Thaum koj paub tias koj muaj mob qog noj ntshav, nws nyuaj rau piav qhia rau hauv cov lus txog koj txoj kev xav. Tab sis thaum tus kws kho mob tham txog kev kho mob thiab koj hnov cov lus zoo li 'chemotherapy', nws yog ib qho ib txwm muaj uas yuav ntshai, xav paub, thiab tsis meej pem ntau dua. Ib qho ntawm cov tshuaj chemo feem ntau siv rau kev kho mob qog noj ntshav yog 'Taxane.' Hnub no, peb yuav tham txog qhov no yooj yim heev, hauv txoj kev uas koj tuaj yeem nkag siab, zoo li koj tab tom tham nrog ib tug phooj ywg zoo.
Taxane yog dab tsi tiag?
Hais yooj yim xwb, cov tshuaj taxanes yog ib pawg tshuaj chemotherapy uas tua cov hlwb qog noj ntshav thiab tiv thaiv kev loj hlob ntawm cov qog nqaij hlav. Kev kho mob chemotherapy suav nrog kev ntxiv cov tshuaj no rau hauv peb cov ntshav, uas mus thoob plaws lub cev kom nrhiav thiab rhuav tshem cov hlwb qog noj ntshav.
Qhov ua rau cov tshuaj taxane no tshwj xeeb yog tias lawv yog los ntawm cov ntoo ntuj. Lawv tau rho tawm thawj zaug los ntawm cov tawv ntoo ntawm tsob ntoo 'Yew' . Qhov tseeb, taxanes yog ib qho ntawm ob hom tshuaj chemo uas tau los ntawm cov nroj tsuag. Lwm hom yog ib pawg tshuaj hu ua 'Vinca alkaloids', uas tau los ntawm cov nroj tsuag 'Mella'.
Niaj hnub no, cov kws tshawb fawb tab tom kawm txog cov qauv tshuaj ntawm cov taxanes tau los ntawm cov nroj tsuag no thiab txawm tias ua haujlwm los tsim lawv hauv cov chaw soj nstuam.
Cov tshuaj no tua cov hlwb mob qog noj ntshav li cas?
Yuav kom nkag siab qhov no, peb yuav tsum xub nkag siab txog seb cov hlwb qog nqaij hlav kis tau li cas. Mob qog nqaij hlav kis tau los ntawm kev faib ib lub hlwb qog nqaij hlav ua ob, uas tom qab ntawd faib ua plaub, thiab tom qab ntawd nthuav dav sai sai. Hauv kev kho mob, cov txheej txheem uas ib lub hlwb faib ua ob hu ua mitosis .
Cov tshuaj taxane ua yog cuam tshuam rau cov txheej txheem ntawm kev faib cell.
Xav txog tias thaum ib lub cell faib, cov khoom siv caj ces hauv lub cell ntawd yuav tsum tau faib ua ob thiab xa mus rau ob lub cell tshiab. Muaj cov qauv hauv lub cell uas pab ua txoj haujlwm no, zoo li cov hlua khi me me. Cov no hu ua microtubules . Cov no yog cov uas rub cov khoom tsim nyog rau ob lub cell tshiab sib nrug.
Thaum cov tshuaj taxane raug coj mus rau hauv lub cev, nws ua rau cov xov hlau no hu ua microtubules tawv tsis tsim nyog . Tom qab ntawd lawv tsis tuaj yeem quav lossis nthuav tawm kom raug. Yog li ntawd, cov txheej txheem ntawm kev faib lub cell ua ob qho nres ib nrab. Thaum qhov kev faib no tsis tuaj yeem ua tiav, lub cell niam txiv tuag tom qab ib pliag.
Cov tshuaj Taxane tswj cov mob qog noj ntshav los ntawm kev rhuav tshem lub peev xwm ntawm cov hlwb qog noj ntshav kom faib thiab loj hlob.
Cov tshuaj taxane siv rau hom mob qog noj ntshav twg?
Taxanes yog ib hom tshuaj tseem ceeb heev uas siv los kho ntau yam mob qog noj ntshav. Ib txhia ntawm cov no siv ua kev kho mob thawj zaug rau qee yam mob qog noj ntshav, thaum lwm tus siv rau cov mob qog noj ntshav uas kis mus rau lwm qhov chaw.
| Cov hom mob qog noj ntshav uas kho nrog Taxane | |
|---|---|
| Feem ntau siv rau mob qog noj ntshav | |
| Mob qog nqaij hlav zes qe menyuam | Mob qog noj ntshav hauv lub mis |
| Lwm hom mob qog noj ntshav uas tau kho | |
| Mob qog nqaij hlav | Mob qog nqaij hlav ntawm lub tsev menyuam |
| Mob qog noj ntshav hauv plab hnyuv | Mob qog noj ntshav hauv taub hau thiab caj dab |
| Mob qog nqaij hlav prostate | Mob qog nqaij hlav ntsws (Mob qog nqaij hlav ntsws uas tsis yog hom me) |
| Mob qog nqaij hlav hauv tsev menyuam | Lymphoma |
Muaj tej lub sij hawm, cov tshuaj taxanes raug muab ua ke nrog lwm cov tshuaj chemotherapy. Koj tus kws kho mob yuav txiav txim siab seb kev kho mob twg zoo tshaj plaws rau koj tus mob.
Kev kho mob no muab li cas? Thiab cov kev mob tshwm sim yog dab tsi?
Yuav muab kev kho mob li cas
Cov tshuaj Taxanes raug muab rau hauv cov hlab ntsha (IV) . Lawv raug muab los ntawm lub cannula (catheter), zoo ib yam li cov kua saline. Kev kho mob no yuav siv sijhawm ib teev lossis ob peb teev. Tej zaum koj yuav tsum tau txais kev kho mob no ib zaug ib lub lim tiam, lossis ib zaug txhua ob peb lub lim tiam. Koj tus kws kho mob yuav txiav txim siab lub sijhawm kho mob raws li koj tus mob.
Cov kev mob tshwm sim uas pom ntau zaus
Txawm hais tias cov tshuaj kho mob chemotherapy tsom mus rau cov hlwb qog nqaij hlav uas faib sai sai, qee zaum lawv kuj tuaj yeem cuam tshuam rau cov hlwb noj qab haus huv uas faib sai sai hauv peb lub cev. Piv txwv li, tej yam xws li peb cov hlwb plaub hau, cov hlwb tawv nqaij, thiab cov hlwb ntshav. Qhov no yog vim li cas cov kev mob tshwm sim.
| Cov teebmeem sab | Ib qho lus piav qhia yooj yim |
|---|---|
| Neutropenia | Kev txo qis ntawm cov neutrophils, ib hom qe ntshav dawb uas tawm tsam kev kis kab mob hauv lub cev, uas ua rau muaj kev pheej hmoo ntawm kev kis kab mob. |
| Kev mob neuropathy ntawm cov hlab ntsha sab nraud | Kev puas tsuaj rau cov hlab ntsha hauv caj npab thiab ceg. Qhov no tuaj yeem ua rau tsis hnov mob, mob, lossis tsis muaj zog hauv caj npab thiab ceg . |
| Kev poob plaub hau | Qhov no yog ib qho kev mob tshwm sim uas feem ntau tshwm sim, tab sis cov plaub hau yuav rov qab loj hlob tom qab kev kho mob tiav. |
| Ntuav thiab xeev siab | Nws yog ib qho uas tshwm sim ntau thaum lub sijhawm kho mob. Cov tshuaj tau muab los tswj qhov no. |
| Mob nqaij thiab mob pob qij txha | Tej zaum yuav muaj mob hauv lub cev thiab mob pob qij txha. |
| Kev hloov pauv ntawm cov ntshav siab | Ntshav siab yuav nce lossis poob. |
| Cov qe ntshav tsawg zuj zus | Qhov txo qis ntawm cov qe ntshav liab tuaj yeem ua rau muaj ntshav tsis txaus thiab qhov txo qis ntawm cov platelets (thrombocytopenia) tuaj yeem ua rau muaj kev pheej hmoo ntawm kev los ntshav. |
Cov kev mob tshwm sim no tsis tshwm sim rau txhua tus. Tsis tas li ntawd, ntau yam ntawm lawv tuaj yeem tswj tau. Nws yog ib qho tseem ceeb heev uas yuav tsum qhia rau koj tus kws kho mob lossis cov neeg ua haujlwm saib xyuas neeg mob txog txhua yam kev tsis xis nyob uas koj xav.
Puas muaj kev pheej hmoo rau kev kho mob no?
Cov tshuaj Taxanes yog ib txoj kev kho mob zoo heev uas tau ua rau cov neeg mob qog noj ntshav muaj sia ntev dua. Txawm li cas los xij, zoo li txhua txoj kev kho mob, muaj qee qhov kev pheej hmoo.
Qee zaum, cov kev mob tshwm sim uas tau hais los saum toj no tuaj yeem ua rau mob hnyav. Hauv cov xwm txheej zoo li no, koj tus kws kho mob yuav txiav txim siab hloov koj lub sijhawm kho mob lossis tsum tsis txhob kho ib ntus.
Lwm yam tseem ceeb yog tias dhau sijhawm, cov qog nqaij hlav tuaj yeem pib 'siv' cov tshuaj no. Ntawd yog, lawv tsim kev tiv thaiv kab mob chemoresistance . Tom qab ntawd cov tshuaj cov nyhuv yuav txo qis. Tab sis yog tias qhov ntawd tshwm sim, koj tus kws kho mob yuav tig mus rau cov kev xaiv xws li sim cov tshuaj sib xyaw ua ke lossis pom zoo rau kev kho mob sib txawv.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- Taxane yog ib hom tshuaj kho mob muaj zog heev uas tau los ntawm cov nroj tsuag uas tiv thaiv cov hlwb qog noj ntshav kom tsis txhob faib.
- Qhov no kho tau ntau hom mob qog noj ntshav, suav nrog mob mis, mob zes qe menyuam, thiab mob ntsws.
- Tej zaum yuav muaj tej yam tshwm sim xws li plaub hau poob, loog, thiab mob lub cev, tab sis feem ntau ntawm lawv tuaj yeem tswj tau.
- Nws yog ib qho tseem ceeb heev uas yuav tsum qhia rau koj tus kws kho mob lossis tus nais maum txog tej yam me me uas koj hnov mob thaum lub sijhawm kho mob.
- Kev kho mob qog noj ntshav yog ib txoj kev taug kev. Nco ntsoov tias koj tsis yog tib tug neeg nyob hauv txoj kev taug kev no thiab koj muaj ib pab neeg kho mob uas muaj peev xwm los pab koj.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus