Di mɛrɛsin we yu de gi yu vayrɔs nɔ de wok? Lɛ wi tɔk bɔt Antiviral Resistance!

"Oh mai God, dokta, i luk laik se dis flu medisin no de wok rait nau..." Maybe yu don tink dat tu, no bi so? Ɔ sɔntɛm yu dɔn yɛri yu padi ɔ fambul tɔk dat. Sɔm vayral infɛkshɔn kin de, ɛn afta sɔm tɛm di mɛrɛsin we dɛn kin gi fɔ dɛn nɔ kin wok. Tide wi go tɔk bɔt sɔntin we dɛn kɔl antiviral resistance . Dis kin tan lɛk se na kɔmplikɛt wɔd, bɔt i simpul fɔ ɔndastand.

Wetin na Antivayrɔs Rɛsistɛns?

Fɔ tɔk am simpul wan, antivayrɔs rɛsistɛns na we wan vayrɔs stɔp fɔ ansa to wan antivayrɔs mɛrɛsin we wi de gi am. Tink bɔt am lɛk natin pikin we nɔ de lisin to di mɛrɛsin. Wetin kin apin na dat di vayrɔs kin chenj in nature. Dɔn di mɛrɛsin we bin de wok bifo nɔ kin ebul fɔ kɔntrol di vayrɔs igen, ɔ in ifɛkt kin ridyus bad bad wan. I rili at fɔ trit wan vayrɔs we dɔn evolv fɔ mek i nɔ ebul fɔ tek dis mɛrɛsin.

Dis antivayrɔs rɛsistɛns na pat pan wan big tɔpik. Dat na di antimaikrobial rɛsistɛns . I min se nɔto jɔs vayrɔs, bɔt baktri, parasayt, fɛns, ɛn ɔda tin dɛn, kin bigin fɔ nɔ ansa di mɛrɛsin dɛn we dɛn mek fɔ trit dɛn. I tan lɛk ɛnimi we de ayd pan wɛpɔn we de tray fɔ kil dɛn ɛn fɛn nyu we fɔ protɛkt insɛf.

Wetin na di mɛrɛsin dɛn we dɛn kin yuz fɔ fɛt di vayrɔs? Aw dɛn kin wok?

Naw yu kin de wɔnda, wetin na dɛn antivayrɔs mɛrɛsin ya ? Dis na di kayn mɛrɛsin wae wi kin yuse fɔ trit sik ɛn infekshɔn wae sɔm infɛkshɔn vayrɔs kin kam wit. Na sɔm ɛgzampul dɛn ya:

• Influenza, ɔ as wi kin kɔl am, di flu.
• Hɛpis we de na di bɔdi.
• Human Imyunodeficiency Virus, ɔ HIV .

Insay sɔm vayrɔs, lɛk HIV ɛn hεpi, dɛn antivayrɔs mɛrɛsin ya kin ridyus di chans fɔ mek di sik go to ɔda pipul dɛn. Dɔn bak, sɔmtɛm if yu sɔprayz ɔ no fɔ tru se yu dɔn gɛt wan vayrɔs, yu kin tek dɛn antivayrɔs mɛrɛsin ya ivin if yu nɔ sik.

Okay, naw mek wi si aw dis mɛrɛsin de wok.

We vayrɔs kam insay wi bɔdi, i de go insay wi wɛlbɔdi sɛl dɛn ɛn yuz dɛn sɛl dɛn de fɔ mek kɔpi fɔ insɛf, we min se di vayrɔs patikyula dɛn de bɔku. Wi kɔl dis di vayrɔs we de riplikɛt . Antivayrɔs mɛrɛsin dɛn de wok bay we dɛn de stɔp di vayrɔs fɔ mek kɔpi fɔ insɛf.

Wan we we dɛn drɔgs ya de fɛt di vayrɔs na fɔ blok di vayrɔs fɔ ebul fɔ go insay wi sɛl dɛn, ɔ fɔ atak wan sɛl. Tink bɔt am, vayrɔs nid ‘os’ fɔ liv ɛn infɛkt. Da os de na wi sɛl dɛn. So, if i nɔ ebul fɔ go insay da os de, di vayrɔs nɔ go ebul fɔ bɔku.

Wetin mek dɛn vayrɔs ya kin bi pɔsin we nɔ ebul fɔ tek drɔgs?

Dis na di pɔynt we impɔtant pas ɔl. Antivayrɔs drɔgs de ridyus di vayrɔs we de na wi bɔdi, dat na di vayral lod . Bɔt bɔku tɛm di vayrɔs nɔ kin dɔn kpatakpata, i kin de na di bɔdi. So, if yu nɔ tek di mɛrɛsin jɔs lɛk aw di dɔktɔ tɛl yu, fɔ ɛgzampul, if yu mis di mɛrɛsin sɔm dez, ɔ if yu stɔp fɔ tek di mɛrɛsin bifo di dɔktɔ tɛl yu fɔ tek am, wetin go apin? Di vayrɔs kin bigin fɔ bɔku bak.

As di vayrɔs de bɔku, chenj kin apin na di vayrɔs in jɛnɛtik mek-ap . Wi kɔl dis fɔ chenj chenj . I tan lɛk se pɔsin de chenj in apia.

If di vayrɔs chenj tumɔs da we de, di antivayrɔs mɛrɛsin we dɛn bin dɔn yuz trade nɔ go ebul fɔ no dis nyu vayrɔs vayriet, dat na di vayrɔs we difrɛn . Na da tɛm de di vayrɔs kin ebul fɔ bia wit di mɛrɛsin. Afta dat, di mɛrɛsin nɔ go ebul fɔ stɔp di vayrɔs fɔ ambɔg am.

Sɔntɛnde, fɔ no rizin, wan vayrɔs kin nɔ ebul fɔ ansa di mɛrɛsin dɛn we bin de wok fayn bifo. Dɛn kɔl dis spontan resistance . I tan lɛk se di vayrɔs disayd wantɛm wantɛm se, "A nɔ go gɛt dis drɔg."

Udat dɛn de pan denja mɔ?

Dis risk nɔr kin bi di sem fɔ ɔlman. Sɔm pipul dɛn kin gɛt ay risk fɔ gɛt antivayrɔs rɛsistɛns .

• Pipul wae gɛt krɛse sik , lɛk HIV, genital herpes, hepatitis B, ɔ epatitis C, kin gɛt bɔrku risk bikɔs dɛn kin tek antivayral mɛrɛsin fɔ lɔng tɛm. Mɛmba se we yu kɔntinyu fɔ tek di sem mɛrɛsin, di vayrɔs kin gɛt mɔ tɛm fɔ adap to am ɛn fɛn we fɔ fɛt am.
• Dɔn bak, pipul dɛn we gɛt prɔblɛm wit dɛn imyun sistɛm . Fɔ ɛgzampul, pipul dɛn we gɛt ɔtoimyun sik , di wan dɛn we dɛn dɔn transplant dɛn ɔgan , ɔ di wan dɛn we de gɛt kansa tritmɛnt lɛk kemotɛrapi kin gɛt mɔ risk. Bikɔs dɛn bɔdi in natura l ebul fɔ fɛt sik dɔn ridyus, di vayrɔs kin izi fɔ chenj ɛn i kin ebul fɔ bia wit di drɔgs.

Yu tink se vayrɔs dɛn we nɔ de tek drɔgs kin pas?

Yɛs, i sɔri fɔ no se dis na tru.Vayrɔs dɛn we nɔ de fɛt di vayrɔs kin kɔmɔt frɔm wan pɔsin to ɔda pɔsin. Wi kin kɔl dis kɔndishɔn transmitted drug resistance . Imajin se sɔmbɔdi dɔn ɔlrɛdi gɛt wan kayn vayrɔs we nɔ ebul fɔ tek wan mɛrɛsin. Dɛn kin transmit da vayrɔs de to ɔda pɔsin tru di chenj we dɛn de chenj di wata we de na di bɔdi lɛk swɛlin, saliva, ɛn blɔd. If yu gɛt bɛlɛ, yu pikin kin gɛt dɛn vayrɔs ya we nɔ de tek drɔgs bak we i de bɔn pikin.

Di prɔblɛm wit dis transmitted resistance na dat ivin if yu nɔ ɛva yuz di antiviral drug we dɛn de tɔk bɔt, di vayrɔs kin stil resistant to dat drug we yu gɛt di sik. If dat apin, yu dɔktɔ go gɛt fɔ tray ɔda mɛrɛsin dɛn we de fɛt di vayrɔs.

Aw yu kin no di vayrɔs dɛn lɛk dis?

If yu gɛt infekshɔn lɛk HIV, yu kin du blɔd tɛst fɔ si if yu gɛt antivayrɔs rɛsistɛns . Tu men kayn dɛn de:

• Jεnotaypik antirεtroviral rεsistεns tεst (GART): Dis de luk fכ chenj dεm na di HIV jin dεm we de mek i rεsistεnt to drog. I tan lɛk we yu de chɛk di DNA fɔ di vayrɔs fɔ si if ɛni chenj de we ‘drɔg-rɛsistant’ de insay.
• Fεnotaypik antirεtroviral rεsistεns tεst: Dis de mכsu aw di HIV strayn de rεspכnd to difrεn kכnsantreshכn dεm fכ antivayral dεm. Dat min se, i de luk aw di vayrɔs de rɛsist to ɛni doz fɔ di mɛrɛsin.

Nɔto dis nɔmɔ, bɔt ɔganayzeshɔn dɛn lɛk di Wol Ɛlth Ɔganayzeshɔn (WHO) ɛn di Sɛntral fɔ Kɔntrol Sik (CDC) de yuz blɔd tɛst bak fɔ si if vayrɔs dɛn lɛk flu ɛn COVID-19 de kam fɔ bi pɔsin we nɔ de tek drɔgs.

Aw dɛn kin trit di vayrɔs dɛn we nɔ de tek drɔgs?

If wan vayrɔs sho sayn dɛm fɔ se i nɔ ebul fɔ tek di mɛrɛsin, yu dɔktɔ kin inkrisayz di doz ɔ chenj yu to difrɛn antivayrɔs mɛrɛsin. Bɔt, smɔl tritmɛnt dɛn de we dɛn dɔn gri fɔ fɔ sɔm vayrɔs dɛn.

Sɔm pipul dɛm wae gɛt krɛse sik , lɛk HIV, wae kin mek dɛn layf de pan denja, kin tek tu antivayral mɛrɛsin di sem tɛm. Dɛn kɔl dis kɔmbayn tɛrapi . Dɛn kin du dis bikɔs i nɔ kin izi fɔ mek wan vayrɔs gɛt rɛsistɛns to ɔl tu di mɛrɛsin dɛn di sem tɛm. Dɔn, wan mɛrɛsin kin ɛp fɔ kɔntrol di vayrɔs.

Wi go ebul fɔ protɛkt wisɛf frɔm dis kayn tin?

Yɛs, di bɛst we fɔ mek yu nɔ gɛt antivayrɔs na fɔ tek di mɛrɛsin jɔs lɛk aw yu dɔktɔ tɛl yu, di rayt tɛm, ɛn fɔ di ful tɛm. Dis rili impɔtant.

Yu kin du am na yu fon.Set wan mɛmba fɔ tek yu mɛrɛsin di sem tɛm ɛvride. Aks yu dɔktɔ wetin fɔ du if yu mis wan doz. Yu go nid fɔ tek am jɔs afta yu mɛmba.

Antivayrɔs mɛrɛsin na wan pan di men tin dɛm we wi gɛt fɔ kɔntrol di vayral infɛkshɔn dɛm we kin mek pɔsin in layf de pan denja. Dɛn mɛrɛsin ya kin stɔp di vayrɔs fɔ bɔku ɛn mek i gɛt sɔm sayn dɛm.

So, if yu nɔ tek di mɛrɛsin jɔs lɛk aw yu dɔktɔ tɛl yu, di vayrɔs kin bi aktif bak ɛn bɔku. As i de bɔku, di vayrɔs kin chenj ɛn di mɛrɛsin we yu de tek nɔr kin woke. If yu gɛt antivayrɔs rɛsistɛns , yu dɔktɔ kin gɛt fɔ chenj di mɛrɛsin ɔ di doz. So, i impɔtant fɔ fala yu dɔktɔ in instrɔkshɔn dɛn ɛksaktɔli.

Sɔm tin dɛn fɔ mɛmba insay shɔt (Take-Home Message)

Okay, so lɛ wi sɔma sɔm pan di impɔtant pɔynt dɛn frɔm wetin wi dɔn tɔk bɔt so dat yu go mɛmba dɛn izi wan:

• Antivayrɔs rɛsistɛns na we wan vayrɔs kin bi rɛsistɛns to di mɛrɛsin dɛn we dɛn gi am.
• Di men rizin fɔ dis na fɔ nɔ tek di mɛrɛsin jɔs lɛk aw di dɔktɔ tɛl yu, fɔ di ful tɛm.
• Dis risk kin pasmak fɔ pipul dɛm wae gɛt lɔng tɛm infekshɔn lɛk HIV, hεpi, ɛn epataytis, ɛn fɔ di wan dɛm wae gɛt wik imyun sistɛm.
• Wan vayrɔs we nɔ de tek drɔgs kin pas frɔm wan pɔsin to ɔda pɔsin.
• Di bɛst we fɔ mek dis nɔ apin na fɔ fala yu dɔktɔ in instrɔkshɔn dɛn di rayt we. I impɔtant fɔ tek di mɛrɛsin di rayt tɛm, di rayt doz, ɛn fɔ di rayt tɛm.
• If yu gɛt ɛni kwɛstyɔn ɔ dawt bɔt mɛrɛsin, mek shɔ se yu tɔk to yu dɔktɔ.

A op se dis infɔmeshɔn go yusful to yu. Stay wit wɛlbɔdi!

` Antivayral Resistans, Antivayral Drug, Vayral Infɛkshɔn, HIV, Influenza, Drug Resistance, Drug Resistance