Yu bayl dakt dɛn dɔn big? Lɛ wi tɔk bɔt Karɔli Sik!

Sɔntɛnde yu kin fil lɛk se yu bɔdi de tɔn yɔlɔ, ɔ yu kin fil lɛk se yu de gɛt pen na yu rayt say na yu bɛlɛ? Sɔm pipul kin gɛt fiva ɛn vɔmit wit dɛn sik ya. Wan poshubul rizin bihayn dis na di kondishon wae wi go tok bout tide wae dem kol ‘Caroli’s disease.’ Lɛ wi si wetin na in, wetin mek i kin apin, aw dɛn kin no bɔt am, ɛn wetin na di tritmɛnt.

Fɔ tɔk am simpul wan, wetin na Karɔli Sik?

Imajin, insay wi liva, smɔl smɔl tiub dɛn de we dɛn kɔl bayl dakt . dis tכb dεm de kכri di dijestiv wata we dεn k כl bayl we de kכmכt na di liva go na di sכmכl intestin. naw, dis Caroli sik na wan kכndyushכn we di bayl dakt dεm kin big pas nכmal, dat na, dεn kin dilayt . Dis na sik we wi kin gɛt frɔm wi jɛnɛtiks , dat min se na bikɔs wi jɛnɛtiks chenj. we dεn tכb dεm ya big lεk dis, di bayl de bigin fכ kכmכt insted fכ fכlכ fayn fayn wan. we dis kin kכmכt, di bayl dakt ston kin fכm, infεkshכn kin apin, εn sכmtεm sist kin ivin fכm.

Fɔ tɔk am simpul wan, di bayl fɔ ebul fɔ flɔ izi wan we i nɔ go stɔp. Bɔt we di bayl dakt dɛn tu big, i izi fɔ mek di bayl gɛda. As tɛm de go, dis bayl we dɔn gɛda kin mek smɔl smɔl ston dɛn.

If yu gɛt Caroli sik, yu kin gɛt bɔrku sayn dɛm fɔ dis sik ɔl yu layf. Bɔrku tɛm, di sayn dɛm kin bigin arawnd di ej 30 , bɔt i kin apin pan ɛni ej. Yu kin notis se yu skin ɛn yu yay wayt de tɔn yɔlɔ (wi kin kɔl dis janda ), ɛn yu kin bigin fɔ gɛt sɔm sayn dɛn bak lɛk kol ɛn flu bɔku tɛm. Pan ɔl we dis sik kin afɛkt yu wɛlbɔdi ɛn kwaliti layf, tritmɛnt dɛn de we go ɛp fɔ kɔntrol yu sik dɛn.

Ɛni kayn sik de we dɛn kɔl Caroli?

Yɛs, tu men kayn dis de:

• Caroli sik: Dis kayn kin jɔs afɛkt yu bayl dakt dɛm. I nɔ de kɔz ɛni ɔda prɔblɛm wit yu liva.
• Caroli syndrome: Dis na di kayn we we kin rili bad. Insay dis, di liva kin gɛt skata, we wi kin kɔl fibrosis .

Aw dis sik kin bɔku?

Caroli sik na wan sik we nɔ kin apin so ɔltɛm . Dɛn se na wan pan ɛvri milyɔn pipul dɛn nɔmɔ kin gɛt am . So i nɔto sik we de ambɔg bɔku pipul dɛn.

So, wetin na di sayn dɛn we de sho se pɔsin gɛt Karɔli in sik?

כltεm, sכm sכm stכn dεm we de fכm na di bayl dakt dεm nכ de mek εni big simptom. Bɔt if ston blok wan bayl dakt, i kin inflam. Wi kin kɔl dis kɔlangitis . Dis na wae de sayn dɛm fɔ Caroli in sik kin apia:

• Pen na di rayt say na yu bɔdi , bɔku tɛm na di ɔp bɛlɛ.
• Fɔ vɔmit .
• Fiva ɛn kol .
• Di skin kin yɔlɔ ɛn di yay kin wayt (jaundice) .
• I de it .

na sכm tεm, dis akyumuleshכn fכ bayl kin mek wan kayn kεnsar tכmכro we dεn kכl cholangiocarcinoma insay di bayl dakt dεm. Na dat mek i impɔtant fɔ tek tɛm wit dis.

Wetin mek di sik we Karɔli gɛt kin apin? Wetin na di tin dɛn we kin mek i apin?

Caroli sik na wan sik we pɔsin kin gɛt frɔm in jɛnɛtiks . Dis min se na bikɔs di jin dɛn we de na wi bɔdi chenj. Bɔku tɛm, i kin apin wan wan tɛm, we min se i nɔ kin pas frɔm wan jɛnɛreshɔn to ɔda jɛnɛreshɔn. Bɔt insay sɔm famili dɛn, dɛn dɔn ripɔt se na ɔtosomal dominant , we min se if wan mama ɔ papa gɛt am, di pikin dɛn bak kin gɛt am.

Caroli syndrome de kכz bay wan jεnεtik mכtεshכn na wan jin we dεn kכl PKHD1 . dis jin de mek wan protin we de εp di bayl dakt dεm εn di kidni dεm fכ divεlכp di tεm we di εmbrayo de, dat na we di pikin de insay di bεlε. Bikɔs Caroli sik ɛn Caroli syndrome gɛt fɔ du wit dɛnsɛf, di wan dɛn we de stɔdi bɔt dis biliv se di PKHD1 jin de involv bak pan Caroli sik. Bɔt dɛn nid fɔ du mɔ risach fɔ no dis.

Aw dɔktɔ dɛn kin no se i gɛt Karɔli in sik?

We yu go to dɔktɔ, dɛn go fɔs du yu bɔdi ɛgzam ɛn aks bɔt yu sik dɛn. Dɔn, dɛn go ɔda fɔ mek dɛn du sɔm blɔd tɛst dɛn, lɛk wan Kɔmprɛhɛnsif Mɛtabolik Panɛl (CMP), we gɛt di liva ɛnzaym dɛn . if patεn de fכ εlevεshכn insay dεn εnzym dεm ya, i kin sho se wan bayl dakt dכn blכk.

Apat frɔm blɔd tɛst, yu dɔktɔ go mɔs ɔda fɔ mek dɛn du sɔm imej/raydiɔlɔji tɛst , we na tɛst dɛn we de luk insay yu bɔdi. Dɛn tin ya na:

• Ɔltrasɔund na di bɛlɛ
• Wan CT skan (kɔmpyuta tomografi skan) .
• Wan MRI skan (magnɛtik rɛsɔnans imej skan) .

Apat frɔm dat, yu dɔktɔ kin aks yu bak fɔ mek dɛn du ERCP (endoscopic retrograde cholangiopancreatography) tɛst. Dis min se yu fɔ put wan smɔl tiub we kin chenj (we dɛn kɔl ɛndoskɔp ) tru yu mɔt ɛn go dɔŋ yu bɛlɛ insay yu bayl dakt dɛn. Wit dis ERCP, yu dɔktɔ kin luk yu bayl dakt ɛn liva fɔ si if ɛni tumbu ɔ skata de.

Wan ɔda tin na dat, yu dɔktɔ kin aks yu bak fɔ du wan spɛshal kayn MRI we dɛn kɔl MRCP (magnetic resonance cholangiopancreatography) . Dis kin mek yu no aw yu bayl dakt dɛn wayd. I kin chɛk bak fɔ si if yu gɛt galston.

Wetin na di tritmɛnt dɛm fɔ dis? Yu tink se dɛn kin mɛn am?

Fɔ tɔk tru, na Karɔli in sikNo mɛrɛsin nɔ de yet fɔ mɛn am. Bɔt sɔm tritmɛnt dɛn de we kin ɛp fɔ kɔntrol di sik dɛn ɛn fɔ mek dɛn nɔ gɛt prɔblɛm dɛn. Dis go mek yu fɔ wok wit wan tim we gɛt dɔktɔ dɛn we spɛshal pan difrɛn tin dɛn. Dɛn tin ya na:

• Wan man we de stɔdi bɔt di jɛnɛtiks
• Gastroenterɔlɔjis we de mɛn di bɔdi
• Liva spɛshal pɔsin/Epatɔlɔjis
• Wan urologist ( as di kidni dεm de afekt bak) .
• Dɔktɔ we spɛshal pan kidni sik dɛn (Nephrologist) .
• Radiologist ( fɔ tin dɛn lɛk skan) .
• Transplant ɔspitul (if nid de) .

di tritmεnt fכ di sik we Caroli gεt de dipכnt pan usay insay di liva di dilated bile duct de.

• Sɔntɛnde, dɛn kin du am ɔpreshɔn: If di bayl dakt we dɔn big de na di lɛft ɔ rayt say nɔmɔ na di liva, yu dɔktɔ kin ɔpreshɔn fɔ pul jɔs da pat de na di liva. Dɛn kɔl dis , ɛmi-ɛpatɛktomi . Pipul wae gɛt sɔm pat pan dɛn liva we dɛn pul dis kayn we, nɔ kin gɛt di sik igen.
• Mɛrɛsin: Bɔt if di bayl dakt dɛn we dɔn dilayt dɔn skata ɔlsay na di liva, yu dɔktɔ kin gi yu antibayɔtik fɔ mek yu nɔ gɛt wan sik we dɛn kɔl cholangitis . Dɔn bak, wan mɛrɛsin we dɛn kɔl ursodeoxycholic acid kin ɛp fɔ sɔm pan di prɔblɛm dɛn we di sik we dɛn kɔl Caroli kin kam wit.
• Ɔda ɔpreshɔn dɛn: Sɔntɛnde, yu dɔktɔ kin tɛl yu fɔ yuz intanɛnt biliary bypass fɔ ɛp fɔ pul di bayl na di liva.
• Liva transplant: If i rili siriɔs, liva transplant na di bɛst tritmɛnt opshɔn.

Aw lɔŋ yu kin liv wit Caroli sik?

Caroli sik insɛf nɔr de sho aw yu go liv yu layf dairekt wan. Di prɔblɛm dɛn we i kin gɛt kin afɛkt di we aw pɔsin de liv in layf. Dɛn tin ya na:

• Cholangitis: Dis akyu cholangitis, we kin kam bikɔs ɔf gal ston na di bayl dakt, nid fɔ gɛt mɛrɛsin kwik kwik wan ɛn i kin kil pɔsin insay sɔm awa to sɔm dez.
• di bayl dakt kεnsar (cholangiocarcinoma): Dis kansa kin kam bikoz fכ di inflameshn we de fכ lכng tεm εn di bayl dakt dεm we de blok. Fɔ no am kwik kwik wan ɛn fɔ trit am impɔtant fɔ mek yu gɛt gud tin fɔ du.
• Liva we nɔ de wok fayn:If di inflamɛns na di bayl dakt dɛn kɔntinyu, i kin mek pɔsin gɛt siriɔs sik dɛn lɛk we di liva nɔ de wok fayn.

Di tin we impɔtant pas ɔl na di manejmɛnt. If dɛn trit kɔllangitis fayn ɛn dɔktɔ de chɛk di prɔblɛm dɛn ɔltɛm, pipul dɛn we gɛt Karɔli sik kin liv ful layf.

Yu tink se we de fɔ mek dɛn nɔ gɛt dis sik we dɛn kɔl Caroli?

Caroli sik na wan sik we wi kin gɛt frɔm wi jɛnɛtiks , so wi nɔ kin ebul fɔ avɔyd am bikɔs na sɔntin we kin kam wit wi jɛnɛtiks.

Ustɛm a fɔ go to dɔktɔ?

If yu gɛt sɔm sayn dɛm fɔ Caroli in sik – lɛk pen na yu rayt say na yu bɛlɛ, vɔmit, fiva, ɛn janda – yu fɔ rili go to dɔktɔ. Nɔ delay.

Us kwɛstyɔn dɛn a fɔ aks di dɔktɔ?

I fayn fɔ aks dɛn kwɛstyɔn ya we yu go si dɔktɔ:

• A gɛt Karɔli sik ɔ Karɔli sindrom?
• Aw siriɔs mi kɔndishɔn bi bay di rizɔlt fɔ mi skan?
• Wetin na di bɛst tritmɛnt plan fɔ mi?
• Ɛni mɛrɛsin de we go ɛp fɔ kɔntrol mi sik ɔ fɔ mek a nɔ gɛt prɔblɛm dɛn?
• A go ebul fɔ du ɔpreshɔn? If na so i bi, us kayn ɔpreshɔn a fɔ du?
• Wetin na di bad tin dɛn ɛn bɛnifit dɛn we pɔsin kin gɛt we dɛn du ɔpreshɔn?
• Wetin na di sayn dɛm fɔ kɔmplikeshɔn dɛm we a fɔ no bɔt?

Wetin na di difrɛns bitwin di sik we dɛn kɔl Polycystic Liver Disease (PCLD) ɛn di sik we dɛn kɔl Caroli?

di polisistik liva sik (PCLD) εn Karoli sik dεn tu de afekt di bayl dakt dεm na di liva. Bɔt big difrɛns de bitwin dɛn tu. insay PCLD, bכku sist dεm we fulכp wit wata (cyst) de fכm ɔlsay na di liva. Dɛn tin ya tan lɛk sak dɛn we nɔmal. pan ɔl we sist kin fɔm bak pan Karɔli sik, i kin mɔs involv dilayshɔn fɔ spɛshal bayl dakt dɛn insay di liva.

So wetin na di rilayshɔn bitwin di sik we Caroli gɛt ɛn di kɔledokal sist?

di sik we dɛn kɔl karoli kin afɛkt di bayl dakt dɛn we de insay di epatik, we na di bayl dakt dɛn we de insay di liva . di sist dεm we de fכm insay dεn intrahεpatik bayl dakt dεm ya na wan kayn k כledokal sist . So, if yu gɛt sɔm pan dɛn sist ya, dɛn kin kɔl dat Karɔli sik. Fɔ tɔk am simpul wan, Caroli sik na wan kayn kɔledokal sist.

Fɔ dɔn, di tin dɛn we impɔtant pas ɔl we yu fɔ mɛmba

Caroli Disease kin mek yu fred smɔl fɔ yɛri bɔt. Bɔt we di sayɛns bɔt mɛrɛsin dɔn go bifo, fayn we dɛn de naw fɔ mɛn dis sik. We yu de chɛk yu ɔltɛm, yu ɛn yu dɔktɔ go ebul fɔ wach yu sik gud gud wan. Bɔrku pipul dɛm wae gɛt Caroli Disease kin gɛt fridɔm frɔm dɛn sik wae de kam wit mɛrɛsin , ɛnMinimally invasive, we min se no big insishɔn nɔ de, bɔku tɛm di mɛrɛsin dɛn we dɛn kin du na opshɔn.

Mɛmba se, di tin we dɛn de pe atɛnshɔn pan ya na fɔ mek yu gɛt wɛlbɔdi ɛn fɔ du tin fɔ lɔng tɛm. So, nɔ panik, jɔs fala yu dɔktɔ in instrɔkshɔn dɛn fayn fayn wan. Nɔ fred fɔ aks kwɛstyɔn if yu gɛt ɛni wan.

` Caroli Sik, Liva, Bayl Dakt, Jɛnɛtik Sik, Jandis, Galston