Wetin na Glucagonoma? Lɛ wi tɔk bɔt dis sik we nɔ kin apin so ɔltɛm!

Di pankrias na smɔl bɔt rili impɔtant ɔgan na yu bɔdi. I de mek bɔku ɔmon dɛn we wi bɔdi nid. So, sɔmtɛm, wan kayn kansa we nɔ kin bɔku we kin kam na di pankrias kin mek prɔblɛm. Na dat dɛn kɔl dis sik Glucagonoma . Sɔntɛm yu dɔn gɛt dayabitis wantɛm wantɛm, ɔ yu dɔn gɛt sɔntin lɛk wan strenj rash na yu skin, i rili impɔtant fɔ no bɔt dis.

Wetin na glukagonoma? Fɔ tɔk am simpul wan...

Glucagonoma na wan kansa we nɔ kin bɔku ɛn we kin kam na yu pankrias. Dis tumbu de mek tumɔs pan wan ɔmon we dɛn kɔl glukagɔn. Naw yu kin de wɔnda wetin na dis glukagon.

Glucagon na wan rili impɔtant ɔmon we de ɛp fɔ kɔntrol di shuga lɛvɛl na wi bɔdi, dat na, di glukɔs lɛvɛl na wi blɔd . Na di alfa sɛl dɛn, we na wan spɛshal kayn sɛl we de na yu pankrias, mek am. Imajin if yu nɔ it fɔ sɔm tɛm, if yu rili ɛksesaiz, ɔ if yu it tin we gɛt bɔku prɔtin, yu blɔd shuga kin go dɔŋ, nɔto so? Na da tɛm de dis glukagon kin kam insay, i kin pul di shuga we dɛn dɔn kip na yu liva, dat na glycogen , ɛn i kin mek di blɔd shuga lɛvɛl bak ɔp. I tan lɛk pɔsin we de ɛp fɔ mek di shuga balans na wi bɔdi.

Bɔt we glukagɔnoma de, dis glukagɔn ɔmon kin kɔmɔt pasmak. Dɔn wi bɔdi nɔ kin ebul fɔ bia wit am. di kכmbaynshכn fכ di simptom dεm we de apin bikoz fכ dis dεn kכl am Glucagonoma Syndrome . Dis kin mek yu gɛt bɔku prɔblɛm dɛn lɛk prɔblɛm wit yu skin ɛn dayabitis.

Dis kayn kansa we dɛn kɔl glukagonoma de insay di kategori we dɛn kɔl pankrias nyuroɛndokrin tɔŋ , ɔ aylet sɛl tɔŋ . Bɔku tɛm, dɛn tin ya kin apin na di tel ɔ midul pat na di pankrias.

Yu tink se dis rili kansa?

Yɛs, bɔku tɛm, glukagonoma na kansa . Di tin we sɔri na dat, ivin we dɛn no se i gɛt am, insay lɛk 50% pan di kes dɛm, dat na lɛk wan pan tu pipul dɛm, dis kansa kin dɔn spre (metastasized) to ɔda pat dɛm na di bɔdi, mɔ di liva .

Aw dis sik kin kɔmɔn?

Glucagonoma na rili wan sik we nɔ kin apin so ɔltɛm . I nɔ rich wan pan ɛvri milyɔn nyu wan dɛn we gɛt di sik ɛvri ia. Bɔrku tɛm e kin afɛkt pipul dɛm wae ol bitwin 50 ɛn 70 ia .

Wetin na di sayn dɛm fɔ dis?

Bɔku tɛm di glukagonoma dɛn kin gro sloslo . So, pas yu bɔdi prodyuz inof glukagon fɔ mek yu gɛt prɔblɛm, yu nɔ go gɛt ɛni sayn.

Bɔt we glukagɔn de mek tumɔs glukagon ɛn di bɔdi nɔ ebul fɔ bia wit am, di glukagɔnoma sindrom we wi bin dɔn tɔk bɔt kin apin.I kin apin. Dɔn, yu go si klia sayn dɛn. If yu gɛt dɛn sik ya, i rili impɔtant fɔ go to dɔktɔ kwik kwik wan.

Skin rash (Nɛkrɔlaytik Maygrɛt Ɛritɛm - NME) .

Dis na di men ɛn kɔmɔn sayn fɔ glukagonoma syndrome. Na lɛk 90% pan di pipul dɛm wae gɛt dis sik kin gɛt dis prɔblɛm wit dɛn skin. Dɛn kɔl am nɛkrɔlaytik maygrɛt ɛritɛma (NME) .

Imajin, yu skin, mɔ na di prayvet pat dɛn, yu bɔdi, ɛn yu leg dɛn we de dɔŋ, kin bigin fɔ gɛt say dɛn we rɛd, i kin it, ɛn sɔntɛnde yu kin fil pen. Leta dɛn tin ya kin tɔn to blista, krak krak, ɛn krɔst oba. Ivin afta dɛn dɔn wɛl, wan brawn spat kin stil de. Dis kin fɔm na wan ples, wɛl, dɔn i kin apia bak na ɔda ples. I tan lɛk rash we de muf frɔm wan ples to ɔda ples.

Ɔda tin dɛn we NME gɛt:

• Dis kin kam ɛn go, ɛn i kin muv rawnd di bɔdi .
• I kin rili it ɛn pen fɔs.
• Di rash kin tɔn rɛd ɛn afta dat i kin gɛt blista ɛn mek wan krɔkrɔs. Afta i dɔn wɛl, wan brawn spat kin lɛf.
• Dis kin mek yu gɛt tin dɛn lɛk tɔng sos (glossitis ), mɔt sos, lip dɛn we chap, ɛn angular cheilitis .
• Di aylid dɛn kin swel ( blepharitis ), yu ia kin lɔs, ɛn yu nel kin gɛt prɔblɛm wit yu nel bak.

Di sayn dɛn we de sho se pɔsin gɛt dayabitis

Dis sik kin mek yu blɔd shuga bɔku ( hyperglycemia ), we kin mek yu gɛt dayabitis. Di sayn dɛm wae de sho se yu gɛt dayabitis na:

• Fɔ bi tin fɔ no rizin.
• Fɔ tɔsti pasmak bɔku tɛm (Polydipsia) .
• Fɔ pis bɔku tɛm ( polyuria ), mɔ na nɛt.
• Angri pasmak ( Polyphagia ).

Ɔda sayn dɛm fɔ (glucagonoma syndrome) .

Bɔku ɔda sayn dɛn de we kin sho se yu gɛt dis sik:

• Dayarɛa we nɔ de dɔn .
• Di ɛmoglobin we nɔ bɔku na di blɔd (anemia ). Dis kin mek yu taya ɛn mek yu ed tɔn.
• di bכdi kin kכlכt, spεshal wan na di dip vein dεm na di leg dεm ( Deep Vein Thrombosis (DVT) ).

Di simptom dɛm wae gɛt fɔ du wit di mental ɛn nervous system

Sɔmtɛm, yu kin si bak sɔm kayn sik wae gɛt fɔ du wit yu maynd ɛn nervɔs sistɛm, lɛk:

• Pwɛl at
• Dimɛnshɔnal sik
• Agiteshɔn
• Hyperreflexia (we di bɔdi de ansa kwik kwik wan) .
• Di we aw yu de waka we de mek yu nɔ ebul fɔ waka (ataxia ) .
• Disɔda wae de kam pan pɔrsin in maynd ( Psychosis) .) .
• Fɔ fred ɛn sɔprayz we nɔ gɛt rizin ( Paranoid Delusions ) .

Wetin kin mek pɔsin gɛt glukagonoma?

Bɔku tɛm, dɔktɔ dɛn nɔ kin no di rayt tin we kin mek pɔsin gɛt glukagonoma. Bɔt insay lɛk 10% pan di kes dɛm, dis kansa gɛt fɔ du wit wan jɛnɛtik kɔndishɔn we dɛn kɔl Multiple Endocrine Neoplasia type 1 (MEN type 1) .

Bɔt nɔto ɔlman we gɛt MEN tayp 1 kin gɛt glukagonoma. Dat sɛf na rili smɔl pasɛnt.

Aw yu no dis?

If yu gɛt di skin kɔndishɔn we dɛn kɔl necrolytic migratory erythema (NME) we wi bin dɔn tɔk bɔt, dɔktɔ kin sɔprayz se yu gɛt glukagonoma. Dɔn dɛn kin du tɛst dɛn lɛk:

• Fast Blɔd Shuga Tɛst: If di shuga lɛvɛl ay, dɛn kin sɔprayz se glukagonoma ɛn dɛn kin kɔnfɔm se i gɛt dayabitis we gɛt fɔ du wit am.
• Fasting Glucagon Blood Test: di glucagon lεvεl dεm de abnכmal hכy na glucagonoma – כltεm i pas 500 pikogram pan wan mililita (pg/mL). di nכmal fasting glukagon lεvεl dεm de less dan 150 pg/mL.
• Amino Asid Blɔd Tɛst: Glucagonoma kin mek di amino asid dɛn we de na di blɔd nɔ bɔku ( hypoaminoacidemia ).
• Kɔmplit Blɔd Kɔnt (CBC): Dis de chɛk fɔ anemia , bikɔs anemia kin apin wit glukagonoma.

Imej tɛst dɛn lɛk dis kin ɛp fɔ no if wan lump de:

• CT Skan we dɛn kin du
• MRI Skan we dɛn kin du
• Ɛndoskopik Ɔltrasɔund

Aw dɛn kin trit am?

di tritmεnt fכ glukagonoma de dipכnt bכku pan if di kεnsar de limited to di pankrias (localized) כ i dכn spre to כda pat dεm na di bכdi (metastasized) .

Aw fɔ kɔntrol di sik dɛn fɔs

di fכs tin we yu fכ du na fכ kכntrכl di simptom dεm εn di kכmplikεshכn dεm we dεn kin kכz fכ di glukagon we pasmak. Dɛn kin trit dis lɛk dis:

• Mεdikeshכn dεm fכ kכntrכl di glukagon we pasmak: Injεkshכn dεm we dεn kכ l Octreotide εn Lanreotide de εp fכ ridyus di ifekt dεm we di glukagon we pasmak de gi εn stכp glukagon prodakshכn. Dɛn mɛrɛsin ya kin ivin mek di tumbu dɛn nɔ gro kwik kwik wan. Dɛn kin gi rilif bak frɔm di sayn dɛm fɔ NME, dayabitis, dayarɛa, ɛn dizayd dɛm na di nervɔs sistɛm.
• Dayabitis mɛnejɛmɛnt: Yu kin nid fɔ tek ɔral dayabitis mɛrɛsin ɔ insulin injɛkshɔn fɔ mek yu blɔd shuga kɔntinyu fɔ de di rayt say.
• Sɔpɔt we gɛt fɔ du wit nyutrishɔn:Tכtal Parenteral Nutrition (TPN) , amino asid εn zink supliment dεm kin gi fכ ridyus di ifekt dεm we di malnutrishכn kin gi.
• Tritmɛnt fɔ NME skin sik: Antibayɔtik ɛn kɔtikosterɔyd kin mek NME bɛtɛ.
• Antikoagulant Tɛrapi: Blɔd tin dɛn lɛk ɛparin kin ɛp fɔ mek yu nɔ gɛt dip vein trombosis (DVT) .

If i limited to di pankrias...

If di kansa de na di pankrias nɔmɔ, ɔpreshɔn na di men tritmɛnt . If di dɔktɔ ebul fɔ pul di tumbu kpatakpata, bɔku tɛm di sik kin wɛl . afta dεn dכn pul di glukagonכma, yu glukagon lεvεl dεm fכ kam bak to nכmal. Yu simptom dɛm fɔ go bak.

If i dɔn spre to ɔda ples dɛn (metastasized)...

Ɛnitɛm we i pɔsibul, dɔktɔ dɛn kin se dɛn fɔ du ɔpreshɔn fɔ pul di tumbu dɛn. Dis kin inklud fɔ pul di tumbu dɛn na di pankrias, di limf no dɛn we de nia de, ɛn di liva.

Bɔt if di dɔktɔ we de du di ɔpreshɔn nɔ ebul fɔ pul ɛni wan ɔ ɔl di lump, yu mɛdikal tim kin tɛl yu wan ɔ mɔ pan dɛn tritmɛnt ya:

• Kimotɛrapi: Dis tritmɛnt de wok bay we i de pwɛl di kansa sɛl dɛn ɛn mek dɛn nɔ gro.
• Radiofrequency Ablation: Dis de yuz di wam we de kɔmɔt na di redio wev fɔ kil di kansa sɛl dɛn.
• Cryosurgical Ablation: Dis de yuz kemikal dεm we kol pasmak, lεk likwid naytrojen, fכ pwεl di kεnsar sεl dεm.
• Chemoemboliization: Dis tritmɛnt de blok di blɔd saplai to di kansa.

Wetin na di prɔgnosis fɔ wɛl frɔm dis kɔndishɔn?

De luk fɔ pɔrsin wae gɛt glukagonoma kin dipen pan sɔm tin dɛm:

• Yu ej ɛn ɔl yu wɛlbɔdi biznɛs .
• Di sayz fɔ di kansa tumbu .
• Ilɛksɛf di kansa dɔn skata ɔ nɔ skata .

If di kansa de na di pankrias nɔmɔ, di we aw pɔsin kin si am kin fayn . כpεrayshכn fכ pul di tכmכro kin kכl, bכt dis kin bi fכ כnli lεk 20% pan di wan dεm we gεt glukagonoma.

Bikɔs glukagonoma nɔ kin bɔku, nɔto inɔf data de fɔ tɔk ustɛm yu go ebul fɔ liv ɔ wetin go apin if di kansa skata. Yu mɛdikal tim go ebul fɔ gi yu mɔ infɔmeshɔn bay di patikyula tin we de apin to yu.

Yu tink se dɛn go ebul fɔ stɔp dis?

Bikɔs sayɛnsman dɛn nɔ no wetin kin mek bɔku pan di wan dɛn we gɛt glukagonoma, rili natin nɔ de we yu go du fɔ mek i nɔ gɛt am .

Bɔt if dɛn dɔn no se wan pan yu fɔs digri fambul dɛn (di mama ɛn papa ɛn brɔda ɛn sista dɛn) gɛt MEN (Multiple Endocrine Neoplasia) , tɔk to yu dɔktɔ bɔt aw fɔ tɛst yu jɛnɛtiks. If yu gɛt MEN bak, jenɛtik tɛst kin ɛp fɔ no di kansa dɛn we dɛn de bigin.

We dɛn no se yu gɛt kansa, dat kin rili mek yu at pwɛl. We na sɔntin we nɔ kin bɔku lɛk glukagonoma, i kin ivin tranga mɔ. Bɔt mɛmba se yu mɛdikal tim de fɔ ansa yu kwɛstyɔn dɛn ɛn sɔpɔt yu. If yu fil se yu wan gɛt glukagonoma na yu maynd ɛn fil, aks yu dɔktɔ bɔt program ɛn savis dɛm wae kin ɛp yu.

Fɔ dɔn, tin dɛn fɔ mɛmba (Take-Home Message) .

So, pan ɔl we glukagonoma na wan sik we nɔ kin apin so ɔltɛm, i impɔtant fɔ no bɔt am. Ɛspɛshali if yu gɛt sɔm kayn sik dɛn we tan lɛk dayabitis wantɛm wantɛm wit wan strenj skin rash (NME), lɛk aw wi bin dɔn tɔk, go to dɔktɔ we yu nɔ go te. If dɛn no am kwik, dɛn kin trit am. Pan ɔl we dis nɔ kin apin so ɔltɛm, tritmɛnt dɛn de.

Nɔ wɔri, nɔto yu wan de. Yu dɔktɔ ɛn di mɛdikal tim go ɛp yu fɔ du dis waka. Stay strɔng ɛn fala di advays we dɛn de gi yu.

` Glucagonoma, pankreas kansa, glukagon, dayabitis, skin simptom, ɔmon, kansa we nɔ kin bɔku