Sɔntɛnde yu kin si sɔntin we dɛn kɔl "Blast Cells" na yu blɔd ripɔt. Na nɔmal tin fɔ fil smɔl we yu si am. Ivin we yu yɛri di wɔd "blast" kin mek yu fred smɔl. Bɔt bifo yu fred, lɛ wi tɔk smɔl bɔt wetin rili dɛn blast sɛl ya, wetin mek dɛn impɔtant to wi bɔdi, ɛn wetin kin apin if dɛn bɔku?
Wetin na blast sɛl dɛn? Na dat nɔmɔ yu nid fɔ no?
Yɛs, i impɔtant fɔ no dis. Fɔ tɔk am simpul wan, blast sɛl na wan kayn yɔŋ sɛl we nɔ machɔ, ɔ we nɔ dɔn rili divɛlɔp, na wi bɔdi. dis na di sεl dεm we de gi difrεn kayn sεl dεm na wi bכdi. Bɔt if yu gɛt lab ripɔt we se "blasts," i kin min blɔd sɛl dɛn we nɔ machɔ. Bikɔs dɔktɔ dɛn we de mɛn blɔd ɛn kansa kin yuz tin dɛn lɛk di nɔmba fɔ di blast sɛl dɛn we de na yu blɔd fɔ no sɔm sik dɛn we gɛt fɔ du wit blɔd, lɛk akyu lukimiya.
If yu gɛt blast sɛl dɛn we nɔ shep ɔ yu gɛt bɔku bɔku pan dɛn na yu blɔd, dat kin bi sayn fɔ sɔm blɔd kansa. Na dat mek yu fɔ wɔri bɔt dis.
So, wetin na di difrɛns bitwin blɔd stem sɛl ɛn blast sɛl?
Dis kin tan lɛk se i kɔmplikt smɔl, bɔt fɔ tru, i rili simpul. Tink bɔt dis, dɛn tu impɔtant stej ya na di divɛlɔpmɛnt fɔ wi sɛl dɛn.
Blɔd stem sɛl dɛn tan lɛk mama sɛl dɛn we de mek ɔl ɔda kayn sɛl dɛn bɔn.
di blast sεl dεm de divεlכp frכm dεn stεm sεl dεm ya. dεn kכl dεm bak "progenitor" כ "precursor" sεl dεm. dat min se dεn na "pre" stej bifo wan ful machכ sεl de divεlכp. difrεnt lεk stεm sεl, blast sεl dεn dכn כlrεdi disayd fכ bi wan spεshal kayn sεl. I tan lɛk se yu go na yunivasiti ɛn stɔdi jenɛral sɔbjɛkt dɛn fɔs, dɔn yu de pe atɛnshɔn pan wan patikyula fild.
Wetin na di bɛnifit dɛn we blast sɛl dɛn gɛt fɔ wi bɔdi?
Blast sɛl na jɔs di fɔs tɛm we di blɔd sɛl dɛn de mek. Yu bɔdi de mek nyu blɔd sɛl dɛn ɔltɛm (wit blast sɛl dɛn) fɔ tek di ol sɛl dɛn in ples. dis we aw blɔd de mek na in dɛn kɔl ɛmatopoiesis . Dis kin apin bɔku tɛm na yu bon mɛrɔ .
insay yu bon mכro, wan kכmכn stεm sεl de we dεn kכl "hεmatopoietic stεm sεl" (HSC). dis de mek tu men tכp dεm fכ blast sεl dεm:
- Myeloblast: Dis kayn blast sel de kכmכt frכmRɛd blɔd sɛl dɛn, wayt blɔd sɛl dɛn (fɔ ɛgzampul, granulosayt, monosayt, nyutrofil, basofil, ɛn eosinofil), ɛn pletlɛt dɛn kin mek.
- Limfoblast: Dis kayn blast sɛl de gi limfosayt, we na wan kayn wayt blɔd sɛl.
Di blɔd sɛl dɛn we dɔn ful-ɔp ɛn machɔ, kin kɔmɔt na di bon mɛro ɛn travul tru yu blɔd. Bɔt di blast sɛl dɛn we stil de divɛlɔp de insay yu bon mɛro, nɔto insay yu blɔd. Na dat mek wan lab ripɔt we de sho blast sɛl dɛn na yu blɔd kin bi prɔblɛm.
Wetin mek dɛn blast sɛl ya de bɔku? Yu tink se sɔntin nɔ fayn?
If lab ripɔt sho se yu gɛt bɔku bɔku blast sɛl dɛn na yu bon mɛrɔ ɔ blɔd, dat kin bi sayn fɔ blɔd kansa, lɛk lukimiya. εspεshali if di sεl dεm de luk abnכmal we dεn luk am wit maykroskכp. nכmal wan, na כnli 5% pan di tכtal bכdi sεl dεm na yu bon mכro fכ bi blast sεl dεm. I nɔ fayn fɔ gɛt ɛni blast sɛl na yu blɔd atɔl.
difrεn men rizin dεm de we mek di blast sεl dεm de inkrεs:
- Akyu mayloid lukimiya (AML) .
- Maylodisplastik sindrom (MDS) we gɛt di sik.
- Kronik maylɔyd lukimiya (CML) .
- Akyu limfoblastik lukimiya (ALL) .
- Sɔm kɔndishɔn ɛn tritmɛnt dɛm wae nɔr gɛt kansa
Lɛ wi luk ɛni wan pan dɛn tin ya smɔl mɔ.
Lɛ wi lan bɔt Akyu Maylɔyd Lukimiya (AML) .
Bɔku tɛm, we dɔktɔ dɛn kin tɔk bɔt blast sɛl, dɛn kin tɔk bɔt akyu mayloid lukimiya (AML) . AML na wan kayn kansa we kin rili bad ɛn we kin skata kwik kwik wan. So, i rili impɔtant fɔ no di sik ɛn bigin fɔ trit am kwik kwik wan. Fɔ tɛst fɔ dɛn blast sɛl ya na impɔtant we fɔ no di sik kwik kwik wan.
Insay AML, abnɔmal blast sɛl dɛn kin gɛda na yu bon mɛrɔ ɛn lik kɔmɔt na yu blɔd. Bɔku pan dɛn tin ya na wan kayn sɛl we dɛn kɔl mayloblast. dis dεm rεdi fכ bi wayt bכdi sεl dεm (granulocytes) bifo dεn bi kεnsar sεl dεm.
Bikɔs dɛn blast sɛl ya nɔ machɔ ɛn dɛn nɔ de du ɛnitin we go ɛp di bɔdi. Bifo dat, dɛn kin tek bɔku ples na di bon mɛro so dat dɛn kin stɔp yu bɔdi fɔ mek di nyu blɔd sɛl dɛn we gɛt wɛlbɔdi we i nid. If yu nɔ de wok fayn ɛn machɔ blɔd sɛl dɛn, yu bɔdi nɔ go ebul fɔ wok di rayt we.
If yu gɛt 20% ɔ mɔ blast sɛl dɛn na yu bon mɛrɔ ɔ blɔd, na sayn fɔ AML.
Wetin na di sik we dɛn kɔl Myelodysplastic Syndrome (MDS)?
Myelodysplastic syndrome (MDS) na wan kayn blɔd kansa bak. wetin kin apin ya na dat di blast sεl dεm nכ de divεlכp to nכmal bכdi sεl dεm. Bɔku tɛm, dɛn blast sɛl ya kin day bifo dɛn machɔ fayn fayn wan. pan ɔl we blast sɛl dɛn bɔku, we machɔ sɛl dɛn we kin du dɛn wok nɔ bɔku, prɔblɛm dɛn lɛk anemia kin apin. Dɔn bak, yu kin gɛt infɛkshɔn bɔku tɛm (bikɔs yu wayt blɔd sɛl dɛn nɔ bɔku) ɛn yu kin blɔd ɔ brus izi wan (bikɔs yu nɔ gɛt bɛtɛ pletlɛt dɛn).
if yu gεt bitwin 5% εn 20% blast sεl dεm na yu bon mכro, na sayn fכ wan kכndyushכn we dεn kכl `MDS.` lεk 30% pan pipul dεm we gεt `MDS` go εva divεlכp `AML.`
Lɛ wi luk bak pan Kronik Maylɔyd Lukimiya (CML).
Kronik mayloid lukimiya (CML) na wan kansa wae de kam wit blɔd fɔ lɔng tɛm (kronik). I kin mek bak di nɔmba fɔ di blast sɛl dɛn we de na di bon mɛrɔ ɔ blɔd go ɔp. Dɔktɔ dɛn kin klas di kayn sik bay aw yu blast sɛl lɛvɛl:
- Kronik Faz CML: less dan 10% pan di sεl dεm na yu bכdi כ bon mכro na blast sεl dεm.
- Aksεlεrayt Faz CML: bitwin 10% εn 19% pan di sεl dεm na yu bכdi na blast sεl dεm.
- Blast Phase CML (blast crisis): mכr dan 20% pan di sεl dεm na yu bכdi na blast sεl dεm. Dis na di sem tin lɛk AML.
Wetin na Akyu Limfoblastik Lukimiya (ALL)?
Akyu limfoblastik lukimiya (ALL) na di kayn kansa we kin kam pan pikin dɛn. insay כL, di bon mכro de mek abnכmal (kansa) sεl dεm we dεn kכl limfoblast. Dɛn nɔmal sɛl dɛn ya kin sheb kwik kwik wan ɛn dɛn kin mek bɔku kɔpi fɔ dɛnsɛf. dis kin mek i at fכ di bon mכro fכ mek di nכmal sεl dεm we yu bכdi nid.
insay כL, at le 20% pan di bכdi sεl dεm na yu bon mכro na blast sεl dεm. Bɔrku pipul dɛm wae dɛn kin no se gɛt dis sik (lɛk 90%) kin gɛt blast sɛl dɛm bak na dɛn blɔd.
Yu tink se di blast sɛl dɛn kin bɔku bikɔs ɔf ɔda tin dɛn pas kansa?
Yɛs, dis rili impɔtant. Nɔ tink se kansa na di rizɔlt fɔ wan lab ripɔt we sho se di blast sɛl dɛn we bɔku. sכm kכndishכn dεm εn kכz dεm we nכ de kכnεs kin mek bak di blast sεl dεm inkrεs fכ sכm tεm. Sɔm ɛgzampul dɛn na:
- Sivεr infεkshכn: If yu bכdi gεt siriכs sik, lεk siriכs infεkshכn (sepsis), blast sεl dεm kin go insay di bכdi.
- Granulocyte-colony stimulating factor (G-CSF) tritmεnt: dεn kin stil si blast sεl dεm na di bכdi afta dεn gεt wan kayn injεkshכn we dεn kכl G-CSF. Dɛn injɛkshɔn ya kin mek yu bon mɛro mek mɔ wayt blɔd sɛl dɛn fɔ protɛkt yu frɔm infɛkshɔn. Dɛn tin ya kin nid if yu de tek kemotɛrapi ɔ if yu gɛt smɔl wayt blɔd sɛl (nyutropenia).
- Stem sel transplant: If yu dɔn gɛt stem sɛl transplant as tritmɛnt fɔ wan mɛrɛsin, yu kin gɛt inkris bak pan blast sɛl. I kin nid fɔ transplant stem sɛl fɔ tin dɛn lɛk blɔd dizayd, kansa, ɔ ɔtoimyun sik dɛn we yu bɔdi nɔ kin ebul fɔ mek nɔmal blɔd sɛl.
Bɔt di impɔtant tin na dat, nɔ lɛk di blast sɛl dɛn we gɛt fɔ du wit kansa, di blast sɛl dɛn we dɛn kin si pan dɛn kayn tin ya kin luk fayn ɔnda maykroskɔp. Dɛn kin divɛlɔp bak to nɔmal blɔd sɛl dɛn. As tɛm de go, dis nɔmba kin go dɔŋ.
Aw yu kin chɛk di lɛvɛl we di blast sɛl dɛn de kɔrɛkt wan? Wetin na dɛn tɛst dɛn de?
difrεn tεst dεm de we de sho di blast sεl lεvεl dεm:
- Peripheral blood smear (PBS): Dis tɛst de sho se blast sɛl dɛn de na yu blɔd. Insay PBS, wan dɔktɔ we de mɛn yu blɔd kin luk yu blɔd ɔnda maykroskɔp fɔ si if blast sɛl dɛn bɔku ɔ if dɛn nɔ luk fayn.
- bon mכro tεst: Lab tεst dεm we dεn du afta dεn du bon mכro bayopsi כ aspirash כn kin no di blast sεl dεm na di bon mכro. dis kin inklud tεst dεm lεk fכ fכlכ saytכmetri, imyunohistochεmistri, כ fכrosεns in situ haybridayzεshכn (FISH) fכ luk fכ jεnεtik chenj dεm na di sεl dεm .
- Yu kin nid bak fɔ gɛt kɔmplit blɔd kɔnt (CBC) wit difrɛns fɔ chɛk yu rɛd ɛn wayt blɔd sɛl ɛn pletlɛt kɔnt, bikɔs di nɔmba fɔ di blɔd sɛl dɛn we gɛt wɛlbɔdi kin go dɔŋ as di nɔmba fɔ di blast sɛl dɛn de go ɔp.
Dɔktɔ dɛn kin tink bɔt difrɛn tɛst rizɔlt ɛn tin dɛn bifo dɛn no se pɔsin gɛt wan sik lɛk lukimiya. Dɛn nɔ kin disayd fɔ du big tin bay we dɛn jɔs du wan tɛst.
Fɔ dɔn, na sɔm tin dɛn we wi fɔ mɛmba
Di tin we impɔtant pas ɔl na fɔ nɔ panik we yu si di wɔd "blasts" na yu lab ripɔt.Na tru se if yu gɛt blast sɛl na yu blɔd, dat kin bi sayn fɔ se yu gɛt siriɔs sik. Bɔt i dipen pan yu wɛlbɔdi. Sɔntɛnde, we di blast sɛl dɛn kin bɔku, na fɔ shɔt tɛm nɔmɔ. Di nɔmba kin go dɔŋ as tɛm de go. Ɔda tɛm, e kin bi sayn fɔ sɔmtin we siriɔs pasmak, lɛk akyu lukimiya. Na yu dɔktɔ nɔmɔ go ebul fɔ ɛksplen klia wan wetin yu rizɔlt min fɔ yu wɛlbɔdi. So, if yu gɛt ɛni kwɛstyɔn, nɔ shem fɔ aks yu dɔktɔ.
` Blast sel dεm, lukimiya, bכdi kεnsar, bon mכro, bכdi tεst, sεl dεm, hεlth
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