Yu bɔdi de pwɛl yu yon rɛd blɔd sɛl dɛn? Na dis na wetin yu nid fɔ no bɔt Autoimmune Hemolytic Anemia (AIHA)!

Sɔntɛnde, yu kin fil taya ɛn taya fɔ natin? Sɔntɛm yu skin dɔn tɔn smɔl smɔl ɔ yɔlɔ. Sɔntɛnde, yu nɔ kin ebul fɔ no wetin mek dis de apin, nɔto so? Wan rizin fɔ dɛn sik ya kin bi yu bɔdi in yon imyun sistɛm, di sojaman dɛn we de protɛkt yu frɔm sik dɛn, we de atak yu yon rɛd blɔd sɛl dɛn. Na dat wi kin kɔl `Autoimmune Hemolytic Anemia` (AIHA) na mɛrɛsin. Fɔ tɔk am simpul wan, yu bɔdi in difɛns sistɛm de mistek yu yon rɛd blɔd sɛl dɛn as "ɛnimi" ɛn pwɛl dɛn. Pan ɔl we dis na siriɔs tin smɔl, dɛn kin ebul fɔ mɛn am fayn if dɛn trit am fayn . Bɔt if dɛn nɔ trit am, i kin mek pɔsin in layf de pan denja. So, i rili impɔtant fɔ no bɔt dis ɛn go to dɔktɔ kwik kwik wan. Lɛ wi tɔk mɔ bɔt dis.

Wetin na `Ɔtoimyun Ɛmolaytik Anemia` (AIHA)?

Fɔ tɔk am simpul wan, `Autoimmune Hemolytic Anemia` (AIHA) na wan sik we yu imyun sistɛm mistek fɔ no yu yon rɛd blɔd sɛl dɛm as "fɔrin," we min sɔntin we de ambɔg di bɔdi. Dis dɔn mek yu bɔdi de mek antibodi dɛn we de pwɛl di rɛd blɔd sɛl dɛn. Dɛn antibodi dɛn ya kin atak di rɛd sɛl dɛn ɛn pwɛl dɛn. Wetin kin apin da tɛm de? Di nɔmba fɔ di rɛd blɔd sɛl dɛn na yu bɔdi kin go dɔŋ. Na dat wi kin kɔl "anemia."

Imajin, wetin de hapun hia na laik di ami we de protekt wi kontri, mistek atak wi oun sitizin. Dis na rili kɔmplikɛt smɔl, bɔt i nɔ at fɔ ɔndastand.

Wetin na di difrɛns bitwin praymari ɛn sɛkɔndari AIHA?

Tu men kayn AIHA de dipen pan aw i kin apin.

• Praymari AIHA: Sɔntɛnde, AIHA kin divɛlɔp witout ɛni klia ɔndalayn mɛdikal kɔndishɔn. Dis min se dɔktɔ dɛn nɔ kin ebul fɔ no wetin mek i kam wantɛm wantɛm. Dɛn kɔl dis praymari AIHA.
• Sɛkɔndari AIHA: Wan ɔda kayn AIHA na we AIHA kin kam wit ɔda kɔndishɔn. Fɔ ɛgzampul, i kin kam bikɔs ɔf sɔm vayral infɛkshɔn, ɔtoimyun sik (we di bɔdi in imyun sistɛm kin atak in yon tisu dɛm), sɔm mɛrɛsin dɛm, ɔ wan ɔndalayn blɔd kansa lɛk limfoma.

Wetin na di men kayn AIHA?

Tu men kayn AIHA de. Dɛn na ``Wɔm ɔtoimyun ɛmolaytik anemia`` ɛn ``Kɔl ɔtoimyun ɛmolaytik anemia`` . Dɛn kin sheb dɛn tin ya akɔdin to di kayn antibodi dɛm we de insay di sik. Dat min se di nem kɔmɔt frɔm di tɛmpracha we di antibodi dɛn we de atak di rɛd blɔd sɛl dɛn kin wok.

Wam ɔtoimyun ɛmolaytik anemia

Dis na di kayn AIHA we kɔmɔn pas ɔl. na ya, di antibodi dεm we di tכp `IgG` de tay pan rεd bכdi sεl dεm. di spεshal tin na dat dεn antibodi dεm ya de aktv na wi bכdi in nכmal tεmprachכ (i.e., insay "wכm" envayroment). Bɔrku tɛm, di sayn dɛm kin bigin fɔ sho smɔl smɔl, fɔ sɔm wiks. Bɔt sɔm tɛm, di sayn dɛn kin tranga ivin insay sɔm dez.

Kol ɔtoimyun ɛmolaytik anemia

Dis kayn we dɛn kin si pan 10% to 20% pan di AIHA pasɛnt dɛn nɔmɔ. i involv wan kayn כtoantibodi we dεn kכl `IgM`. dis כtoantibodi dεm de tay pan rεd bכdi sεl dεm we yu bכdi de na tεmprachכ we lכw pas yu bכdi in kכr tεmprachכ, we dεn kכl ``kol''. Dis ``kol'' tεmprachכ kin difrεn frכm pכsin to pכsin. Dis min se fɔ sɔm pipul dɛn, dɛn antibodi ya kin wok we dɛn kol smɔl, ɛn fɔ ɔda pipul dɛn, dɛn kin nid fɔ kol pasmak.

Udat dɛn kin afɛkt mɔ pan dis AIHA kɔndishɔn?

AIHA kin divɛlɔp pan ɛnibɔdi, ilɛksɛf na in ej ɔ if na man ɔ uman. Bɔt dis sik kin mɔs pan uman dɛn we dɔn pas 40 ia .

Pan ɔl we i kɔmɔn, AIHA na wan sik we nɔ kin apin so ɔltɛm . I kin afɛkt lɛk wan ɔ tu pipul dɛn pan ɛvri ɔndrɛd tawzin ɛvri ia.

Wetin na di sayn dɛm fɔ AIHA?

AIHA kin mek yu gɛt difrɛn kayn sayn dɛm. Sɔm kin rili kɔmɔn, ɔda wan dɛn kin difrɛn difrɛn wan bay di kayn AIHA we yu gɛt.

Na sɔm kɔmɔn sayn dɛn ya:

• Fiva
• Ekstrim taya (tu taya fɔ du ɛnitin fayn) .
• Wik
• Di at we de blo
• I nɔ kin izi fɔ yu fɔ blo (ivin if yu tray smɔl) .
• Pale skin (lɛk we yu gɛt lɔw blɔd prɛshɔn) .
• Jaundice (we di skin ɛn di yay dɛn de yɔlɔ) .
• Ɛd we de at (ed we de at) .
• Mɔsul dɛn kin pen
• Dak urine (lɛk ti wata) .
• Vɔmit ɛn nɔs
• Shot we yu de blo
• Rɔnbɛlɛ
• Injury na yu tɔng
• Palpitations (fɔ fil yu at de bit sote yu kin yɛri am) .

Mɛmba se, fɔ gɛt wan ɔ tu pan dɛn sik ya nɔ min se yu gɛt AIHA. Bɔt if dɛn sik ya kɔntinyu, i go fayn fɔ mek yu go to dɔktɔ.

Di sayn dɛm kin difrɛn, mɔr lɛk di kayn AIHA:

Dɛn kin si wam AIHA mɔ pan:

• Taya
• Diziz we pɔsin kin gɛt
• Jaundice (we di skin de yɔlɔ) .
• Fɔ fil di at bit

Kol AIHA kin mek yu gɛt sɔm kayn sik lɛk:

• Taya
• Diziz we pɔsin kin gɛt
• An ɛn fut kol (dɛn kin fil kol pas ɔda pipul dɛn) .
• Jandis we gɛt di sik
• Chɛst de pen
• Pen na di bak pat pan di leg dɛn
• Raynaud in sik (na wan sik we di finga dεm εn di fut dεm kin tכn wayt/blu εn nכm we dεn de kכl) .
• Blu diskɔlɔreshɔn na di an ɛn fut
• At bit irɛgyulariti `(Aritmia)`
• Fɔ yɛri wan at de grɔmbul
• At nɔ de wok fayn (dis kin bi pan siriɔs kes dɛm) .

Wetin na di tin dɛn we kin mek pɔsin gɛt AIHA?

Na lɛk af pan ɔl di wan dɛn we gɛt AIHA (lɛk 50%), dɛn nɔ kin ebul fɔ no di rayt tin we mek dɛn gɛt AIHA . wi kכl dis ``idiopathic autoimmune hemolytic anemia.'' Dat min se "dεn nכ no di kכz."

Insay di ɔda haf, AIHA gɛt fɔ du wit ɔda mɛrɛsin dɛn.

Ɔda mɛrɛsin dɛn we kin mek pɔsin gɛt AIHA na:

Bɔku ɔtoimyun sik dɛn de we kin mek pɔsin gɛt sɛkɔndari AIHA. Dat min se, ɔda sik dɛn we di bɔdi in imyun sistɛm kin atak di bɔdi in yon wɛlbɔdi sɛl dɛn.

• Lupus : Dis na sik we kin afɛkt difrɛn ɔgan sistɛm dɛn, lɛk di skin, jɔyn, kidni, ɛn bren.
• Rimatɔyd at : Na wan sik we kin mɔs afɛkt di jɔyn dɛn, we kin mek pɔsin fil pen ɛn swel.
• Sjogren’s syndrome : Dray yay ɛn mɔt na di men sayn dɛm.
• Tayroyd sik : Imbalans na di tayroyd ɔmon.
• Ulcerative colitis : Inflameshɔn ɛn ɔlsa na di kɔlon.
• Hashimoto in sik : Na wan sik we di imyun sistεm de atak di tayroyd gland.

Sɔntɛnde, AIHA kin kam bak bikɔs ɔf wan vayral infɛkshɔn . Bɔt bɔku tɛm dis anemia kin bɛtɛ wans di vayral infɛkshɔn dɔn dɔn. Sɔm vayrɔs dɛm wae kin gɛt fɔ du wit AIHA na:

• Epstein-Barr vayrɔs (di vayrɔs we de mek pɔsin gɛt mononucleosis) .
• Mizɛl
• Mumps we de mek pɔsin gɛt bɔdi
• Rubɛla we de na di wɔl
• Nyumonia we nɔ kin apin
• Varicella virus, we kin mek pɔsin gɛt chukchuk
• `HIV`
• Epataytis (vayrɔs dɛn we kin afɛkt di liva spɛshal wan) .
• Saytomegalovayrɔs `(Saytomegalovayrɔs)`

Sɔm mɛrɛsin dɛn kin mek pɔsin gɛt AIHA bak. If dɛn tink se na wan mɛrɛsin we yu de tek de mek yu gɛt di sik, yu dɔktɔ kin stɔp di mɛrɛsin.

• Antibayɔtik (espɛshali penisilin) ​​.
• Nכnstεroyd anti-inflammatory drog dεm (NSAID) (e.g. ibuprofen) .
• Drug dɛn we de agens kansa

Aw dɛn kin no se pɔsin gɛt AIHA?

If yu dɔktɔ tink se yu gɛt sayn dɛn we de sho se yu nɔ gɛt blɔd, dɛn go ɔda fɔ mek dɛn kɔnt yu blɔd kɔmplit wan (CBC) . Dis kin no di sayn dɛm we de wɔn pɔsin fɔ gɛt anemia. Speshal, dis tɛst de mɛzhɔ:

• Ɔmɔs rɛd blɔd sɛl, wayt blɔd sɛl, ɛn pletlɛt de na yu blɔd.
• Di sayz fɔ yu rɛd blɔd sɛl dɛn (big, smɔl, nɔmal).
• εmoglobin lεvεl - Dis na di protin we de insay yu bכdi we de kכri כksijεn כlsay na yu bכdi.
• εmatokrit valyu (aw bכku spεs yu rεd bכdi sεl dεm de tek na yu bכdi).

Ɔda tɛst dɛm wae kin ɛp fɔ no if yu gɛt AIHA

If yu dɔktɔ tink se yu nɔ gɛt bɛtɛ blɔd, i go tɛl yu fɔ du sɔm ɔda tɛst dɛn. Dɛn tɛst ya kin ɛp fɔ no if di anemia na AIHA ɔ ɔda tin.

• Peripheral smear: Dis na fɔ tek wan sɛmpul pan yu blɔd ɛn luk am ɔnda maykroskɔp. Dis kin luk fɔ tin dɛn lɛk if yu rɛd blɔd sɛl dɛn dɔn pwɛl ɔ dɛn dɔn chenj dɛn shep.
• rεtikulכsayt kכnt: Dis tεst de mכsu di nכmba fכ yכng (nyu fכ fכm) rεd bכdi sεl dεm na yu bכdi. Mɛmba se we di rɛd blɔd sɛl dɛn dɔn pwɛl, di bon mɛro kin bigin fɔ mek mɔ rɛd blɔd sɛl dɛn fɔ tek dɛn ples. dis de mek di rεtikulכsayt kכnt inkrεs.
• Bilirubin test: We dɛn pwɛl di rɛd blɔd sɛl dɛn, dɛn kin mek wan tin we dɛn kɔl bilirubin. We dis kin bɔku, di jaundice (di skin kin yɔlɔ) kin apin. So, if di bilirubin we de na di blɔd bɔku, dat na sayn fɔ sho se di rɛd blɔd sɛl dɛn de brok.
• Coombs in test: Dis na wan rili impɔtant tɛst fɔ no AIHA. I de chɛk fɔ si if yu bɔdi de mek antibodi dɛn we de agens di rɛd blɔd sɛl dɛn.
• Haptoglobin test: Haptoglobin na wan protin we de pul di dɔti tin dɛn we de na di rɛd blɔd sɛl dɛn we dɔn pwɛl. We bɔku rɛd blɔd sɛl dɛn dɔn pwɛl, di bɔdi kin yuz bɔku pan dis haptoglobin. dis kin mek di lεvεl fכ haptoglobin na di bכdi de dכn.
• Laktat dihaydrojenεz (LDH): LDH na εnzym we de insay rεd bכdi sεl dεm. we dεn dכn pwεl di rεd bכdi sεl dεm, dis LDH εnzym de kכmכt insay di bכdi. Dis kin mek di LDH lɛvɛl go ɔp.
• Kol agglutinin tayta: If yu dɔktɔ sɔspɛkt kol AIHA, i kin ɔda dis tɛst. dis de mכsu di lεvεl fכ di antibodi dεm we de atak di rεd bכdi sεl dεm we kol tεmprachכ.

Aw dɛn kin trit AIHA?

We dɛn de trit AIHA, di fɔs tin we dɛn kin du na fɔ no if ɛni ɔndalayn kɔz de we dɛn kin trit. Fɔ ɛgzampul, if yu AIHA gɛt fɔ du wit lupus, yu dɔktɔ go mɔs trit di lupus fɔs. If di tin we kin mek pɔsin gɛt AIHA na wan sik lɛk lymphoma, i impɔtant fɔ trit da sik de. If wan mɛrɛsin de mek yu gɛt AIHA, yu kin nid fɔ stɔp fɔ tek da mɛrɛsin de.

Bɔt fɔ sɔm pipul dɛn, AIHA nɔ kin rili saful.. Dat min se di sayn dɛm nɔr kin so bad. Da tɛm de, i nɔ go nid fɔ gɛt ɛni tritmɛnt.

Di mɛrɛsin dɛn we dɛn kin yuz

• Kɔtikosterɔyd: Dɛn kin bi di fɔs layn tritmɛnt fɔ AIHA. Dɛn mɛrɛsin ya kin wok bay we dɛn de stɔp yu bɔdi in imyun sistɛm, ɛn dis kin mek i nɔ pwɛl yu rɛd blɔd sɛl dɛn.
• Immunosuppressants: If kɔtikosterɔyd nɔmɔ nɔ go du fɔ kɔntrol di sik, yu dɔktɔ kin gi yu dɛn kayn mɛrɛsin ya. dis dεm de wok bay we dεn de stכp di imyun sistεm fכ atak di bon mכro.

Splenectomy (ɔpareshɔn fɔ pul di spleen) .

If dɛn nɔ ebul fɔ kɔntrol AIHA wit mɛrɛsin nɔmɔ, yu go nid fɔ mek dɛn du ɔpreshɔn fɔ pul yu splin. di splin na wan כgan na wi bכdi we de filta di rεd blɔd sεl dεm we nכ de nכmal, lεk di rεd bכdi sεl dεm we gεt antibodi dεm we de atak dεm. di splin gεt sεl dεm bak we de mek antibodi dεm. So if yu pul di splin, dat kin mek yu nɔ pwɛl di rɛd blɔd sɛl dɛn ɛn i kin mek yu nɔ gɛt bɔku blɔd.

Blɔd transfyushɔn

If AIHA rili bad , di wan dɛn we sik kin nid fɔ tek blɔd, we na blɔd we dɛn kin tek frɔm ɔdasay. Dis kin mek di nɔmba fɔ di rɛd blɔd sɛl dɛn bɔku kwik kwik wan ɛn ɛp fɔ kɔntrol di sayn dɛm.

Di tritmɛnt fɔ ‘wam’ ɛn ‘kol’ AIHA difrɛn?

Yes, di tritmɛnt fɔ praymari ‘kol AIHA’ difrɛn frɔm ‘wɔm AIHA’.

Dɛn kin yuz kɔtikosterɔyd ɔ imyunosuprɛsiv drɔgs fɔ ‘wɔm AIHA’. If dat nɔ wok, i kin nid fɔ du ɔpreshɔn fɔ pul di splin. If dɛn gɛt siriɔs anemia, dɛn kin tek blɔd transfyushɔn bak as sɔpɔt tritmɛnt we dɛn de trit di sik.

Bɔt ‘kol AIHA’ nɔ de ansa fayn to kɔtikosterɔyd ɔ splinɛktɔmi. If ‘kol AIHA’ nɔ tu, dɛn kin kɔntrol di sik bay we dɛn de kip di bɔdi wam (e.g., yuz han/fut wam, wɛr glɔv, sɔks, ɛn sɔntɛm fɔ travul go na say we wam). If tritmɛnt nid fɔ de, di drɔg `Rituximab` (sɔntɛnde wit ɔda imyunosuprɛsant drɔgs) na di fɔs layn tritmɛnt.

Yu tink se dɛn kin ridyus di risk fɔ gɛt AIHA?

Awtoimyun Ɛmolaytik Anemia nɔ kin ebul fɔ stɔp ɔltɛm. Sɔntɛnde, i kin apin fɔ no rizin. Bɔt if yu gɛt vayral infɛkshɔn ɔ yu de tek mɛrɛsin we dɛn no se gɛt fɔ du wit AIHA, yu dɔktɔ kin wach yu kɔndishɔn ɛn ɛp fɔ ridyus yu risk fɔ gɛt di sik.

AIHA na siriɔs kɔndishɔn?

Sɔntɛnde, Autoimmune Hemolytic Anemia kin so smɔl dat yu nɔ go nid ɛni tritmɛnt. Bɔt sɔntɛnde, i kin so bad dat yu go nid fɔ du ɔpreshɔn ɔ tek blɔd. If dɛn no se yu gɛt AIHA, yu dɔktɔ kin tɔk to yu bɔt aw yu sik bad ɛn di tritmɛnt we yu go pik.

Di tin we impɔtant pas ɔl na dat, AIHA kin kil pɔsin if dɛn nɔ trit am, na dat mek i impɔtant fɔ mek dɛn du mɛrɛsin kwik kwik wan.

Yu tink se dɛn kin mɛn AIHA?

Yɛs. Bɔrku pipul dɛm wae gɛt AIHA nid smɔl tritmɛnt ɔr nɔr nid tritmɛnt. Bitwin 20% ɛn 30% pan di sik pipul dɛn nid mɛrɛsin, ɔpreshɔn, ɔ blɔd transfyushɔn.

Ustɛm a fɔ go to dɔktɔ?

If yu bigin fɔ gɛt sɔm sayn dɛm fɔ lɛ yu nɔ gɛt blɔd – lɛk fɔ taya pasmak, fɔ wik, fɔ gɛt janda (yu skin de yɔlɔ), ɔ fɔ gɛt prɔblɛm fɔ blo – go to dɔktɔ wantɛm wantɛm . If yu gɛt diagnosis ɛn tritmɛnt kwik, yu kin wɛl kwik ɛn kam bak to yu nɔmal layf.

Fɔ sɔmtin (Tek-Home Message) .

Autoimmune Hemolytic Anemia (AIHA) na wan sik wae yu yone imyun sistεm de atak yu rεd blɔd sεl dεm, we kin mek yu gɛt anemia.

• Di sayn dɛm kin bi smɔl ɔr kin tranga. Taya, paleness, jaundice, ɛn i nɔ kin izi fɔ blo na di men tin dɛn.
• Di tin dɛn we kin mek i apin kin difrɛn. Sɔmtɛm dɛn nɔ kin fɛn ɛni kɔz (primary), sɔmtɛm i kin kam wit ɔda sik, infɛkshɔn, ɔ mɛrɛsin (sɛkɔndari).
• Bɔku tritmɛnt dɛn de we yu kin gɛt. Dɛn tin ya na fɔ tek mɛrɛsin, fɔ pul di splin, ɛn fɔ gi blɔd. Di tritmɛnt dɛn kin difrɛn difrɛn wan bay di kayn ‘wɔm’ ɛn ‘kol’.
• Pan ɔl we AIHA na sik we pɔsin kin rili ebul fɔ kɔntrol , i kin rili bad, ivin i kin mek pɔsin in layf de pan denja , if dɛn nɔ trit am.

So, if yu gɛt dɛn sik ya, nɔ panik ɛn nɔ delay, bɔt go to dɔktɔ. Yu dɔktɔ kin du di tɛst dɛn we yu nid, no di sik we yu gɛt kɔrɛkt wan, ɛn tɛl yu di tritmɛnt we fit yu pas ɔl. Dɔn yu go ebul fɔ wɛl kwik kwik wan ɛn kɔntinyu fɔ du di tin dɛn we yu de du ɛvride!

` awtoimyun hεmolaytik anemia, AIHA, anemia, rεd blכd sεl dεm, antibodi dεm, imyun sistεm, janda, taya