Yu ɔ sɔmbɔdi na yu famili gɛt at prɔblɛm? If na so, yu go mɔs bisin bɔt di mɛrɛsin dɛn we yu dɔktɔ gi yu ɔltɛm. We yu at fil taya smɔl, i rili impɔtant fɔ no ɔltɛm bɔt di mɛrɛsin dɛn we go ɛp am. Tide wi go tɔk bɔt wan nyu mɛrɛsin we dɔn sho se i rili fayn fɔ trit dis sik. Dat na ARNI.
Fɔ tɔk am simpul wan, wetin na ARNI?
ARNI na rili wan kɔmbaynshɔn fɔ tu drɔgs. I ful nem na Angiotensin Risɛptɔ/Neprilysin Inhibitor. Pan ɔl we di nem kin tan lɛk se i kɔmplikt smɔl, fɔ tru, i rili simpul. Dɛn mek am fɔ trit pipul dɛn we gɛt at prɔblɛm.
Di tu men tin dɛn we de insay dis mɛrɛsin na:
1. ARB (Angiotensin II Receptor Blocker): di drog ‘Valsartan’ de pan dis grup.
2. Neprilysin Inhibitor: Di drɔg ‘Sacubitril’ de pan dis grup.
Di onli ARNI drɔg we de naw na di wɔl we de jɔyn dɛn tu tin ya na Sacubitril/Valsartan . Dɛn bin gri fɔ dis insay 2015.
Aw dis mɛrɛsin de wok insay di bɔdi?
Okay, naw lɛ wi si aw dɛn tu mɛrɛsin ya togɛda kin ɛp yu at.
Tink bɔt di blɔd vesel dɛn na yu bɔdi lɛk paip dɛn we de kɛr wata. Sɔntɛnde, dɛn paip ya kin lɔk ɛn smɔl, ɛn dis kin mek i nɔ izi fɔ yu at fɔ pɔmp blɔd.
- Valsartan (ARB klas): Dis mɛrɛsin de wok bay we i de rilaks ɛn mek di blɔd vesel dɛn we dɔn smɔl. I tan lɛk se yu de mek paip we dɔn lɔk big. Dɔn di blɔd kin flɔ ɔlsay na di bɔdi ɛn nɔ gɛt ɛnitin fɔ ambɔg am. Dis kin mek di blɔd prɛshɔn go dɔŋ.
- Sacubitril (Neprilysin Inhibitor): Dis kin du sɔntin we impɔtant pas dat. Wi bɔdi kin mek ɔmon dɛn we kin ɛp wi at. Bɔt wan ɛnzaym we dɛn kɔl ‘Neprilysin’ de pwɛl dɛn gud ɔmon ya. Sacubitril de stɔp da bad ɛnzaym de fɔ mek i nɔ wok. We i stɔp, wi bɔdi kin:
- Put sɔdiɔm (sɔl) we nɔ nid fɔ kɔmɔt na di bɔdi tru di urine.
- Mek di blɔd vesel dɛn big.
- Prodyuz mכr urine εn ridyus di wata we pasmak na di bכdi.
Fɔ tɔk am simpul wan, we dɛn put dɛn tu mɛrɛsin ya togɛda, dat kin mek di at nɔ bɔku ɛn i kin mek i izi fɔ du am. I tan lɛk se yu gɛt tu ɔda pipul dɛn we kam fɔ ɛp pɔsin we de wok tranga wan.
Udat dɛn kin rɛkɔmɛnd ARNI fɔ?
Dis mɛrɛsin nɔto fɔ ɔlman. Yu dɔktɔ go disayd if dis mɛrɛsin fayn fɔ yu bay sɔm tin dɛn.
| Di wan dɛn we fit fɔ gɛt di wok | Tɔk bɔt |
|---|---|
| Fɔ di wan dɛn we gɛt ridyus at pɔmp abiliti | If dɛn jɔs dɔn no se yu gɛt At Fayla ɛn yu Ejection Fraction (EF) , we de mɛzhɔ di at in pɔmp efyushɔn, na 40% ɔ less (insay pɔrsin wae gɛt wɛl bɔdi, dis valyu de arawnd 55%-65%). |
| Fɔ di wan dɛn we de chenj frɔm ɔda mɛrɛsin dɛn | If yu dɔn ɔlrɛdi de tek ACE inhibitor ɔ ARB fɔ at pwɛl, yu kin chenj to ARNI insted. |
I rili impɔtant: If yu de chenj frɔm ACE inhibitor (e.g. Enalapril, Lisinopril) to ARNI, wet 36 awa afta yu dɔn stɔp di ACE inhibitor bifo yu stat di ARNI. If yu nɔ du dat, i kin mek yu gɛt wan denja alɛji (angioedema), we de swel ɔnda di skin. Yu dɔktɔ go advays yu bɔt dis.
Di bɛnifit dɛn we ARNI gɛt ɛn di rizin dɛn we mek yu fɔ yuz am
Bɔku pipul dɛn kin chenj to ARNI bikɔs ɔf di sayd ɛfɛkt dɛm, lɛk fɔ kɔf ɔltɛm, we kin kam wit ol mɛrɛsin lɛk ACE inhibitors. Bɔt nɔto dat nɔmɔ na di rizin. Bɔku bɛnifit dɛn de we pɔsin kin gɛt we i yuz ARNI.
- I de mek pipul dɛn liv lɔng: Stɔdi dɔn sho se dis mɛrɛsin de ridyus di risk fɔ day we gɛt fɔ du wit at sik.
- I de mek yu layf bɛtɛ: I de ridyus di sayn dɛm lɛk fɔ taya ɛn taya, ɛn ɛp yu fɔ wok fayn fayn wan.
- Kɔntrol di sik we de go bifo: I de slo di rεt we di at fεil de wɔs.
- I de ridyus di ɔspitul: Dɛn dɔn pruv se pipul dɛn we de tek dis mɛrɛsin nɔ kin gɛt bɔku ɔspitul fɔ dɛn at pwɛl.
- I de mek di at wok fayn: Wan stכdi sho se afta dεn tek ARNI fכ wan ia, di pasεnshכn in ejekshכn frakshכn inkrεs frכm avεj 28% to 38%. dis min se di hat in pawa fכ pכmp bכku bכku wan.
Akɔdin to wan big stɔdi, pipul dɛm wae de tek ARNI gɛt 20% ridyus risk fɔ day ɔr go na ɔspitul bikɔs ɔf at sik.
Udat nɔ fɔ yuz dis mɛrɛsin?
Dis mɛrɛsin nɔ fayn fɔ sɔm pipul dɛn. If yu de pan ɛni wan pan dɛn grup ya, dɔktɔ dɛn se yu nɔ fɔ tek dis mɛrɛsin.
| Pozishɔn | Rizin |
|---|---|
| Mama dɛn we gɛt bɛlɛ ɔ we de gi pikin in bɛlɛ | Na bikɔs i kin ambɔg di pikin. |
| Pipul wae bin dɔn gɛt angioedema bifo | If yu bin dɔn gɛt angioedema bifo tɛm, we na wan swel na yu fes ɔ yu lip, bikɔs ɔf wan ACE inhibitor ɔ ARB mɛrɛsin. |
| Di wan dɛn we dɔn ɔlrɛdi tek ACE inhibitor/ARB | I denja fɔ tek ɔl tu di mɛrɛsin dɛn togɛda. |
| Pipul wae gɛt siriɔs liva sik | Dis mɛrɛsin nɔ fayn if yu liva nɔ de wok fayn. |
| Pipul dɛn we de tek Aliskiren | I nɔ fayn fɔ tek ARNI if yu de tek Aliskiren wit dayabitis ɔ kidni sik. |
Lɛ wi lan bak bɔt di bad tin dɛn we kin apin to wi.
Lɛk ɛni mɛrɛsin, ARNI kin mek smɔl smɔl sayd ɛfɛkt dɛn. Bɔt, nɔto ɔlman kin gɛt dɛn.
- Lɔw blɔd prɛshɔn (Hypotension): Yu kin fil lɛk yu ed de tɔn ɛn yu ed layt.
- Di tin dɛn we kin apin to di kidni wok: Sɔm pipul dɛn kin gɛt smɔl smɔl we di kidni kin wok.
- di potashכm lεvεl we de go כp na di bכdi (Hyperkalemia): Dis kin apin bak pan sכm pipul dεm.
- Angioedema: Di fes, di lip, ɛn di tɔŋ kin swel. Dis nɔ kin apin so ɔltɛm , bɔt i kin rili denja if i apin.
Dis na di rizin we mek yu dɔktɔ go chɛk yu blɔd (fɔ chɛk yu kidni ɛn potashɔm lɛvɛl) ɛn blɔd prɛshɔn fɔ di fɔs wik dɛn we yu bigin fɔ tek dis mɛrɛsin. If ɛni prɔblɛm de, yu dɔktɔ go ridyus di doz ɔ tɛl yu wetin fɔ du. Nɔ ɛva stɔp fɔ tek dis mɛrɛsin if yu dɔktɔ nɔ advays yu.
Dɛn sayd ɛfɛkt ya kin dɔn insay tu wiks. If dɛn kɔntinyu fɔ du dat, tɛl yu dɔktɔ wantɛm wantɛm.
Ustɛm a fɔ go to dɔktɔ?
If yu gɛt ɛni wan pan dɛn sayn ya we yu de tek ARNI, mek shɔ se yu tɔk to yu dɔktɔ.
- Diziz we pɔsin kin gɛt ɔltɛm
- Layt ed we pɔsin kin gɛt
- Sɔntɛnde, i kin fɔdɔm
- di bכdi prεshכn we rili lכw (if di sistolik ridin dεn dכn dכn 90) .
Yu kin fred smɔl fɔ chenj to nyu mɛrɛsin we yu dɔn yus to ol wan. Bɔt fɔ lan bɔt nyu tritmɛnt dɛn we go wok fayn ɛn fɔ tɔk to yu dɔktɔ bɔt di gud ɛn bad tin dɛn we dɛn kin du, rili impɔtant fɔ yu wɛlbɔdi.
Mɛsej we dɛn kin kɛr go na os
- ARNI na wan saksesful, modna drɔg we dɛn mek wit tu drɔgs we dɛn jɔyn fɔ trit at pwɛl.
- Dis kin mek di blɔd vesel dɛn big, i kin pul sɔl ɛn wata we nɔ nid na di bɔdi, ɛn i kin mek di at nɔ bɔku.
- Dis mɛrɛsin de gi bɔku bɛnifit, lɛk fɔ liv lɔng, fɔ mek yu liv bɛtɛ layf, ɛn fɔ mek yu nɔ de na ɔspitul.
- Dis mɛrɛsin nɔ fayn fɔ uman dɛn we gɛt bɛlɛ, di wan dɛn we dɔn gɛt angioedema bifo, ɛn di wan dɛn we gɛt sɔm ɔda mɛrɛsin dɛn.
- Sɔm sayd ɛfɛkt lɛk diziz ɛn lɔw blɔd prɛshɔn kin apin. So, i impɔtant fɔ lɛ dɔktɔ de kia fɔ yu ɔltɛm.
- Nɔ ɛva bigin ɔ stɔp fɔ tek dis mɛrɛsin if yu nɔ gɛt dɔktɔ advays. If yu gɛt ɛni prɔblɛm, go to yu dɔktɔ wantɛm wantɛm.
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