Koj puas tau hnov ​​txog hom tshuaj no? Cia peb kawm txog nws yooj yim (Phosphodiesterase Inhibitors)

Tej zaum koj twb tau hnov ​​txog cov tshuaj zoo li Viagra. Cov neeg feem coob paub tias cov no yog cov tshuaj uas muab rau kev ua tsis taus haujlwm ntawm kev sib deev. Tab sis koj puas paub tias cov tshuaj hauv ib pawg sib txawv, hu ua Phosphodiesterase Inhibitors, yog siv los kho ntau yam mob, los ntawm kab mob plawv mus rau kab mob ntsws, kab mob tawv nqaij, thiab kab mob pob qij txha? Hnub no, cia peb tham txog cov tshuaj zoo kawg no. Cia peb nkag siab yooj yim tias lawv yog dab tsi, lawv ua haujlwm li cas, thiab qhov zoo thiab qhov tsis zoo yog dab tsi.

Hauv lwm lo lus, cov tshuaj Phosphodiesterase Inhibitors (PDE inhibitors) yog dab tsi?

Cov no yog ib hom tshuaj uas ua rau cov hlab ntsha hauv peb lub cev dav dua, txo lawv qhov nruj, thiab ua rau cov ntshav ntws yooj yim dua. Xav txog tias thaum cov yeeb nkab dej raug txhaws, yog tias koj ua kom nws loj me ntsis, cov dej ntws yooj yim dua. Qhov no txo ​​cov ntshav siab thiab txhim kho cov ntshav ntws mus rau ntau qhov ntawm lub cev. Vim yog lub peev xwm no, hom tshuaj no yog siv los kho ntau yam kab mob.

Cov tshuaj no ua haujlwm li cas?

Yuav kom nkag siab qhov no, peb yuav tsum paub txog tus neeg xa xov me me hauv peb lub cev. Nws lub npe yog Phosphodiesterases , lossis PDE luv. PDE no yog ib hom enzyme . Cov enzymes zoo li cov neeg pab me me uas ua kom sai thiab pab txhawb lwm cov txheej txheem tshuaj lom neeg hauv peb lub cev.

Muaj ntau hom PDE enzymes no hauv peb lub cev. Cov kws tshawb fawb tau siv cov lej los cais lawv. Qhov tshwj xeeb yog tias txhua hom PDE ua haujlwm tshaj plaws hauv cov cheeb tsam tshwj xeeb ntawm lub cev.

• PDE-3: Hom no feem ntau pom muaj nyob rau hauv koj lub plawv thiab cov hlab ntsha . Nws kuj koom nrog rau hauv cov txheej txheem ntshav txhaws.
• PDE-4: Qhov no feem ntau pom muaj nyob rau hauv lub ntsws . Nws ua haujlwm los ntawm kev ua kom cov leeg nqaij hauv txoj hlab pa nruj.
• PDE-5: Hom kab mob no pom muaj nyob rau hauv lub ntsws thiab cov txiv neej lub noob qes .

Yog li, cov tshuaj hu ua Phosphodiesterase Inhibitors (PDE inhibitors) ua haujlwm los ntawm kev thaiv cov haujlwm ntawm PDE enzymes uas tau hais los saum toj no. Nws zoo li kaw lub qhov rooj. Qee cov tshuaj PDE inhibitor ua haujlwm xaiv heev. Ntawd yog, lawv tsuas yog tsom rau ib hom tshwj xeeb, xws li PDE-5. Muaj lwm cov tshuaj uas ua haujlwm tsis xaiv . Ntawd yog, lawv tuaj yeem cuam tshuam rau txhua hom PDE rau qee qhov.

Cov tshuaj no kho tau cov mob twg?

Cov tshuaj hu ua PDE inhibitors tau txais kev pom zoo los ntawm cov koom haum xws li Teb Chaws Asmeskas Lub Chaw Saib Xyuas Khoom Noj thiab Tshuaj (FDA) los kho ntau tshaj kaum ob yam mob. Nov yog qee yam ntawm lawv.

Cov txiaj ntsig ntawm PDE inhibitors yog dab tsi?

Hom tshuaj no muaj txiaj ntsig zoo rau kev kho qee yam mob. Muaj ntau yam ua rau qhov no.

• Siv tau yooj yim: Cov tshuaj no muaj ntau hom. Lawv muaj ua cov tshuaj noj, cov tshuaj pleev rau sab nraud, thiab cov tshuaj txhaj IV. Qee cov tshuaj yuav tsum tau noj txhua hnub, thaum lwm cov tsuas yog noj tau thaum xav tau xwb.
• Kev kho mob rau lub hom phiaj: Raws li kuv tau hais ua ntej, qee cov tshuaj tsuas yog rau ib hom PDE xwb, yog li lawv yuav tsis ua rau muaj kev phiv tsis xav tau (kev phiv sab) rau lwm qhov ntawm lub cev. Zoo li cov tshuaj ua haujlwm raws nraim qhov chaw uas tus kab mob nyob.
• Ntau yam txiaj ntsig ntawm ib yam tshuaj: Qee zaum ob yam mob cuam tshuam tuaj yeem tshwm sim rau tib tus neeg. Piv txwv li, benign prostatic hyperplasia (BPH) thiab erectile dysfunction (ED) tuaj yeem tshwm sim ua ke. PDE-5 inhibitor tadalafil tau pom zoo los kho ob qho mob. Ib yam li ntawd, muaj cov tshuaj uas tuaj yeem kho ob qho tib si gout thiab mob pob qij txha.

Cov tshuaj no muaj tej yam tshwm sim thiab tej yam txaus ntshai li cas?

Cov kev mob tshwm sim tseem ceeb nyob ntawm seb hom tshuaj PDE inhibitor twg yog cov tshuaj no.

Leej twg yuav tsum tsis txhob noj cov tshuaj no?

Rau qee tus neeg, hom tshuaj no hu ua PDE inhibitors tej zaum yuav tsis haum vim lawv lwm yam mob lossis lwm yam tshuaj uas lawv noj. Peb hu cov no ua contraindications . Muaj ob hom ntawm cov no:

1. Cov kev tsis pom zoo kiag li:

• Rau ib yam tshuaj PDE inhibitor: Yog tias koj tau muaj kev tsis haum tshuaj hnyav (ua xua rau tshuaj no lossis lwm yam tshuaj zoo sib xws) ua ntej.
• Rau Cilostazol: Yog tias koj muaj ib hom mob plawv tsis ua haujlwm.
• Rau cov tshuaj PDE-5 inhibitors (xws li Sildenafil, Tadalafil): mob plawv hnyav, mob hauv siab tsis ruaj khov (angina tsis ruaj khov), mob plawv nres lossis mob hlwb tsis ntev los no.

2. Cov kev tsis sib haum xeeb:

• Rau cov tshuaj PDE-5 inhibitors: Yog tias koj noj cov tshuaj nitrates lossis alpha-blockers, koj yuav tsum nrog koj tus kws kho mob tham vim tias lawv tuaj yeem ua rau koj cov ntshav siab poob qis txaus ntshai.
• Rau Cilostazol: Yog tias koj muaj teeb meem los ntshav.
• Rau Pentoxifylline: Yog tias koj nyuam qhuav muaj ntshav hauv lub hlwb lossis lub qhov muag.

Yog tias koj cev xeeb tub, tab tom sim cev xeeb tub, lossis pub niam mis, nrog koj tus kws kho mob tham ua ntej noj tshuaj twg. Muaj pov thawj tias qee cov tshuaj PDE inhibitors yuav cuam tshuam rau tus menyuam hauv kev tshawb fawb txog tsiaj.

Thaum twg koj yuav tsum mus ntsib kws kho mob?

Yog tias koj cov tsos mob hloov pauv lossis cuam tshuam rau koj cov dej num txhua hnub, nws yog qhov zoo tshaj plaws los qhia rau koj tus kws kho mob. Txawm li cas los xij, yog tias koj ntsib ib qho ntawm cov hauv qab no , mus rau tsev kho mob lossis chav kho mob ceev (ETU) tam sim ntawd.

• Cov tsos mob ntawm tus kab mob plawv nres: mob hauv siab, ua tsis taus pa, tawm hws, kiv taub hau, xeev siab.
• Kev Mob Plawv: Kev mob uas kav ntev tshaj 4 teev yam tsis muaj kev txhawb nqa kev sib deev. Qhov no tuaj yeem ua rau puas tsuaj mus tas li yog tias tsis kho sai.
• Tsis pom kev lossis hnov ​​lus tam sim ntawd: Yog tias koj pom kev tsis pom kev tam sim ntawd, tsis pom kev, lossis hnov ​​lus tsis tau, nrhiav kev kho mob tam sim ntawd. Kev ncua sij hawm yuav ua rau puas tsuaj mus tas li.