Yu fil se yu bɔdi de fɛt yu frɔm insay? I kin bi di sik we dɛn kɔl Antisynthetase Syndrome!

Sɔntɛnde, yu kin fil lɛk se sɔntin de mɔna yu frɔm insay? I kin bi se yu jɔyn dɛn jɔs de at, yu kin fil smɔl fɔ blo, ɔ yu kin ivin notis sɔm smɔl chenj dɛn na yu skin. Nɔ jɔs dismis dɛn tin ya as sɔntin we de apin. Sɔntɛnde, wan mɔ kɔmplikɛt stori kin de biɛn dɛn. Tide wi go tɔk bɔt wan sik we nɔ kin bɔku, bɔt we pɔsin kin ebul fɔ manej we dɛn kɔl Antisynthetase Syndrome.

Wetin na di Antisynthetase Syndrome? Fɔ tɔk am simpul wan...

Antisynthetase Syndrome na wan sik we nɔ kin apin so ɔltɛm. Wetin kin apin pan dis na dat inflamɛns de ɔlsay na wi bɔdi, dat na, wan kɔndishɔn lɛk inflamɛns. Dis na rili wan sik we pɔsin kin gɛt we i de fɛt insɛf. Naw yu de aks wetin na ɔtoimyun sik.

Imajin, wi bɔdi gɛt wan imyun sistɛm . I tan lɛk ami we de protɛkt wi kɔntri. Di sɛl ɛn ɔgan dɛn we de na dis sistɛm de protɛkt wi frɔm jem, baktri, ɛn vayrɔs dɛn we de mek wi gɛt sik. Bɔt pan ɔtoimyun sik, dis difɛns sistɛm nɔ kin go fayn. i de tink se wi yon hεlty sεl dεm εn tisu dεm na "εnεmi" εn i de bigin fכ atak dεm. I tan lɛk se wi yon ami de atak wi yon os. Ivin dɔktɔ dɛn stil nɔ ebul fɔ no di rayt tin we mek dis kin apin.

Insay Antisynthetase Syndrome, wi imyun sistεm kin afekt dεn εria dεm ya na wi bכdi:

• Mɔsul dɛn
• Jɔyn dɛn
• Lɔng
• Kanda
• Blɔd vesel dɛn

Di tin we impɔtant pas ɔl na fɔ go to dɔktɔ if yu notis ɛni nyu jɔyn pen, chenj na yu skin, ɔ i nɔ izi fɔ blo, ɛn yu nɔ fɔ pe atɛnshɔn to am.

Aw dis sik nɔ kin bɔku?

Dis (Antisynthetase Syndrome) na sik we nɔ kin bɔku . I nɔ kin izi fɔ tɔk di rayt we ɔmɔs pipul dɛn gɛt am. Na bikɔs na smɔl pipul dɛn nɔmɔ dɛn kin ripɔt ɛvri ia. Sɔmtɛm, dɛn sayn ya kin tan lɛk de sayn dɛm fɔ ɔda sik dɛm, ɛn i kin go wae pɔrsin nɔr notis.

Wetin na di sayn dɛm wae de sho se yu gɛt Antisynthetase Syndrome?

Us sayn dɛm wae yu go gɛt go dipen pan aw yu imyun sistɛm de woke fayn fayn wan na yu bɔdi ɛn aw i de pwɛl am bad bad wan.

Bɔrku tɛm, pipul dɛm wae gɛt Antisynthetase Syndrome kin gɛt sɔm ɔda sik dɛm togɛda. Lɛ wi tek wan luk pan wetin dɛn bi:

• Mayosaytis: Dis na we di mɔsul dɛn kin gɛt inflamɛns fɔ lɔng tɛm. Dis kin mek di mɔsul dɛn pen ɛn wik.I kin apin. Imajin, yu fil so wik dat yu nɔ ebul ivin es yu an. Sɔntɛnde, di mɔsul dɛn na yu trot kin wik, ɛn dis kin mek i nɔ izi fɔ swɛla it ɛn drink. Wi kin kɔl dat disfagia .

• "Mechanic's hands": Dis no bi bit of strenj nem? Dis na di say we di skin na di an ɛn di sayd dɛn na di finga dɛn kin tik ɛn krak. I tan lɛk mɛkanik in an we de wok wit gris ɛn ɔyl ɔl di de.

• Intastitial lכng sik (ILD): Dis na we di tisu bitwin di sכm sכm εya sak dεm (alveoli) na wi lכng dεm εn di blכd vεsεl dεm we de rawnd dεm de pwεl. Dis kin mek yu nɔ ebul fɔ blo fayn (dyspnea) , yu kin kɔf dray , yu taya , ɛn yu nɔ kin fil fayn na yu chɛst . I tan lɛk se yu fɔdɔm dɔŋ wan stej.

• Polyarthritis: Dis na we fayv ɔ mɔ jɔyn dɛn kin afɛkt di sem tɛm. Dis kin mek di jɔyn dɛn pen, stif, ɛn swel . Yu kin fil stiff we yu wek na mɔnin.

• di tin we de apin to Raynaud (sεkɔndari Raynaud in sεndrכm): pan dis, di finga dεm εn di tכd dεm de chenj kכla (dεn de tכn blu, dεn de tכn blu, dεn de rεd) εn dεn de sכmtεm sכmtεm, spεshal wan we dεn de na kol. I tan lɛk se yu finga dɛn de go numb afta yu dɔn pul ays kiub na friza.

• Fiva: Sɔm pipul kin jɔs gɛt fiva we nɔ gɛt ɛni infekshɔn na dɛn bɔdi. dis min se di bכdi tεmprachכ de go כp bikoz fכ dis imyun sistεm aktiviti.

Wetin kin mek pɔsin gɛt Antisynthetase Syndrome?

Dɛn nɔ no yet di rayt tin we kin mek pɔsin gɛt dis sik . Bɔt dɔktɔ dɛn dɔn kam fɔ no se bɔku pipul dɛn we gɛt dis sik gɛt spɛshal kayn antibodi dɛn na dɛn blɔd. Dɛn antibodi ya de sho se dɛn imyun sistɛm de atak dɛn yon bɔdi instead fɔ protɛkt dɛn. wi kכl dεm (autoantibodies) , we min "sεlf-antibodies".

Naw, luk, antibodi na protin we de protɛkt wi we bad tin kam insay wi bɔdi. Dɛn tan lɛk kemikal signal dɛn we wi imyun sistɛm de yuz. dis antibodi dεm de mak bad bad invayda dεm lεk baktri dεm εn vayrus dεm as "dεnja." Bɔt if yu gɛt ɔtoimyun sik, yu imyun sistɛm kin mistek mek ɛn pul antibodi dɛn we de atak wɛlbɔdi tisu.

Pipul dεm we gεt Antisynthetase Syndrome kin gεt כtoantibodi dεm we de atak εnzym dεm we dεn kכ l tRNA synthetases . dis tRNA sεntez dεm na imכtant εn yusful εnzym dεm we wi bכdi nid fכ wok fayn fayn wan.

i stil bi mistiri wae mek wi imyun sistεm de stat fכ mek dεn כtoantibodi dεm ya. Bɔt if yu gɛt pruf fɔ dɛn ɔtoantibodi ya na yu blɔd, i go mɔs bi se yu gɛt Antisynthetase Syndrome.

I tan lɛk dis, imajin se sɔmbɔdi de bɔn faya krak bifo yu os. We yu luk am di nɛks mɔnin, faya krak ɛn rod dɛn we dɔn bɔn de skata ɔlsay na di grɔn. Sɔntɛm yu nɔ go no gud gud wan udat bin bɔn di fayakrɛk, ustɛm dɛn bɔn am, ɔ wetin mek. Bɔt pruf de fɔ se na dat apin. Insay Antisynthetase Syndrome, insted ɔf di nɔys we yu kin yɛri we yu bɔn faya krak ɛn di dɔg dɛn kin fred, yu kin gɛt di sayn dɛm we wi bin dɔn tɔk bɔt.

Udat de pan denja fɔ gɛt dis sik?

Ɛnibɔdi kin gɛt Antisynthetase Syndrome. Bɔt uman ɛn pipul dɛn we dɔn pas 50 ia kin gɛt dis sik. Uman dɛn kin gɛt dis sik lɛk tu tɛm pas man dɛn.

Aw dɛn kin no se pɔsin gɛt Antisynthetase Syndrome?

Dɔktɔ kin no dis sik bay di sayn dɛn we yu gɛt, we dɛn de chɛk yu bɔdi, ɛn sɔm ɔda tɛst dɛn.

Yu go nid fɔ go to dɔktɔ we spɛshal pan sik dɛn we pɔsin kin gɛt we i de fɛt insɛf, we dɛn kɔl rεumatɔlɔjis . I go chɛk yu ɛn aks yu bɔt di sayn dɛn we yu gɛt. Yu go nid fɔ tɛl di dɔktɔ wetin na yu sik, ustɛm yu fɔs notis dɛn, ɛn if ɛnitin de mek dɛn wɔs.

Apat frɔm dat, yu go nid fɔ du bɔku tɛst fɔ no se yu gɛt Antisynthetase Syndrome ɛn fɔ pul ɔda tin dɛn we kin mek yu gɛt di sem kayn sik.

Us tɛst dɛn kin yuz fɔ no di sik?

Dis nɔto wan tɛst we kin rili kɔnfɔm di diagnosis. dis kin bi pat pan wan prכsεs we dεn k כl difrεnt diagnosis . Dis min se yu dɔktɔ go du bɔku tɛst fɔ no wetin de mek yu gɛt di sik, fɔ pul ɔda sik dɛn, ɛn dɔn fɔ no se yu gɛt Antisynthetase Syndrome. Sɔm pan di tɛst dɛn we yu kin gɛt na:

• Blɔd tɛst: Fɔ chɛk aw yu imyun sistɛm de wok ɛn fɔ si if yu gɛt ɔtoantibodi, we na sayn fɔ Antisynthetase Syndrome. Blɔd tɛst kin chɛk bak fɔ si if sɔm ɛnzaym dɛn we kin kɔmɔt na di blɔd dɔn go ɔp we di mɔsul dɛn dɔn pwɛl.
• Urinalysis: Fɔ chɛk aw di kidni de wok ɛn fɔ chɛk fɔ si if infɛkshɔn ɔ ɔda prɔblɛm dɛn de na di urine we kin mek yu gɛt di sik.
• Pulmonary function tests: Chɛk fɔ si if yu lɔng ɔ yu respiratory system dɔn afɛkt.
• Kɔmpyuta tomografi (CT) skan ɔ ɔda imej tɛst: Tek pikchɔ fɔ di tisu ɛn ɔgan dɛn we de insay di bɔdi.
• (Ilektromayografi - EMG): .Chek di we aw di mɔsul dɛn de wok.
• wan magnεtik rεsכnans imej (MRI) skan fכ di mכsul dεm we dεn afekt: fכ chεk fכ inflameshn.
• Bayɔpsi na tɛst we dɛn kin tek wan smɔl pat pan di mɔsul ɔ di lɔng tisu.

Aw dɛn kin trit di Antisynthetase Syndrome?

Nɔr mɛrɛsin nɔr de fɔ Antisynthetase Syndrome. Bɔt yu dɔktɔ kin ɛp yu fɔ fɛn ɔda tritmɛnt dɛn we go ɛp yu fɔ kɔntrol yu sik dɛn, fɔ ridyus di impak we dɛn kin gɛt pan yu ɛvride layf, ɛn fɔ mek yu ɔgan dɛn nɔ pwɛl bɛtɛ.

De kayn tritmɛnt wae yu nid go dipen pan usai yu sik de ɛn aw dɛn kin tranga. Na sɔm pan di tritmɛnt dɛn we dɛn kin yuz mɔ:

• Kɔtikosterɔyd: Dɛn mɛrɛsin ya na mɛrɛsin dɛn we dɛn kin gi pɔsin we kin mek pɔsin nɔ fil pen ɛn nɔ swel. Dɔktɔ dɛn kin gi kɔtikosterɔyd wit mɛrɛsin dɛn we dɛn kɔl immunosuppressants.
• Immunosuppressants: Dɛn mɛrɛsin ya de wok bay we dɛn de stɔp yu imyun sistɛm fɔ atak di wɛlbɔdi sɛl ɛn tisu dɛn. Di kayn mɛrɛsin we yu nid go dipen pan us ɔgan dɛn go afɛkt. di mכst kכmכn imyun supεrshכn dεm na mεthotrexate, azathioprine, εn mycophenolate . Yu kin nid sayklofosfamid, rituximab, ɔ takrolimus bak .
• Tritmɛnt fɔ Interstitial Lung Disease (ILD): Dɛn kin gi yu mɛrɛsin fɔ mek i izi fɔ yu fɔ blo, ɔ ɔksijɛn tɛrapi if yu nid ɛkstra ɔksijɛn. Yu go nid fɔ wok wit dɔktɔ we de mɛn yu pulmon fɔ mɛn yu prɔblɛm dɛn we yu gɛt fɔ blo.
• Fizik tritmɛnt: Pɔsin we de mɛn yu bɔdi kin ɛp yu fɔ mek yu bɔdi ebul fɔ muv fayn fayn wan. Dɛn kin ɛp fɔ kɔntrol di sik dɛn we gɛt fɔ du wit di mɔsul dɛn ɔ dɛn kin tɛl yu fɔ du ɛksɛsayz fɔ blo fɔ mek yu lɔng dɛn strɔng. Yu kin nid bak fɔ gɛt pulmonary rehab .

Wetin kin apin if a gɛt Antisynthetase Syndrome?

Yu dɔktɔ kin ɛp yu fɔ fɛn ɔda tritmɛnt dɛn we go ebul fɔ kɔntrol yu sik dɛn.

Antisynthetase Syndrome na wan sik we nɔ de mɛn . Dis min se yu go gɛt fɔ kɔntrol di sayn dɛm fɔ lɔng tɛm (i kin bi yu ɔl yu layf).

Yu tink se (Antisynthetase Syndrome) kin kil pɔsin?

Antisynthetase Syndrome nɔ kin kil pɔsin . Bɔrku tɛm, de layf wae pipul dɛm wae gɛt dis sik kin gɛt nɔr kin afɛkt bɛtɛ. Bɔrku pipul dɛn kin liv wit dis sik fɔ di res ɔf dɛn layf, bɔt dɛn kin kɔntrol dɛn sik wit tritmɛnt.

Bɔt if yu gɛt siriɔs intastitial lɔng sik ɔ ɔda prɔblɛm we de afɛkt yu respiratory system, i kin kil yu. Bɔt i rili rare. Yu dɔktɔ go tɛl yu wetin fɔ ɛkspɛkt, ɛn wetin kin chenj di sayn dɛm we kin bi di fɔs sayn dɛm fɔ siriɔs prɔblɛm wit yu briz.

A kin mek a nɔ gɛt di sik we dɛn kɔl Antisynthetase Syndrome?

No we nɔ de fɔ mek yu nɔ gɛt Antisynthetase Syndrome, bikɔs masta sabi pipul dɛn nɔ rili shɔ wetin de mek i gɛt am ɔ wetin de mek di sik bɔku.

Ustɛm a fɔ go to dɔktɔ?

If yu gɛt nyu sayn dɛn, mɔ if dɛn de wɔs, go to dɔktɔ . If yu fil lɛk se dɛn nɔr de kɔntrol yu sik dɛn fayn lɛk aw dɛn bin de kɔntrol yu tritmɛnt, ɔr if yu sik de mek i nɔr izi fɔ du yu ɛvride woke, tɔk to yu dɔktɔ.

Ustɛm a fɔ go na di imejensi rum?

If yu gɛt ɛni wan pan dɛn sik ya, go na di imejensi rum wantɛm wantɛm ɔ kɔl 911 (ɔ yu lokal imejensi nɔmba) :

• I nɔ kin izi fɔ yu fɔ blo wantɛm wantɛm.
• Bɔrku shɔt briz (fɔ fil lɛk yu nɔr ebul fɔ blo).
• Blu kɔlɔ na di skin, lip, ɔ finga nel (cyanosis).
• Chɛst de pen ɔ we i ebi.

Us kwɛstyɔn dɛn a fɔ aks mi dɔktɔ?

• A gɛt Antisynthetase Syndrome ɔ ɔda ɔtoimyun sik?
• Us kayn tɛst dɛn a go gɛt fɔ du?
• Wetin na di bɛst tritmɛnt fɔ kɔntrol mi sik?
• A go nid fɔ gɛt fizik tritmɛnt ɔ fɔ mek a ebul fɔ blo fayn?
• Aw a de pan risk fɔ gɛt siriɔs lɔŋ kɔmplikeshɔn?

Wetin na ɔda nem dɛm fɔ Antisynthetase Syndrome?

Sɔntɛnde, dɔktɔ dɛn kin kɔl Antisynthetase Syndrome wit ɔda nem dɛn. Fɔ ɛgzampul:

• (Antisintɛtaz dɛfisiɛns sindrom) .
• (AS sindrom) we gɛt di sik.
• (Anti-Jo1 sindrom) we gɛt di sik.

Dis ɔl na difrɛn nem fɔ di sem kɔndishɔn.

Fɔ dɔn, wetin fɔ mɛmba (Take-Home Message) .

Antisynthetase Syndrome na wan sik wae nɔr kin bɔrku wae yu imyun sistɛm kin atak yu bɔdi instead fɔ protɛkt yu. Tɔk to yu dɔktɔ bɔt di tritmɛnt dɛm wae go ɛp fɔ mek yu nɔr gɛt bɛtɛ impak pan yu ɛvride layf.

Fɔ liv wit ɔtoimyun sik kin rili mek yu at pwɛl – e kin fil lɛk se yu bɔdi de tif yu. If yu nid ɛp fɔ ajɔst to di chenj dɛm na yu layf ɔr fɔ bia wit de sik, aks yu dɔktɔ bɔt aw fɔ gɛt kɔyl fɔ yu maynd wɛl bɔdi. Fɔ fil sɔri ɛn pwɛl hat na nɔrmal tin, bɔt yu nɔr nid fɔ go tru am yu wan.

`Antisynthetase Syndrome, ɔtoimyun sik, myositis, intastitial lכng sik, Raynaud in fεnomen, כtoantibodi, joyn pen, mכsul wik