Siriɔs infɛkshɔn ɔltɛm: Wi fɔ no bɔt dis kayn sik we nɔ kin apin so ɔltɛm (Chronic Granulomatous Disease - CGD)?

Yu smɔl pikin kin sik ɔltɛm? We wan sik bɛtɛ, ɔda wan kin kam. Sɔntɛnde, i kin gɛt siriɔs infɛkshɔn na in skin, in lɔng, ɔ ivin insay in bɔdi? Bɔku mama ɛn papa dɛn kin wɔri bɔt dɛn kayn prɔblɛm dɛn de. Tide wi go tɔk bɔt wan rare bɔt impɔtant jenɛtik kɔndishɔn we kin mek dɛn gɛt dis kayn infɛkshɔn ɔltɛm. Wi kin kɔl dis Chronic Granulomatous Disease, ɔ CGD fɔ shɔt wan pan dɔktɔ dɛm.

Fɔ tɔk am simpul wan, wetin na CGD?

Fɔ ɔndastand dis, lɛ wi fɔs tɔk smɔl bɔt di we aw wi bɔdi de fɛt. Imajin se wi bɔdi tan lɛk kɔntri. I gɛt ami we ebul fɔ protɛkt am frɔm ɔda kɔntri ɛnimi dɛn (jɛm). Dat na wi imyun sistɛm . Wan spɛshal pat pan dis ami na wayt blɔd sɛl dɛn .

Naw, na dis kin apin to pɔsin we gɛt CGD. wan spεshal grup de fכ wayt bכdi sεl dεm we dεn kכl soja, fכ egzampl, `(nyutrofil)`, `(monosayt)`, `(makrofag)` εn `(eosinofil)`. di men wok we dεn sεl dεm ya de du na fכ fכnshכn sכm kayn bכdi εn fכn dεm we de kam insay di bכdi, kech dεm, εn pwεl dεm.

Bɔt pan pɔsin we gɛt CGD, dɛn spɛshal sojaman ya, ɔ wayt blɔd sɛl ya nɔ kin ebul fɔ yuz dɛn wɛpɔn dɛn fayn fayn wan. Dɛn nɔ kin ebul fɔ mek di spɛshal ɛnzaym we dɛn nid fɔ kil dɛn jem dɛn de. I tan lɛk se yu gɛt gɔn bɔt yu nɔ gɛt bulɛt. So wetin kin apin? Wi imyun sistɛm kin ful-ɔp, i nɔ kin ebul fɔ fɛt sɔm baktri ɛn fɛns dɛn we kin kam insay di bɔdi.

Bɔku tɛm, dɛn infɛkshɔn ya kin apin na di skin, di lɔng dɛn, di limf no dɛm, ɛn di liva . Dɛn kin mek bak abses , we na lumps we ful-ɔp wit pus insay di bɔdi in ɔgan dɛn.

Dis nɔto sik we bɔku pipul dɛn kin gɛt. Na lɛk wan pan ɔl tu ɛn af milyɔn pipul dɛn ɔlsay na di wɔl kin gɛt dis sik. Dɔn bak, dɛn dɔn si se bɔy pikin dɛn kin gɛt am mɔ .

Us sayn dɛm pɔrsin wae gɛt CGD kin sho?

Di sayn dɛm fɔ CGD kin bigin we dɛn smɔl. Bɔt sɔntɛnde, dɛn kin apia pan ɛni ej. Di men ɛn kɔmɔn sayn na we yu kin gɛt siriɔs baktri ɛn fɛns infɛkshɔn we kin kam bak.

Lɛ wi tek wan luk pan dɛn sayn ya fɔ ɔndastand wetin dɛn bi izi wan.

Wetin mek dis CGD kin apin? Wetin na di kɔz?

Fɔ tɔk am simpul wan, CGD na wan sik we pɔsin kin gɛt we i kam pan jɛnɛtiks.. Dat min se dis na sɔntin we wi kin gɛt frɔm wi mama ɛn papa. Na tin dɛn we dɛn kɔl jin de kɔntrol ɔltin we wi bɔdi de du. Dɛn wayt blɔd sɛl dɛn we wi bin dɔn tɔk bɔt, gɛt di ‘instrɔkshɔn’ dɛn we de mek di ɛnzaym dɛn we dɛn nid fɔ kil di jem dɛn.

insay CGD, mכtεshכn de insay wan pan di fayv jin dεm we gεt dεn instrכkshכn dεm ya. Bikɔs ɔf dis muteshon, wayt blɔd sɛl dɛn nɔ kin ebul fɔ mek di ɛnzaym, ɔ if dɛn mek am, i nɔ kin wok fayn. Di tin we kin apin na dat dɛn nɔ kin ebul fɔ fɛt di smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl.

CGD dεn sheb am to tu tכp dεm dipכnt pan aw dis jεnεtik difεkt de apin.

• X-linked CGD: Dis na di kayn we we dɛn kin yuz mɔ. i de kכz fכ wan mכtεshכn insay wan jin (di `CYBB` jin) na di X kromozom. Man dɛn gɛt wan X kromozom, we uman dɛn gɛt tu X kromozom. Dis na di rizin we mek dis sik kin bɔku pan bɔy pikin dɛn .
• כtosom rεsεsiv CGD: dis de kכz fכ mכtεshכn insay כda jin dεm (`CYBA`, `NCF1`, `NCF2`, `CYBC1` כ `NCF4`). Dis kayn kin afɛkt man ɛn uman ikwal.

Wetin na de risk ɛn kɔmplikeshɔn wae kin kam bikɔs ɔf dis sik?

Pɔsin wae gɛt CGD kin de pan denja pasmak if pɔrsin na dɛn famili gɛt dis sik. Bɔt, na smɔl tɛm nɔmɔ, dɛn kin ripɔt kes dɛm fɔ dis sik we kin apin fɔ dɛnsɛf, we nɔ gɛt ɛni famili histri.

Bɔku kɔmplikeshɔn dɛn de we kin apin bikɔs ɔf CGD.

• Prɔblɛm dɛn we de na di dijestiv: Ɔlsa ɛn inflamɛns na di intestinal kin ambɔg di dijestiv prɔses.
• Bɔwel sik: Fɔ ɛgzampul, di risk de fɔ mek yu gɛt tin dɛn lɛk Inflammatory Bowel Disease (IBD), we na wan inflamɛns we de na di intestin dɛn we nɔ de dɔn.
• Prɔblɛm fɔ gro: If yɔŋ pikin ɛn bebi dɛn gɛt dis sik, dɛn bɔdi kin delay.
• Ɔda sik dɛm: Dipen pan di kayn jenɛtik dɛfɛkt we de mek CGD, sɔm pipul dɛn kin gɛt at sik bak, kidni sik, dayabitis, ɔ ɔda ɔtoimyun kɔndishɔn dɛm.

Aw yu go no if yu gɛt CGD?

Yu dɔktɔ go aks yu ɛn yu pikin fɔs bɔt yu sik ɛn famili mɛdikal histri. Dɔn, dɛn go ɔda fɔ du sɔm tɛst fɔ no if dɛn dɔn no di sik.

• Fɔ chɛk di bɔdi: Di ​​dɔktɔ kin tek tɛm luk di bɔdi fɔ si if i gɛt swɛlin, abses, ɛn granulomas.
• Blɔd tɛst: Wan spɛshal blɔd tɛst de we kin no di kɔrɛkt we aw pɔsin gɛt CGD. Dɛn kɔl dis DHR tɛst (dihaydrorɔdamin tɛst) . Dis tɛst de sho aw di wayt blɔd sɛl dɛn ebul fɔ kil di smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl.
• Tɛst fɔ di jɛnɛtiks:Dɛn kin tek blɔd sɛmpul ɔ tisu sɛmpul fɔ luk fɔ di patikyula jenɛtik dɛfekt we de mek CGD. Dis kin ɛp bak fɔ no di rayt kayn sik.

Wetin na di tritmɛnt dɛm fɔ CGD?

Pan ɔl we dɛn nɔ kin ebul fɔ mɛn CGD ɔltogɛda, naw bɔku gud tritmɛnt dɛn de we kin ɛp fɔ kɔntrol di sik dɛn, protɛkt frɔm siriɔs infɛkshɔn, ɛn ɛp pipul dɛn fɔ liv nɔmal layf.

Tritmɛnt wit mɛrɛsin

• Antibayɔtik: Bɔku pipul dɛn we gɛt CGD go nid fɔ tek antibayɔtik fɔ di res ɔf dɛn layf fɔ mek dɛn nɔ gɛt baktriyal infɛkshɔn ɛn fɔ trit infɛkshɔn we kin apin.
• Antifungal: Dɛn kin yuz drɔgs lɛk `(itraconazole)` fɔ mek dɛn nɔ gɛt ɛn trit fɔŋs infɛkshɔn.
• intafεron-gama injεkshכn: Dis na sεntetik fכm fכ wan protin we wi כwn imyun sistεm mek. Dis injεkshכn de εp fכ ridyus di frεkuεns εn di siriכs infεkshכn.

Sɔm sik pipul dɛn, mɔ di wan dɛn we gɛt siriɔs sik, kin gɛt stem sɛl transplant . Dis kin min fɔ injɛkt stem sɛl dɛn frɔm pɔsin we gɛt wɛlbɔdi insay di pɔsin in bɔdi, we kin tek di wayt blɔd sɛl dɛn we nɔ de wok fayn wit wɛlbɔdi sɛl dɛn. Bɔt dis na tritmɛnt we kɔmpleks ɛn we kin mek i gɛt prɔblɛm, so dɔktɔ dɛn kin tɛl am fɔ du am bay bɔku tin dɛn lɛk di pɔsin in ej ɛn in wɛlbɔdi.

Wetin wi fɔ du fɔ protɛkt wisɛf frɔm infɛkshɔn?

• Tek tɛm wit wata: Nɔ swim na riva, si, ɛn lek ɔltogɛda. Dɛn tin ya nɔ gɛt klorin, so i izi fɔ mek yu bɔdi gɛt smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl. So if yu swim, na pul we gɛt klorin nɔmɔ yu fɔ swim .
• Tek kia ɔf yu gadin: Nɔ tɔch ɔ hang rawnd di gadin dɔti, kɔmpɔst hip, haystack, ɛn dray lif. Sɔm pan di fɛns dɛm we dɛn kin si na dɛn wan ya kin mek yu gɛt siriɔs nyumonia we kin mek pɔsin in layf de pan denja if pɔsin we gɛt CGD inhal am. So, yu fɔ rili tek tɛm wit dis.

Tin dɛm fɔ no bɔt aw fɔ liv wit dis sik

We yu yɛri bɔt dis sik kin mek yu fred. Bɔt di tru tin na dat, if yu gɛt di rayt tritmɛnt ɛn yu kin tɔk to yu dɔktɔ ɔltɛm, bɔku pipul dɛn we gɛt CGD kin liv nɔmal, aktif, ɛn gladi layf. Di tin we impɔtant pas ɔl na fɔ no se yu gɛt infekshɔn ɛn bigin fɔ trit am kwik, bifo i wɔs.

If yu ɔ yu pikin de sɔfa wit infekshɔn bɔku tɛm we yu nɔ ebul fɔ ɛksplen, go to yu dɔktɔ wantɛm wantɛm ɛn tɔk bɔt dis.

If yu pikin gɛt CGD, ɔndastand se nɔto yu fɔlt. Na wan sik we pɔsin kin gɛt frɔm in jɛnɛtiks. If yu pikin gi yu di rayt advays, i go gɛt gud chans fɔ liv lɔng ɛn gladi at. Di impɔtant tin na fɔ no gud gud wan bɔt di sik ɛn fala yu dɔktɔ in instrɔkshɔn dɛn gud gud wan.