Sɔntɛnde, yu kin fɔgɛt tin dɛn? Ɔ i nɔ kin izi fɔ yu fɔ muv yu an ɛn yu fut? Yu kin slɔk yu wɔd dɛn we yu de tɔk? If i tan lɛk se dɛn tin ya de bɔku, sɔntɛm i impɔtant fɔ mek yu no bɔt dis kɔndishɔn we wi de tɔk bɔt tide we dɛn kɔl `(Corticobasal Degeneration)`. Nɔ wɔri, lɛ wi tɔk bɔt dis simpul wan.
Wetin na ``Kɔtikobasal Dijɛnɛreshɔn''?
Fɔ tɔk am simpul wan, `(Corticobasal Degeneration)` na nyurolɔjik kɔndishɔn we de afɛkt wi bren. Sɔm pipul dɛn kin kɔl am bak `(Corticobasal Syndrome).` Wetin kin apin pan dis na dat sɔm sɛl dɛn na wi bren kin pwɛl ɛn smɔl smɔl dɛn kin pwɛl. Jɔs lɛk aw sɔm ikwipmɛnt dɛn kin pwɛl as tɛm de go. Bikɔs ɔf dis, di we aw wi kin ebul fɔ tɔk, swɛla it, muv wi bɔdi, ɛn mɛmba tin dɛn kin stɔp smɔl smɔl. De sad tin na wae dis sik kin de inkris (progres) smɔl smɔl as tɛm de go.
di wod "corticobasal" na di nem de tכk bכt tu pat dεm na di bren we di sik de pwεl fכs:
- di sεribra kכtεks: Dis na di כta pat pan di nεv tisu dεm na wi bren. Dis pat rili impɔtant fɔ wi mɛmori, lan, fɔ muv bay wilful, ɛn fɔ fil.
- di basal ganglia: Dis na wan kכlekshכn fכ di nεv sεl dεm we de dip insay di bren. I impɔtant fɔ lan ɛn fɔ mek di motoka wok fayn.
di wɔd "dijεnεreshכn" min "dεtεryushכn" כ "lכs כf fכnshכn." So wetin kin apin pan dis sik na dat, di wok we dɛn tu pat ya na di bren de du kin stɔp smɔl smɔl.
dis kכndyushכn, ``Corticobasal Degeneration``, kin sכt pכsin in layf εn mek i gεt kכmplikεshכn dεm we de mek i in layf de pan denja. As de sik de skata ɔlsay na di bɔdi, i kin tranga fɔ wok fɔ insɛf.
Wetin na di simptom dɛm fɔ `(Corticobasal Degeneration)`?
De sayn dɛm fɔ dis sik kin difrɛn frɔm wan pɔrsin to ɔda pɔrsin, bɔt de abiliti wae kin afɛkt in jɛnɛral na:
- difεlεns fכ muv (`Apraxia`): Dis min se tin dεm lεk fכ bכtכm כ fכ ol spun fכ it kin tranga. Pan ɔl we di bren kin sɛn mɛsej to di an dɛn, dɛn nɔ kin ebul fɔ du am fayn.
- I nɔ kin mɛmba fayn: I kin at fɔ mɛmba nyu tin dɛn, ɛn smɔl smɔl pipul dɛn kin fɔgɛt ol tin dɛn.
- Wae pɔrsin nɔr kin si fayn: Sɔm pipul kin gɛt prɔblɛm bak fɔ si.
- Difikulti fɔ tɔk (`Aphasia`): I nɔ kin izi fɔ fɛn wɔd, fɔ slɔr wetin yu want fɔ tɔk, ɛn sɔm tɛm dɛn kin lɔs fɔ tɔk kɔmplit wan.
- I nɔ izi fɔ swɛla: Yu kin fil lɛk se yu de chok we yu de swɛla it ɛn drink.
Apat frɔm dis, yu kin si ɔda sayn dɛm lɛk dis bak:
- Mɔsul dɛn de spam, twitch, mɔsul dɛn we stif, ɔ we de shek shek.
- I nɔ izi fɔ du smɔl, dilik wok dɛn (e.g., fɔ bɔtin shirt, rayt wit pen).
- Alien hand syndrome: Na di nɔ ebul fɔ kɔntrol wan an ɔ leg lɛk aw yu want (`Alien hand syndrome`). Imajin se wan pan yu an de du tin dɛn we yu nɔ want am fɔ du, ɛn yu fil lɛk se yu nɔ ebul fɔ kɔntrol am.
- Wan filin we de mek pɔsin nɔ fil fayn na wan say na di bɔdi.
- di muvmεnt dεm de rili slo (`Bradykinesia`) כ di inability fכ muv di limb dεm (`Akinesia`).
- Di mental fכnshכn we de dכn, dat na di dכn intεlεjεns (Dementia).
- I nɔ izi fɔ waka we pɔsin nɔ ɛp am.
- Chenj na di mud ɛn bihayvya (nɔ de pe atɛnshɔn, vɛks wantɛm wantɛm, nɔ bisin bɔt ɔda pipul dɛn).
Dis sik nɔ kin afɛkt ɔlman di sem we. Bɔku tɛm, i kin go bifo smɔl smɔl. Sɔntɛnde, di sik kin bigin na wan an, dɔn i kin go na di ɔda an ɛn leg. Yu kin bigin fil lɛk se yu de stɔp we yu de waka, dɔn yu nɔ go ebul fɔ waka we yu nɔ ɛp yu. Yu kin bigin fɔ swɛ yu wɔd dɛn we yu de tɔk, ɛn as tɛm de go, yu nɔ go ebul fɔ tɔk wan sɛntɛns we gɛt minin.
As di sik de afɛkt mɔ ɛn mɔ pat dɛn na di bren, de sik kin wɔs smɔl smɔl. Dis kin apin smɔl smɔl.
Ustɛm di sayn dɛm fɔ `(Corticobasal Degeneration)` kin bigin?
Bɔrku tɛm de sik kin bigin bitwin 50 ɛn 70. Bɔrku pipul dɛn kin gɛt dɛn sik lɛk aw dɛn ol 64 ia.
Wetin na di tin dɛm we kin mek pɔsin gɛt `(Corticobasal Degeneration)`?
Di men rizin fɔ dis na bikɔs di bren sɛl ɛn tisu dɛn kin brok smɔl smɔl ɛn day. Bɔku tɛm, dis damej kin bigin na di say dɛn we wi bin dɔn tɔk bɔt bifo tɛm we dɛn kɔl di sɛribra kɔtɛks ɛn di basal ganglia. As di sik de go bifo, i kin afɛkt ɔda pat dɛn na di bren bak.
Risach pipul dεm biliv se wan protin we dεn kכl "Tau" de involv pan dis sik. dis protin de nכmal fכ de na di bren sεl dεm. Bɔt insay dis sik, dis prɔtin nɔ kin gɛda togɛda ɛn mek klɔmp. dεn kכl dεn kכlכmp dεm ya "nyurofibrillar tangles." Dɛn grup ya kin mek di bren sɛl dɛn pwɛl ɛn day. Dis kin mek prɔblɛm dɛn we kin apin we pɔsin de muv, we i de tɔk, ɛn we i de mɛmba.
di ekzak rizin we mek di Tau protin de kכlכm tכgeda dεn nכ no yet. dεn fכnshכn se bכku pipul dεm we gεt Kכtikobasal Dijεnεreshכn gεt wan jεnεtik vεryכnt (mכtεshכn) we dεn kכl di H1 haplotayp pan kromozom 17. dis jεnεtik vεryushכn kin mek di Tau protin prodyuz pasmak εn kכlכm togeda, כ i kin bi se wan mεtil grup de atak di Tau jin, we de afekt in wok.
Bɔt di wan dɛn we de stɔdi bɔt dis no se nɔto dis jin nɔmɔ de mek dis sik. biכs bכku pipul dεm na di jεnarכl pכpulεshכn gεt dis jin, dεn nכ de divεlכp di simptom dεm fכ ``Corticobasal Degeneration.`` So dεn stil de du risεch fכ fכn di εksakεt kכz fכ dis kכndyushכn.
Na `(Kɔtikobasal Dijɛnɛreshɔn)` na ɛritayt?
Di wan dɛm wae sabi bɔt mɛrɛsin stil nɔr no wetin mek sɔm pipul dɛm kin gɛt Kɔtikobasal Dijɛnɛreshɔn. E nɔr kin izi fɔ mek pipul dɛm na di sem famili gɛt dis sik. Dat min se i at fɔ se na sik we pɔsin kin gɛt frɔm in mama ɛn papa.
Wetin na di prɔblɛm dɛn we kin apin?
As di sik de go bifo, de risk fɔ gɛt prɔblɛm dɛn we de mek pɔsin in layf de pan denja lɛk:
- Baktri infεkshכn dεm
- Blɔd klɔt ɛn pulmonari ɛmbolizm
- Aksidɛnt dɛn we kin apin to pɔsin in bɔdi (lɛk we pɔsin fɔdɔm) .
- Nyumonia
- Sepsis (na wan bad bad infεkshכn we di jεm dεm we de kam insay di bכdi) .
Aw dɔktɔ dɛn kin no bɔt dis sik? (`Diagnosis`) .
di pekul we de fכ no di sik `(Corticobasal Degeneration)` na dat dεn kin כnli kכnfכm am difinitiv wan bay we dεn egzamin di bren afta dεn day. Na da tɛm de nɔmɔ dɔktɔ ɔ pɔsin we de stɔdi bɔt sik dɛn go ebul fɔ no kɔrɛkt wan aw di bren dɔn pwɛl.
Bɔt insay yu layf, yu dɔktɔ kin kɔl dis sik "Corticobasal Syndrome" bay di sayn dɛm we yu gɛt.
Fɔ no if yu gɛt di sik, yu dɔktɔ go du fɔs fɔ chɛk yu bɔdi. Dɛn go tek tɛm luk pan yu sayn dɛm.
Bikɔs bɔku sik dɛn kin gɛt di sem sayn, yu dɔktɔ kin du difrɛn tɛst dɛn fɔ no di rayt tin we kin mek dɛn sik. Dɛn tin ya kin bi:
- Blɔd tɛst dɛn
- Bren imej test (`Imaging scans`) - fכ egzampl `(MRI)` כ `(CT scan`)
- Nyurosaykolojik tεst fכ ases di bren fכnshכn εn mεmכri
pan tap dat, di dכkta kin כda nyuklia mεdisin skan dεm lεk `(FDG-PET (Fluorodeoxyglucose Positron Emission Tomography))` εn `(DAT (Dopamine Transporter))`. Sɔntɛnde, `skin biopsy` kin ɛp bak fɔ no di sik.
Wetin na di tritmɛnt dɛm fɔ `(Corticobasal Degeneration)`?
Yu dɔktɔ kin gi yu difrɛn mɛrɛsin fɔ kɔntrol di difrɛn difrɛn sayn dɛm fɔ dis sik.
Mɛmba se naw, no mɛrɛsin nɔr de fɔ dis sik ɔr mɛrɛsin fɔ stɔp di sik wae de kam pan pɔrsin. Bɔt tin dɛn de wae kin ɛp fɔ ridyus de diskɔmfɔt wae de kam wit de sik.
Di mɛrɛsin fɔ di sik dɛn we gɛt fɔ du wit di mɔsul dɛn kin bi:
- Slow muvmεnt כ mכsul dεm stiff: `(Levodopa)`
- Fɔ di mɔsul dɛn we de spam: Klɔnazepam (Bɛnzodiazepines) .
- Fɔ mek di mɔsul dɛn stiff ɔ fɔ kɔntrol di muvmɛnt: `(Botulinum toxin)` (Botox injection)
- fכ di mכsul dεm stiff: `(Cyclobenzaprine)`, `(Levetiracetam)` כ `(Baclofen)`
Fɔ mɛmori prɔblɛm, yu dɔktɔ kin gi yu wan pan dɛn kayn mɛrɛsin ya we dɛn kɔl ``Cholinesterase inhibitors'':
- `(Dɔnɛpezil)`
- `(Rivastigmin)`
- `(Galantamin)`
Sɔm mɛrɛsin nɔr kin woke fayn fɔ ɔlman in sik, so yu dɔktɔ kin tray difrɛn kayn mɛrɛsin fɔ fɛn di wan wae go woke fayn fɔ yu.
Dɔn bak, lɛk ɔl di mɛrɛsin dɛn, sɔm bad tin dɛn de we kin apin to pɔsin. Yu dɔktɔ go tɔk to yu bɔt dis. Dɛn go de chɛk yu ɔltɛm fɔ mek shɔ se di mɛrɛsin de wok fayn ɛn if ɛni prɔblɛm de. If yu gɛt ɛni sayd ɛfɛkt, yu fɔ tɛl yu dɔktɔ wantɛm wantɛm.
Di tin we impɔtant pas ɔl na dat, naw, no tritmɛnt nɔ de fɔ stɔp dɛn sik ya we de go bifo ɔ fɔ mɛn di sik kpatakpata.
Aw fɔ kɔntrol di sayn dɛm?
We yu de liv wit di simptom dɛm fɔ ``Corticobasal Syndrome,'' dɛn tritmɛnt ya kin ɛp fɔ mɛn dɛn:
- Occupational therapy: Dis kin ɛp yu fɔ lan nyu we fɔ du ɛvride wok ɛn kip yu indipɛndɛns fɔ lɔng tɛm. If nid de, yu kin lan bak aw fɔ yuz tin dɛn we go ɛp yu fɔ muv.
- Fizik tritmɛnt: Dis kin ɛp fɔ mek di bɔdi kɔntinyu fɔ muv ɛn fɔ mek i nɔ fil fayn bikɔs ɔf di sik dɛn we gɛt fɔ du wit di mɔsul dɛn. Ɛksesaiz kin ɛp fɔ mek yu mɔsul dɛn strɔng ɛn fɔ mek yu ebul fɔ chenj chenj.
- Spich therapy: Dis kin ɛp fɔ mek yu nɔr ebul fɔ tɔk ɛn swɛla. I kin ɛp wit tin dɛn lɛk aw fɔ tɔk bɔt aw pɔsin de tink, aw fɔ kɔl wɔd dɛn, ɛn aw fɔ swɛla it fayn fayn wan.
Yu dɔktɔ go wok wit yu fɔ fɛn di bɛst we fɔ mɛn yu sik dɛn. Dɛn strateji ya kin difrɛn frɔm pɔrsin to ɔda pɔrsin, ɛn yu kin nid fɔ ajɔst as yu kɔndishɔn de chenj as tɛm de go.
Ustɛm yu fɔ go to dɔktɔ?
If yu ɔ pɔsin we yu lɛk gɛt ɛni wan pan dɛn sayn ya fɔ `(Corticobasal Degeneration)`, go to dɔktɔ wantɛm wantɛm:
- If i nɔ izi fɔ yu fɔ waka ɔ fɔ kɔntrol yu an ɛn fut dɛn.
- If yu de gɛt prɔblɛm wit yu mɛmori ɔr de simptom dɛm fɔ dis maynia sik.
- If i nɔ izi fɔ yu fɔ tɔk, fɔ swɛla, ɔ fɔ blo.
- If tin dɛn we de shek shek de.
Wetin na di prɔgnosis fɔ `(Kɔtikobasal Dijɛnɛreshɔn)`?
Fɔ tɔk tru, di luk fɔ Kɔtikobasal Dijɛnɛreshɔn nɔ rili prɔmis. Na sik we de go bifo, we min se di sayn dɛm kin wɔs as tɛm de go.Bɔt bɔku tɛm dis kin apin smɔl smɔl, fɔ lɔng tɛm. Yu dɔktɔ go gi yu tritmɛnt fɔ ɛp yu fɔ bia wit ɛn kɔntrol yu sik dɛn. Pan ɔl we dɛn tritmɛnt ya kin mek yu nɔr gɛt bɛtɛ sik, dɛn nɔr kin ebul fɔ stɔp dɛn fɔ wɔs. As yu de sik de wɔs, e kin tranga fɔ kɔntrol dɛn fɔ yusɛf.
Bikɔs dis sik kin go bifo smɔl smɔl, yu kin gɛt tɛm fɔ plan fɔ yu tumara bambay. Yu nɔr nid fɔ du dɛn tin ya wantɛm wantɛm we yu gɛt diagnosis. Yu nid fɔ tek tɛm tink bɔt wetin bɛtɛ fɔ yu. Yu nid fɔ wok wit yu dɔktɔ ɛn pipul dɛn we yu trɔst fɔ ɔganayz wetin yu want ɛn us kia yu nid.
Wetin na di layf we pɔsin we gɛt `(Corticobasal Degeneration)` kin liv?
Na avrej, bɔku pipul dɛn kin liv lɛk siks to et ia afta di fɔs sayn dɛm fɔ Kɔtikobasal Dijɛnɛreshɔn dɔn apia. Bɔt dis nɔ kin bi di sem fɔ ɔlman, ɛn sɔm pipul dɛn kin liv lɔng pas dat. Yu sityueshɔn nɔ go fit di statystik, so di bɛst pɔsin fɔ tɔk to bɔt dis na yu dɔktɔ.
Us ɔda sik dɛn we gɛt di sem kayn sayn?
Sɔm pan di sayn dɛm fɔ `(Corticobasal Degeneration)` kin tan lɛk di sayn dɛm fɔ ɔda sik dɛm, lɛk:
- Bren kansa (`Bren kansa / bren tumor`)
- `(Frontotemporal dimɛnshɔn)`
- Dis sik we dɛn kɔl Alzaima
- `(Mɔltipɛl sistɛm atrofi)`
- Dis sik we dɛn kɔl Parkinson
- `(Progresiv supranuklyar palsi)`
- Strok
So, i rili impɔtant fɔ go to dɔktɔ wantɛm wantɛm if yu gɛt ɛni sayn, bikɔs if yu trit yu kwik kwik wan, dat kin sev yu layf, mɔ pan kes dɛm lɛk paralayz.
i kin tranga fכ mεnεj di imyushכn dεm we de kam wit diagnosis lεk `(Corticobasal Degeneration)`. Yu kin fil fred ɛn wɔri bɔt tumara bambay. As di sayn dɛm de kam bifo as di ia dɛn de go, yu kin de wɔnda aw fɔ yuz ɛvri mɔnt fayn fayn wan. I kin tranga fɔ du ɔl dis wan tɛm. Yu kin want fɔ tɔk bak to pɔrsin wae sabi bɔt mɛntɛl hεlth fɔ sɔpɔt yu insay dis tranga tɛm.
Mɛmba se nɔto yu wangren de du ɔl dis. If yu nid ɛp, nɔ ɛva shem fɔ kɔntak yu mɛdikal tim.
Fɔ dɔn, tin dɛn we wi fɔ mɛmba
Okay, so na sɔm tin dɛn we wi dɔn tɔk bɔt `(Corticobasal Degeneration)` we a tink se go impɔtant to yu:
- Dis na wan sik wae kin afɛkt di bren ɛn de sik kin bɔku smɔl smɔl as tɛm de go.
- dεn nכ fכnshכn di εksakεt kכz fכ dis yet, bכt dεn tink se i riliyt to wan protin we dεn kכl `(Tau)`.
- Naw, no tritmɛnt nɔ de fɔ mɛn di sik ɔltogɛda.
- Bɔt, tritmɛnt dɛn de fɔ kɔntrol di sayn dɛm ɛn mek layf izi.(Lɛk mɛrɛsin, fizik tɛrapi, ɔkupeshɔn tɛrapi, tɔk tɛrapi).
- I impɔtant fɔ go to dɔktɔ kwik kwik wan.
- Plan fɔ tumara bambay ɛn gɛt di sɔpɔt we yu nid.
- Nɔto yu wan de. I rili impɔtant bak fɔ mek yu kɔntinyu fɔ gɛt trɛnk na yu maynd. Gɛt ɛp frɔm dɔktɔ dɛn, yu fambul dɛn, ɛn yu padi dɛn.
A op se dis infɔmeshɔn go ɛp yu. If yu gɛt ɛni kwɛstyɔn, nɔ shem fɔ tɔk to yu dɔktɔ.
` Kɔtikobasal Dijɛnɛreshɔn, Bren Sik, Nyurolɔjik Sik, Muvmɛnt Dizayd, Mɛmori Impayrmɛnt, Tɔk Disɔda, Tau Protein, CBS, Bren Atrofi, Apraxia, Aphasia, Dimɛnshɔn
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