We yu kam fɔ no se yu gɛt kansa, yu kin fred bad bad wan ɛn yu kin shɔk. Dɔn, we di dɔktɔ dɛn de tɔk bɔt di tritmɛnt, yu kin yɛri bɔku nyu mɛrɛsin ɛn nyu wɔd dɛn we yu nɔ ɔndastand. Sɔntɛnde, we yu nɔ ɔndastand dɛn tin ya fayn, yu de fred mɔ ɛn mɔ. Avastin na wan mɛrɛsin we difrɛn smɔl we dɛn kin yuz fɔ mɛn kansa . So tide, lɛ wi tɔk bɔt dis mɛrɛsin we dɛn kɔl Avastin (Bevacizumab) insay wan simpul we we yu go ɔndastand.
Fɔs, lɛ wi si us Angiogenesis inhibitors dis drɔg de pan.
Fɔ ɔndastand dis, lɛ wi yuz wan simpul ɛgzampul. Imajin wan kansa sɛl tumbu lɛk wan bad bad gras we de gro na wi gadin. Wetin dis gras nid fɔ gro ɛn skata ɔlsay na di gadin? I rili nid wata. Semweso, kansa tumbu nid blɔd bak fɔ mek i gro ɛn go na ɔda pat dɛn na di bɔdi.
So dis kansa na rili kɔni kɔni. I kin sɛn “sayn” to wi bɔdi fɔ gɛt di blɔd we i nid ɛn fɔ mek nyu blɔd vesel dɛn gro . Jɔs lɛk aw da gras plant de gro nyu paip sistɛm ɔnda grɔn fɔ briŋ wata. Drug dεm we dεn kכl angiogenesis inhibitors de stכp di growth fכ dεn nyu bכdi vεsul dεm ya. Dat min se dɛn kin blok di “blɔd vesel dɛn” we de go to di kansa. Dɔn, we di blɔd dɔn lɔs, di kansa nɔ kin ebul fɔ gro ɔ skata.
So aw Avastin (Bevacizumab) de wok?
Avastin na wan drɔg we de pan di Angiogenesis inhibitor klas we wi bin tɔk bɔt ɔp. Fɔ tɔk di kɔrɛkt tin, dis na wan mɛrɛsin we de insay wan spɛshal klas we dɛn kɔl Monoclonal antibody .
Naw yu kin de wɔnda wetin na monoklɔnal antibodi. Fɔ tɔk am simpul wan, na wan prɔtin we dɛn mek spɛshal wan na lɛbɔtri, we fiba di antibodi dɛn we wi bɔdi kin mek fɔ fɛt sik dɛn. Di spɛshal tin bɔt dis na dat i nɔ de afɛkt ɔl di sɛl dɛn na di bɔdi lɛk di mɛrɛsin dɛn we dɛn kin yuz ɔltɛm fɔ kimotɛrapi, bɔt i kin afɛkt di kansa sɛl dɛn nɔmɔ we de na di tritmɛnt we dɛn de tɔk to .
Avastin de tכk bכt VEGF (Vaskul εndoteyl Grכwth Fכktכr) .Di mɔlyul. Wi bin dɔn tɔk bifo tɛm se di kansa de sɛn “sayn” fɔ mek nyu blɔd vesel, ɛn da signal de na VEGF. wetin Avastin de du na we i de atak dis VEGF mכlikul εn stכp am fכ wok. I tan lɛk se yu de “ɔf” di signal. We VEGF stɔp fɔ wok, nyu blɔd vesel dɛn nɔ de fɔm, ɛn di kansa kin lɔs in it.
A nid kemotɛrapi if a tek Avastin?
Yɛs, dis na prɔblɛm fɔ bɔku pipul dɛn. Pan ɔl we Avastin na tritmɛnt we dɛn kin yuz fɔ mɛn pipul dɛn, i nɔ kin wok in wan . I tan lɛk pɔsin we de sɔpɔt am. Di men pɔsin we de ple di stori, we na kemotɛrapi, stil nid am.
Kimotɛrapi na pawaful kayn mɛrɛsin we de kil sɛl dɛn we de sheb kwik kwik wan (lɛk kansa sɛl dɛn). Avastin de wok bay we i de ɛp fɔ tek kemotɛrapi.
Bɔt di bɛst pat na dat, we dɛn miks Avastin wit kemotɛrapi, di tin dɛn we kin kɔmɔt frɔm kemotɛrapi kin wok fayn mɔ. Dat min se we dɛn put dɛn tu mɛrɛsin ya togɛda, di fɛt agens kansa kin strɔng mɔ ɛn mɔ. We di kemo drɔgs dɛn de ridyus di blɔd we de go na di tumbu, dat de kil di kansa sɛl dɛn.
Us kayn kansa dɛn kin trit wit Avastin?
Dɛn dɔn gri fɔ mek Avastin gɛt bɔku kayn kansa . Bɔt dɛn nɔ kin gi am fɔ ɔl di kansa dɛn. Yu dɔktɔ go disayd if dis mɛrɛsin fayn fɔ yu bay di kayn kansa we yu gɛt, di stej we i gɛt, ɛn yu ɔl wɛlbɔdi.
Di tebul we de dɔŋ ya de sho sɔm pan di kayn kansa dɛn we dɛn kin yuz Avastin fɔ.
| Di kayn kansa we yu gɛt | Impɔtant tin dɛn fɔ no bɔt |
|---|---|
| Kɔlɔn ɔ Rɛktal Kansa | Dɛn kin yuse am mɔ pan kes dɛm wae di kansa dɔn spre to ɔda pat dɛm na di bɔdi (metastatic). Dɛn kin gi am wit kemotɛrapi drɔgs lɛk 5-fluorouracil (5-FU) ɔ capecitabine (Xeloda) . |
| Kansa na di Lɔng | Dɛn kin yuz am fɔ sɔm kayn advans lɔng kansa. |
| Kidni Kansa | Yuz fɔ mɛtastas rεnal sɛl kansa. |
| Kansa na di ovarian | Dɛn kin yuz am as tritmɛnt fɔ sɔm kes dɛm we gɛt ovarian kansa. |
| Kansa na di sεvikal | Dɛn kin yuz am fɔ sɛvikal kansa we dɔn kam bak ɔ we dɔn skata. |
| Glioblastoma we gɛt di sik | Dis na wan kayn bren kansa, ɛn dɛn kin gi dis tritmɛnt if i kam bak. |
Dɛn nɔ de gi Avastin fɔ bɔdi kansa?
Pan ɔl we dɛn bin de yuz Avastin fɔs fɔ mɛn bɔdi kansa, leta stɔdi dɛn sho se di bad tin dɛn we kin apin to pɔsin pas di bɛnifit dɛn we dis mɛrɛsin kin gi. So, institiushɔn dɛn lɛk FDA na Amɛrika nɔ gri igen fɔ yuz Avastin fɔ brɔst kansa.
Avastin kin mɛn kansa na di kɔlon kpatakpata?
Nɔ, Avastin nɔto “majik” mɛrɛsin we go mɛn kansa kpatakpata . Bɔt di klinik trial dɛn dɔn sho se dis mɛrɛsin kin rili ɛkstɛnd di layf fɔ di sikman dɛn . Fɔ ɛgzampul, sɔm stɔdi dɛn dɔn sho se di wan dɛn we bin tek Avastin wit kemotɛrapi bin liv lɛk 5 mɔnt pas di wan dɛn we bin gɛt kemotɛrapi nɔmɔ. Wi no aw dis tɛm valyu to pɔsin we de fɛt kansa.
Wetin na di sayd ɛfɛkt dɛm we Avastin gɛt?
Lɛk ɛni pawaful mɛrɛsin, Avastin kin gɛt sayd ɛfɛkt dɛn. Bɔt nɔto ɔlman we tek am go gɛt dɛn bad bad tin ya . Bɔt, i rili impɔtant fɔ mek wi no bɔt dis. Dis go ɛp yu fɔ no ɛni sayn ɛn tɛl yu dɔktɔ wantɛm wantɛm.
Dis dɔŋ ya na sɔm pan de siriɔs ɛn kɔmɔn sayd ɛfɛkt dɛm wae kin apun.
| Avastin sayd ɛfɛkt dɛn | |
|---|---|
| Sayd ɛfɛkt we pɔsin kin gɛt | Wetin fɔ no bɔt dis |
| Siriɔs sayd ɛfɛkt dɛm we dɛn fɔ ripɔt to di dɔktɔ wantɛm wantɛm | |
| Pɔrfɔreshɔn na di bɛlɛ | Dis na wan sik we rili siriɔs. Di sayn dɛm kin bi bad bad bɛlɛ pen, fiva, ɛn nɔs. Sɔntɛm dɛn go nid fɔ du ɔpreshɔn. |
| Blɔd we de kɔmɔt insay pɔsin in bɔdi | Dis kin mek yu gɛt tin dɛn we kin mek yu layf de pan denja lɛk strok. |
| Dilay we wund de wɛl | Di dɔktɔ kin tek tɛm mɔ fɔ gi dis mɛrɛsin bifo ɔ afta di ɔpreshɔn. |
| At we nɔ de wok fayn | Di risk kin bɔku mɔ we dɛn tek am wit ɔda kemo drɔgs we kin afɛkt di at. |
| Kidni dɛn we dɔn pwɛl | di simptom dεm lεk we di protin we de bכku na di urine kin apin. |
| Ɔda kɔmɔn sayd ɛfɛkt dɛn (infɔm di dɔktɔ) . | |
| Ay Blɔd Prɛshɔn | I impɔtant fɔ wach di blɔd prɛshɔn ɔltɛm we dɛn de trit am. |
| Taya | Dis na kɔmɔn sayd ɛfɛkt bak we kemotɛrapi kin gɛt. |
| Blɔd kin klɔt na di vein dɛn | Yu fɔ no bɔt di sayn dɛm lɛk fɔ swel yu leg ɛn fɔ fil pen. |
| Dayarɛa, ed we de at, we yu nɔ de want fɔ it, yu mɔt de sɔfa | Dɛn tin ya kin bi sayd ɛfɛkt dɛn we pɔsin kin ebul fɔ kɔntrol. |
| Blɔd we de na di urine | Yu fɔ tɛl yu dɔktɔ wantɛm wantɛm if yu notis dis. |
De tin wae impɔtant pas ɔl na, if yu gɛt ɛni wan pan dɛn kayn sik ya, nɔr jɔs tink se, "Dis na natin." Notis yu dɔktɔ ɔ di dipatmɛnt we gɛt fɔ du wit di ɔspitul usay dɛn de trit yu wantɛm wantɛm. Di kwik we yu ripɔt am, na di mɔ i go izi fɔ mek yu ebul fɔ kɔntrol di sik.
Mɛsej we dɛn kin kɛr go na os
- Avastin (Bevacizumab) nɔto tradishɔnal kemotɛrapi mɛrɛsin. Na tritmɛnt we dɛn kin yuz fɔ mɛn pipul dɛn we de stɔp di blɔd vesel dɛn we de gi blɔd to di kansa sɛl dɛn.
- Dɛn nɔ kin yuz dis mɛrɛsin in wan. Dɛn kin gi am togɛda wit kemotɛrapi fɔ mek i wok fayn.
- Dis na fɔ sɔm patikyula kayn kansa nɔmɔ, lɛk di kɔlon, lɔng, kidni, ɛn ovarian.
- Bikɔs siriɔs sayd ɛfɛkt kin apin, i impɔtant fɔ tɛl yu dɔktɔ wantɛm wantɛm bɔt ɛnitin we nɔ kɔmɔn we yu de trit yu.
- If dɛn dɔn gi yu ɔ pɔsin we yu lɛk Avastin as tritmɛnt fɔ kansa, mek shɔ se yu tɔk to yu dɔktɔ bɔt ɛni kwɛstyɔn ɔ tin we de mɔna yu . Dɛn go ebul fɔ gi yu di tin dɛn we kɔrɛkt pas ɔl.
Avastin, Bevacizumab, kansa, kansa tritmɛnt, kemotɛrapi, angiogenesis inhibitor, kansa mɛrɛsin, sayd ifɛkt, pilaka prathikara, anathuru abada, kansa tritmɛnt sinhala
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