Yu want fɔ no bak bɔt dis blɔd kansa? Lɛ wi tɔk bɔt Akyu Monosaytik Lukimia (AMoL)!

Yu dɔn ɛva yɛri bɔt Acute Monocytic Leukemia, ɔ AMoL? Di nem kin tan lɛk se i strenj smɔl, bɔt na wan kayn kansa we kin afɛkt di blɔd. Imajin if sɔntin rɔng na wi bɔdi in blɔd we de mek blɔd, ɛn instead fɔ gɛt wɛlbɔdi blɔd sɛl, kansa sɛl dɛn bigin fɔ mek? Na dat kin apin. Pan ɔl we dis na siriɔs stori, lɛ wi tɔk bɔt am simpul wan, di we we yu go ɔndastand.

Wetin na dis tin we dɛn kɔl Acute Monocytic Leukemia?

Fɔ tɔk am simpul wan, Acute Monocytic Leukemia (AMoL) na wan kayn kansa we de pan di lukimiya grup we dɛn kɔl Acute Myeloid Leukemia (AML). Yu no se lukimiya na blɔd kansa. So dis AMoL na blɔd kansa bak . I kin apin we wan prɔblɛm de na di prɔses fɔ mek blɔd sɛl dɛn insay wi bɔdi. Fɔ tɔk di kɔrɛkt tin, di sɛl dɛn we nɔ machɔ we fɔ bi wɛlbɔdi blɔd sɛl, dat na di sɛl dɛn we dɛn kɔl blast , kin chenj ɛn bi kansa sɛl.

insay AMoL, dεn sεl dεm we nכ machכ, כ blast dεm, de stכp na dεn trak as dεn de divεlכp to wan kayn wayt bכdi sεl we dεn k כl monosayt . Bɔt instead fɔ bi wɛlbɔdi monosayt, dɛn kin stɔp na di stej we nɔ machɔ, ɔ blast, ɛn bi kansa sɛl.

Akyu monosaytik lukimiya na wan kansa we rili siriɔs, we kin skata kwik kwik wan . Yu dɔktɔ go ɛp yu fɔ fɛn di bɛst tritmɛnt fɔ yu sik. Nɔ wɔri, wi go tɔk mɔ bɔt dis.

Yu tink se kayn tin dɛn de we kin apin to dis?

yes, di Wol Wεlth כganayzeshכn (WHO) de klas AMoL bay di tכp sεl we de bi kεnsar (i.e., monosayt dεm). Dɛn kin kɔl am bak AML-M5 akɔdin to di ol Frɛnch-Amɛrikan-British (FAB) klasifikeshɔn sistɛm. Ɔnda dis sistɛm, dɛn sheb AML-M5 mɔ to tu kategori:

Akyu monoblastik lukimiya (AML-M5a) .

insay dis kayn we, at le 80% pan di sεl dεm kin bi kεnsar bifo dεn fulכp divεlכp. Dɛn kin si dis kayn tin pan yɔŋ pikin dɛn ɛn yɔŋ pipul dɛn .

Akyu monosaytik lukimiya (AML-M5b) .

insay dis, di sεl dεm we rili abnכmal kin bi kεnsar we di sεl dεm de gro sכmtεm. Dis kayn nɔ de afɛkt wan patikyula ej grup .

Dɛn klasification ya kin ɛp dɔktɔ dɛn fɔ no di sik. Bɔt wan kayn we nɔ siriɔs pas di ɔda wan. Dɛn tu tin ya na kɔndishɔn dɛn we nid di sem lɛvul fɔ pe atɛnshɔn.

Wetin na di sayn dɛm fɔ dis?

Bɔku tɛm di sayn dɛm fɔ AMoL kin apia ɛn kin go bifo kwik kwik wan . Na sɔm pan di sayn dɛm wae de sho se yu gɛt dis sik:

• I izi fɔ brus ɛn blɔdI kin apin (blɔd na yu gɔm, yu nos kin blɔd ɔltɛm, ɛn ɔda tin dɛn) Imajin se yu gɛt big brus ivin if yu jɔs bɔmp sɔmsay, ɔ yu gam kin blɔd bɔku we yu de brus yu tit.
• Smɔl, pepul, rɛd, ɔ brawn dɔt dɛn ɔnda di skin ( petechiae ). Dɛn tin ya kin tan lɛk smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl.
• di gכm dεm we de swel כ di gכm tisu we de gro pasmak.
• Wiknɛs ɛn taya pasmak . Jɔs fil lɛk se yu nɔ gɛt ɛni ɛnaji. Fɔ fil taya ivin we yu wek na mɔnin.
• I nɔ kin izi fɔ yu fɔ blo.
• Di it nɔ de te.
• We yu de lɔs yu wet fɔ natin . If yu de lɔs yu wet we yu nɔ de it, na sɔntin we yu fɔ pe atɛnshɔn to.
• Pale skin.
• Diziz we pɔsin kin gɛt.
• Fiva.

Sɔntɛnde, akyu monosaytik lukimiya kin afɛkt yu bren ɛn yu sɛntral nɛvɔ sistɛm . If dis kin apin, yu kin gɛt sɔm kayn sik lɛk fɔ mɛmba ɛn fɔ pe atɛnshɔn pan sɔntin.

Wetin mek dis kayn sik kin apin?

Di wan dɛn we sabi bɔt mɛrɛsin stil nɔ no bɛtɛ bɛtɛ wan wetin kin mek pɔsin gɛt AMOL. Bɔt dɛn tink se na bikɔs ɔf di chenj dɛn we de apin na di jɛnɛtiks , ɔ di chenj dɛn we de apin na di DNA na di sɛl dɛn. Na dɛn chenj ya kin mek wan wɛlbɔdi sɛl gɛt kansa.

Risach pipul dεm dכn si se pan sכm pipul dεm we gεt AMoL, wan jεnεtik dizayd de we dεn k כl kromozom riarenjmεnt. Dis min se wan pat pan wan kromozom kin brok ɛn atak ɔda kromozom. Dɛn kɔl dis kromozom translokeshɔn . Dis sik kin mek wan sɛl stɔp fɔ divɛlɔp lɛk monosayt ɛn bi kansa sɛl. Tink bɔt am lɛk sɔntin we dɔn rɔng.

Risach bɔt dɛn jɛnɛtik chenj ya stil de go bifo. If yu ɔndastand di jenɛtiks we de biɛn kansa, dat go ɛp masta sabi pipul dɛn fɔ mek bɛtɛ tritmɛnt fɔ fɛt am.

Wetin na de tin wae kin mek pɔrsin gɛt dis sik?

Bɔku tin dɛn de we kin mek pɔsin gɛt Acute Monocytic Leukemia. Na sɔm pan dɛn:

• Smok ɛn fɔ de pan sɛkɔnhand smok . Ivin if yu nɔ de smok, fɔ de nia pipul dɛn we de smok kin gɛt prɔblɛm bak.
• If yu dɔn gɛt kansa tritmɛnt bifo, fɔ ɛgzampul , kemotɛrapi ɛn redyushɔn tɛrapi.
• Fɔ lɔng tɛm we yu de gɛt tin dɛn we kin mek yu gɛt kansa , lɛk kemikal dɛn lɛk bɛnzin ɛn fɔmaldehayd (we yu kin fɛn na sɔm faktri ɛn pent dɛn).
• Fɔ gɛt raytin afta nyuklia riaktɔ aksidɛnt ɔ atɔmik bɔm.
• If yu gɛt wan sik we yu kin gɛt frɔm yu jɛnɛreshɔn, fɔ ɛgzampul , Li-Fraumeni syndrome .
• If yu gɛt sik dɛn we gɛt fɔ du wit di bon mɛro, lɛk myeloproliferative neoplasms .

Bɔt i impɔtant fɔ mɛmba se if yu gɛt sɔntin we de mek yu gɛt kansa, dat nɔ min se yu go rili gɛt kansa . Bɔt i bɛtɛ pasmak fɔ avɔyd di prɔblɛm dɛn we yu go ebul fɔ kɔntrol, lɛk fɔ nɔ smok.

Wetin na de prɔblɛm wae kin kam wit dis sik?

We yu gɛt AMoL, abnɔmal sɛl dɛn kin gɛda na yu bon mɛrɔ . As yu no, na di bon mɛro na di say we dɛn kin mek blɔd sɛl dɛn. So we dɛn kansa sɛl ya de gro, dɛn kin krawd di blɔd sɛl dɛn we gɛt wɛlbɔdi. Dis kin mek di rɛd blɔd sɛl dɛn, wayt blɔd sɛl dɛn, ɛn di pletlɛt dɛn go dɔŋ, ɛn dis kin mek difrɛn prɔblɛm dɛn apin. Fɔ ɛgzampul:

• Anemia : Na wan sik wae de kam wae di rεd blɔd sɛl dεm de dכn. Dis kin mek yu taya ɛn mek yu bɔdi nɔ gɛt bɛtɛ blɔd.
• Nyutropenia : Na di nyutrofil dεm we de dכn, we na wan kayn wayt bכdi sεl, we de mek di risk fכ infεkshכn bכku.
• Trombocytopenia : Na di pletlet dεm we de dכn, we de εp fכ blכd kכlכt. Dis kin mek yu blɔd bɔku ivin if yu wund smɔl.

Aw yu kin no dis sik?

Dɔktɔ dɛn kin yuz sɔm tɛst dɛn fɔ no if pɔsin gɛt AML. Di Wol Ɛlth Ɔganayzeshɔn se dɛn kin tek pɔsin se i gɛt AML if 20% ɔ mɔ pan in blɔd sɛl dɛn na nɔmal, sɛl dɛn we nɔ machɔ. כlso, mכr dan 80% pan dεn abnכmal sεl dεm fכ bi monosayt כ monosayt prεkursכr.

Yu dɔktɔ go tek blɔd sɛmpul, ɔ sɛmpul fɔ tisu, wata, ɔ bon mɛro. Dɛn kin rili tɛst dɛn tin ya na lab.

Dis na di tɛst dɛm we dɛn kin yuz fɔ no AMoL:

• Blɔd tɛst : If yu kɔnt di blɔd kɔmplit wan (CBC ) i kin sho sayn dɛn fɔ AMoL, lɛk we di wayt blɔd sɛl dɛn go bɔku. Wan periferik blɔd smyuɛl kin chɛk fɔ si if di sɛl dɛn we nɔ fayn.
• Bone marrow biopsy : Fɔ dis tɛst, yu dɔktɔ kin tek wan sampul pan tisu ɔ wata frɔm yu bon (bɔku tɛm na yu hip bon). Dɔn dɛn kin chɛk di sampul ɔnda maykroskɔp fɔ chɛk fɔ si if di kansa sɛl dɛn de. Dis kin mek yu fil pen smɔl, bɔt i impɔtant fɔ no if yu gɛt di sik.
• Spinal tap : Fɔ si if di kansa sɛl dɛn dɔn skata to di bren ɔ di sɛntral nervɔs sistɛm, di dɔktɔ kin tek wan sɛmpul pan yu spɛshal wata ɛn tɛst am.
• Imyunofenotayp we dɛn de yuz: Dis tεst de luk fכ spεsifi k protin dεm na di sεl dεm. dis protin dεm de εp fכ no di sεl dεm as AMoL sεl dεm.
• Saytojεnik analisis : Dis kayn analisis de chεk fכ translokeshכn כ riarenjmεnt dεm na di kromozom dεm insay sεl dεm we de asai wit AMoL.

Wetin na di tritmɛnt fɔ dis?

Di men gol fɔ tritmɛnt na fɔ put di kansa insay rɛmishɔn . Dat min se, te to wan say we nɔ gɛt kansa sɛl dɛn igen na yu bon mɛrɔ ɔ blɔd. Bɔt dis nɔ fɔ kɔnfyus wit mɛrɛsin . Wan mɛrɛsin na wan stet usay di kansa dɔn go ɔlsay ɛn nɔ kam bak.

Kimotɛrapi

Di men tritmɛnt fɔ akyu monosaytik lukimiya na kemotɛrapi . Dis kin inklud dɛn stej ya:

• Indukshɔn tɛrapi : Dis tritmɛnt de yuz wan kɔmbayn kemotɛrapi drɔgs fɔ put AMoL insay rɛmishɔn. Bɔku tɛm, di tritmɛnt kin bi fɔ bɔku tɛm we dɛn kin tek sɔm dez, ɛn dɛn kin nid fɔ go bak.
• Kɔnsolidɛshɔn tɛrapi : Insay dis tritmɛnt, yu go kɔntinyu fɔ gɛt ay doz kemo fɔ kil ɛni kansa sɛl we lɛf. Dis go ridyus di chans fɔ mek di kansa sɛl dɛn kam bak. Bɔrku tɛm, di tritmɛnt kin te fɔ tri to 4 mɔnt, fɔ sɔm dez.
• Mentɛnans tɛrapi : Afta stebilizayshɔn tɛrapi, yu kin nid fɔ gɛt smɔl doz kemo fɔ sɔm mɔnt ɔ ivin ia.

Targeted therapy

Dis tritmɛnt de tɔch sɔm patikyula muteshon ɔ chenj dɛn na di kansa sɛl dɛn. If kemotɛrapi nɔ dɔn wok, yu kin nid fɔ gɛt tritmɛnt we yu want fɔ gi yu . Ɔ, if wan patikyula jɛnɛtik muteshon de na di kansa sɛl dɛn, dɛn kin gi yu wan targeted therapy drug we de wok agens da mutation de.

Stem sɛl we dɛn kin transplant

di onli we fכ kכmplit kכl akyu monosaytik lukimiya na fכ transplant allojenik stεm sεl . Dis kin nid afta yu dɔn go insay rɛmishɔn. Ɔ, if di kansa kam bak afta yu dɔn go na rɛmishɔn, dɛn kin du dis transplant. Insay dis we aw dɛn kin du dis, dɔktɔ kin chenj yu yon stem sɛl dɛn wit stem sɛl dɛn we pɔsin we gi yu gi yu. Bɔku tɛm, di pɔsin we gi di blɔd na pɔsin we de nia di blɔd. Ɔ, i kin bi pɔsin we nɔ gɛt ɛnitin fɔ du wit di mɔni we de na di nashɔnal ɔ intanashɔnal rɛjista.

Bɔt nɔto ɔlman kin gɛt stem sɛl transplant. I kin mek pɔsin gɛt siriɔs sayd ɛfɛkt bak. If yu dɔktɔ tɛl yu fɔ du am, dɛn go ɛksplen to yu di gud ɛn bad tin dɛn.

Klinik trial dɛn we dɛn kin du

Klinik trial na stɔdi we de tɛst if nyu tritmɛnt dɛn sef ɛn if dɛn wok fayn. Dipen pan aw yu gɛt di sik, dis kin bi di bɛst tritmɛnt fɔ yu. Aks yu dɔktɔ if yu fɔ tek pat pan klinik trial.

Aw yu de liv wit dis sik? / Wetin na di chans fɔ mek yu wɛl?

Di lukin-grɔn fɔ pɔsin we gɛt akyu monosaytik lukimiya (AMoL) kin jɔs tan lɛk fɔ pɔsin we gɛt akyu maylɔyd lukimiya (AML). Na lɛk 3 pan ɛvri 10 pipul dɛn we gɛt AMoL stil de alayv fayv ia afta dɛn dɔn no se dɛn gɛt am .

Bɔt, e fayn fɔ mɛmba se dɛn nɔmba ya nɔr de sho nyu tritmɛnt. Nyu tritmɛnt dɛn de alaw pipul dɛn fɔ liv lɔng wit AMoL. Dɔn bak, di prɔgnosis , ɔ di chans fɔ mek yu wɛl, dipen pan bɔku tin dɛn. Fɔ ɛgzampul:

• Ej : Pipul wae nɔr rich 65 ia gɛt ay chans fɔ wɛl frɔm AMoL.
• Wait blɔd sɛl kɔnt : Di wan dɛn we gɛt smɔl wayt blɔd sɛl kin gɛt ay chans fɔ wɛl.
• Rispכns to tritmεnt : If dεn achyv rεmishכn afta di fכs kεmothεrapi (indukshכn kεmothεrapi), di chans fכ rεkכvεshכn de hכy.

Aw yu de kia fɔ yusɛf?

Fɔ liv wit lukimiya kin mek yu strɛs . Ivin afta yu dɔn gɛt rɛmishɔn, yu kin stil gɛt fɔ dil wit de fred se di kansa go kam bak. Yu kin gɛt fɔ dil bak wit di lɔng tɛm sayd ɛfɛkt dɛm we pɔsin kin gɛt we i de mɛn kansa. Di bɛst we fɔ kia fɔ yusɛf na fɔ yuz ɔl di tin dɛn we yu gɛt . Dɛn tin ya kin bi:

• Kansa sɔvayv program : Fɔ kɔnɛkt wit ɔda pipul dɛm wae gɛt kansa kin gi yu de sɔpɔt wae yu nid ɛn ɛp yu fɔ fil lɛk se yu nɔr de yu wan.
• Palliative care : Palliative care de ɛp yu fɔ manej di sayn dɛm fɔ kansa ɛn di sayd ɛfɛkt dɛm fɔ kansa tritmɛnt. I nɔ mata wetin yu prɔgnosis, dis na valyu tin.
• Tɛrapi : Bɔrku pipul dɛm wae gɛt kansa kin gɛt wɔri ɛn pwɛl hat. Yu kin gɛt ɛp bay we yu mit wit wan mental wɛlbɔdi advaysa we de wok wit pipul dɛn we dɔn gɛt kansa. Wan advaysa kin ɛp yu fɔ kɔntrol di strɛs dɛm wae kin kam ɛvride wae yu gɛt kansa.

Ustɛm yu nid fɔ go to dɔktɔ?

Yu go nid fɔ go to yu dɔktɔ ɔltɛm fɔ wach aw yu de du tritmɛnt. Dɛn go mek yu no if ɛni chenj de na yu bɔdi we go sho se di kansa de kam bak. Tɔk to yu dɔktɔ we yu nɔ ol ɛnitin .

Us kwɛstyɔn dɛn yu fɔ aks di dɔktɔ?

Na sɔm kwɛstyɔn dɛn we yu kin aks yu dɔktɔ:

• Us tritmɛnt a nid?
• Us sayd ɛfɛkt dɛn a fɔ ɛkspɛkt, ɛn aw a go ebul fɔ kɔntrol dɛn?
• A nid fɔ tek pat pan klinik trial?
• Aw ɔltɛm a go gɛt fɔ kam fɔ fala-ap apɔntinmɛnt?
• Us tin dɛn de we go ɛp mi?

Fɔ dɔn, tin dɛn we wi fɔ mɛmba

We yu no se yu ɔ yu pikin gɛt akyu monosaytik lukimiya (AMoL) kin mek yu shɔk. Blɔd kansa na siriɔs sik, ɛn di tritmɛnt dɛn kin tranga. I go mɔs bi se yu go gɛt bɔku tritmɛnt dɛn insay di de, wik, ɛn mɔnt dɛn we de kam.

Bɔt i impɔtant fɔ mɛmba dis: Dɛn tritmɛnt ya de ɛp pipul dɛn fɔ liv lɔng pas aw dɛn bin de liv bifo . Fɔ sɔm, di tritmɛnt dɛn kin ivin pul di kansa kɔmɔt kpatakpata. Aks yu dɔktɔ us rizulyt yu kin ɛkspɛkt. Tɔk to dɛn bɔt di gud ɛn bad tin dɛn we ɛni tritmɛnt we yu kin gɛt. Dɛn kin ɛp yu fɔ bia wit wetin de kam afta dat.

Mɛmba dis: Nɔto yu wan de pan dis waka. Dɔktɔ dɛn, fambul dɛn, ɛn padi dɛn ɔl de fɔ ɛp yu. Stay strɔng!

` Akyu monosaytik lukimiya, AMoL, blɔd kansa, lukimiya simptom dɛm, kemotɛrapi, bon mɛrɔ transplant, kansa tritmɛnt