Yu dɔn yɛri bɔt wan kayn bɛlɛ kansa we pɔsin kin gɛt frɔm in mama ɛn papa? (Hereditary Diffuse Gastric Cancer - HDGC) Lɛ wi tɔk bɔt dis!

Tide wi go tɔk bɔt wan siriɔs kɔndishɔn we bɔku pipul dɛn nɔ no bɔt. Dis na wan kayn bɛlɛ kansa we pɔsin kin gɛt frɔm in mama ɛn papa. Dɔktɔ dɛn kin kɔl am `(Hereditary Diffuse Gastric Cancer)` ɔ `(HDGC)` fɔ shɔt. If pɔsin na yu famili dɔn gɛt dis sik, ɔ if yu want fɔ no mɔ bɔt am, dis atikul go rili impɔtant to yu. Nɔ wɔri, lɛ wi tɔk bɔt am simpul wan.

Wetin na dis `(HDGC)`?

Fɔ tɔk am simpul wan, HDGC na wan sik we pɔsin kin gɛt we i gɛt kansa. Dis min se yu layf-taym risk fɔ gɛt bɛlɛ kansa (Gastric cancer) de go ɔp bay lɛk 70%. nכto dat nכmכ, uman dεm we gεt dis kכndyushכn gεt 42% inkrεs risk fכ gεt wan spεsifi k tכp brεst kεnsar , Lobular Breast Cancer (LBC) .

Pipul dεm we gεt dis `(HDGC)` kכndishכn kin gεt wan mutated jin (`(mutated gene)`) frכm wan pan dεn mama εn papa. כltεm, dis na wan jin we dεn kכl `(CDH1)` . Bɔt sɔntɛnde, ɔda jin dɛn kin gɛt fɔ du wit dis. `(CDH1)` na wan tכmכro sכpreshכn jin (`(tכmכr sכpreshכn jin)`). We dɛn chenj dis, i nɔ de wok fayn fɔ kɔntrol kansa. Tink bɔt dis, dis jin tan lɛk polisman na wi bɔdi we de stɔp kansa sɛl dɛn fɔ gro. So wetin go apin if da polisman de wik? Na dat de apin na ya bak.

Wetin na "diffuse" gastric kansa?

Naw lɛ wi si wetin na dis `(Diffuse Gastric Cancer)`. Dis na wan kayn bɛlɛ kansa. Bɔt instead fɔ gro na wan ples lɛk ɔda kansa dɛn, dis wan de skata ɔlsay na di bɛlɛ wɔl insay smɔl smɔl grup dɛn we gɛt sɛl dɛn. I tan lɛk se wata lik we de skata along wan wɔl. fכ dis, di bכdi wכl de tik εn i de at. Smɔl smɔl, i kin go na di dip layers dɛn na di bɛlɛ wɔl.

Dis kayn bɛlɛ kansa at fɔ no smɔl bikɔs dɛn nɔ kin si am klia wan pan standad imej tɛst. Dɔn bak, bɔrku tɛm, di sayn dɛm kin apin afta di sik dɔn skata, na di leta stej dɛm. na da tεm de, di kansa kin dכn spre (mεtastas) tru di bεlε wכl to di tisu dεm we de nia, lεk di liva כ di bon dεm.

Aw dis sik kin kɔmɔn?

We wi de tɔk bɔt di kɔndishɔn `(HDGC)`, dɛn se lɛk fayv to tɛn pipul dɛn pan tɛn tawzin kin gɛt dis sik we dɛn bɔn dɛn. bכt 20% pan כl di bεlε kεnsar dεm na di `(diffuse)` tכp. כlmost 2% pan dεn difεs kεnsar dεm na dεn kin gεt `(HDGC).` Pan כl we bεlε kεnsar kin jεnarali mכr kכmכn na Eshia kכntri dεm pas na Wεst kכntri dεm, dεn kin ripot dis `(HDGC)` kכndyushכn mכr na Wεst kכntri dεm.

Wetin na di sayn dɛm fɔ `(HDGC)` kɔndishɔn?

As wi bin dɔn tɔk, di sayn dɛm fɔ dis kayn difyuz gastric kansa nɔ kin apin te di sik dɔn skata (metastasized). Na dat mek e fayn fɔ no bɔt de risk wae dis sik kin rɔn na famili. Insay HDGC, di kansa kin divɛlɔp we i yɔŋ smɔl pas ɔda kansa dɛn. Bɔrku pipul dɛn kin no bɔt dis sik bifo dɛn ol 40 ia.

Di men sayn dɛm kin bi:

• Bɛlɛ pen (espɛshali na di ɔp pat na di lɛft pat na di bɛlɛ) .
• Bɛlɛ de blo, we yu bɔdi de blo
• Nɔs ɛn vɔmit
• Fil fɔ it
• We yu de lɔs yu wet
• Taya pasmak, taya
• I nɔ izi fɔ swɛla it
• Blɔd in poop (`(Blɔd in poop)`)
• Blɔd we de vɔmit (`(Blɔd we de vɔmit)`)
• Jaundice (we yu yay ɛn yu skin de yɔlɔ) .

Sɔntɛnde, wan prɔblɛm we dɛn bɔn we dɛn kɔl cleft lip ɔ cleft palate kin bi bak di fɔs sayn fɔ dis sik. dis na biכs dis jεnεtik mכtεshכn kin mek dεn bכn dis dεfεkt. Bɔt bɔku tɛm, klif lip nɔ kin gɛt ɛnitin fɔ du wit HDGC. Bɔt if dɛn bɔn yu wit dis kayn prɔblɛm we dɛn bɔn yu ɛn sɔmbɔdi na yu famili dɔn gɛt dɛn kayn kansa ya, yu kin sɔprayz smɔl.

Wetin na di rizin fɔ mek dis `(HDGC)` fɔm?

HDGC na wan sik we de mek pɔsin gɛt jɛnɛtiks . i kin apin we wan mכtεshכn na wan pan di jin dεm we de sכpres di tכmכro we wi bin tכk bכt fכ chenj di program we de na yu DNA. di jin dεm we de sכpres di tכmכro de tεl di sεl dεm fכ kכntrכl di sεl dεm we de sheb εn di gro. So we dɛn jin ya nɔ de wok fayn, kansa kin kam.

Yu kin gɛt dis jin we dɔn chenj frɔm yu mama ɔ yu papa. wan mכtεshכn we dεn gεt dis we dεn kכ l am jεmlayn mכtεshכn . I de afɛkt di jenɛtik kɔd fɔ yu riprodaktiv sɛl dɛn.

Aw dis `(HDGC)` de inhɛrit?

HDGC na ɔtosom dכminant kכndishכn. Dis min se yu jɔs nid fɔ gɛt wan kɔpi fɔ di jin we dɔn chenj fɔ mek yu gɛt di sik. Yu kin gɛt am frɔm yu mama ɔ yu papa. If wan pan yu mama ɛn papa gɛt di muteshon, yu ɔ yu brɔda ɛn sista dɛn gɛt 50% chans fɔ gɛt am. Tink bɔt am lɛk di chans we kɔyn kin kam ɔp ed ɔ tel.

Yu tink se ɔlman we gɛt di jin we de chenj kin gɛt kansa?

Nɔ, di chenj we yu gɛt frɔm yu mama ɛn papa kin afɛkt wan kɔpi nɔmɔ pan di jin we de mek yu nɔ gɛt kansa na ɛni sɛl. Bɔt ɛni sɛl gɛt tu kɔpi fɔ dis jin, wan na yu mama ɛn wan na yu papa. So ivin if yu nɔ gɛt di sem muteshon frɔm yu mama ɛn papa, yu stil gɛt kɔpi fɔ di jin we de wok nɔmal wan.

fכ mek kεnsar divεlכp, sεkכn mכtεshכn (`(somatic mutation)`) .i fכ apin na di tisu usay di kεnsar de fכm (i.e., di layn na di bכdi כ di lכbul dεm na di brεst) insay yu layf. dis sεkכn mכtεshכn de dεaktiv di כda kכpi fכ di jin bak. Na da tɛm de di kansa kin bigin fɔ gro.

Wetin na di kɔz fɔ dis sɛkɔn mutation?

Fɔ tɔk tru, wi nɔ no di rayt rizin fɔ dis. Bɔt difrɛn tin dɛn kin ɛp fɔ du sɔntin. di envayroment εksposh כn kin ple rol fכ "trigεr" jεnεtik sik dεm. Ɔda jin dɛn bak kin gɛt fɔ du wit dis. Sɔm famili dɛn we gɛt di HDGC jin gɛt bɔku kansa pas ɔda wan dɛn.

Sɔm tin dɛn we kin mek pɔsin gɛt bɛlɛ kansa na:

• Fɔ smok
• Fɔ drink rɔm pasmak
• Fɔ it tumɔs rɛd mit (lɛk bif, ship) .
• (H. pylori) infεkshכn (dis na baktri we de mek yu bכdi כlsa) .

Aw di tɛst prɔses fɔ `(HDGC)` de?

Ivin if yu nɔ gɛt di sik yet, if rizin de fɔ tink se yu de pan denja (fɔ ɛgzampul, if sɔmbɔdi na yu famili dɔn gɛt dɛn kayn kansa ya, ɔ if yu dɔn gɛt jɛnɛtik tɛst we fɛn wan muteshɔn na di `(CDH1)` jin), dɔktɔ kin rifer yu fɔ tɛst fɔ `(HDGC)`.

Yu dɔktɔ go kɔl yu risk bay yu famili histri ɛn/ɔ di rizɔlt fɔ yu jenɛtik tɛst. Dɛn kin luk bak fɔ tin dɛn we kin mek yu gɛt kansa na yu tisu dɛn. fכ egzampl, dεn kin luk fכ wan kכndyushכn we dεn kכl Lobular Carcinoma In Situ (LCIS) na di brεst כ signet-ring-type sεl dεm na di layn na di bεlε. Dis na di chenj dɛm we kin apin kwik kwik wan we kin bi kansa.

Aw dɛn kin no if pɔsin gɛt HDGC?

If yu gɛt sayn dɛm fɔ mɛtastatik bɛlɛ kansa, yu dɔktɔ go luk fɔ pruf fɔ kansa na yu bɛlɛ wɔl. Dɛn go tek di tisu sɛmpul dɛn ɛn chɛk dɛn ɔnda maykroskɔp. If dɛn si se kansa na yu bɛlɛ we dɔn pas, ɛn if pɔsin na yu famili dɔn gɛt dis kayn kansa, yu dɔktɔ go tɛl yu fɔ du tɛst fɔ yu jɛnɛtiks .

Naw, dεn fכnshכn se lεk 40% pan di pasεn dεm we gεt HDGC gεt dis CDH1 mכtεshכn. כda mכtεshכn dεm kin involv, bכt CDH1 na di men wan we wi no εn wi kin no. If yu gɛt am, na shɔ we fɔ no if yu gɛt HDGC. Bɔt if yu gɛt famili histri fɔ dis kayn difyuz gastric kansa, dɛn kin no se yu gɛt HDGC ivin if yu nɔ gɛt di CDH1 muteshon.

Us tɛst dɛn kin yuz fɔ no `(HDGC)`?

Dɛn kin du dɛn tɛst ya fɔ no if yu gɛt di sik:

• Tɛst fɔ di jɛnɛtiks:Dis na blɔd tɛst. Dɛn kin tek wan sɛmpul pan yu blɔd ɛn analayz fɔ si if ɛni jɛnɛtik chenj de we gɛt fɔ du wit jɛnɛtik sik dɛn. Sɔm pipul dɛn kin gɛt dis tɛst bikɔs dɛn gɛt famili histri bɔt sik dɛn we dɛn kin gɛt frɔm dɛn jɛnɛtiks. Ɔda pipul dɛn kin gɛt dis kayn jenɛtik tɛst bikɔs dɛn nɔ no dɛn famili wɛlbɔdi istri, fɔ dɛn yon infɔmeshɔn, ɔ bikɔs dɛn de plan fɔ bɔn pikin.
• כp εndoskopi (EGD tεst): Dis na tεst fכ luk insay yu כp gεstrointestinal trakt (i.e., εsophagus, bεlε) εn tek tisu sεmpl dεm. Dis impɔtant fɔ no if yu gɛt bɛlɛ kansa, mɔ dis kayn kansa we dɔn skata. Wan dɔktɔ we de mɛn di bɛlɛ (dɔktɔ we spɛshal pan sik dɛn we de na di bɛlɛ) kin du dis. I kin put wan lɔng tiub (ɛndoskɔp) wit smɔl kamɛra tru yu mɔt ɛn dɔŋ yu ɛsophagus insay yu bɛlɛ. di tisu sεmpl dεm kin tek bak tru di tכb. Bɔt ivin wit dɛn we ya, i kin at fɔ fɛn bɛlɛ kansa we dɔn pas ɔlsay. Bikɔs i de ɔlsay, di dɔktɔ nɔ go ebul fɔ si am ɔ gɛt am na di tisu sɛmpul dɛn. So, dɔktɔ we de luk fɔ dis kayn kansa fɔ gɛt spɛshal trenin ɛn ɛkspiriɛns.
• Breast MRI: Bikɔs dɛn nɔ kin no di lobular breast cancer bay we dɛn de tek mammogram ɔltɛm, di dɔktɔ dɛn kin se dɛn fɔ du MRI. If di MRI sho ɛnitin we nɔ kɔmɔn, dɛn kin mak am ɛn ɔda dɔktɔ kin tek wan tisu sɛmpul.
• Bayopsi: Di ​​dɔktɔ tek wan sampul pan di tisu ɛn sɛn am na lab fɔ mek dɛn chɛk am ɔnda maykroskɔp. dis bayopsi kin kכnfכm if di tisu sεmpl gεt kεnsar sεl dεm.

Wetin kin apin afta dɛn no se i gɛt `(HDGC)`?

If yu dɔn gɛt kansa, yu dɔktɔ go tɔk to yu bɔt aw fɔ trit yu. Ivin if yu nɔ gɛt kansa yet, if yu gɛt dis sik, yu dɔktɔ go tɛl yu fɔ du tɛst ɔltɛm fɔ chɛk yu kansa, lɛk aw wi bin dɔn tɔk. Prɛventiv ɔpreshɔn na ɔda tin we yu kin tɔk to yu dɔktɔ bɔt.

Aw dɛn kin trit mɛtastas bɛlɛ kansa?

Bɔku tɛm, ɔpreshɔn na di fɔs tritmɛnt fɔ kansa we dɛn kin pul we dɛn du ɔpreshɔn. If yu gɛt HDGC, bɔku tɛm yu dɔktɔ go tɛl yu fɔ pul yu bɛlɛ ɔl . Dis na bikɔs HDGC gɛt ay risk fɔ skata fa bifo dɛn fɛn am.

Insay tɔtal gastrectomy, di dɔktɔ we de du ɔpreshɔn kin pul yu wan ol bɛlɛ ɛn kɔnɛkt di ɛnd pan yu ɛsophagus dairekt to yu smɔl intestin. I pɔsibul fɔ liv we yu nɔ gɛt bɛlɛ, bɔt sɔm bad bad tin dɛn de we kin apin to yu. Afta dɛn dɔn ɔpreshɔn yu, yu kin gɛt ɔda tritmɛnt dɛn (adjuvant therapies) lɛk redyushɔn tɛrapi ɔ kemotɛrapi.

Bikɔs uman dɛn we gɛt `(HDGC)` kin gɛt risk bak fɔ gɛt lobular breast cancer (`(LBC)`), dɛn nid fɔ no ɔltɛm bɔt di simptom dɛm fɔ `(LBC)` we dɛn de trit dɛn. If yu gɛt `(LBC)`, di tritmɛnt kin bigin wit bɔdi kansa ɔpreshɔn. Dɔn dɛn kin gi ɔda tritmɛnt dɛn.

Wetin na di layf ɛkspɛkteshɔn wit `(HDGC)` kɔndishɔn?

Di layf we pɔsin kin liv kin dipen pan fɔ fɛn ɛn trit di kansa kwik kwik wan. Ivin if yu de chɛk yu ɔltɛm, dis kin tranga. if dεn kech di mεtastas bכdi kεnsar εn trit am kwik, di fayv ia rεt we de liv pas 90%. כltu, if dεn fכnshכn am let, afta i dכn invayd di bεlε wכl, di rεt de dכn to less dan 30%.

Na dat mek wi se i rili impɔtant fɔ no bɔt yu famili histri ɛn go to dɔktɔ if yu de pan denja.

We de fɔ mek dɛn nɔ du `(HDGC)`?

If yu gɛt di `(CDH1)` jin muteshon (we gɛt fɔ du wit di risk we de go ɔp fɔ gɛt kansa), sɔm tin dɛn de fɔ mek yu nɔ gɛt kansa. fכ pipul dεm we nכ gεt dis spεsifi k jin mכtεshכn, dεn nכ dεfεn di risk dεm εn di mεzhɔ dεm klia wan. Yu kin tɔk to yu dɔktɔ bɔt yu yon prɔblɛm dɛn ɛn di tin dɛn we yu go ebul fɔ du.

Prɔfylaktik ɔpreshɔn

If dɛn dɔn no se yu gɛt HDGC fɔ at le 20 ia ɛn yu nɔ gɛt ɛni ɔda big prɔblɛm wit yu wɛlbɔdi, yu dɔktɔ kin tɛl yu fɔ du profylaktik tɔtal gastrectomy . Pan ɔl we di bɛlɛ we yu lɔs kin gɛt sɔm ifɛkt pan yu dijestiv sistɛm, dɛn sayd ɛfɛkt ya kin izi fɔ kɔntrol pas fɔ dil wit bɛlɛ kansa we dɔn go bifo.

fכ dεn wan dεm we nכ rεdi fכ tek dεn stεp dεm ya, dεn kin tek wan "wet-εn-watch" we fכ du, we involv fכ fכs כp intestinal εndoskopi εn random bayopsi sεmpl dεm. Bɔt ivin wit dis kayn klos monitarin, dɛn nɔ kin no ɔltɛm fɔ no HDGC kwik kwik wan (we di tritmɛnt de wok fayn pas ɔl).

Di sayd ɛfɛkt dɛn we di tɔtal gastrektomi kin gɛt:

• Dumping syndrome: We it pas dairekt frɔm di esophagus to di smɔl intestin, i de pas tru di smɔl intestin fast pas aw i nɔmal. Dis kin mek big chenj na di ɔmon dɛm na di dijestiv sistɛm, we kin mek yu gɛt sɔm sayn dɛm lɛk nɔs, dayarɛa, ɛn blɔd shuga we nɔ bɔku. Yu kin kɔntrol dɛn sik ya bay we yu chenj di we aw yu de it. Dɛn sayn ya go stɔp as tɛm de go.
• Malabsorption and malnutrition: We dεn pul di bεlε, di pat pan di bεlε we gεt di asid εn εnzym dεm we de εp fכ digεst di it de lכs. Dis kin mek di it nɔ brok fayn ɛn i kin mek di bɔdi nɔ tek di tin dɛn we de insay di bɔdi. Dis kin mek i nɔ gɛt bɛtɛ it. Dis kin ɛp if yu chenj di tin dɛn we yu de it ɛn tek tin dɛn we de ɛp yu fɔ it.

Jɛnɛtik advays ɛn famili planin

Fכ pipul dεm we gεt di CDH1 jin mכtεshכn, jεnεtik kכnsεl kin rili εp fכ tכk bכt famili planin. Dis kin ɛp yu fɔ ɔndastand di risk fɔ mek yu pikin gɛt di HDGC kɔndishɔn. If yu de plan fɔ bɔn pikin, wan tin we yu kin du fɔ kɔntrol da prɔblɛm de na fɔ pik In Vitro Fɛtilayzeshɔn (IVF) .

insay IVF, dεn kin tek eg εn sεl frכm di mama εn papa εn fεtilayz am na lab. afta di εmbrayo dεm divεlכp, dεn kin tek wan sεl frכm εvri εmbrayo εn tεst fכ di CDH1 mכtεshכn. di mama εn papa kin pik εmbrayo dεm we nכ gεt di mכtεshכn εn put dεm na di mama in uterus.

Fɔ dɔn, wetin fɔ mɛmba

Fɔ no se yu gɛt Hereditary Diffuse Gastric Cancer Syndrome (HDGC) kin rili mek yu fil bad, ɛn yu kin gɛt fɔ disayd fɔ du big tin. Dɛn tin ya kin afɛkt yu ɛn yu famili. Tek yu tɛm fɔ tink bɔt tin dɛn ɛn nɔ panik. Aks bɔku kwɛstyɔn dɛn we yu nid. Yu mɛdikal tim de ya fɔ ɛp yu fɔ fɛn di bɛst we fɔ go na dis joyn. Mɛmba se fɔ no na di fɔs tin we yu fɔ du. Nɔto yu wan de.

` HDGC, kansa we pɔsin kin gɛt frɔm in mama ɛn papa, bɛlɛ kansa, CDH1 jin, bɛlɛ kansa, brɔst kansa, jɛnɛtik tɛst, ɛndoskopi, gastrectomy, kansa prɛvɛnshɔn