob ces no muab cov lus qhia rau peb cov hlwb txog kev ua haujlwm. Yog li, thaum muaj qhov yuam kev hauv cov lus qhia no, uas yog, 'kev hloov pauv', txawm tias cov hlwb noj qab haus huv pib hloov mus ua 'cov hlwb mob qog noj ntshav'. Tom qab ntawd cov hlwb mob qog noj ntshav no sib sau ua ke thiab tsim 'qog'.

Feem ntau, cov qog nqaij hlav NUT no tshwm sim hauv nruab nrab ntawm peb lub cev, lossis raws "nruab nrab" . Yog vim li ntawd lawv thiaj li hu ua NUT-midline carcinoma yav dhau los. Txawm li cas los xij, cov qog no kuj tuaj yeem tshwm sim hauv lwm qhov ntawm lub cev.

Cov qog nqaij hlav no tuaj yeem loj hlob qhov twg?

Cov neeg uas kuaj pom tias muaj NUT Carcinoma muaj cov qog nqaij hlav hauv cov chaw hauv qab no ntawm lawv lub cev:

• Lub taub hau, tshwj xeeb tshaj yog nyob rau hauv lub sinuses (qhov no yog qhov feem ntau)
• Ntawm lub caj dab (qhov no kuj pom ntau zaus)
• Hauv lub ntsws (qhov no kuj yog ib qho uas tshwm sim ntau)
• Hauv nruab nrab ntawm lub hauv siab, qhov chaw uas lub plawv thiab lub ntsws nyob (lub 'mediastinum') (qhov no kuj yog ib qho uas tshwm sim ntau)
• Pancreas
• Cov raum
• Cov qog adrenal
• Plab
• Lub zais zis
• Hauv cov pob txha ('Cov pob txha')

Kab mob qog noj ntshav no, hu ua NUT Carcinoma , tuaj yeem loj hlob thiab kis tau sai heev, txawm tias nws tau kho los xij . Qhov ntawd yog qhov txaus ntshai tshaj plaws txog nws.

NUT Carcinoma tsawg npaum li cas?

Qhov no yeej suav tias yog ib hom mob qog noj ntshav uas tsis tshua muaj . Txawm li cas los xij, tej zaum yuav muaj ntau tus neeg mob dua li peb xav. Lub Koom Haum International NUT Midline Carcinoma Registry tshaj tawm tsuas yog 20 tus neeg mob tshiab hauv ib xyoos.

Ib qho laj thawj rau tus lej tsawg no yog qhov nyuaj rau kev kuaj mob no. Cov kws tshawb fawb tsuas yog pom qhov tseem ceeb ntawm tus mob qog noj ntshav no, qhov "hloov pauv" hauv "NUTm1" gene, xyoo 2004. Yog li, tsis yog txhua lub tsev kho mob muaj "cov ntaub ntawv kuaj" uas tuaj yeem ntes tau tus gene no.

Xav txog qhov no zoo li nrhiav pom ib yam kab mob tshiab. Nws yuav siv sijhawm ntev me ntsis kom cov kev kuaj mob zoo thiaj li muaj tau txhua qhov chaw.

Tsis tas li ntawd xwb, NUT Carcinoma yooj yim to taub nrog lwm hom mob qog noj ntshav uas feem ntau pom. Tsuas yog ua tau kom paub tseeb tias mob qog noj ntshav puas yog NUT Carcinoma yog tias pom qhov kev hloov pauv ntawm cov noob caj noob ces 'NUTm1'. Qee tus neeg uas kuaj pom tias muaj 'mob qog noj ntshav taub hau thiab caj dab', 'mob qog noj ntshav ntsws', thiab qee hom mob qog noj ntshav lwm yam tej zaum yuav muaj qhov kev hloov pauv ntawm cov noob caj noob ces no.

Tab sis tam sim no, vim tias kev paub txog hom mob qog noj ntshav no tau nce ntxiv, thiab vim tias cov thev naus laus zis los nrhiav qhov kev hloov pauv caj ces no tau zoo dua, nws tau yooj yim dua rau cov kws kho mob qog noj ntshav los kuaj mob NUT carcinoma dua li yav dhau los.

Leej twg thiaj tau tus kab mob NUT Carcinoma?

Feem ntau cov neeg uas kuaj pom tus mob qog no yog cov hluas . Lub hnub nyoog nruab nrab thaum kuaj pom tias muaj tus mob no yog li ntawm 24 xyoos. Qhov no txhais tau tias kwv yees li ib nrab ntawm cov neeg uas kuaj pom tias muaj hnub nyoog qis dua 24 xyoos, thiab ib nrab ntxiv yog cov laus dua.

Txawm li cas los xij, tus mob qog noj ntshav no tuaj yeem tshwm sim rau txhua tus neeg . Nws tau pom muaj nyob rau hauv cov menyuam mos tshiab, thiab rau cov neeg uas muaj hnub nyoog 80 xyoo. Yog li ntawd, nws tsis tuaj yeem xav tias nws yuav tsis tshwm sim tsuas yog raws li hnub nyoog xwb.

Cov tsos mob ntawm NUT Carcinoma yog dab tsi?

Feem ntau, tus mob qog noj ntshav no tsis muaj tsos mob dab tsi thaum pib mob . Cov tsos mob pib tshwm sim thaum tus mob qog noj ntshav loj me ntsis thiab pib cuam tshuam rau cov nqaij mos nyob ib puag ncig lub qog. Lub sijhawm ntawd, koj feem ntau yuav xav tias nkees thiab tsis xis nyob.

Vim tias cov qog nqaij hlav feem ntau tshwm sim hauv cov qhov ntswg thiab lub ntsws, cov tsos mob feem ntau uas tau tshaj tawm yog cuam tshuam nrog lawv.

Cov tsos mob feem ntau:

• Kev qaug zog heev/kev nkees heev (`Kev nkees`)
• Kev poob phaus tsis paub meej
• Ib pawg mob heev

Cov tsos mob ntawm tus kab mob sinus:

• Kev nyem ntawm lub qhov ntswg, qhov nruj, lossis qhov mob
• Ntsws ntshav ntau zaus
• Qhov ntswg txhaws los yog txhaws
• Poob koj txoj kev hnov ​​tsw ntxhiab

Cov tsos mob ntawm tus mob qog ntsws:

• Ua tsis taus pa lossis ua pa nyuaj
• Hnoos tas li (hnoos tas li uas tsis ploj mus)

Tsis txhob ntshai NUT Carcinoma tsuas yog vim koj muaj cov tsos mob no xwb. Tab sis yog tias cov tsos mob no tseem muaj,Nws yog ib qho tseem ceeb heev uas yuav tsum mus ntsib kws kho mob thiab tau txais cov lus qhia.

Dab tsi ua rau NUT Carcinoma?

Tus mob qog noj ntshav no yog tshwm sim los ntawm kev sib xyaw ua ke ntawm ob lub noob caj noob ces sib txawv, tsim ib lub noob caj noob ces sib xyaw txawv txawv ('hybrid gene' lossis 'fusion gene'). Hauv txhua tus neeg mob uas muaj NUT Carcinoma, lub noob caj noob ces 'NUTm1' raug sib xyaw nrog lwm lub noob caj noob ces uas tsis xav kom sib xyaw nrog nws. Lub noob caj noob ces 'NUTm1' tsis ua rau mob qog noj ntshav ntawm nws tus kheej, tab sis lub noob caj noob ces sib xyaw tshiab no yog qhov ua rau cov hlwb qog noj ntshav loj hlob.

Kwv yees li ntawm 75% ntawm cov neeg uas muaj mob qog nqaij hlav NUT, cov noob caj noob ces `NUTm1` raug sib xyaw nrog cov noob caj noob ces `BRD4`. Kwv yees li ntawm lwm 15%, cov noob caj noob ces `NUTm1` raug sib xyaw nrog cov noob caj noob ces `BRD3`. Tsis tshua muaj, nws tuaj yeem sib xyaw nrog lwm cov noob caj noob ces.

Cov kws tshawb fawb tseem tsis tau paub meej tias yog dab tsi ua rau muaj cov kev hloov pauv caj ces no. Tab sis muaj ib qho meej meej: lawv tsis yog los ntawm noob caj ces. Thiab cov yam uas ua rau muaj mob qog noj ntshav, xws li kev haus luam yeeb thiab kev raug cov tshuaj carcinogens, zoo li tsis koom nrog. Yuav tsum tau tshawb fawb ntxiv kom nkag siab tias dab tsi cuam tshuam rau cov kev hloov pauv caj ces no.

Yuav kuaj mob NUT Carcinoma li cas?

Cov kws kho mob kuaj pom tus kab mob no los ntawm kev kuaj nqaij. Qhov no suav nrog kev siv ib rab koob tshwj xeeb los rho ib qho qauv me me ntawm lub qog. Tom qab ntawd cov qauv ntawd raug xa mus rau chav kuaj mob kom kuaj seb puas muaj cov qog nqaij hlav.

Koj tus kws kho mob kuj tseem yuav siv cov txheej txheem tshwj xeeb los saib cov qog hauv koj lub cev thiab txiav txim siab nws theem. Kev ntsuas qib qog yog cov txheej txheem ntawm kev txiav txim siab seb qog loj npaum li cas, raws li qhov loj ntawm cov qog, nws qhov chaw, thiab seb nws puas tau kis (metastasized) los ntawm cov qog thawj mus rau lwm qhov ntawm lub cev. Cov qog metastasis tshwm sim thaum cov hlwb qog tawg ntawm cov qog thawj, mus ncig los ntawm cov kua dej lymph lossis cov ntshav, thiab tsim cov qog tshiab hauv cov kabmob lossis cov nqaij nyob deb.

Daim duab CT scan thiab daim duab MRI scan tuaj yeem qhia qhov chaw uas tus mob qog nyob hauv lub cev. Daim duab PET scan tuaj yeem qhia tau seb tus mob qog puas tau kis mus rau lwm qhov.

Yuav ua li cas thiaj kuaj tau tus kab mob no?

Muaj kev kuaj tshwj xeeb hu ua 'Immunohistochemistry' ua hauv chav kuaj mob kom paub seb puas muaj cov noob 'NUTm1' nyob hauv cov qauv kuaj mob. Yog tias muaj cov noob 'NUTm1' nyob hauv cov qauv kuaj mob ('positive'), ces yuav kuaj tau tias yog NUT Carcinoma.

Lwm yam kev kuaj uas ua tau los txheeb xyuas cov noob caj noob ces no yog kev kuaj Fluorescence In Situ Hybridization (FISH) lossis lwm yam kev kuaj noob caj noob ces tshwj xeeb.

Yuav kho tus kab mob NUT Carcinoma li cas?

Koj tuaj yeem tshem tawm qhov qog.Tej zaum yuav xav tau kev phais thiab kev kho mob hluav taws xob. Yog tias tus mob qog noj ntshav tau kis mus dhau qhov qog, kuj tseem yuav muab tshuaj kho mob qog noj ntshav . Feem ntau, ib lossis ntau yam kev kho mob no raug muab ua ke.

Txawm li cas los xij, kev kho mob qog nqaij hlav NUT yog qhov nyuaj heev. Feem ntau, txawm tias kev kho mob tiv thaiv kom tsis txhob mob qog nqaij hlav ntxiv lawm los xij, nws yuav pib loj hlob thiab kis mus rau lwm qhov tom qab ib ntus.

Qhov tseem ceeb tshaj plaws rau lub sijhawm zoo li no yog kom peb ua siab loj. Peb yuav tsum mloog cov kws kho mob hais thiab ntsib qhov no ua ke nrog lawv.

Yog tias koj raug kuaj pom tias muaj NUT Carcinoma, kev sim tshuaj kho mob yuav yog qhov kev xaiv kho mob zoo tshaj plaws . Kev sim tshuaj kho mob yog kev tshawb fawb uas sim cov kev kho mob tshiab lossis cov hau kev kho mob. Cov kws tshawb fawb tam sim no tab tom tshawb nrhiav kev kho mob rau NUT Carcinoma. Kev kho mob rau lub hom phiaj yog kev kho mob uas tsom mus rau qhov kev hloov pauv caj ces uas ua rau lub cell noj qab haus huv dhau los ua mob qog noj ntshav.

Ib qho ntawm cov kev kho mob uas tsom mus rau NUT carcinoma yog 'BET' inhibitors . Cov tshuaj no tsom mus rau ob lub noob caj noob ces, 'BRD4' thiab 'BRD3', uas feem ntau cuam tshuam nrog 'NUTm1' noob caj noob ces. Cov inhibitors no, ua ke nrog lub noob caj noob ces 'NUTm1', nres kev loj hlob ntawm cov hlwb qog noj ntshav.

Puas kho tau NUT Carcinoma?

Tu siab kawg li, tsis muaj tshuaj kho tau NUT Carcinoma. Nws yog ib hom mob qog noj ntshav uas loj sai heev thiab kis mus rau lwm qhov ntawm lub cev sai heev. Qhov nruab nrab, cov neeg uas tau txais kev kho mob yuav nyob tau li 10 lub hlis tom qab kuaj pom tias muaj tus kab mob no. Ob mus rau peb ntawm txhua kaum tus neeg uas kuaj pom tias muaj NUT Carcinoma yuav nyob tau ob xyoos.

Tiam sis, ib yam li lwm yam mob qog noj ntshav, koj qhov kev kwv yees, lossis koj yuav teb tau zoo li cas rau kev kho mob, nyob ntawm ntau yam. Qhov chaw ntawm lub qog, seb nws puas tuaj yeem raug tshem tawm tag nrho nrog kev phais lossis kev kho mob hluav taws xob, thiab qee qhov kev tshawb fawb tau qhia tias lwm cov noob caj noob ces uas tau ua ke nrog NUTm1 noob caj noob ces kuj ua lub luag haujlwm.

Koj tus kws kho mob yuav piav qhia txog lub hom phiaj ntawm kev kho mob raws li koj qhov kev kuaj mob.

Kuv yuav saib xyuas kuv tus kheej li cas?

Nws yog ib qho tseem ceeb uas yuav tsum nyob ib puag ncig koj tus kheej nrog cov neeg uas koj ntseeg siab thiab txhawb nqa thaum lub sijhawm no. Siv txhua yam kev pab uas muaj los pab koj kov yeej cov teeb meem uas los nrog tus kab mob no.

Kev kho mob palliative los ntawm koj tus kws kho mobKawm txog cov kev pabcuam. Cov kws tshaj lij saib xyuas kev mob nkeeg tuaj yeem pab koj tswj cov kev xav tau tshiab ntawm koj lub neej vim yog qhov kev kuaj mob no. Lawv tuaj yeem pab koj tswj cov kev phiv los ntawm kev kho mob chemotherapy thiab kev kho mob hluav taws xob, thiab pab koj daws cov luag haujlwm txhua hnub uas los nrog mob qog noj ntshav.

Nco ntsoov tias koj tsis nyob ib leeg xwb. Tsis txhob yig thov kev pab thiab kev txhawb nqa.

Kuv yuav tsum nug kuv tus kws kho mob li cas?

Muaj ntau yam uas koj xav nug koj tus kws kho mob thaum lub sijhawm zoo li no. Nov yog qee cov piv txwv:

• Tus mob cancer puas tau kis mus rau lwm qhov?
• Kuv puas yuav tsum tau mus ntsib kws kho mob tshwj xeeb lossis mus rau tsev kho mob tshwj xeeb kom tau kev kho mob?
• Koj pom zoo kom siv hom kev kho mob twg?
• Cov txiaj ntsig thiab tej zaum yuav muaj kev pheej hmoo ntawm kev kho mob yog dab tsi?
• Lub hom phiaj ntawm kev kho mob yog dab tsi?
• Koj puas tuaj yeem pab kuv tau txais lwm yam kev pabcuam txhawb nqa, suav nrog kev saib xyuas palliative?

Kev kho mob rau NUT Carcinoma feem ntau yuav mob heev. Nrog rau kev teem caij mus ntsib kws kho mob qog nqaij hlav ntau zaus thiab kev ntxhov siab ntawm lub neej txhua hnub, kev daws teeb meem nrog kev kuaj mob qog nqaij hlav tuaj yeem nyuaj. Cov peev txheej kho mob xws li kev saib xyuas palliative tuaj yeem pab tau. Thiab kev ncav tes mus rau koj cov neeg hlub tuaj yeem yog qhov chaw zoo ntawm lub zog. Txij thaum koj tau txais koj qhov kev kuaj mob, nws yog ib qho tseem ceeb uas yuav tsum tham nrog koj pab neeg saib xyuas qog nqaij hlav kom nkag siab txog cov kev xaiv kho mob zoo tshaj plaws mus tom ntej. Txhua tus neeg txoj kev paub txog qog nqaij hlav txawv. Koj pab neeg kho mob nyob ntawd los coj koj hla lub sijhawm nyuaj no.

Tej yam tseem ceeb uas yuav tsum nco ntsoov (Cov Lus Qhia Coj Mus Tsev)

Zoo, yog li cia peb sau cov ntsiab lus tseem ceeb tshaj plaws uas koj yuav tsum nco ntsoov los ntawm qhov peb tau tham txog:

• NUT Carcinoma yog ib hom mob qog noj ntshav uas tsis tshua muaj, tab sis nws kis tau sai heev, thiab ua rau neeg mob hnyav heev.
• Qhov no yog tshwm sim los ntawm kev hloov pauv hauv cov noob caj noob ces "NUTm1". Qhov no tsis yog ib yam dab tsi uas tau txais los ntawm noob caj noob ces.
• Feem ntau cov tsos mob tshwm sim tom qab mob qog noj ntshav loj zuj zus lawm. Tsis txhob tsis quav ntsej txog nws, thiab nrhiav kev pab kho mob yog tias koj muaj tej yam tsos mob txawv txawv uas tseem muaj.
• Yuav tsum tau kuaj mob thiab kuaj noob caj noob ces tshwj xeeb rau kev kuaj mob.
• Kev kho mob nyuaj heev, tab sis kev tshawb fawb tab tom ua rau muaj kev kho mob tshiab. Kev sim tshuaj kho mob tej zaum yuav yog ib qho kev xaiv zoo.
• Kev saib xyuas palliative thiab kev txhawb nqa ntawm koj cov neeg hlub yog qhov tseem ceeb heev rau txoj kev no.
• Tham txog txhua yam nrog koj pab neeg kho mob.

Vam tias cov ntaub ntawv no yuav pab tau koj. Kev paub txog tus kab mob no yuav pab koj txiav txim siab zoo thaum lub sijhawm los txog.

` NUT Mob qog noj ntshav, mob qog noj ntshav, kev hloov pauv caj ces, mob qog noj ntshav tsawg tsawg, mob qog noj ntshav squamous cell carcinoma, cov tsos mob ntawm mob qog noj ntshav, kev kho mob qog noj ntshav