Wetin na Castleman Disease? Lɛ wi tɔk bɔt am simpul wan!

Yu dɔn ɛva notis se yu kin gɛt dɛn smɔl smɔl bɔmp dɛn ya na yu nɛk ɔ yu armpit? Sɔmtɛm dɛn kin apin we yu gɛt kol ɔ flu. Bɔt, dis nɔto bɔt sɔntin we simpul lɛk dat. Dis na tin wae nɔr kin bɔrku bɔt impɔtant fɔ no bɔt. Wi kin kɔl am Kastɛlman Sik .

Fɔ tɔk am simpul wan, Castleman Disease na wan sik wae de mek wi bɔdi in imyun sistɛm kin wok pasmak . Imajin, we wan jem we de mek wi sik kam insay wi bɔdi, wi imyun sistɛm de fɛt am lɛk sojaman we de go fɛt. We di sik dɔn wɛl, da sojaman de sɛt mɔt bak. Bɔt pan pɔsin we gɛt Castleman Disease, dis imyun sistɛm de ‘on’ ɔltɛm. Dis kin mek di bɔdi inflamɛns fɔ lɔng tɛm, ɛn dis kin pwɛl wi ɔgan dɛn.

dis tεm, wi limf no dεm – dεn sכm sכm bכmp dεm na dεn wi kכl dεm – de akt lεk filta. כl di jεm dεm εn di imyun sεl dεm de filta tru dεm. So, biכs di imyun sistεm de wok כltεm, dεn limf no dεm ya de wok ova tεm bak. Dɔn di sɛl dɛn we de insay dɛn kin gro pasmak, ɛn di limf no dɛn kin swel. nכto dis swel nכmכ, bכt insay Castleman Disease, ivin chenj dεm de na di tisu dεm na dεn limf no dεm ya.

Dis na sik we nɔ kin apin so ɔltɛm . Fɔ ɛgzampul, na Amɛrika, na 4,300 to 5,200 nyu wan dɛn nɔmɔ kin gɛt di sik ɛvri ia. So dɔktɔ dɛn stil de lan bɔku tin bɔt dis. Bɔt if dɛn no se yu gɛt dis sik, yu go gɛt sɔm patikyula tritmɛnt dɛn we gɛt fɔ du wit yu.

Wetin na di men kayn sik we dɛn kɔl Castleman Disease?

Tu men kayn dis sik de.

Yunisɛntrik Kastɛlman Disiz (UCD) .

Unicentric Castleman disease (UCD) na we wan ɔ sɔm limf no dɛm nɔmɔ na wan eria na yu bɔdi kin big . Tink jɔs yu nɛk, ɔ jɔs yu armpit. Na lɛk tri-kwata pan di wan dɛn we sik na Kastɛlman kin fɔdɔm insay dis kategori.

Di sik we dɛn kɔl Multicentric Castleman Disease (MCD) .

Multicentric Castleman disease (MCD) na wan kכndyushכn we di limf no dεm de swεla na bכku pat dεm na di bכdi, pas fכ jכs wan. Fɔ tɔk di kɔrɛkt tin, dɔktɔ dɛn kin sheb dis kayn MCD mɔ to:

• MCD we gɛt fɔ du wit POEMS: POEMS na wan sik we nɔ kin apin na di blɔd we nɔ kin apin so ɔltɛm. Sɔntɛnde, POEMS kin apin wit MCD.
• MCD we gɛt fɔ du wit HHV-8: Dis kayn tin kin kam we pɔsin gɛt wan vayrɔs we dɛn kɔl Human Herpes Virus-8 (HHV-8) . If yu gɛt HIV ɔ yu nɔ gɛt bɛtɛ imyun, yu go gɛt dis kayn MCD.
• MCD we dɛn nɔ no bɔt di kɔz (Idiopathic MCD - iMCD):Dis na di kayn MCD we dɛn kin gɛt mɔ. ‘Idiopathic’ min se dεn nכ no di εksakεt kכz.

Naw dis kɔz we wi nɔ no iMCD gɛt tri sɔb-pat dɛn bak:

• iMCD we gɛt fɔ du wit TAFRO sindrom: Sɔntɛnde iMCD kin kam wit wan sik we dɛn kɔl TAFRO sindrom. Dɛn pul di nem TAFRO frɔm di fɔs lɛta dɛn we de sho di sik dɛn we i gɛt. Dɛn tin ya na: Thrombocytopenia (di blɔd pletlɛt dɛn we nɔ de bɔku), Anasarca (we di bɔdi de swel wit wata), Fiva , di rεnal (kidni) we nɔ de wok fayn, ɛn Organomegaly (we di splin ɔ di liva de big).
• iMCD wit Idiopathic Plasmacytic Lymphadenopathy (iMCD-IPL): Insay dis sכbtayp, di pletlet dεm kin εlevεt. Yu wayt blɔd sɛl dɛn kin mek bak tumɔs antibodies.
• iMCD we dɛn nɔ tɔk ɔda we (iMCD-NOS): Dɛn nɔ no di rayt tin we mek dis kayn tin apin, we dɛn kɔl iMCD-NOS, bak, ɛn i nɔ gɛt natin fɔ du wit TAFRO.

Wetin na di sayn dɛm fɔ Castleman Disease?

De sayn dɛm fɔ Castleman disease kin difrɛn difrɛn wan fɔ di kayn wae yu gɛt. Bɔrku tɛm, if yu gɛt unicentric Castleman disease (UCD), yu nɔr kin gɛt ɛni big big sayn. Di limf no dɛm we dɔn swel kin bi di wangren sayn we yu go notis. Bɔt sɔntɛnde, di sayn dɛn kin apin if di limf node we dɔn swel prɛs pan ɔda ɔgan we de nia am.

Bɔt if yu gɛt MCD, di sayn dɛn go mɔs bi klia wan. Apat frɔm di limf no dɛm we dɔn swel, yu kin si sɔm sayn dɛm lɛk:

• Fiva
• Taya (dis kin bi sayn fɔ lɛ yu nɔ gɛt bɛtɛ blɔd) .
• We yu de swet na nɛt
• Nɔs ɛn vɔmit
• We yu de lɔs yu wet fɔ natin
• Swel na yu fut, yu ankles, ɔ yu bɛlɛ
• di splin we big (splenomegaly) ɔ di liva we big (hepatomegaly) .
• Di an ɛn fut dɛn kin swɛla (peripheral neuropathy) .

Wetin kin mek pɔsin gɛt Castleman Disease?

Dɛn nɔ no yet di rayt tin we kin mek pɔsin gɛt di sik we dɛn kɔl unicentric Castleman disease (UCD), bɔt dɛn dɔn si se if pɔsin gɛt wan vayrɔs we dɛn kɔl HHV-8 na in kin mek pɔsin gɛt di sik we dɛn kɔl multicentric Castleman disease (MCD).

Sayɛnsman dɛn stil de chɛk ɔda tin dɛn we kin mek pɔsin gɛt UCD ɛn iMCD. Fɔ ɛgzampul, dɛn de luk fɔ ɔda infɛkshɔn dɛn pas HHV-8, jin muteshon , ɛn ɔtoimyun rispɔns .

Udat de pan denja fɔ gɛt dis sik?

Dɛn nɔ dɔn no yet sɔm patikyula risk factor dɛm fɔ UCD ɔ iMCD. Bɔt if yu gɛt HIV ɔ ɔda tin we de mek yu imyun sistɛm wik, yu go gɛt mɔ risk fɔ gɛt HHV-8-associated MCD.

Castleman disease kin apin pan ɛni ej, bɔt dɛn kin no am mɔ pan pipul dɛm wae ol bitwin 30 ɛn 60 ia .

Wetin na di prɔblɛm dɛn we kin kam wit di sik we dɛn kɔl Castleman Disease?

Dis sik we dɛn kɔl Castleman kin mek yu gɛt kansa mɔ ɛn mɔ .

Dɔn bak, pan ɔl we i nɔ kin apin so ɔltɛm, pipul dɛn we gɛt UCD kin gɛt wan siriɔs sik we dɛn kɔl Paraneoplastic Pemphigus (PNP) . MCD kin mek bak yu gɛt infɛkshɔn we kin pwɛl yu ɔgan dɛn. Dis damej kin mek pɔsin in layf de pan denja if dɛn nɔ trit am fayn.

Nɔ wɔri, yu dɔktɔ go de wach yu sik ɔltɛm ɛn ɛp yu fɔ mek yu nɔ gɛt dɛn kayn prɔblɛm dɛn ya ɛnitɛm we i pɔsibul.

Aw dɔktɔ dɛn kin no se pɔsin gɛt Castleman Disease?

De sayn dɛm fɔ Castleman Disease kin tan lɛk ɔda sik dɛm wae kin kam pan pɔrsin, lɛk flu ɔr kol. So yu dɔktɔ go fɔs pul dɛn tin dɛn de. Dɔn, dɛn go du tɛst fɔ no if pɔsin gɛt di sik we dɛn kɔl Castleman Disease ɛn no di kayn sik.

Test ɛn prosidur kin inklud:

• Lab test: Yu dɔktɔ go chɛk yu blɔd sɛl kɔnt fɔ abnɔmal tin ɛn ɔda maykroskɔpik sayn dɛm fɔ Castleman sik. Dɛn kin ɔda bak fɔ mek dɛn du HIV tɛst . If yu gɛt MCD we gɛt fɔ du wit HHV-8, yu HIV tɛst kin bi pɔsitiv.
• Imej tɛst: Tɛst lɛk CT skan ɛn PET skan kin ɛp fɔ fɛn di limf no dɛm we dɔn swel na yu bɔdi, ɛn bak fɔ chɛk fɔ ɔda sayn dɛm fɔ di sik we dɛn kɔl Castleman, lɛk we di liva ɔ splin dɔn big.
• Limf node bayɔpsi: Di ​​wangren we fɔ no fɔ tru if yu gɛt Castleman sik na fɔ gɛt bayɔpsi. Dis na fɔ tek wan smɔl pat pan di tisu frɔm wan limf node ɛn chɛk am ɔnda maykroskɔp. Dis go sho if ɛni sayn de fɔ di sik.

Aw dɛn kin trit di sik we dɛn kɔl Castleman Disease?

De tritmɛnt fɔ Castleman disease kin difrɛn difrɛn wan fɔ di kayn wae yu gɛt.

Tritmɛnt fɔ Yunisɛntrik Kastɛlman Disizin (UCD) .

Di men tritmɛnt fɔ UCD na fɔ ɔpreshɔn fɔ pul di limf no dɛm we afɛkt. Sɔntɛnde, yu kin nid fɔ tek redyushɔn tɛrapi ɔ imyunotɛrapi bifo dɛn du yu ɔpreshɔn. Dɛn tritmɛnt ya kin mek di tin dɛn we de gro na di limf no dɛn smɔl, ɛn dis kin mek i izi fɔ pul dɛn.

Bɔt if dɔktɔ dɛn we de du ɔpreshɔn nɔ ebul fɔ pul di limf node we dɔn afɛkt, ɛn yu nɔ gɛt ɛni sayn, yu dɔktɔ kin wach am instead fɔ trit am. If yu gɛt sɔm sayn dɛm ɛn yu nɔ ebul fɔ gɛt ɔpreshɔn, dɛn kin tɛl yu fɔ gi yu tritmɛnt fɔ MCD.

Tritmɛnt fɔ di sik we dɛn kɔl multicentric Castleman disease (MCD) .

MCD na tin we at fɔ trit smɔl pas UCD. Bikɔs i kin skata ɔlsay na di bɔdi, dɛn nɔ kin yuz ɔpreshɔn ɔ redyushɔn tɛrapi. Bifo dat, di tritmɛnt de dipen pan if yu gɛt HHV-8 infɛkshɔn ɛn aw di sik tranga.

Yu dɔktɔ kin yuz tritmɛnt dɛn lɛk:

• Kɔtikosterɔyd: Dɛn mɛrɛsin ya kin ɛp fɔ ridyus di inflamɛns ɛn gi fridɔm frɔm di sayn dɛm.
• Kimotɛrapi drɔgs: Kimotɛrapi drɔgs de kɔntrol di ɔva gro we di sɛl dɛn de gro pasmak na yu limfatik sistɛm. Rituximab na wan mɛrɛsin we dɛn kin gi fɔ HHV-8-asɔsiet MCD.
• Immunotherapy: Dis tritmɛnt involv fɔ yuz tin dɛn lɛk monoclonal antibodies . Dɛn tin ya kin ɛp fɔ mek yu bɔdi in imyun rispɔns kol. Siltuximab (Sylvant®) na di wan ol tritmɛnt we di U.S. Food and Drug Administration (FDA) dɔn gri fɔ fɔ iMCD.
• Antivayral drɔgs: If yu gɛt MCD we gɛt fɔ du wit HHV-8, yu kin nid antivayral drɔgs fɔ trit HIV ɔ HHV-8 infɛkshɔn.

Ustɛm a fɔ go to dɔktɔ?

If yu notis se yu nɛk, yu armpit, ɔ yu groin dɔn gro ɔ gro, go to dɔktɔ wantɛm wantɛm . Dɔn bak, if yu gɛt ɛni ɔda sayn dɛm fɔ Castleman Disease wae wi dɔn tɔk bɔt wae nɔr de bɛtɛ afta sɔm wiks, tɛl yu dɔktɔ bɔt dɛm bak.

Aw lɔŋ yu kin liv wit dis sik?

Fɔ bɔrku pipul dɛm wae gɛt UCD, de prognosis, ɔr aw fɔ si tin, kin rili fayn. If yu pul di limf no dɛm we dɔn afɛkt, i kin mɛn di sik. Wit tritmɛnt, UCD nɔ kin afɛkt di layf we pɔsin kin liv.

Bɔt de luk fɔ pipul dɛm wae gɛt MCD kin dipen pan di kayn MCD wae dɛn gɛt ɛn aw di sik kin tranga. Fɔ sɔm pipul dɛn, de sik kin kam wantɛm wantɛm ɛn kin mek dɛn layf de pan denja. Fɔ ɔda pipul dɛn, di sik kin te fɔ lɔng tɛm. Bitwin 65% ɛn 75% pan di pipul dɛn we dɛn no se gɛt MCD stil de alayv afta fayv ia . Wit nyu tritmɛnt dɛm, op de fɔ se dis tin go bɛtɛ.

No izi ansa nɔ de we i kam pan di sik we dɛn kɔl Castleman. Yu ɛkspiriɛns go dipen pan di kayn Castleman sik we yu gɛt. Ɔda tin dɛn lɛk HIV, ɔ tin dɛn we gɛt fɔ du wit am, lɛk TAFRO ɛn POEMS, kin afɛkt yu ɛkspiriɛns bak. Sɔntɛnde, dɛn kin du ɔpreshɔn ɛn wach am gud gud wan. Ɔ, yu kin nid difrɛn tritmɛnt ɔlsay na yu layf fɔ mek yu nɔ gɛt prɔblɛm. Aks yu dɔktɔ aw di sik we yu gɛt go afɛkt yu tritmɛnt ɛn aw yu de si tin.

So, wetin na di impɔtant tin dɛn we wi fɔ mɛmba frɔm dis?

• Castleman Disease na wan sik wae nɔr kin bɔrku bɔt kin bi siriɔs imyun sistɛm wae wi imyun sistɛm kin wok pasmak.
• Tu men kayn dɛn de: UCD ɛn MCD. insay UCD, di limf no dεm de swεla na wan ples, we insay MCD, dεn de swεla na plεnti ples.
• Di sayn dɛn we pɔsin kin gɛt kin difrɛn. Sɔntɛnde, i nɔ kin gɛt ɛni sayn atɔl, na jɔs wan swɛlin. Ɔ i kin gɛt sayn dɛn lɛk fiva, taya, ɛn fɔ lɛf fɔ it bɔku bɔku it.
• Nɔto ɔltɛm di tin dɛn we kin mek i apin kin klia, bɔt dɛn dɔn tɔk se di HHV-8 vayrɔs gɛt sɔntin fɔ du wit MCD. Pipul wae gɛt HIV kin gɛt bɔrku risk.
• Bɔku tɛm, if pɔsin no di pɔsin kwik kwik wan ɛn trit am fayn, dat kin mek i gɛt gud tin fɔ du. So if yu notis se yu bɔdi gɛt smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl. Di tin we impɔtant pas ɔl na fɔ no bɔt sɔntin ɛn nɔ fɔ fred.

` Castleman Disease, Limf Nodes, Limfadenopathy, Imyun Sistem, UCD, MCD, HHV-8, Simptom, Tritmɛnt