Yu bɔdi de lik wata lɛk dis? Lɛ wi tɔk bɔt di Kapilari Lik Sindrom!

Yu dɔn ɛva yɛri bɔt di sik we dɛn kɔl Capillary Leak Syndrome? Di nem kin tan lɛk se i kɔmplikt smɔl. Bɔt fɔ tɔk am simpul wan, na tin we di wata we de na di blɔd we dɛn kɔl plasma, de lik kɔmɔt na di smɔl smɔl blɔd vesel dɛn na wi bɔdi, we dɛn kɔl kapilari. Dis wata de lik insay wi mɔsul dɛn, tisu dɛn, ɔgan dɛn, ɛn di say dɛn we wi bɔdi de. Dis kin bi siriɔs sik, so i impɔtant fɔ no bɔt am.

Wetin na dis tin we dɛn kɔl kapilari lik sindrom?

Okay, mek wi ɛksplen smɔl mɔ. Imajin se yu bɔdi gɛt wan sistem we gɛt wata paip dɛn. Dɛn paip ya na wi blɔd vesel. di rili fayn, sכm sכm paip dεm we de insay dis dεn kכl dεm kapilari. Dis na di tכb dεm we כksijεn εn nyutriεnt dεm de go tru to כl di pat dεm na wi bכdi. so, insay `(Capillary Leak Syndrome)`, di likwid pat pan di bכdi, dat na di plasma , de lik kכmכt tru dεn sכm sכm kapilari dεm ya. I tan lɛk se wata de lik kɔmɔt na wata paip.

dis wata we de lik de mek wata de kכmכt na difrεn pat dεm na di bכdi. fכ egzampl, dis wata kin lik insay di mכsul dεm, tisu dεm, difrεn כgan dεm, כ di spεs dεm (bכdi kכva) usay di כgan dεm de.

di episod dεm fכ dis `(Capillary Leak Syndrome)` kin apin bכku tεm insay di ia, כ jכs wan tεm insay di layf. Bɔt if dɛn nɔ trit am kwik, yu blɔd prɛshɔn kin go dɔŋ wantɛm wantɛm, ɛn dis kin mek yu ɔgan dɛn nɔ wok fayn ɛn sɔntɛnde yu kin ivin day. So dis nɔto sɔntin we wi fɔ tek am layt.

No mɛrɛsin nɔ de fɔ dis fɔ ɔltɛm yet. Bɔt i impɔtant fɔ go to dɔktɔ kwik kwik wan fɔ kɔntrol di sik dɛn. Sɔntɛnde, i pɔsibul fɔ mek yu nɔ gɛt atak tumara bambay bay we yu kɔntinyu fɔ yuz mɛrɛsin ɔ tek salin infushɔn.

Ɛni kayn we de fɔ dis? Aw dɛn difrɛn?

Yes, tu men kayn `(Capillary Leak Syndrome)` de. Lɛ wi si wetin dɛn bi.

• Systemic Capillary Leak Syndrome: Dɛn kin kɔl am bak ``Primary Capillary Leak Syndrome'' ɔ ``Clarkson's disease'', dis na kɔndishɔn we atak kin apin bɔku bɔku tɛm , ivin pan pɔsin we nɔmal fɔ gɛt wɛlbɔdi.
• Sɛkɔndari Kapilari Lik Sindrom: Dis na we di atak kin apin wan tɛm bikɔs ɔf ɔda sik, kɔndishɔn, ɔ mɛrɛsin.

Fɔ tɔk am simpul wan, wan na sɔntin we kin apin ɔltɛm, ɛn di ɔda wan na sɔntin we kin apin fɔ sɔm tɛm fɔ ɔda rizin.

Udat kin gɛt dis sik?

``Systemic Capillary Leak Syndrome'' na wan sik we nɔ kin bɔku.Dɛn ripɔt se nɔr rich 500 pipul dɛm ɔlsay na di wɔl gɛt dis sik. E kin bɔrku pan pipul dɛm wae dɔn pas midul ej. I nɔ kin apin so ɔltɛm pan yɔŋ pikin dɛn. Bɔt bikɔs sɔm tɛm dɛn nɔ kin no se pipul dɛn we gɛt dis sik nɔ kin no se dɛn gɛt ɔda sik, di rial nɔmba fɔ pipul dɛn we gɛt dis sik kin bɔku pasmak.

Bɔt, Sɛkɔndari Kapilari Lik Sindrom kin apin pan ɛni ej. Sɔm infɛkshɔn, mɛrɛsin, ɛn mɛrɛsin kin mek i gɛt am.

Wetin kin apin to di bɔdi we dis kin apin? (Tri stej dɛn)

wetin de apin na wi bכdi di tεm we dis `(Capillary Leak Syndrome)` atak kin sheb to tri stej dεm. Lɛ wi si wetin dɛn bi.

Fɔs pat: Bifo di sayn dɛm sho (Prodromal phase) .

Dis na di tɛm wan ɔ tu dez bifo pɔsin atak am. Insay dis tɛm, yu kin bigin fɔ gɛt sɔm sayn dɛn.

• Fɔ fil se yu taya
• Di tɔsti fɔ wata mɔ ɛn mɔ
• Tin dɛn lɛk we pɔsin kin gɛt wet wantɛm wantɛm kin apin.

Sɛkɔn pat: Lik ɔ risasayz faz

Dis na di tɛm we di atak kin rili apin. wetin kin apin na dat wata εn albumin (wan kayn protin we de insay di bכdi) de lik frכm yu kapilari dεm go na di spεs bitwin yu tisu dεm. Dis kin mek di blɔd we de kɛr ɔksijɛn nɔ bɔku. Yu blɔd prɛshɔn de go dɔŋ, ɛn di rɛd blɔd sɛl dɛn kin gɛda togɛda, ɛn dis kin mek yu blɔd tik. Dis wata we de lik de mek di blɔd volyum go dɔŋ, we dɛn kɔl hypovolemia .

Tɔd pat: Afta di atak `(Post-lik faz ɔ rikrutmɛnt faz)`

Dis na di tɛm afta di atak dɔn. wetin kin apin na we yu kapilari dεm kin bigin fכ abzכp wata εn albumin frכm di tisu dεm bak. Bɔt insay dis tɛm, yu bɔdi kin gɛda bɔku bɔku wata (fluid overload) . Dis kin mek yu bɔdi kin mek bɔku bɔku urine (polyuria) ɛn yu lɔng dɛn kin ful-ɔp wit wata (pulmonary edema).

Tink bɔt am, i tan lɛk spɔnj we de absɔb wata. Fɔs, di wata kin kɔmɔt na di bɔdi, dɔn we i absɔb am bak tumɔs kwik, i kin absɔb mɔ pas aw i fɔ absɔb am.

Wetin kin mek dis apin?

Lɛ wi luk naw wetin kin mek dis `(Capillary Leak Syndrome)`.

Di tin dɛn we kin mek pɔsin gɛt `(Sistemik Kapilari Lik Sindrom)`

Fɔ tɔk tru, dɛn nɔ stil no di rayt tin we kin mek pɔsin gɛt di sik we dɛn kɔl Systemic Capillary Leak Syndrome. Risach pipul dɛn biliv se i kin bi bikɔs wi imyun sistɛm de ansa sɔm sik ɔ infɛkshɔn.

Di tin dεm we de mek yu gεt `(Sεkכndεri Kapilari Lik Sεndrכm)`

Bɔku rizin dɛn de fɔ dis. Di tin we kin mek pɔsin gɛt dis sik pas ɔl na wan sik we dɛn kɔl sɛpsis . Dat min se, na kɔmplikeshɔn we kin mek pɔsin in layf de pan denja we infɛkshɔn kin kam wit. Apat frɔm dat, ɔda tin dɛn de we kin mek i apin:

• Di sik dɛn we pɔsin kin gɛt we i de fɛt insɛf:Wetin kin apin pan dis na we wi yon imyun sistεm de atak wi yon hεlty sεl dεm.
• Difrɛns sindrom: Na kɔmplikeshɔn we kin apin we dɛn de trit sɔm kayn lukimiya (akyu promyelocytic leukemia ɔ acute myeloid leukemia).
• Engraftment syndrome: Na kɔmplikɛshɔn we kin apin afta dɛn dɔn transplant bon mɛrɔ.
• hεmophagocytic lymphohistiocytosis: Na wan kכndyushכn we kin mek yu layf de pan denja we di imyun sistεm we de wok pasmak.
• ovarian hyperstimulation syndrome: Na komplikashכn we kin apin we dεn de trit fεtiliti.
• Risin we gɛt pɔyzin.
• Snek we de bit pɔsin.
• Vayrɔs ɛmoraji fiva: Na grup fɔ sik dɛn we pɔsin kin gɛt we vayrɔs kin kam wit.

Sɔm mɛrɛsin dɛm, lɛk di mɛrɛsin dɛm we de agens kansa we dɛn kɔl gemcitabine (gemcitabine - Gemzar®) ɛn tagraxofusp (tagraxofusp - Elzonris®) , kin mek dis sik bak (Secondary Capillary Leak Syndrome).

Wetin na di sayn dɛm wae kin kam bifo dis sik bigin?

Tipikli, wan ɔ tu de bifo yu atak ``Capillary Leak Syndrome'', dat na, di tɛm we di ``prodromal phase'', yu kin gɛt sɔm sayn dɛm lɛk:

• Bɛlɛ pen ɔ mɔsul pen (myalgia).
• Taya pasmak ɔ wik pasmak.
• Ed de at .
• Di tɔsti fɔ wata mɔ ɛn mɔ.
• Iritability, we pɔsin kin vɛks.
• Vɔmit.
• We yu de gɛt bɔku bɔku wet wantɛm wantɛm.
• Di sayn dɛm fɔ vayral infɛkshɔn ɔ ɔpa respiratɔri trakt infɛkshɔn.

If yu gɛt sɔm kayn sik lɛk dis, nɔr tek am layt, se, "O, i go mɔs bi se na jɔs kol," mɔ if yu dɔn gɛt dis kayn ɛkspiriɛns bifo.

Us sayn dɛm kin kam wae yu gɛt sik?

di tεm we di `(Capillary Leak Syndrome)` atak, dat na, di tεm we di `(lik כ rεsusitεshכn fεz)` de, di simptom dεm kin difrεn frכm pכsin to pכsin. Bɔt dɛn tin ya na di kɔmɔn sayn dɛm wae yu kin si:

• di bכdi de swεla, spεshal wan di limb dεm (pεriferal εdima).
• Rɔnbɛlɛ.
• Lɔw blɔd prɛshɔn (haypɔtɛnshɔn).
• di bכdi we de kכlכt (hypercoagulability) - dis kin bi we di nכmba fכ di rεd bכdi sεl dεm (hematocrit) כ di nכmba fכ di wayt bכdi sεl dεm de inkrεs (leukocytosis).

Aw dɔktɔ dɛn kin no dis?

Dɔktɔ go no se yu gɛt Kapilari Lik Sindrom bay we i aks yu bɔt yu mɛdikal histri ɛn du yu bɔdi ɛgzam. Dɛn go chɛk fɔ si if yu blɔd prɛshɔn smɔl.

Dɔn bak, bifo yu kɔnfyus se dis na Kapilari Lik Sindrom, dɛn nid fɔ pul ɔda tin dɛn we de apin. Dɛn kin du bɔku blɔd tɛst fɔ du dis:

• Chek fɔ si if i gɛt ay hematocrit (di nɔmba fɔ di rɛd blɔd sɛl dɛn we de na di blɔd).
• Chek fɔ si if di ɛmoglobin lɛvɛl bɔku (wan prɔtin we de na di rɛd blɔd sɛl dɛn).
• Chek fɔ si if di prɔtin nɔ de na di blɔd (hypoalbuminemia).

pan tap dat, dεn kin du bכdi tεst fכ chεk fכ wan abnכmal imyun protin we dεn kכl ``monoclonal gammopathy, כ M protin'' insay di bכdi. Pipul dεm we gεt ``Capillary Leak Syndrome'' kin gεt dis abnכmal ``M protin'' na dεn bכdi.

Aw dɛn kin trit am? Yu tink se dɛn kin mɛn am?

Bɔt i sɔri fɔ no se, no mɛrɛsin nɔ de fɔ ɔltɛm fɔ di Kapilari Lik Sindrom. Dɔktɔ dɛn kin tray fɔ kɔntrol di sik dɛn ɛn mek dɛn nɔ gɛt prɔblɛm dɛn.

we dεn de atak ``Capillary Leak Syndrome'', dכkta dεm de tray fכ kכntrכl bכdi prεshכn εn mεnten di bכdi fכ fכlכ fayn fayn wan to di כgan dεm. Dɛn kin tray bak fɔ mek dɛn nɔ swel pasmak ɛn fɔ mek wata nɔ gɛda. Dɛn kin yuz:

• Glucocorticoids: Dis na wan kayn stεroyd we de εp fכ ridyus di wata we de lik frכm di kapilari dεm.
• Fluid we de insay di bɛlɛ: Dɛn kin gi tin dɛn lɛk salin fɔ mek di blɔd flɔ mɔ to ɔgan dɛn lɛk di kidni.

Bɔku tɛm, yu go nid fɔ go na ɔspitul afta yu dɔn atak yu. We yu de du tritmɛnt, yu dɔktɔ go kɔntinyu fɔ wach yu blɔd prɛshɔn ɛn blɔd prɛshɔn fɔ mek shɔ se yu nɔ gɛt bɔku wata na yu bɔdi, we kin mek yu gɛt ɔda prɔblɛm dɛn, lɛk we yu pulmonari ɛdima ɛn yu at kin stɔp wantɛm wantɛm.

Afta yu gɛt atak we dɛn kɔl Capillary Leak Syndrome, we dɛn kɔl di post-leak phase ɔ rikrutmɛnt faz, dɔktɔ kin gi yu wan diuretic (wan mɛrɛsin we de mek yu prodyuz mɔ urine) fɔ ridyus di ɛkstra wata we de na yu bɔdi.

Yu tink se dɛn kin mek di sik we dɛn kɔl Systemic Capillary Leak Syndrome (SCLS) nɔ kam bak?

Yu nɔ go ebul fɔ mek di Systemic Capillary Leak Syndrome nɔ de divɛlɔp fɔs. Bɔt, wans yu gɛt atak, yu no se yu gɛt di kɔndishɔn.

Bɔt if yu tek mɛrɛsin ɔltɛm ɔ yu de gi yu salin, dat kin ɛp fɔ mek yu nɔ atak yu tumara bambay ɛn i kin mek yu nɔ atak yu. Dɛn tritmɛnt ya kin bi:

• Fɔ gɛt imyun globulin (IVIG) we dɛn kin put insay dɛn bɛlɛ ɛvri mɔnt .
• Mεdikeshכn dεm we dεn kin tek fכ asma, lεk tiofilin (tiofilin - Elixophyllin®), tεrbutalin (tεrbutalin - Brethine®), εn mכntelukast (montelukast - Singulair®) .
• Ridyus di inflamɛnsStɛroyd dɛn we dɛn kin yuz.

Wetin na di fiuja fɔ di wan dɛn we de liv wit dis sik? `(Autluk)`

Sεstεmik Kapilari Lik Sεndrכ m kin כlwayz mεnεj wit prεvεntεtiv tritmεnt dεm. Di tritmɛnt kin go bifo we dɛn no di sik kwik kwik wan ɛn di prɔblɛm dɛn we kin apin nɔ kin bɔku. Sɔm pan de siriɔs prɔblɛm dɛm wae kin apun wit Kapilari Lik Sindrom na:

• Compartment syndrome: di prεshכn we de insay di mכsul de go כp εn di bכdi fכ fכlכ dכn.
• di wata we de kכmכt rawnd di at εn di lכng dεm (kadyak tamponad, pεrikardial efyushכn, εn pleura efyushכn).
• At we nɔ de wok fayn.
• Kidni we nɔ de wok fayn.
• Nyuropati we pɔsin kin gɛt.
• Ɛdima we de na di pulmonari.
• Rhabdomyolysis: di kidni dεm de fεil bikoz fכ di mכsul dεm we dεn dכn pwεl.
• Strok.

Dɛn tin ya kin tan lɛk se yu de mek yu fred, bɔt lɛk aw wi bin dɔn tɔk, fɔ trit yu kwik kwik wan ɛn fɔ mɛn yu fayn fayn wan rili impɔtant.

Ustɛm a fɔ go to dɔktɔ?

If yu tink se yu gɛt Capillary Leak Syndrome atak, go to dɔktɔ wantɛm wantɛm. Dɛn kin ɛp fɔ kɔntrol yu sayn dɛm ɛn gi yu rilif.

Mɛmba se pan ɔl we dis nɔ kin apin so ɔltɛm, i impɔtant fɔ no bɔt di sayn dɛm ɛn go to dɔktɔ kwik kwik wan if yu gɛt dawt.

Mɛsej we dɛn kin kɛr go na os

Okay, so lɛ wi rikap di impɔtant pɔynt dɛn we wi dɔn tɔk bɔt:

• Dis na we di wata pat pan di blɔd (plasma) de lik kɔmɔt na di smɔl smɔl blɔd vesel dɛn (kapilari dɛn) na wi bɔdi.
• Dis kin apin wan tɛm ɔ bɔku tɛm.
• If dɛn nɔ trit am, siriɔs prɔblɛm dɛn kin apin, so i impɔtant fɔ go to dɔktɔ kwik kwik wan.
• Pan ɔl we no mɛrɛsin nɔ de fɔ ɔltɛm, tritmɛnt dɛn de fɔ kɔntrol di sik dɛn ɛn fɔ mek dɛn nɔ atak dɛn tumara bambay.
• If yu tink se yu gɛt ɛni wan pan dɛn sayn ya, go to dɔktɔ wantɛm wantɛm. Di kwik we yu no se yu gɛt di sik ɛn bigin fɔ trit yu, na di mɔ yu go gɛt chans fɔ wɛl.

So, a op se dis infɔmeshɔn go yusful to yu. Stay wit wɛlbɔdi!

` Kapilari Lik Sindrom, Plasma Lik, Lɔw Blɔd Prɛshɔn, Klaksin Sik, Ɛdima, Fluid Lik na di Bɔdi