Yu tink se pipul dɛn de na yu famili we dɔn gɛt at atak bifo dɛn ol, dat na, we dɛn ol 40-50 ia? Ɔ i kɔmɔn fɔ mek pipul dɛn na yu famili kin se ɔltɛm, "High cholesterol, high cholesterol"? Bɔku tɛm, wi kin tink se di rizin fɔ dis na tin dɛn lɛk wetin wi de it ɛn drink, ɛn nɔ de du ɛksɛsayz. Dat na tru, ɛn dat kin afɛkt bak. Bɔt sɔntɛnde, di rial rizin biɛn dis ay kɔlɔstrel kin bi prɔblɛm insay wi bɔdi, insay wi jin dɛn. Na dat wi kin kɔl `Familial Hypercholesterolemia` ɔ `FH` na mɛrɛsin. Tide, wi go tɔk bɔt dis simpul wan, di we we yu go ɔndastand.
Fɔ tɔk am simpul wan, wetin na Familial Hypercholesterolemia (FH)?
Familial Hypercholesterolemia na wan sik wae de kam pan pɔrsin in mama, papa, ɔr ɔl tu. dis na we di "bad" kכlestכl, כ LDL kכlestכl, na wi bכdi de rili hכy frכm we dεn bכn am.
Tink bɔt wi blɔd vesel dɛn lɛk at. dis `LDL` kכlestכl lεk yכlכ, waks layεr we de stik pan di wכl dεm fכ dεn at dεm de. Nɔmal wan, dɛn tin ya kin bil smɔl smɔl. bכt pan pכsin we gεt `FH`, di `LDL` kכlestכl lεvεl so hכy dat dis waks layεr de bigin fכ bil כp bכku bכku wan εn rili tik insay di bכdi vεsul dεm. Wi kin kɔl dis `atherosclerosis`. As tɛm de go, dis layt de gro ɛn mek di blɔd vesel dɛn smɔl, ɛn sɔntɛnde i kin blok dɛn kpatakpata. Na da tɛm de tin dɛn we kin mek pɔsin in layf de pan denja lɛk at atak ɛn strok kin apin.
di `LDL` kכlestכl lεvεl fכ nכmal hεlty pכsin fכ less dan 100 mg/dL. כltu, pan pכsin we gεt `FH`, dis valyu kin b כku bכku wan, lεk 160 mg/dL, 190 mg/dL . insay sכm siriכs kes dεm, i kin ivin pas 400 mg/dL. Di tin we denja pas ɔl na dat bikɔs dis sik dɔn de frɔm we i smɔl, if dɛn nɔ trit am, di risk fɔ gɛt at sik kin rili bɔku we i yɔŋ pas di avɛrej pɔsin.
Dis stori kin tan lɛk se yu de fred smɔl, bɔt di gud nyus na dat if yu no am kwik, tek di rayt mɛrɛsin, ɛn chenj yu layf, i go lɛf smɔl fɔ lɛ yu kɔntrol am ɛn liv fayn layf.
Tu men kayn FH de.
Dis kɔndishɔn kin gɛt tu men kayn tin bay aw wi kin gɛt am. Dis na tin we rili simpul fɔ ɔndastand.
Imajin se wi bɔdi gɛt tu ‘instrɔkshɔn’ fɔ kɔntrol kɔlɔstrel. Wan wi kin gɛt frɔm wi mama, ɛn di ɔda wan frɔm wi papa.
1. Hεterozaygכs FH: Dis na di tכp we kכmכn pas כl. wetin de apin ya na dat wan defεkt de na di ‘instrכkshכn buk’ (jin) we dεn kin gεt frכm wan mama εn papa nכmכ, we na di mama כ di papa. Dis min se wan buk gud, ɛn di ɔda buk gɛt smɔl mistek. Dis kin mek di kɔlɔstrel kɔntrol nɔ de wok smɔl.
2. Homozygous FH: Dis kin rili rare, ɛn i kin rili bad bak.Kayn. Wetin kin apin ya na dat ɔl tu di ‘instrɔkshɔn’ we dɛn kin gɛt frɔm mama ɛn papa ɔl tu gɛt fɔlt. Dɔn di we aw dɛn de kɔntrol di kɔlɔstrel kin rili wik. di `LDL` kכlestכl lεvεl dεm fכ dεn pipul ya rili hכy.
`FH` na jεnεtik sik we de insay di `autosomal dominant` kεtכgrεf. Dis jɔs min se pikin nɔ nid fɔ gɛt di jin we nɔ fayn frɔm in mama ɛn papa fɔ gɛt di sik, i go du fɔ gɛt am frɔm wan mama ɔ papa nɔmɔ .
Dis min se if yu gɛt `FH`, 50% chans de fɔ mek yu pikin gɛt di kɔndishɔn. Semweso, 50% chans de fɔ mek yu brɔda ɛn sista dɛnsɛf gɛt dis sik.
Aw dis sik kin kɔmɔn? Wetin na di sayn dɛm we de sho se yu gɛt dis sik?
dεn εstimat se wan pan εvri 250 pipul dεm na di wכl gεt di kכmכn kכndyushכn `Heterozygous FH`. Bɔt di tin we rili sɔri na dat 9 pan ɔl 10 pan dɛn pipul ya nɔ no se dɛn gɛt dis sik .
Bɔrku tɛm, FH nɔr kin sho ɛni patikyula simptom na di fɔs stej. Yu nɔ go no se yu gɛt FH te yu gɛt at atak, lɛk we yu de fil pen na yu chɛst. Bɔt afta dat, i kin bi se i dɔn tu let. Dis na bikɔs di kɔlɔstrel we de na di blɔd vesel dɛm fɔ pɔsin we gɛt FH kin bigin fɔ fɔm frɔm di de we dɛn bɔn am.
As tɛm de go, we di kɔlɔstrel bɔku kin mek yu gɛt dɛn sik ya.
| Di sayn we de sho se di sik de | Simpul ɛksplen |
|---|---|
| At sik we dɛn yɔŋ | Chɛst pen (angina) we kin apin we yu de du ɛksɛsayz ɔ we yu de rɛst, at atak ɔ strok we yu yɔŋ (man - ɔnda 55 ia, uman - ɔnda 65 ia). |
| Xanthomas we dɛn kɔl Xanthomas | Yɔlɔ lumps we kin kam bikɔs ɔf di kɔlɔstrel we de ɔnda di skin. Dɛn kin si dɛn tin ya mɔ na di ɛlb, ni, finga jɔyn, ɛn rawnd di Akilis tɛndon (ɔp di il). |
| Xanthelasmas we dɛn kɔl Xanthelasmas | yכlכ kכlestכl dεposit dεm we de fכm כnda di skin rawnd di aylid dεm. |
| Kɔnia Aks we dɛn kɔl | Wan wayt, grey, ɔ blu ring we de rawnd di blak yay. Dis kin apin mɔ pan pipul dɛn we dɔn ol, bɔt if dɛn si am pan pɔsin we nɔ rich 45 ia yet , i kin bi sayn fɔ FH. |
| Flip di kɔyn | Pen na di leg dɛn we de dɔŋ, mɔ we yu de waka. Dis kin bi bikɔs di vein dɛn we de gi blɔd to di leg dɛn kin smɔl. |
Aw dɛn kin no se pɔsin gɛt FH?
If yu dɔktɔ sɔspɛkt se yu gɛt FH, dɛn go luk sɔm tin dɛn fɔ kɔnfirm di diagnosis.
- Blɔd tɛst: Dis na di tin we impɔtant pas ɔl. wan bכdi tεst we dεn kכl `Lipid Profile`, we de chεk yu kכlestכl lεvεl, de luk fכ abnכmal hכy lεvεl dεm fכ `LDL` kכlestכl. if i pas 190 mg/dL pan big pɔsin, ɔ pas 160 mg/dL pan pikin, dɛn kin sɔprayz se `FH`.
- Famili mɛdikal istri: Dis rili impɔtant. Yu dɔktɔ go mɔs aks yu kwɛstyɔn dɛn lɛk, "Yu papa, mama, grani ɛn granpa, ɔ yu brɔda ɛn sista dɛn dɔn ɛva gɛt at atak we dɛn yɔŋ?" "Ɛnibɔdi na yu famili gɛt ay kɔlɔstrel?"
- Fɔ chɛk yu bɔdi: Di dɔktɔ go chɛk yu bɔdi fɔ ɛni sayn fɔ xanthomas (skin lumps) ɔ kɔnia arcus (ay sɛklɔ) we wi bin dɔn tɔk bɔt.
- Jɛnɛtik tɛst (DNA tɛst): Sɔntɛnde, dɛn kin du jɛnɛtik tɛst fɔ no if pɔsin gɛt di sik. dis kin chεk fכ difεkt dεm na di men jin dεm we de mek FH (lεk APOB, LDLR, כ PCSK9).
Wetin na di tritmɛnt dɛn?
`FH` nɔto sik we wi kin mɛn. Na bikɔs na sɔntin we kin kam wit wi jin. Bɔt dɛn kin kɔntrol am fayn fayn wan . Di men gol fɔ tritmɛnt na fɔ ridyus di `LDL` kɔlɔstrel lɛvɛl as i pɔsibul, we go ridyus di risk fɔ gɛt at sik.
1. Mɛrɛsin (di kayn mɛrɛsin dɛn) .
di chenj na layf stayl nכmכ nכ go inof fכ kכntrכl kכlestכl fכ pכsin we gεt `FH`. So dɛn fɔ tek wan ɔ mɔ mɛrɛsin fɔ di res ɔf dɛn layf .
- Statin dɛn: .Dɛn mɛrɛsin ya na di mɛrɛsin dɛn we dɛn kin yuz mɔ ɛn we dɛn kin tek fɔs. Dɛn kin wok bay we dɛn de ridyus di kɔlɔstrel we di liva de mek.
- PCSK9 inhibito dεm: Dis na rili nyu klas fכ injεkt mεdikeshכn dεm. Dɛn kin rili woke fɔ pipul dɛm wae dɛn nɔr kin ebul fɔ kɔntrol dɛn kɔlɔstrel wit statin nɔmɔ.
- Ezetimibe: Dis mεdikeshכn de wok bay we i de ridyus di kכlestכl we de kכmכt frכm di it dεm we wi de it. Bɔku tɛm dɛn kin gi am togɛda wit statin.
- כda mεdikeshכn dεm: pan tap dat, כda mεdikeshכn dεm de lεk `Bile acid sequestrants` εn `Fibrates`. Yu dɔktɔ go disayd us mɛrɛsin go fayn fɔ yu.
2. Di chenj we pɔsin de liv in layf
Apat frɔm we yu de tek mɛrɛsin, i impɔtant bak fɔ fala wɛlbɔdi layf. Dis nɔr kin jɔs mek di mɛrɛsin woke fayn fayn wan, bɔt i kin ridyus di risk fɔ gɛt at sik mɔr.
| Wetin fɔ du | Wetin fɔ avɔyd |
|---|---|
| Fɔ it dɛn we go ɛp yu at: Vɛjitebul, frut, ligɛm, fayv grens (brawn rays, ɔts), fish (salmon, makrɛl, ɛring), dairy we nɔ gɛt bɔku fat ɛn mit. | Satyuret ɛn trans fat: Fried it, fast fud, bekeri prodakt (kek, pati), mit we gɛt fat, yuz kokonat ɔyl ɛn pam ɔyl pasmak. |
| Ɛksesaiz ɔltɛm: Du ɛksɛsayz lɛk fɔ waka kwik kwik wan, rɔn, ɔ bayk fɔ at le 30 minit insay di de, at le 5 dez insay di wik. | Smok ɛn rɔm: Dɛn fɔ stɔp fɔ smok kpatakpata. I kin pwɛl di blɔd vesel dɛn bad bad wan. Dɛn fɔ smɔl fɔ drink rɔm. |
| Fɔ mek yu gɛt wɛl bɔdi wet: If yu kɔntrol yu bɔdi wet, dat kin mek di at nɔ strɛs. | Swit drink ɛn it dɛn we gɛt bɔku shuga: Dɛn tin ya kin mek yu gɛt bɔku bɔku bɔdi ɛn ɔda prɔblɛm dɛn wit yu wɛlbɔdi. |
3. Ɔda patikyula tritmɛnt dɛn
Fɔ pipul dɛm we gɛt rili siriɔs homozygous FH, mɛrɛsin nɔmɔ nɔ go ebul fɔ kɔntrol dɛn kɔlɔstrel. Fɔ dɛn pipul ya, dɛn kin du wan tritmɛnt we dɛn kɔl LDL apheresis. Dis tan lɛk dayalaysis. Dɛn kin tek smɔl blɔd, pas am tru wan mashin, we kin pul di bad LDL kɔlɔstrel, dɔn dɛn kin put am bak insay di bɔdi. Dɛn kin du dis wan ɔ tu tɛm insay di wik.
If yu geht FH, wetin yu shud du?
If dɛn no se yu gɛt `FH`, i nɔ jɔs de bɔt yu. Na impɔtant mɛsej fɔ yu wan ol famili.
If yu gɛt FH, na yu wok fɔ mek dɛn tɛst yu mama ɛn papa, brɔda ɛn sista, ɛn pikin dɛn fɔ si if dɛn gɛt kɔlɔstrel. Wi kɔl dis ‘kaskad skrinin.’ Dis kin ɛp fɔ no ɔda pipul dɛn na yu famili bifo di sik kam ɛn bigin fɔ trit dɛn bak.
If pikin gɛt famili histri fɔ `FH`, dɛn kin tɛst di kɔlɔstrel ivin frɔm we i ol 2. Bikɔs di kwik we dɛn bigin fɔ trit dis sik, na di mɔ di prɔblɛm dɛn we kin apin kin smɔl tumara bambay.
If yu get `FH`, no panik. Stay in kɔntakt wit yu dɔktɔ. Tek yu mɛrɛsin di rayt tɛm. Mek chenj di we aw yu de liv yu layf. Dɔn yusɛf kin liv lɔng layf we gɛt wɛlbɔdi lɛk ɔlman.
Mɛsej we dɛn kin kɛr go na os
- Familial Hypercholesterolemia (FH) na wan sik we de kɔmɔt frɔm di jɛnɛreshɔn to di ɔda wan ɛn i kin mek di bad kɔlɔstrel (LDL) go ɔp frɔm we dɛn bɔn am.
- If ɛnibɔdi na yu famili dɔn gɛt at sik we i yɔŋ ɔ gɛt ay kɔlɔstrel, i rili impɔtant fɔ mek dɛn du tɛst fɔ FH.
- Bɔrku pipul wae gɛt dis sik nɔr kin no se dɛn gɛt dis sik. If yu no am kwik kwik wan, dat kin sev pipul dɛn layf.
- Fɔ tek mɛrɛsin fɔ ɔl yu layf ɛn fɔ liv fayn layf na impɔtant tin fɔ mek yu ebul fɔ kɔntrol FH.
- If dɛn no se yu gɛt `FH`, mek dɛn tɛst yu mama ɛn papa, brɔda ɛn sista, ɛn pikin dɛn bak. I go ɛp fɔ sev dɛn layf.
- If yu gɛt di rayt tritmɛnt, yu go ebul fɔ liv wɛl bɔdi ɛn lɔng layf. So nɔ fred, go to yu dɔktɔ ɛn gɛt tritmɛnt.
💬 Comments (0)
No kɔmɛnt nɔ de yet. Ad yu kɔmɛnt ya fɔ di fɔs tɛm.
Ad yu kɔmɛnt