Yu blɔd kin klot izi wan? Lɛ wi lan bɔt Antithrombin Deficiency!

Ivin if smɔl wund de na wi bɔdi, di blɔd kin stɔp afta sɔm tɛm ɛn di blɔd kin klɔt, nɔto so? I rili wɔndaful fɔ mek wi bɔdi protɛkt insɛf. Bɔt if dis blɔd klɔt de bɔku pas aw i nid, ɔ if blɔd klɔt fɔm insay di bɔdi fɔ natin? Dɔn i kin bi prɔblɛm. Tide wi go tɔk bɔt wan spɛshal rizin we kin mek blɔd klɔt we nɔ nid fɔ de. Dat na Antithrombin Deficiency , sɔm pipul dɛn kin kɔl am bak Antithrombin III Deficiency.

Wetin rili na Antithrombin Deficiency?

Fɔ tɔk am simpul wan, we wi nɔ gɛt antithrombin na wan sik we gɛt fɔ du wit di we aw wi blɔd de klɔt. insay dis, di protin we dεn kכl antithrombin, we na wan imכtant tin na wi bכdi we de mek blכd kכlכt pasmak, de dכn, כ i nכ de wok fayn.

Tink bɔt am dis we. Yu de ful bathtub wit wata. Sɔmbɔdi fɔ ɔf di pɔt bifo i ful-ɔp, ɔ ɔl di wata go rɔn kɔmɔt. na so, we wi bכdi bigin fכ kכlכt, na dis tin we dεn kכl antithrombin de "stכp" am na jכs di rayt tεm, we de mek i nכ apin tu mכch. So, if yu nɔ gɛt inof antithrombin na yu bɔdi, ɔ if i nɔ de wok fayn, yu kin gɛt blɔd we kin kɔntinyu fɔ apin, lɛk we di bathtub de ful-ɔp. Dis na di rizin we mek yu de pan risk fɔ gɛt abnɔmal blɔd klɔt .

Pipul dεm we gεt dis kכndyushכn kin de pan risk fכ divεlכp blכd kכlכt na di dip vein dεm na di leg (`Deep Vein Thrombosis` כ `DVT`) εn di risk fכ blכd kכlכt brok εn stכk na wan vein na di lכng (`Pulmonary Embolism` כ `PE`) . Dɛn tin ya kin rili denja.

Aw dis sik kin kɔmɔn?

Antithrombin Deficiency na rili wan tin we nɔ kin apin so ɔltɛm . Dɛn se na wan pan ɛvri 2,000 to 3,000 pipul dɛn nɔmɔ gɛt am. Dat nɔ min se i nɔ kin apin to ɔlman.

Wetin na di sayn dɛm wae de sho se yu nɔr gɛt antithrombin?

Nɔto ɔlman wae gɛt dis sik go gɛt di sem sayn. Sɔm pipul dɛn nɔ kin gɛt ɛni sayn atɔl. Bɔt bɔku tɛm, di fɔs blɔd we kin klɔt kin apin bifo i ol 40 ia .

De sayn dɛm wae dɛn kin si mɔr na:

• Dip Vein Thrombosis (DVT): Dis kin mek di leg swel, i kin rεd, i kin at, εn i kin fil wam we yu tɔch am.
• Pulmonary Embolism (PE): Dis kin mek yu nɔ blo fayn wantɛm wantɛm, yu de fil pen na yu chɛst (espɛshali we yu de blo), yu kin blo kwik kwik wan, yu kin kɔf (sɔntɛnde wit blɔd), ɛn yu nɔ kin blo fayn. Dis na wan sik wae nid fɔ gɛt tritmɛnt kwik kwik wan.

Apat frɔm dɛn tin ya, pan ɔl we i nɔ kin apin so ɔltɛm, na di bren veins , ɔ na di bɛlɛ veinsI pɔsibul fɔ mek blɔd klɔt.

Wetin mek dis antithrombin dɛfisiɛns kin apin?

Bɔrku tɛm, de kɔz fɔ dis sik na jenɛtik , we min se na sɔntin we wi kin gɛt frɔm wi mama ɛn papa.

• Jin Mכtεshכn: Antithrombin Dεfisiεns de apin pan pipul dεm we gεt mכtεshכn (chεnj) na di jin we dεn kכl `SERPINC1`. dis jin de instrakt di bכdi fכ mek antithrombin.
• Inheritance: Yu kin gɛt dis jin muteshon frɔm ɛni wan pan di mama ɔ papa. If na so, yu gɛt 50% chans fɔ gɛt di sik. I nɔ mata if na gyal pikin ɔ na bɔy pikin. כltu, pikin dεm we gεt dis jin mכtεshכn frכm dεn tu mama εn papa nכ kin liv. Dis nɔ kin apin so ɔltɛm.

Di impɔtant tin na dat nɔto ɔlman we gɛt dis jin muteshɔn kin gɛt blɔd klɔt. Sɔm pipul dɛn kin liv dɛn wan ol layf ɛn nɔ gɛt ɛni prɔblɛm.

Aw dɔktɔ dɛn kin no dis?

If yu gɛt dɛn kayn sik ya, ɔr no se pɔrsin na yu famili gɛt dis sik, i go fayn fɔ mek yu go to dɔktɔ ɛn chɛk yu. Bɔku tɛm, di dɔktɔ go du dɛn tin ya:

• Fɔ ɛgzam fɔ yu bɔdi: Dɛn go chɛk yu bɔdi.
• Mɛdikal histri: Dɛn go aks yu bɔt yu sik ɛn if ɛnibɔdi na yu famili dɔn gɛt dis kayn prɔblɛm.
• Blɔd tɛst: Di tin we impɔtant pas ɔl na fɔ mek yu gɛt spɛshal blɔd tɛst we de chɛk di lɛvɛl we di antithrombin de na yu blɔd.

Dɛn tɛst ya na di wangren we fɔ kɔnfɔm if dis kɔndishɔn de ɔ nɔ de.

Wetin yu de du as tritmɛnt?

Di tritmɛnt dipen pan if yu gɛt blɔd we de klɔt ɔ yu nɔ gɛt.

• If yu gɛt blɔd we de rɔtin: Yu dɔktɔ go disayd fɔ bigin yu fɔ tek wan mɛrɛsin we de mek yu blɔd tan . Dis kin bi warfarin (yu kin dɔn yɛri bɔt am as Coumadin). Dis kin tek sɔm mɔnt, ɔ i kin tek ɔl in layf.
• If yu nɔ ɛva gɛt blɔd klɔt: Ivin if yu nɔ gɛt antithrombin, if yu nɔ ɛva gɛt blɔd klɔt, bɔku tɛm yu nɔ nid fɔ kɔntinyu fɔ tek blɔd tin fɔ mek yu blɔd tan. Bɔt sɔm tɛm dɛn (fɔ ɛgzampul, bifo dɛn du big ɔpreshɔn) dɛn kin gi dɛn fɔ shɔt tɛm.
• we uman bεlε: biכs bitwin 3% εn 50% pan di bεlε uman dεm we gεt dis kכndyushכn kin gεt bכdi we dεn bεlε, di dכkta kin disayd fכ gi injεkshכn fכ wan mεdisin we dεn kכl `Heparin` fכ mek blכd kכlכt nכ fכm insay da tεm de.

Aw a fɔ kia fɔ misɛf? (We dɛn de gɛt tritmɛnt)

If yu de tek blɔd tin dɛn lɛk Warfarin ɔ Heparin, i rili impɔtant fɔ tek di mɛrɛsin jɔs lɛk aw yu dɔktɔ tɛl yu.Dɔn bak, mek shɔ se yu go na ɛni apɔntinmɛnt we yu gɛt wit di dɔktɔ.

Bikɔs dis mɛrɛsin kin mek yu blɔd kɔmɔt, yu dɔktɔ fɔ chɛk ɔltɛm if yu de tek di rayt doz. Dɛn kin yuz blɔd tɛst lɛk di `Prothrombin Time` (PT) tɛst fɔ chɛk if di doz fɔ Warfarin kɔrɛkt.

If yu kɔntrol di mɛrɛsin fayn fayn wan dis we, yu go ebul fɔ mek di blɔd nɔ klɔt we de mek yu gɛt prɔblɛm ɛn yu go mek yu nɔ gɛt blɔd we nɔ nid fɔ kɔmɔt.

Wetin a go du fɔ mek a nɔ gɛt bɔku blɔd?

If yu nɔ gɛt antithrombin, bɔku tin dɛn de we yu kin du fɔ mek yu nɔ gɛt bɔku blɔd:

• Nɔ tek bɔn kɔntrol pils: mɔ di wan dɛn we gɛt ɛstrojen. Tɔk to yu dɔktɔ bɔt dis.
• Nɔ tek ɔmon tritmɛnt: Sɔm ɔmon tritmɛnt dɛn we dɛn kin tek afta yu dɔn menɔpauz kin mek yu gɛt mɔ prɔblɛm bak.
• Nɔ de na di sem pozishɔn fɔ tu lɔng: Ɛspɛshali we yu de travul fɔ lɔng tɛm ɔ we yu de wok na wan ples fɔ tu lɔng, grap at le ɛvri tu awa ɛn waka rawnd smɔl ɛn shek yu leg.
• Nɔ smok ɛn yuz tin dɛn we dɛn kin yuz fɔ smok: If yu smok, i kin rili ambɔg yu blɔd vesel ɛn i kin mek yu blɔd klɔt bad bad wan.
• Mek yu gɛt wɛl bɔdi wet: Fɔ fat na ɔda tin we kin mek yu blɔd klɔt.

Apat frɔm dat, tin dɛn lɛk big big trauma, ɔpreshɔn, bɛlɛ, bɔn pikin, ɛn ol kin mek yu blɔd klɔt bak. If yu nid fɔ du ɔpreshɔn ɔ yu de wet fɔ bɔn pikin, tɛl yu dɔktɔ bɔt yu sik. I kin gi yu spɛshal antithrombin kɔnsɛntret as injɛkshɔn we dɛn kin put insay yu bɛlɛ (IV), if nid de.

Yu tink se we de fɔ mek dis tin nɔ apin?

Bɔt i sɔri fɔ no se bikɔs na tin we pɔsin kin gɛt frɔm in jɛnɛtiks, no we nɔ de fɔ mek dɛn nɔ gɛt di antithrombin we dɛn kin gɛt frɔm dɛn mama ɛn papa . Wi nɔ go ebul fɔ chenj di jin dɛn we wi gɛt frɔm wi mama ɛn papa. Bɔt tin dɛn de we wi kin du fɔ mek wi nɔ gɛt bɔku blɔd.

Wetin fɔ ɛkspɛkt if yu gɛt antithrombin dɛfisiɛns?

Na lɛk wan pan ɔl tri pipul dɛm wae gɛt dis sik go gɛt blɔd we dɛn big.

• Ɔpreshɔn ɛn nɔ ebul fɔ muv: If yu de du ɔpreshɔn ɛn yu nɔ de muv fɔ lɔng tɛm (e.g., if yu fɔ de na bed), yu gɛt ay risk fɔ mek yu blɔd klɔt.
• We pɔsin de ol: Dis risk kin go ɔp smɔl bak we pɔsin de ol.
• Bɛlɛ: Pipul dɛn we nɔ gɛt antithrombin kin gɛt abnɔmal blɔd we dɛn gɛt bɛlɛ ɔ afta dɛn bɔn pikin, so dɛn fɔ pe spɛshal atɛnshɔn to dis.

Aw lɔng dis tin go las?

Bikɔs na jenɛtik kɔndishɔn, dɛn bɔn yu wit am. Na sɔntin we de las fɔ yu layf. Dat min se dɛn nɔ go ebul fɔ mɛn am ɔltogɛda. Bɔt, if yu manej am fayn, yu kin liv wit bɔku prɔblɛm dɛn.

Wetin na di lukin-grɔn fɔ dis sityueshɔn?

Di we aw yu de si tin dipen pan if yu dɔn gɛt blɔd klɔt ɔ yu nɔ gɛt blɔd. If yu tek mɛrɛsin we de mek yu blɔd tan, dat kin ɛp fɔ mek ɔda blɔd klɔt nɔ kam. Bɔt i impɔtant fɔ tek di mɛrɛsin jɔs lɛk aw yu dɔktɔ tɛl yu, di rayt doz, ɛn fɔ di rayt tɛm.

Wetin a fɔ tek tɛm mɔ bɔt?

If yu gɛt antithrombin dɛfisiɛns, i impɔtant fɔ no di wɔnin sayn dɛm fɔ `DVT` (blɔd klɔt na di leg) ɛn `PE` (blɔd klɔt na di lɔng) so dat yu go gɛt ɛp kwik kwik wan.

• DVT simptom dɛm: swel, pen, rɛd, ɛn wam we yu tɔch wan leg (bɔku tɛm na jɔs wan).
• Di sayn dɛm fɔ PE: I nɔ kin blo wantɛm wantɛm, i kin pen na in chɛst (we kin wɔs we i de blo), i kin blo kwik kwik wan, i kin shɔt fɔ blo, i kin kɔf (sɔntɛnde wit blɔd).

If yu de tek mɛrɛsin we de mek yu blɔd tan (e.g. Warfarin), no bɔt dɛn tin ya bikɔs i kin mek yu blɔd kɔmɔt:

• Tek tɛm bad bad wan we yu de yuz shap wɛpɔn dɛn (naif, reza, ɛn ɔda tin dɛn) .
• Nɔ du spɔt dɛn we kin mek pɔsin wund (e.g. rɔgbi, bɔksin) as yu ebul. If nɔto dat, wɛr di rayt tin fɔ protɛkt yusɛf.
• If di blɔd nɔ stɔp ivin frɔm wan simpul wund, ɔ if yu gɛt brus fɔ natin, tɛl yu dɔktɔ.

Ustɛm a fɔ go to di dɔktɔ?

If yu tink se yu gɛt DVT, go to dɔktɔ wantɛm wantɛm. I impɔtant fɔ trit DVT kwik, bikɔs blɔd we de klɔt na di leg kin brok ɛn travul go na di lɔng, we kin mek yu gɛt PE.

If yu de tek mɛrɛsin lɛk Warfarin, tɛl yu dɔktɔ wantɛm if yu fɔdɔm ɔ if yu gɛt blɔd we nɔ kɔmɔn (e.g., frɔm yu nos, yu gam, ɔ yu stɔl).

Ustɛm yu nid fɔ go na di Imejɛnsi Tritmɛnt Yunit (ETU) ?

If dis kayn tin apin , yu fɔ go na ɔspitul in Imejɛnsi Tritmɛnt Yunit (ETU) wantɛm wantɛm :

• If yu gɛt sayn dɛm fɔ `Pulmonary Embolism (PE)` (lɛk fɔ shɔt briz wantɛm wantɛm, pen na yu chɛst).
• Wetin yu go du if yu tink se yu gɛt DVT , bɔt yu nɔ ebul fɔ tɔk to yu dɔktɔ?
• If yu de tek blɔd tina, if yu nak yu ed, if yu de vɔmit blɔd, ɔ if yu nɔ ebul fɔ stɔp fɔ blɔd we yu gɛt wund.

Dis na imejensi we kin mek pɔsin in layf de pan denja, so nɔ de delay.

Wetin na di impɔtant kwɛstyɔn dɛn we a fɔ aks mi dɔktɔ?

Wae yu no se yu gɛt dis sik, yu kin aks yu dɔktɔ kwɛstyɔn dɛn lɛk dis:

• A nid fɔ tek Warfarin ɔ ɔda tin we de mek blɔd tan? Aw lɔng a nid fɔ tek am?
• I fayn fɔ mek dɛn du ɔda pipul dɛn na mi famili (mama ɛn papa, mi brɔda ɛn sista dɛn, pikin dɛn) fɔ tɛst fɔ si if dɛn gɛt Antithrombin Deficiency?
• Us ɛgzampul dɛn a kin du sef wan wit dis sik?
• Ɛni spɛshal tin dɛn de we a fɔ no bɔt bifo a gɛt bɛlɛ?

Aks kwɛstyɔn dɛn lɛk dɛn wan ya so dat yu go ɔndastand di tin we de apin to yu.

Fɔ dɔn, tin dɛn we yu nid fɔ mɛmba (Take-Home Message) .

Bikɔs Antithrombin Deficiency na wan jenɛtik kɔndishɔn, wi nɔ go ebul fɔ kɔntrol am. Bɔt if yu no bɔt dis sik ɛn du di tin dɛn we yu nid, yu go ebul fɔ liv fayn layf.

Di tin we impɔtant pas ɔl na fɔ mek yu ɛn yu famili no di wɔnin sayn dɛm fɔ DVT ɛn PE so dat if sɔntin nɔ go fayn, yu go no am kwik ɛn go fɛn tritmɛnt kwik kwik wan.

If yu kɔntrol yu wet, de du tin (ɛksɛsayz ɔltɛm), ɛn avɔyd fɔ smok, dat go ɛp yu fɔ mek yu nɔ gɛt bɔku blɔd we yu nɔ want. Dis we ya, yu kin kɔntrol di impak we dis sik kin gɛt pan yu layf te to sɔm mak. Tɔk to yu dɔktɔ ɔltɛm ɛn fala in advays gud gud wan. Nɔ wɔri, nɔto yu wan de!

` antithrombin dεfisiεns, bכdi we de kכlכt, DVT, pulmonary embolism, jεnεtik sik dεm, bכdi tin dεm, wכfarin, hεparin