Peb txhua tus yuav kiv taub hau lossis qaug zog thaum peb sawv ntawm lub rooj zaum lossis txaj. Feem ntau, nws yuav ploj mus li ob peb feeb xwb. Tab sis yog qhov no tshwm sim rau koj ntau zaus, lossis yog tias koj xav tias koj yuav tsaus muag thiab ntog, tej zaum nws yuav tsis yog ib txwm muaj. Hnub no peb yuav tham txog ib qho mob tsis tshua muaj uas ua rau muaj cov tsos mob no. Qhov ntawd yog Pure Autonomic Failure, lossis luv luv PAF.
Hais yooj yim xwb, Pure Autonomic Failure (PAF) yog dab tsi?
Xav txog nws, muaj ntau yam txheej txheem hauv peb lub cev uas tshwm sim yam tsis muaj peb tswj. Piv txwv li, ua pa, lub plawv dhia, zom zaub mov, tswj qhov kub ntawm lub cev, thiab tswj cov ntshav siab. Tag nrho cov no yog tswj los ntawm peb lub paj hlwb Autonomic. Nws zoo li lub kaw lus 'auto-pilot' hauv peb lub cev.
Qhov Ua Tsis Taus Autonomic Pure (PAF) yog ib qho mob tsis tshua muaj uas ua rau lub paj hlwb tsis ua haujlwm zoo li qub. Qhov tseem ceeb uas tshwm sim hauv qhov no yog thaum koj sawv ntsug sai sai los ntawm qhov zaum lossis pw, koj cov ntshav siab poob qis heev . Hauv kev kho mob, peb hu qhov no ua orthostatic hypotension . Tab sis qhov no tsis yog tib qho teeb meem xwb, PAF tuaj yeem ua rau muaj ntau yam teeb meem ntxiv.
Feem ntau pom muaj tus mob no rau cov neeg laus hnub nyoog ntawm 40 thiab 60 xyoo. Yav dhau los, tus mob no kuj hu ua Bradbury-Eggleston syndrome.
Cov tsos mob ntawm tus kab mob PAF yog dab tsi?
Zoo li peb tau tham ua ntej lawm, cov tsos mob tseem ceeb tshaj plaws thiab feem ntau yog kiv taub hau thiab tsaus muag thaum sawv ntsug (orthostatic hypotension). Txawm li cas los xij, vim tias lub paj hlwb autonomic no tswj ntau yam hauv peb lub cev, cov tsos mob tsis yog tsuas yog ib qho xwb.
Qhov tseem ceeb yog tias cov tsos mob no tsis tshwm sim tib yam lossis tib qho kev txiav txim rau txhua tus. Qee tus neeg yuav muaj lwm cov tsos mob ua ntej lawv kiv taub hau thaum lawv sawv ntsug.
Cia peb saib seb lwm yam tsos mob dab tsi uas PAF ua rau muaj.
| Lub kaw lus/txheej txheem cuam tshuam | Cov tsos mob uas yuav tshwm sim |
|---|---|
| Kev tawm hws ntawm lub cev | Feem ntau muaj kev txo qis ntawm kev tawm hws (anhidrosis) lossis qee zaum tawm hws ntau dhau (hyperhidrosis). |
| Kev Pom Kev | Pom kev tsis meej vim yog cov menyuam kawm ntawv tsis loj txaus. |
| Kev tso zis | Nyuaj rau kev tso zis kom tag (urinary retention) lossis tsis muaj peev xwm tswj tau kev tso zis (urinary incontinence). |
| Kev zom zaub mov | Cem quav los yog tso zis tsis tau. |
| Kev ua ub ua no ntawm kev sib deev | Cov teeb meem xws li erectile dysfunction lossis anorgasmia. |
Ntxiv rau, kwv yees li ib nrab ntawm cov neeg uas muaj PAF kuj tseem yuav muaj mob ntshav tsis txaus.
Vim li cas ho tsim PAF?
Qhov ua rau qhov no tau txheeb xyuas tias yog qhov tsis zoo ntawm cov protein hu ua alpha-synuclein hauv peb cov hlab ntsha autonomic. Ib yam li cov av txhaws ib lub yeeb nkab, thaum cov protein no sib sau ua ke hauv cov hlab ntsha, lawv txoj haujlwm raug cuam tshuam.
Cov protein no tau tso rau hauv cov hlab ntsha (autonomic ganglia) ntawm ob sab ntawm tus txha caj qaum lossis ze ntawm cov kabmob. Raws sijhawm, tus lej ntawm cov hlwb no txo qis, thiab kev ua haujlwm ntawm lub cev autonomic raug cuam tshuam. Tab sis qhov tseem ceeb tshaj plaws yog tias hauv PAF, tsis yog lub hlwb lossis tus txha caj qaum raug puas tsuaj . Yog li ntawd, nws tsis cuam tshuam rau tej yam xws li kev nco thiab kev xav.
Cov kws tshawb nrhiav tseem tsis tau muaj lub tswv yim meej tias vim li cas cov protein no thiaj li raug tso rau hauv qhov no.
Kev sib raug zoo nrog lwm yam kab mob
Nov yog ib yam tseem ceeb uas yuav tsum paub. Cov protein no, alpha-synuclein, yog yam uas tsim nyob rau hauv lub hlwb hauv cov kab mob xws li Parkinson's disease, Multiple System Atrophy, thiab Lewy Body Dementia. Yog li, qee tus neeg uas muaj PAF (tsis yog txhua tus) muaj feem yuav muaj ib qho ntawm cov kab mob no dhau sijhawm. Koj tus kws kho mob yuav qhia rau koj paub txog qhov no.
Yuav kuaj mob li cas?
Kev kuaj mob PAF yog ib qho txheej txheem nyuaj me ntsis, vim cov kws kho mob yuav xub txiav txim siab seb puas muaj lwm yam mob uas yuav ua rau koj cov tsos mob, tshwj xeeb tshaj yog qhov ntshav siab poob qis thaum koj sawv ntsug.
Cov txheej txheem kuaj mob yuav muaj xws li:
- Nug cov lus nug kom zoo zoo txog koj cov tsos mob thiab keeb kwm kev kho mob.
- Kev kuaj lub cev thiab kev kuaj mob hlwb tag nrho.
Tom qab ntawd, yuav muaj ntau qhov kev kuaj tshwj xeeb los xyuas kom meej tias muaj tus kab mob.
| Kev Ntsuas | Ua qhov no xwb... |
|---|---|
| Kev Ntsuas Rooj Tilt | Koj yuav raug muab tso rau ntawm ib lub txaj tshwj xeeb thiab tom qab ntawd mam li hloov mus rau qhov sawv ntsug. Koj cov ntshav siab thiab koj lub plawv dhia yuav raug saib xyuas. |
| QSART (kev kuaj hws) | Qhov no saib seb cov hlab ntsha uas tswj kev tawm hws ua haujlwm li cas. Qhov no pab txheeb xyuas cov teeb meem nrog lub paj hlwb autonomic. |
| Kev kuaj duab (xws li MRI) | Tej yam xws li kev luam theej duab MRI ntawm lub hlwb raug ua kom paub tseeb tias tsis muaj lwm yam mob uas yuav ua rau muaj cov tsos mob. |
| Kev Kuaj Mob Hauv Chav Kuaj Mob (Ntshav thiab Zis) | Cov tshuaj hu ua norepinephrine hauv cov ntshav thiab zis raug ntsuas thaum pw thiab tom qab sawv ntsug. Hauv PAF, muaj kev hloov pauv tshwj xeeb hauv cov qib no. |
Nws yuav ua rau koj ntxhov siab heev uas yuav tsum kuaj ntau yam, tab sis tsuas yog kuaj pom tus kab mob kom raug xwb peb thiaj li yuav tsim tau txoj kev kho mob zoo tshaj plaws rau koj.
Cov kev kho mob rau PAF yog dab tsi?
Tseem tsis tau muaj tshuaj kho qhov no. Tab sis tsis txhob txhawj. Muaj ntau yam uas koj ua tau los pab tswj koj cov tsos mob thiab ua lub neej zoo li qub. Koj tus kws kho mob thiab pab neeg kho mob yuav ua haujlwm nrog koj los tsim ib txoj kev npaj kho mob uas tshwj xeeb rau koj.
Kev tswj hwm ntawm Orthostatic Hypotension (ntshav qis thaum sawv ntsug)
Qhov no yog qhov teeb meem tseem ceeb. Muaj ob qho kev kho mob uas tsis siv tshuaj thiab tshuaj rau qhov no.
- Ceev faj thaum hloov chaw: Thaum sawv ntawm qhov pw lossis zaum, ua qeeb heev . Tsis txhob sawv tam sim ntawd.
- Dej thiab ntsev: Koj tus kws kho mob yuav pom zoo kom haus li 3 liv dej ib hnub. Nws kuj tseem yuav qhia koj kom ntxiv ntsev me ntsis rau hauv koj cov zaub mov.
- Npaj txaj pw: Pw tsaug zog nrog lub taub hau ntawm lub txaj tsa li 4-6 ntiv tes. Ua li ntawd, koj yuav tsis hnov qhov sib txawv ntawm cov ntshav siab thaum koj sawv.
- Cov Khaub Ncaws Uas Siv Tau: Hnav cov thom khwm nruj tshwj xeeb (cov khaub ncaws uas siv tau) uas ntev txog ntawm lub duav lossis ob txhais ceg yuav pab txo cov ntshav sib sau ua ke hauv ob txhais ceg thiab ua kom cov ntshav siab ruaj khov.
- Ntxiv rau qhov no, tus kws kho mob kuj tseem pom zoo kom siv cov tshuaj tshwj xeeb uas ua rau ntshav siab ntxiv.
Teeb meem nrog kev quav thiab tso zis
- Rau kev cem quav: Koj tuaj yeem ua tej yam xws li noj cov khoom noj uas muaj fiber ntau (zaub, txiv hmab txiv ntoo, mov nplej) thiab siv cov tshuaj ua kom quav mos.
- Rau cov teeb meem tso zis: Yog tias koj muaj teeb meem tso zis, koj yuav tsum siv lub catheter. Yog tias koj tswj tsis tau koj cov zis, muaj cov tshuaj tshwj xeeb (xws li Oxybutynin, Mirabegron).
Kev ua phem kev sib deev
Txawm hais tias muaj cov tshuaj zoo li sildenafil lossis tadalafil rau qhov no, cov tshuaj no tuaj yeem ua rau muaj kev pheej hmoo ntawm orthostatic hypotension. Yog li ntawd, koj yuav tsum tham qhov no nrog koj tus kws kho mob thiab siv cov no tsuas yog raws li nws cov lus qhia.
Yuav muaj li cas rau yav tom ntej rau ib tus neeg uas muaj tus kab mob no?
Nws nyuaj rau muab ib lo lus teb txog yav tom ntej ntawm ib tus neeg uas muaj tus kab mob no, vim nws txawv ntawm ib tus neeg mus rau ib tus neeg.
PAF yog ib yam kab mob uas zuj zus tuaj. Tab sis rau ntau tus neeg, nws tshwm sim qeeb heev, dhau ntau xyoo, txawm tias ntau xyoo. Qee qhov kev tshawb fawb tau qhia tias lub neej nruab nrab tom qab kuaj pom tias muaj PAF yog li 12.5 xyoo. Tab sis qhov no tsuas yog qhov nruab nrab xwb, thiab nws tuaj yeem sib txawv ntau nyob ntawm koj cov tsos mob thiab kev noj qab haus huv. Yog li ntawd, tsis txhob cia siab rau cov lej ntawd ntau dhau.
Yog koj muaj PAF, nws yog ib qho tseem ceeb uas yuav tsum mus ntsib koj tus kws kho mob tsis tu ncua kom paub tseeb tias koj txoj kev kho mob ua haujlwm thiab koj tus mob zoo li cas. Yog tias koj muaj cov tsos mob ntawm tus kab mob Parkinson (xws li tshee hnyo, nyuaj taug kev), koj yuav tsum qhia rau koj tus kws kho mob tam sim ntawd.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- Kev Ua Tsis Taus Haujlwm Pure Autonomic Failure (PAF) yog ib yam kab mob tsis tshua muaj uas cuam tshuam rau lub paj hlwb uas tswj cov txheej txheem ua haujlwm hauv peb lub cev.
- Cov tsos mob tseem ceeb yog kiv taub hau thiab tsaus muag thaum sawv ntawm qhov zaum lossis pw vim yog ntshav siab poob qis.
- Txawm hais tias tus kab mob no kho tsis tau tag nrho los xij, cov tsos mob tuaj yeem tswj tau zoo thiab muaj lub neej zoo.
- Tsis muaj ib txoj kev twg los tiv thaiv qhov no, thiab nws tsis yog koj qhov txhaum uas nws tau tshwm sim.
- Nws yog ib qho tseem ceeb heev uas yuav tsum tau sib cuag nrog koj tus kws kho mob tsis tu ncua thiab ua raws li koj txoj kev npaj kho mob kom raug. Tsis txhob ntshai tham qhib siab txog koj cov lus nug thiab kev txhawj xeeb.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus