Peb paub tias nws nyuaj npaum li cas rau kev nyob nrog mob qog noj ntshav. Tab sis nrog kev nce qib ntawm kev tshawb fawb kho mob, cov txheej txheem kho mob qog noj ntshav tau zoo dua ntau niaj hnub no. Hloov chaw tsuas yog kev kho mob chemotherapy lossis kev kho mob hluav taws xob zoo li yav dhau los, tam sim no muaj cov kev kho mob tshwj xeeb uas tsom thiab tawm tsam cov hlwb qog noj ntshav xwb. PARP inhibitors yog ib hom tshuaj uas tau coj kev cia siab tshiab hauv ntiaj teb ntawm kev kho mob qog noj ntshav. Niaj hnub no, peb yuav tham txog qhov no yooj yim, hauv txoj kev uas koj tuaj yeem nkag siab.
Hais yooj yim xwb, cov PARP Inhibitors no yog dab tsi?
Yuav kom nkag siab qhov no, cia peb xub xav txog cov cell hauv peb lub cev. Txhua lub cell hauv peb lub cev muaj ib yam hu ua DNA. Cov DNA no zoo li 'master plan' uas muaj tag nrho cov lus qhia uas lub cell xav tau los ua haujlwm. Qee zaum cov DNA no tuaj yeem puas tsuaj. Thaum nws puas tsuaj, peb lub cev muaj ib txoj hauv kev tshwj xeeb los kho nws.
Ib tug ntawm cov neeg ua si tseem ceeb hauv cov txheej txheem kho no yog ib qho protein hu ua PARP. PARP sawv cev rau Poly (ADP-ribose) polymerase. Txawm hais tias lub npe zoo li nyuaj, nws txoj haujlwm yooj yim: Yog tias muaj kev tawg lossis tawg hauv DNA, cov protein PARP mus rau hauv thiab kho nws. Qhov no yog qhov tseem ceeb rau cov hlwb noj qab haus huv.
Tiam sis ntawm no yog qhov teeb meem. Cov qe ntshav qog kuj siv cov protein PARP no kom zoo dua. Thaum cov qe ntshav qog faib sai sai, lawv cov DNA raug puas tsuaj. Tom qab ntawd cov qe ntshav qog siv cov PARP 'bass' no los kho nws cov DNA, loj hlob ntxiv, thiab pib kis mus thoob plaws lub cev.
Cov tshuaj PARP inhibitors ua haujlwm los ntawm kev txwv tsis pub PARP 'bass' ua haujlwm. Yog xav kom meej meej, lawv tiv thaiv cov protein PARP los ntawm kev kho DNA. Qhov no tiv thaiv cov cell mob qog noj ntshav los ntawm kev kho nws cov DNA, thiab thaum kawg lub cell tuag.
Cov no kuj hu ua kev kho mob tsom mus rau ib qho , vim tias cov tshuaj no tsom mus rau thiab tawm tsam qhov tsis muaj zog ntawm cov hlwb qog noj ntshav es tsis yog cov hlwb noj qab nyob zoo ib txwm.
Cov tshuaj no siv rau hom mob qog noj ntshav twg?
Cov tshuaj PARP inhibitor feem ntau yog siv rau cov mob qog nqaij hlav uas mob hnyav dua lossis kis mus rau lwm qhov chaw. Txawm li cas los xij, lawv tsis yog muab rau txhua yam mob qog nqaij hlav. Lawv zoo tshaj plaws rau cov mob qog nqaij hlav uas cuam tshuam nrog kev hloov pauv caj ces tshwj xeeb.
Kev sib raug zoo ntawm BRCA gene thiab PARP inhibitors
Muaj cov noob caj noob ces tiv thaiv hauv peb lub cev uas tiv thaiv kev tsim cov qog nqaij hlav. Ib qho ntawm cov tseem ceeb yog cov noob caj noob ces BRCA . Ib qho ntawm cov haujlwm ntawm cov noob caj noob ces BRCA no yog kho qhov puas tsuaj rau DNA. Qhov no txhais tau tias muaj ob lub tshuab kho DNA tseem ceeb hauv peb cov hlwb: ib qho yog PARP, thiab lwm qhov yog BRCA.
Tam sim no xav txog, ib tug neeg yug los nrog kev hloov pauv hauv BRCA gene.Qhov ntawd txhais tau tias ib qho ntawm nws cov txheej txheem kho DNA twb tsis muaj zog lawm. Tom qab ntawd nws cov qog nqaij hlav yuav luag vam khom lub PARP system ntawd los kho DNA.
Yog li ntawd, yuav ua li cas thaum peb muab PARP inhibitor rau ib tus neeg zoo li ntawd? Ntxiv rau qhov BRCA system uas twb puas lawm, peb kuj tseem nres PARP system uas ua haujlwm zoo. Ces tus cell mob qog noj ntshav tsis muaj txoj hauv kev los kho nws cov DNA. Vim yog qhov 'double hit' no, tus cell mob qog noj ntshav raug rhuav tshem yooj yim heev.
Yog li ntawd, PARP inhibitors yog ib txoj kev kho mob zoo heev rau cov mob qog noj ntshav nrog BRCA gene mutations.
| Cov hom mob qog noj ntshav tseem ceeb uas kho nrog PARP inhibitors |
|---|
| Mob qog noj ntshav hauv lub mis |
| Mob qog nqaij hlav zes qe menyuam |
| Mob qog nqaij hlav ntawm lub raj mis |
| Mob qog nqaij hlav prostate |
| Mob qog nqaij hlav pancreatic |
| Mob qog nqaij hlav peritoneal thawj zaug |
Kev kho mob no yuav muab li cas thiab yuav siv sijhawm ntev npaum li cas?
Ib qho zoo ntawm kev kho mob no yog tias nws tsis tas yuav tsum tau txhaj tshuaj. Tag nrho cov tshuaj PARP inhibitors no tuaj ua cov ntsiav tshuaj lossis tshuaj ntsiav. Lawv feem ntau yog sau tseg kom noj ib lossis ob zaug hauv ib hnub.
Qee zaum, nyob ntawm seb koj muaj hom mob qog noj ntshav li cas, cov tshuaj no yuav raug muab ua kev kho mob nkaus xwb. Los yog, nws yuav raug muab ua ke nrog lwm yam kev kho mob, xws li kev kho mob qog noj ntshav. Piv txwv li, tom qab ib tug neeg tau txais kev kho mob qog noj ntshav thiab cov hlwb qog noj ntshav puas lawm, cov tshuaj PARP inhibitor no yuav pib siv. Tom qab ntawd, nws tshem tawm tag nrho cov sijhawm rau cov hlwb qog noj ntshav uas puas lawm los kho lawv tus kheej.
Lub sijhawm kho mob txawv ntawm ib tus neeg mus rau ib tus neeg. Rau qee tus, cov tshuaj no yog muab rau ib lub sijhawm tshwj xeeb, xws li ob txog peb xyoos tom qab chemotherapy tiav lawm. Rau lwm tus, nws txuas ntxiv mus ntev li ntev tau cov tshuaj ua haujlwm, txhais tau tias mob qog noj ntshav raug tswj hwm. Qhov kev txiav txim siab zoo tshaj plaws txog qhov no yog tham nrog koj tus kws kho mob thiab ntsuas qhov txiaj ntsig ntawm kev kho mob nrog rau cov kev mob tshwm sim.
Cov txiaj ntsig thiab tej zaum yuav muaj kev phiv los ntawm kev kho mob no
Cov tshuaj PARP inhibitors yuav tsis kho tau mob qog noj ntshav tag nrho. Txawm li cas los xij, lawv qhov txiaj ntsig loj tshaj plaws yog tias lawv ua rau "muaj sia nyob yam tsis muaj kev nce qib." Hauv lwm lo lus, cov tshuaj no pab tswj tus mob qog noj ntshav thiab tswj nws ntev dua. Qhov no txhais tau tias tus neeg mob muaj sijhawm ntau dua los ua lub neej noj qab haus huv yam tsis muaj tus kab mob hnyav zuj zus .
Ib yam li kev kho mob qog noj ntshav, cov no tuaj yeem ua rau muaj kev phiv, tab sis tsis yog txhua tus neeg tau txais lawv.
| Cov kev mob tshwm sim feem ntau ntawm PARP inhibitors | |
|---|---|
| Kev tsis xis nyob ntawm lub cev |
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| Kev hloov pauv ntawm kev kuaj ntshav | |
| Kev pheej hmoo tsawg tab sis loj heev | |
Thaum twg koj yuav tsum hu rau kws kho mob tam sim ntawd?
Nws yog ib qho tseem ceeb heev uas yuav tsum sib cuag nrog koj tus kws kho mob thoob plaws lub sijhawm kho mob no. Yog tias koj muaj cov tsos mob tshiab lossis yog tias koj cov tsos mob uas twb muaj lawm hnyav zuj zus, qhia rau koj tus kws kho mob tam sim ntawd. Nws yuav hloov kho koj cov tshuaj lossis sau lwm yam tshuaj los pab txo cov kev mob tshwm sim xws li xeev siab.
Yog tias koj muaj cov tsos mob hauv qab no, hu rau koj tus kws kho mob yam tsis muaj kev ncua :
- Cov cim qhia txog kev kis kab mob: kub taub hau, mob khaub thuas, thiab tshee hnyo.
- Cov tsos mob ntawm tus kab mob ntsws (Pneumonitis): Ua pa nyuaj, xav tias hauv siab nruj, lossis ua pa nrov nrov.
- Cov cim qhia txog cov ntshav txhaws: o sai sai, liab, thiab mob rau ntawm ib ceg, lossis mob hauv siab thiab ua pa nyuaj.
Yog tias koj muaj cov tsos mob hnyav no, koj yuav tsum hu rau koj tus kws kho mob tam sim ntawd lossis mus rau Chav Kho Mob Ceev (ETU) ntawm tsev kho mob ze tshaj plaws.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- Cov tshuaj PARP inhibitors yog ib hom 'kev kho mob tsom' uas tiv thaiv cov hlwb qog noj ntshav los ntawm kev kho lawv cov DNA thiab rhuav tshem lawv.
- Cov no tshwj xeeb tshaj yog zoo rau cov mob xws li mob qog nqaij hlav mis, zes qe menyuam, thiab prostate uas muaj kev hloov pauv BRCA gene.
- Kev kho mob no yog muab ua cov tshuaj ntsiav lossis cov tshuaj ntsiav thiab pab tswj kev loj hlob ntawm tus mob qog noj ntshav thiab ua kom koj muaj sijhawm noj qab haus huv ntau dua.
- Ib yam li lwm yam kev kho mob, cov kev mob tshwm sim tuaj yeem tshwm sim, yog li nws yog ib qho tseem ceeb uas yuav tsum ua haujlwm nrog koj tus kws kho mob thoob plaws lub sijhawm kho mob.
- Koj tus kws kho mob yuav txiav txim siab seb kev kho mob PARP inhibitor puas yog rau koj, suav nrog koj tus mob, cov txiaj ntsig ntawm kev kuaj noob caj noob ces, thiab kev noj qab haus huv tag nrho.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus