Yu gɛt kansa na yu adrenal gland? Lɛ wi tɔk bɔt dis (Adrenocortical Carcinoma)!

Yu de fil pen na yu bɛlɛ ɔ yu de gɛt wet wantɛm wantɛm? Sɔmtɛm dɛn kin kam wit wan sik wae wi nɔr kin tɔk bɔt bɔrku, bɔt i impɔtant fɔ no bɔt. Na wan sik we dɛn kɔl Adrenocortical Carcinoma . Nɔ wɔri, di nem kin tan lɛk se i kɔmplikt smɔl, bɔt lɛ wi kip am simpul.

Wetin na Adrenocortical Carcinoma?

Fɔ tɔk am simpul wan, adrenocortical carcinoma na kansa we de divɛlɔp na di ɔda layt na yu adrenal gland dɛn , we na di adrenal cortex . Tink bɔt dɛn gland ya lɛk tu smɔl hat dɛn we de ɔp yu kidni dɛn. Dɛn rili impɔtant bikɔs dɛn de mek ɔmon dɛn we de kɔntrol bɔku tin dɛn na wi bɔdi, lɛk di we aw wi de chenj in bɔdi , blɔd prɛshɔn, ɛn aw wi de biev we wi strɛs.

naw, insay dis kes fכ adrenocortical carcinoma, kansa tכmכro dεm de divεlכp insay dεn adrenal gland dεm ya. Sɔntɛnde, dɛn tumbu ya kin mek ɔmon dɛn we nɔmal. Dɔn di ɔmon dɛn we de na di bɔdi kin bɔku tumɔs, ɛn dis kin afɛkt di we aw wi bɔdi de wok. Sɔm tumbu kin gro kwik kwik wan ɛn i kin put prɛshɔn bak pan ɔda ɔgan dɛn we de rawnd dɛn. Pan ɔl we sɔntɛnde dɔktɔ dɛn kin trit dis sik, sɔntɛnde dis sik kin kam bak.

Pan ɔl we dis sik kin kam pan big pipul dɛn, sɔntɛnde i kin kam pan yɔŋ pikin dɛn. Bɔt insay dis atikul, wi go tɔk mɔ bɔt adrenocortical carcinoma, we kin afɛkt big pipul dɛn.

Yu tink se kayn adrenocortical carcinoma de?

Yɛs, tu men kayn dɛn de. De sayn dɛm fɔ dɛn tu kayn sik ya kin difrɛn bak frɔm dɛnsɛf.

1. Tכmכro dεm we de wok: Dis na di kayn we we kכmכn pas כl. Dɛn tumbu ya kin mek mɔ ɔmon dɛn lɛk aldosterone , cortisol , estrogen, ɛn testosterone pas aw dɛn fɔ mek. So, di sayn dɛm de dipen pan di kayn ɔmon we dɛn de mek pasmak.

2. Tכmכro dεm we nכ de wok: dεn tכmכro dεm ya nכ de afekt כmon prodakshכn. Bɔt dɛn kin gro big ɛn prɛs pan di ɔgan ɛn tisu dɛn we de rawnd, ɛn dis kin mek dɛn nɔ fil fayn.

Aw dis sik kin kɔmɔn?

Infakt, dis na kansa we nɔ kin apin so ɔltɛm . Pan ɔl we na di kayn kansa we kin apin pas ɔl na di adrenal gland dɛm, i nɔ kin bɔku ɔlsay. Na lɛk wan pan ɔl wan milyɔn pipul dɛn nɔmɔ kin gɛt dis sik ɛvri ia. So nɔ mek yu fred di nem.

Wetin na di sayn dɛm fɔ adrenocortical carcinoma?

E kin amazing aw sɔm pipul kin gɛt dis kansa bɔt nɔr kin gɛt ɛni sayn.I nɔ de kam ɔp. Study dεn sho se bitwin 20% εn 30% pan dεn sik pipul ya dεn kin no di sik insidεnt wan we dεn de du imej tεst fכ כda kכndyushכn.

Bɔt we di sayn dɛn de sho se yu gɛt dis sik, yu kin si tin dɛn lɛk:

• Bɛlɛ pen ɔ nɔ kin fil fayn.
• di ia dεm we nכ de gro na uman in fes כ bכdi (hirsutism). I kin fil lɛk se man in biad de gro.
• di brεst dεm we de big na man dεm (Gynecomastia).
• Di ay blɔd prɛshɔn.
• Di blɔd shuga we bɔku.
• We yu de gɛt bɔku bɔku wet, mɔ na yu fes, yu nɛk, ɛn yu trɔnk. I tan lɛk se sɔmbɔdi dɔn big wantɛm wantɛm.

Aw agresiv na adrenocortical carcinoma?

Dis na kansa we kin rili bad . dis min se di tכmכro kin gro kwik kwik wan εn i kin spre (mεtastas) ausayd di adrenal gland to כda pat dεm na di bכdi, lεk di lכng dεm εn bon dεm. We i dɔn skata, i kin at fɔ trit am mɔ ɛn mɔ.

Wetin na di tin dɛn we kin mek pɔsin gɛt adrenocortical carcinoma?

Risach pipul dɛn stil nɔ dɔn fɛn di rayt rizin . Sɔm pipul dɛn kin gɛt dis sik bikɔs ɔf sɔm jɛnɛtik kɔndishɔn dɛn we kin pas frɔm wan jɛnɛreshɔn to ɔda jɛnɛreshɔn. Dis min se if pɔsin na di famili gɛt dis sik, ɔda pipul dɛn kin gɛt dis sik bak.

Ɔda tɛm dɛn, i kin tan lɛk se sɔm tin dɛn we kin chenj na di jɛnɛtiks kin mek di prɔblɛm bɔku. fכ egzampl, risεch dεn fכnshכn se chenj dεm na di tכmכro sכpresכn jin dεm (TP53) εn (IGF2) kin mek dis kεnsar gεt dis kεnsar. Fɔ tɔk am simpul wan, di tumor suppressor genes na jin dɛn we de kɔntrol aw wi sɛl dɛn de gro. If chenj de na dɛn jin ya, di sɛl dɛn kin sheb ɛn bɔku we dɛn nɔ ebul fɔ kɔntrol ɛn dɛn kin gɛt kansa.

Us tin dɛn we a kin gɛt frɔm mi mama ɛn papa kin mek a gɛt mɔ prɔblɛm?

Yu gɛt ay risk fɔ gɛt adrenocortical carcinoma if yu gɛt ɛni wan pan dɛn kayn tin ya we yu kin gɛt frɔm yu mama ɛn papa:

• Sindrom we dɛn kɔl Beckwith-Wiedemann
• Carney kɔmpleks
• Famili adenomatכs polipos (FAP) .
• Li-Fraumeni sindrom we gɛt di sik
• Lynch sindrom we gɛt di sik
• Mכltipכl εndokrin niכplasia tayp 1 (MEN1) .
• Nyurofibromatosis Tayp 1 (NF1) .
• Von Hippel-Lindau sindrom (VHL sindrom) .

If ɛnibɔdi na yu famili gɛt dɛn sik ya, i go fayn fɔ mek yu tɔk to dɔktɔ ɛn lan bɔt aw fɔ tɛst yu jɛnɛtiks.

Wetin na di poshubul kɔmplikeshɔn dɛm fɔ adrenocortical carcinoma?

Dis kansa de spre (metastasis) kwik kwik wan.Yɛs. I kin rili at fɔ trit we i de skata na do na di adrenal gland. Dɔn bak, sɔm tɔŋ dɛn we de mek ɔmon kin mek pɔsin gɛt tin dɛn lɛk:

• Cushing’s syndrome: Dis kin kam bikɔs di adrenal gland dɛn de mek tumɔs pan di ɔmon we dɛn kɔl kɔtisol. Di sayn dɛm na di fes we ful-ɔp ɛn bɔdi we swel.
• Conn’s syndrome: Dis sik kin kam bikɔs dɛn de mek di ɔmon we dɛn kɔl aldosterone pasmak. I kin mek tin dɛn lɛk ay blɔd prɛshɔn.

Aw dɛn kin no se pɔsin gɛt adrenocortical carcinoma? (Diagnosis) .

If dɛn no se yu gɛt adrenal tumor we dɛn de tɛst fɔ ɔda sik, ɔ if yu gɛt di sayn dɛn we wi dɔn tɔk bɔt, yu dɔktɔ go du tɛst dɛn lɛk:

• Imej tɛst: Tɛst lɛk MRI skan, CT skan, ɔ PET skan fɔ si if tumbu de.
• Blɔd tɛst ɛn urinalysis: Chɛk yu ɔmon lɛvɛl.
• Bayopsi: Dɛn kin du dis tɛst fɔ no if di tumbu gɛt kansa ɔ nɔ gɛt kansa ɛn fɔ gɛt di tisu sɛmpul dɛn.

Wetin na di stej dɛm fɔ adrenocortical carcinoma?

Dɔktɔ dɛn kin yuz kansa stej fɔ plan tritmɛnt ɛn no wetin fɔ ɛkspɛkt afta tritmɛnt (prognosis). di stej fכ adrenocortical carcinoma de ditarmin bay di saiz fכ di tכmכro, usay i de, εn if i dכn spre to di limf no dεm we de nia כ di כgan dεm we de fa.

Na di men stej dɛn ya:

• Stej I: di tכmכro na 5 sεntimita (lεk 2 inch) כ sכmכl. I nɔ dɔn skata na do na di adrenal gland.
• Stej II: di tכmכro big pas 5 sεntimita, bכt i nכ spre pas di adrenal gland.
• Stej III: di tכmכro dכn spre to di limf no dεm we de nia am.
• Stej IV: Di tכmכro dכn spre to di limf no dεm we de nia, כgan dεm we de nia, כ כgan dεm we de fa.

Sɔntɛnde, i kin tan lɛk se di tin dɛn we pɔsin kin no bɔt di stej we pɔsin gɛt kansa kin mek pɔsin kɔnfyus. So nɔ ɛva shem fɔ aks yu dɔktɔ fɔ mek i no yu klia wan. Dɔn bak, aks aw dis kin afɛkt yu sik.

Wetin na di tritmɛnt fɔ adrenocortical carcinoma?

Di tritmɛnt we dɛn kin yuz mɔ na we dɛn kɔl adrenalectomy , we dɛn kin du ɔpreshɔn fɔ pul wan ɔ ɔl tu di adrenal gland dɛn. Apat frɔm dat, bɔku tɛm dɔktɔ dɛn kin gi dɛn mɛrɛsin dɛn lɛk:

• Mitotan (Mitotan (Lysodren®)): we de na di bɔdi.Dis mɛrɛsin de wok bay we i de mek di adrenal gland dɛn nɔ wok fayn. Dis kin mek di kansa nɔ kam bak. Dɛn kin yuz dis mɛrɛsin afta dɛn dɔn pul wan adrenal gland, ɔ we dɛn nɔ ebul fɔ du ɔpreshɔn. Bikɔs dis mɛrɛsin de stɔp di ɔmon fɔ mek, pipul dɛn we de tek am fɔ tek ɔmon pils bak.
• Metyrapone (Metopiron®): Dɛn kin gi dis kayn mɛrɛsin fɔ ridyus di sayn dɛn we di ovaria dɛn de mek di ɔmon we pasmak.

Bɔt sɔm tɛm dɛn de, di tumbu kin tu big fɔ mek dɛn ebul fɔ pul am sef wan we dɛn no se i gɛt di sik. If dɛn kayn tin ya apin, dɔktɔ dɛn kin yuz kemotɛrapi . Pan ɔl we dis tritmɛnt nɔ kin ebul fɔ pul di kansa tɔŋ kpatakpata, i kin mek di sik nɔ bɔku ɛn i kin mek di tumbu nɔ gro kwik kwik wan.

Yu kin tink bak bɔt palliativ kia as pat pan yu tritmɛnt. Palliative care na wan kayn tritmɛnt wae de ɛp fɔ manej di simptom dɛm ɛn di sayd ɛfɛkt dɛm wae de kam wit tritmɛnt. Palliative care spɛshal pipul dɛn kin gi yu sɔpɔt bak pan saykilɔjik ɛn imɔshɔnal.

Wetin na de kɔmplikeshɔn ɔr sayd ɛfɛkt wae de kam wae pɔrsin gɛt tritmɛnt?

Ɔpreshɔn ɛn mɛrɛsin kin mek difrɛn prɔblɛm dɛn ɔ sayd ɛfɛkt dɛn. Fɔ ɛgzampul, ɔpreshɔn fɔ pul wan adrenal gland kin mek tin dɛn lɛk:

• di ifekt dεm pan di כmon prodakshכn: כltεm, di adrenal gland we de rεst de tek ova di wok we di gland we dεn pul de du εn prodyuz inof כmon dεm. Bɔt if dis nɔ apin, yu go nid fɔ tek ɔda ɔmon pil dɛn te di ɔda gland we lɛf fɔ mek ɔmon dɛn fayn fayn wan. Dɛn kin kɔl dis sik bak adrenal insufficiency .
• Infεkshכn: Infεkshכn kin apin na di bכdi כ na di say we dεn de du di כpεrayshכn.
• Blɔd we de kɔmɔt pasmak: Dis kin apin we dɛn de du di ɔpreshɔn ɔ afta dɛn dɔn du di ɔpreshɔn.

Wetin na di kɔmplikeshɔn ɔ sayd ɛfɛkt dɛm we di mɛrɛsin kin gɛt?

Yu dɔktɔ kin tɛl yu fɔ tek mitotane fɔ tu to fayv ia afta dɛn dɔn du di ɔpreshɔn. di sayd ifekt dεm we mitotane kin gεt kin inklud:

• Nɔs ɛn vɔmit
• Rɔnbɛlɛ
• Skin rash we de kɔmɔt na di skin
• Kɔnfyus

Wetin na di rεt dεm we de liv fכ adrenocortical carcinoma?

כlsay, 50% pan di pipul dεm we gεt adrenocortical carcinoma de alayv fayv ia afta dεn no di sik. Bɔt dis rit we pɔsin kin liv kin dipen pan bɔku tin dɛn. Fɔ ɛgzampul:

• Di stej we di kansa de di tɛm we dɛn no se i gɛt am.
• If di tumbu de wok (we de mek ɔmon) ɔ i nɔ de wok.
• yu ej.
• Yu ɔl wɛlbɔdi biznɛs.

di fayv ia sכvayv rεt bay stej na dis:

• Faz I: 81% .
• Faz II: 61% .
• Faz III: 50% .
• Stej IV: 13% .

Dɛn statystik ya kin mek yu fred ɛn wɔri. Dat na nɔmal tin. Bɔt mɛmba se dɛn statystik ya kɔmɔt frɔm ɛkspiriɛns we dɛn bin dɔn gɛt trade. Masta sabi pipul dεm de mεzj dεn rεt dεm ya we de liv εvri fayv ia. Bɔku tin kin chenj insay fayv ia, ɛn dɛn chenj dɛn de kin afɛkt di tin dɛn we kin apin. Dɔn bak, mɛmba se dɛn kayn we ya fɔ liv nɔto fɔ no aw lɔng yu go liv.

If yu gɛt patikyula kwɛstyɔn bɔt aw pipul dɛn kin liv wit kansa, tɔk to yu dɔktɔ. Na in na di bɛst tin fɔ yu, as na in no di tin we de apin to yu pas ɔlman.

Yu tink se dɛn kin mek dɛn nɔ gɛt adrenocortical carcinoma?

Nɔ, i nɔ rili pɔsibul fɔ avɔyd am. Risach pipul dεm no se lεk af pan di adrenocortical carcinoma dεm kin kכz fכ di mכtεshכn dεm na sכm jin dεm we kin mek di kεnsar sεl dεm bכku bכku εn fכm tכmכro. Bɔt dɛn nɔ no yet wetin kin mek dɛn chenj ya kin apin. So, dɛn nɔ kin ebul fɔ rɛkɔmɛnd we fɔ mek dɛn nɔ apin.

Bɔt sɔm tin dɛn we pɔsin kin gɛt frɔm in mama ɛn papa kin mek i gɛt dis sik. If yu gɛt famili histri bɔt dɛn sik ya, i go fayn fɔ tɔk to dɔktɔ ɛn lan bɔt aw fɔ tɛst yu jɛnɛtiks we go ebul fɔ no di chenj dɛn we de apin na yu jɛnɛtiks we de mek yu gɛt dɛn sik ya.

Aw a kin kia fɔ misɛf? (Aw a kin tek kia ɔf misɛf?)

Adrenocortical carcinoma na wan kansa we nɔ kin bɔku, bɔku tɛm i kin kam bak. Dɛn tu prɔblɛm ya kin mek yu fred, yu wan de fil, ɛn wɔri. Bɔt gud tin na dat, sɔm tin dɛn de we yu kin du fɔ ɛp:

• Fɛn sɔpɔt: Aks yu mɛdikal tim bɔt sɔpɔt grup fɔ pipul dɛm wae gɛt adrenocortical carcinoma. If yu spɛn tɛm ɛn tɔk to pipul dɛn we de go tru di sem tin dɛn we yu de gɛt, dat go ɛp yu.
• Tink bɔt di program dɛm fɔ sev frɔm kansa: Bɔrku pipul dɛm wae gɛt adrenocortical carcinoma kin frayd se di kansa go kam bak. Program dɛm fɔ sev frɔm kansa na wan tin fɔ ɛp fɔ dil wit da wɔri de.
• Kɔntinyu fɔ kia fɔ yusɛf: If yu gɛt kemotɛrapi afta dɛn dɔn du yu ɔpreshɔn, yu kin nid ɛp fɔ kɔntrol di sayd ɛfɛkt dɛn we di tritmɛnt gɛt.

Ustɛm a fɔ go to mi dɔktɔ?

Bɔku tɛm, adrenocortical carcinoma kin kam bak, mɔ insay di fɔs tu ia afta dɛn dɔn du di ɔpreshɔn. Yu dɔktɔ go schedul fɔ fala-ap apɔntin fɔ monitar fɔ sayn dɛm fɔ di sik we de kam bak. Fɔ ɛgzampul:

• Imej tɛst: Ɛvri tri mɔnt fɔ tu ia, dɔn ɛvri tri to siks mɔnt fɔ ɔda tri ia.
• Blɔd tɛst: Yu dɔktɔ go du blɔd tɛst ɔltɛm fɔ chɛk di ɔmon lɛvɛl.

Us kwɛstyɔn dɛn a fɔ aks mi dɔktɔ?

Adrenocortical carcinoma na wan sik we nɔ kin apin so ɔltɛm. Yu kin gɛt bɔku kwɛstyɔn dɛn bɔt wetin fɔ ɛkspɛkt. Na sɔm kwɛstyɔn dɛn we wi tink se go ɛp yu:

• Wetin i min we di tumbu de wok ɔ nɔ de wok?
• Di tumbu dɔn skata na do na mi adrenal gland? If na so i bi, aw fa?
• Us tritmɛnt opshɔn dɛn a gɛt?
• Wetin na di sayd ɛfɛkt dɛm we di tritmɛnt kin gɛt?
• A fɔ gɛt jenɛtik tɛst fɔ si if di jin chenj dɛn we kin mek a gɛt adrenocortical carcinoma na mi famili?
• If di tritmɛnt wok fayn, wetin na di chans fɔ mek di tumbu kam bak?

Adrenocortical carcinoma na wan kansa we nɔ kin apin so ɔltɛm, we kin afɛkt yu adrenal gland. I nɔ kin mek pɔsin gɛt ɛni sayn, ɛn dɛn kin no bɔku pipul dɛn we dɛn de du tɛst fɔ wan sik we rili difrɛn. Yu kin wɔri ɛn fred bɔt aw yu dɔn no bɔt yu sik ɛn de nyus se yu adrenocortical carcinoma kin kam bak afta yu dɔn trit yu.

If yu de fil se dis sik de mɔna yu, tek di tɛm we yu nid fɔ ɔndastand wetin de apin. Nɔ ɛva shem fɔ aks kwɛstyɔn bɔt di tritmɛnt dɛn ɛn aw dɛn go afɛkt yu. Yu dɔktɔ dɛn go ɔndastand wetin mek yu de gɛt sɔm tin dɛn we yu de du. Dɛn go de fɔ ansa yu kwɛstyɔn dɛn, frɔm we dɛn no di sik, te to tritmɛnt, ɛn fɔ fala yu fɔ lɔng tɛm.

Mɛsej we dɛn kin kɛr go na os

Pan ɔl we adrenocortical carcinoma na siriɔs sik, i impɔtant fɔ no bɔt am, go to di rayt dɔktɔ fɔ advays, ɛn aks fɔ sɔpɔt.

• Dis na kansa wae nɔr kin bɔrku: so nɔr pwɛl yu at wit di nem.
• Yu fɔ no bɔt di sayn dɛm: Wach yusɛf fɔ tin dɛm lɛk we yu bɛlɛ de at, we yu de gɛt bɔku bɔku bɔdi we nɔ kɔmɔn, ɛn we yu de chenj yu ɔmon.
• Go to dɔktɔ wantɛm wantɛm: If yu gɛt ɛni dawt, go to dɔktɔ ɛn chɛk yu.
• Tritmɛnt dɛn de: ɔpreshɔn, mɛrɛsin, kemotɛrapi, ɛn ɔda tin dɛn Yu dɔktɔ go disayd us tritmɛnt go fayn fɔ yu.
• Saikɔlɔjik sɔpɔt impɔtant: Nɔto yu wan de pan dis joyn. Tɔk to yu fambul dɛn, yu padi dɛn, ɛn sɔpɔt grup dɛn.

Mɛmba se ɔlman we sik difrɛn. Yu kɔndishɔn, yu tritmɛnt, ɛn aw yu de travul fɔ wɛl na difrɛn tin. Nɔ ɛva giv ɔp op. Wok klos wit yu mɛdikal tim ɛn aproch dis chalenj wit fayn abit.

Adrenocortical carcinoma, adrenal kansa, adrenal gland tumor, tumor we de prodyuz ɔmon, kɔtisol, aldosterone, adrenal ɔpreshɔn, mitotane