Yu de gɛt bɔku bɔku mɛthotrexate na yu bɔdi ɛn yu kidni dɛn wik? Dɔn lɛ wi lan bɔt dis Glucarpidase vaysin!

Yu kin de tink se, "Oh my, us kayn strenj mɛrɛsin a de tɔk bɔt?" Yɛs, dis na smɔl spɛshal mɛrɛsin. Sɔntɛnde, we tumɔs wan mɛrɛsin we dɛn kɔl Methotrexate, we dɛn kin yuz fɔ mɛn sik dɛn lɛk kansa, bɔku na di bɔdi, i kin mek yu gɛt prɔblɛm, mɔ if yu kidni nɔ de wok fayn. Na da tɛm de dis injɛkshɔn we dɛn kɔl Glucarpidase kin kam fɔ ɛp wi. Wi go tɔk smɔl mɔ bɔt dis?

Wetin na dis mɛrɛsin we dɛn kɔl Glucarpidase? Fɔ tɔk am simpul wan...

Tink bɔt am lɛk wan smɔl supahiro, Glucarpidase . Na rili wan ɛnzaym . di εnzym dεm lεk sכm sכm εp dεm we de spid εn εp wit difrεn kεmikכl prכsεs dεm na wi bכdi. So, wetin dis enzym we dεn kכl Glucarpidase de du na fכ ridyus di amoun fכ da dכg we dεn kכl Methotrexate we a bin tכk bכt na wi bכdi.

Naw yu de aks, "Wetin mek yu fɔ ridyus mɛtɔtreksɛt? Nɔto dat sɛf na mɛrɛsin?" Yes, methotrexate na wan rili impɔtant, pawaful mɛrɛsin we dɛn kin gi fɔ kɔntrol di grow we di kansa sɛl dɛn de gro ɛn fɔ sik dɛn lɛk at at sik. Bɔt dis mɛrɛsin kin kɔmɔt mɔ na di bɔdi tru di kidni dɛn. So, if pɔsin in kidni wik smɔl, if i nɔ de wok fayn, dis mɛtɔtreks de kɔmɔt na di bɔdi smɔl smɔl. Dɔn wetin kin apin na dat i kin gɛda na di bɔdi ɛn rich di pɔyzin lɛvɛl dɛn . Dat na denja. Na da tɛm de dɛn gi dis spɛshal injɛkshɔn we dɛn kɔl glucarpidase, di mɛtɔtreks we pasmak we dɔn gɛda na di bɔdi kin ridyus kwik kwik wan, ɛn dɛn kin protɛkt di pɔsin.

Yu kin fɛn dis mɛrɛsin ɔnda di brand nem VORAXAZE , bɔt na yu dɔktɔ nɔmɔ go no fɔ tru if yu nid am ɔ yu nɔ nid am.

Udat dɛn gi dis Glucarpidase mɛrɛsin?

Dis nɔto mɛrɛsin fɔ ɔlman. I kin ɛp mɔ fɔ:

• Di drɔg we dɛn kɔl methotrexate na fɔ pipul dɛn we dɔn rich di denja lɛvɛl fɔ pɔyzin na dɛn bɔdi.
• Dɔn bak, dɛn kidni dɛn fɔ nɔ de wok fayn , bikɔs if di kidni dɛn de wok fayn, dɛn kin pul mɛtɔtreksɛt kɔmɔt na di bɔdi nɔmal wan.

Dɛn kin gi dis mɛrɛsin to big pipul dɛn ɛn pikin dɛn bak . Sɔntɛnde, dɛn kin yuz am pan spɛshal kes dɛm, ivin fɔ pikin dɛm we yɔŋ lɛk wan mɔnt. Bɔt we dɛn de gi am to yɔŋ pikin dɛn, dɔktɔ dɛn kin tek tɛm yuz am ɛn akɔdin to spɛshal instrɔkshɔn dɛn . So, if yu de tɔk to yu pikin bɔt dis mɛrɛsin, i go fayn fɔ mek yu tɔk to di dɔktɔ bɔt am gud gud wan ɛn ɛksplen ɔltin.

Wetin na di impɔtant tin dɛn we a nid fɔ tɛl di dɔktɔ bifo a yuz dis mɛrɛsin?

Bifo dɛn gi yu ɔ pɔsin we yu sabi dis Glucarpidase vaysin, na sɔm tin dɛn we yu fɔ rili tɛl yu mɛdikal tim (i.e. dɔktɔ ɛn nɔs):Bɔku pan dɛn de. I nɔ fayn fɔ ayd dɛn tin ya, bikɔs i kin bi sikyɔriti prɔblɛm fɔ yu.

• If yu gɛt ɛni alɛji:
• If yu gɛt alɛji to dis glucoparidase mɛrɛsin.
• If yu gɛt ɛni alɛji to ɛni ɔda mɛrɛsin, it, day, ɔ tin dɛn we de mek yu nɔ pwɛl, tɛl yu dɔktɔ. Sɔntɛnde, alɛji to wan tin kin afɛkt ɔda tin.
• If yu gɛt bɛlɛ ɔ yu de tray fɔ gɛt bɛlɛ: Dis rili impɔtant bikɔs sɔm mɛrɛsin dɛn kin afɛkt di pikin.
• If yu na mama we de gi pikin in mama in bɛlɛ: Sɔm mɛrɛsin kin pas to di pikin tru in mama in milk, so i impɔtant fɔ tɛl yu dɔktɔ bɔt dis bak.

Mɛmba se: If yu tɛl yu dɔktɔ di wan ol tru tin bɔt yu wɛlbɔdi biznɛs, dat go ɛp yu fɔ gɛt tritmɛnt we sef ɛn we go mek yu gɛt di rayt tritmɛnt.

Aw yu kin gi dis mɛrɛsin?

Dis mɛrɛsin we dɛn kɔl Glucarpidase nɔto sɔntin we yu kin kɛr go na os ɛn drink ɔ injɛkt yusɛf wit.

• Dis na injɛkshɔn we dɛn kin put insay wan vein . Fɔ tɔk di kɔrɛkt tin, dɛn kin gi dis mɛrɛsin insay di bɔdi tru wan vein, jɔs lɛk aw dɛn kin gi salin.
• Na pɔsin we tren fɔ kia fɔ wɛlbɔdi biznɛs na ɔspitul ɔ klinik kin gi dis . Dis min se na dɔktɔ ɔ nɔs we dɛn tren spɛshal wan de du am.

Wetin kin apin if yu tek bɔku tin? (Ovadosage):

Bikɔs dɛn kin gi dis mɛrɛsin na ɔspitul we di dɔktɔ de kia fɔ am, i nɔ kin izi fɔ yuz am pasmak. Bɔt if yu tink se dis dɔn apin, dat min se if yu fil se dɛn dɔn ad di doz fɔ di mɛrɛsin, yu fɔ tɛl wan pɔyzin kɔntrol sɛnta ɔ imejensi rum wantɛm wantɛm.

Impɔtant notis: Dɛn gi yu dis mɛrɛsin spɛshal wan . Yu dɔktɔ go gi yu am bay bɔku tin dɛn lɛk aw yu de mɛn yu, aw yu gɛt mɛtɔtreksɛt, ɛn aw yu kidni de wok. So, nɔ gi ɔ sheb dis mɛrɛsin wit ɛni ɔda pɔsin.

Wetin a go du if a mis wan doz?:

Bikɔs dis na mɛrɛsin we dɛn kin gi na ɔspitul, i nɔ kin mata if yu mis di de we dɛn fɔ gi yu. Di mɛdikal tim go tek kia ɔf dat.

Us ɔda tin dɛn kin miks wit dis mɛrɛsin?

Sɔm mɛrɛsin kin "intafya" wit ɔda tin dɛm wae wi kin tek. Dat min se di tin we wan pɔsin de du kin afɛkt di tin we ɔda pɔsin de du. Di men wan we dɛn dɔn no te naw we kin ambɔg glukapidayz na wan mɛrɛsin we dɛn kɔl Leucovorin .

Leucovorin na ɔda impɔtant mɛrɛsin we dɛn kin yuz fɔ trit mɛtɔtreksɛt. I de ɛp fɔ ridyus di sayd ɛfɛkt dɛm we mɛtɔtreksɛt kin gɛt. So, we dɛn de gi ɔl tu di glucoparidase ɛn leucovorin, dɔktɔ dɛn kin rili tek tɛm bɔt di tɛm ɛn di doz. biכs we glukoparidaz de ridyus di mεtotreksεt lεvεl, i kin afekt bak di effektiv we lכkovכrin de wok.

Bɔt dis list nɔ kɔmplit. Tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek (we dɛn gi yu ɔ we yu nɔ de it), ɔyl, vaytamɛn (di it we yu de it), ɛn if yu de smok, drink rɔm, ɔ yu de yuz ɔda drɔgs dɛn we nɔ rayt. Sɔmtɛm, tin dɛm wae yu nɔr bin de ɛkspɛkt kin miks wit yu mɛrɛsin dɛm.

Wetin na di tin dɛn we wi fɔ tek tɛm wit mɔ we wi de tek mɛrɛsin?

We yu gɛt dis Glucarpidase injɛkshɔn, di mɛdikal tim go tek tɛm wach yu . Dis min se dɛn go de chɛk yu kɔndishɔn ɔltɛm.

• Blɔd tɛst: Yu go nid fɔ du blɔd tɛst ɔltɛm we yu de tek dis mɛrɛsin. Yu no wetin mek? Di men tin na fɔ chɛk aw yu mɛtɔtreksɛt lɛvɛl smɔl . Dɛn blɔd tɛst ya kin chɛk bak aw yu kidni de wok ɛn ɔda impɔtant tin dɛn. Dis na aw dɔktɔ dɛn kin disayd if di tritmɛnt de wok ɛn if ɛni ɔda tin nid fɔ du.
• Diziz: Sɔm pipul kin fil smɔl diziz afta dɛn dɔn tek dis mɛrɛsin. So, te yu no gud gud wan aw dis mɛrɛsin de afɛkt yu, nɔ drayv, wok wit mashin, ɔ du ɔda tin dɛn we go mek yu rili wach .
• Tek tɛm we yu de grap kwik: We yu grap frɔm we yu sidɔm ɔ ledɔm, nɔ grap wantɛm wantɛm, bɔt yu grap sloslo . Dis impɔtant mɔ if yu dɔn ol. If nɔto dat, yu go fil lɛk se yu ed de tɔn ɛn fɔdɔm.
• Nɔ drink rɔm: If yu drink rɔm, dat kin mek yu ed de tɔn bad bad wan. So, i bɛtɛ fɔ lɛ yu nɔ drink rɔm ɔl we yu de tek dis mɛrɛsin.

Wetin na di sayd ɛfɛkt dɛm we dis mɛrɛsin kin gɛt?

Lɛk ɛni mɛrɛsin, Glucarpidase kin mek sɔm sayd ɛfɛkt. Bɔt nɔto ɔlman kin gɛt dɛn. Na sɔm pipul dɛn nɔmɔ kin gɛt dɛn. Nɔ wɔri, bɔt i impɔtant fɔ no bɔt dɛn tin ya.

Di sayd ɛfɛkt dɛm we yu fɔ tɛl yu dɔktɔ wantɛm wantɛm:

If yu gɛt ɛni wan pan dɛn sik ya, yu fɔ tɛl yu dɔktɔ ɔ dɔktɔ wantɛm wantɛm ɛn nɔ de te.

• Di tin dɛn we kin mek pɔsin gɛt alɛji:
• Rash na di skin
• I de it ɔ ayv
• Fɔ swel na yu fes, lip, ɔ yu tɔŋ – Dis kin rili denja bikɔs i kin mek i nɔ izi fɔ blo.
• Chenj dεm na di vishכn: Wan wan tεm we yu de si blכr, chenj lεk fכ si insay tu pat.
• Pen, tingling, numbness na di an ɔr fut: Na filin lɛk se di limb dɔn slip, ɔr jɔs de fil pen.
• Tremor: I de shek di an ɛn fut dɛn we yu nɔ ebul fɔ kɔntrol.

Sayd ɛfɛkt dɛn we nɔ kin siriɔs, bɔt yu fɔ ripɔt to yu dɔktɔ if dɛn kɔntinyu fɔ de:

Bɔku tɛm, dɛn tin ya kin go afta sɔm dez. Bɔt if dɛn kɔntinyu fɔ de ɔ dɛn de mɔna yu bad bad wan, tɛl yu dɔktɔ .

• Daya: Na di stɔl we de pas.
• Diziz: Na filin fɔ spin na yu ed.
• Facial flushing: Na di fes de rɛd wantɛm wantɛm ɛn fil se di wam wam de kɔmɔt pan am.
• Ɛd we de at : Ɛd we de at.
• Nɔs, vɔmit: Fɔ fil sik to yu bɛlɛ, fil lɛk se yu go vɔmit.

Dis list nɔto ɔl di sayd ɛfɛkt dɛn we pɔsin kin gɛt. If yu notis ɛni ɔda tin we nɔ kɔmɔn, tɔk to yu dɔktɔ bɔt am. Sɔntɛnde, i nɔ kin bi bikɔs ɔf di mɛrɛsin, bɔt i fayn fɔ no.

Usay yu kin kip di mɛrɛsin?

Yu nɔ nid fɔ wɔri bɔt dis. Bikɔs, dɛn nɔ go alaw yu fɔ tek dis Glucarpidase vaysin go na os. Dɛn kin yuz am na ɔspitul ɔ klinik. So, di wan dɛn we de wok na di mɛrɛsin go tek kia fɔ mek i nɔ pwɛl.

Di tin we impɔtant pas ɔl fɔ mek yu mɛmba (Take-Home Message) .

Okay, so, frɔm wetin wi dɔn tɔk bɔt, dɛn tin ya na di impɔtant tin dɛn we yu nid fɔ mɛmba:

• Glucarpidase na spɛshal ɛnzaym we dɛn kin gi we di pɔyzin lɛvɛl na di mɛrɛsin we dɛn kɔl Methotrexate de go ɔp na di bɔdi, mɔ pan pipul dɛn we dɛn kidni nɔ de wok fayn.
• Dɛn kin gi dis as injɛkshɔn na wan vein , na ɔspitul, bay wan dɔktɔ we tren.
• I rili impɔtant fɔ tɛl yu dɔktɔ bɔt ɛni alɛji we yu gɛt, if yu gɛt bɛlɛ ɔ yu de gi pikin in bɛlɛ, ɛn bɔt ɔl di mɛrɛsin dɛn we yu de tek .
• We yu de tek di mɛrɛsin, dɛn go de wach yu gud gud wan ɛn dɛn go du blɔd tɛst.
• Tek tɛm as diziz ɛn ɔda tin kin apin.
• If yu gɛt ɛni siriɔs sayd ɛfɛkt , tɛl yu dɔktɔ wantɛm wantɛm.
• Dis na spɛshal mɛrɛsin, so tɔk to di dɔktɔ ɛn ɛksplen ɔltin.

Dis na jɔs sɔm tin dɛn we wi de tɔk bɔt. If yu gɛt ɛni ɔda kwɛstyɔn bɔt dis mɛrɛsin, duya nɔ shem fɔ aks yu dɔktɔ, fama, ɔ ɔda pɔsin we de kia fɔ yu wɛlbɔdi biznɛs. Dɛn go ebul fɔ ɛp yu.

` glucarpidase, methotrexate, kidni sik, enzym, dכg intarakshכn, sayd ifekt, vaksin