If yu an ɛn fut dɛn de shek shek ɔ yu fes chenj we yu nɔ ebul fɔ kɔntrol, dat kin rili nɔ izi fɔ yu. I kin mek i nɔ izi fɔ du wok ɛvride ɔ ivin fɔ spɛn tɛm wit 4 pipul dɛn. Bɔrku pipul dɛn kin gɛt pwɛl hat bikɔs ɔf dɛn kayn tin ya. If yu ɔ pɔsin we de nia yu dɔn ɛkspiriɛns dis, dis atikul go rili impɔtant to yu.
Wetin na Tardive Dyskinesia ɛn Chorea?
Fɔ tɔk am simpul wan, dɛn tin ya na tu mɛrɛsin we kin apin we gɛt fɔ du wit di we aw wi bɔdi de muv.
Tardive Dyskinesia (TD): Dis na wan kכndyushכn wae wi kin gεt di bכdi muvmεnt dεm we wi nכ want, jεk, εspεshali di fes εn di limb dεm. Dis kin inklud fɔ stik na yu tɔng we yu nɔ want, fɔ smak yu lip, fɔ blink yu yay, ɔ fɔ jɔk di an ɛn fut dɛn. Dis kכndyushכn kin apun as sayd ifekt wae yu de yuse sכm antisaykotik dεm כ sכm bεlε mεdikeshכn dεm fכ lכng tεm.
Chorea: Dis na wan sik we de mek pɔsin muv bikɔs ɔf wan sik we dɛn kɔl Huntington Disease . Insay di sik we dɛn kɔl Huntington, di nerve cells na di bren kin pwɛl smɔl smɔl. Dis kin mek yu gɛt prɔblɛm wit aw yu de tink, aw yu de kɔntrol aw yu de fil, ɛn aw yu bɔdi de muv. Kɔria kin mek yu an, fut, ɛn fes muv we yu nɔ ebul fɔ kɔntrol.
Di drɔg Ingrezza de ɛp fɔ kɔntrol di muvmɛnt dɛm we dɛn nɔ kin kɔntrol we kin apin na ɔl tu di kɔndishɔn dɛm. Bɔt mɛmba se Ingrezza nɔ de trit ɔda sayn dɛm fɔ di sik we dɛn kɔl Huntington (lɛk prɔblɛm wit di we aw pɔsin de tink).
Aw di drɔg Ingrezza de wok?
Fɔ ɔndastand dis, wi nid fɔ no fɔs bɔt wan smɔl kemikal mɛsenja na wi bren. I nem na Dopamine . Fɔ tɔk di kɔrɛkt tin, Dopamine na nyurotransmitta. Dis Dopamine rili impɔtant fɔ kɔntrol di muvmɛnt dɛm na wi bɔdi.
Imajin wetin go apin if wi bren sɛn tumɔs dopamin? Jɔs lɛk wata tap we de tɔn tu fast, dɛn biliv se we di dopamin signal dɛn bɔku, wi bɔdi nɔ kin want fɔ du am .
Na dis Ingrezza de du. i de tכk to wan protin na wi bren we dεn kכl VMAT2 (vesicular monoamine transporter 2) . dis protin na in de εp fכ rilis dopamin. bay we i de kכntro di aktvכti fכ VMAT2, Ingrezza de ridyus di εksyכs dopamin signal. I tan lɛk se yu dɔn on di pɔt smɔl smɔl. Dis kin mek di muvmɛnt dɛn we dɛn nɔ kin kɔntrol kin stɔp smɔl smɔl.
Aw a fɔ yuz dis mɛrɛsin?
Ingrezza na mɛrɛsin we kin kam insay di fɔm fɔ kapsul. Yu kin tek am wit it ɔ atɔl am. Yu dɔktɔ go gi yu dis mɛrɛsin. Nɔ ɛva tek mɔ ɔ smɔl pas di doz we yu dɔktɔ tɛl yu fɔ tek.
Di ɔspitul doz de na di tebul we de dɔŋ ya, bɔt yu dɔktɔ kin chenj dis dipen pan yu kɔndishɔn.
| Mɛdikal kɔndishɔn | Start doz we yu de yuz | Di doz we dɛn kin gi | Aw fɔ inkrisayz di doz |
|---|---|---|---|
| Tardiv diskinεsia (TD) . | 40mg wan tɛm insay di de | 80mg wan tɛm insay di de | afta wan wik, i de inkrεs to 80mg. |
| Kɔria we dɛn kɔl Chorea | 40mg wan tɛm insay di de | 80mg wan tɛm insay di de | afta 2 wik, i de inkrεs to 60mg, εn afta כda 2 wik, to 80mg. |
Aw fɔ tek Ingrezza Sprinkle kapsul
Sɔm pipul dɛn kin gɛt prɔblɛm fɔ swɛla kapsul. Fɔ dɛn pipul dɛn de, wan spɛshal kayn de we dɛn kɔl "Ingrezza Sprinkle." Dis na aw fɔ yuz am:
1. Tek tɛm opin di kapsul ɛn ad di smɔl smɔl mɛrɛsin grens dɛn (sprinkles) insay to wan ti spɔnj sɔft it lɛk apul sos, yogɔt, ɔ pudin.
2. Nɔ chew ɔ krɔs dis mɛrɛsin .
3. It di wan ol spunful it we dɛn miks wit di mɛrɛsin wantɛm wantɛm .
4. Dɔn drink wan glas wata (we na lɛk 240 ml).
5. Nɔ ɛva miks dis mɛrɛsin wit milk ɔ wata.
Di tin we impɔtant pas ɔl na fɔ fala yu dɔktɔ in instrɔkshɔn dɛn di rayt we. If yu gɛt ɛni prɔblɛm, tɔk to yu dɔktɔ bɔt am.
Aw yu go no if di mɛrɛsin de wok?
Akɔdin to klinik stɔdi, yu kin si sɔm impɔtant improvement pan di simptom dɛm insay lɛk tu wiks afta yu bigin Ingrezza. Yu go notis se dɛn bɔdi we yu nɔ de kɔntrol de muv smɔl smɔl.
Yu dɔktɔ go stat yu pan smɔl doz ɛn ajɔst di doz as nid de fɔ si aw yu bɔdi de ansa. So i kin tek sɔm tɛm fɔ si di bɛst rizɔlt. If yu fil se yu sik nɔr de bɛtɛ ɔr de wɔs, tɛl yu dɔktɔ wantɛm wantɛm. I kin ajɔst di doz, ad ɔda mɛrɛsin, ɔ chenj yu to ɔda mɛrɛsin if nid de.
Sɔm sayd ɛfɛkt dɛn we pɔsin kin gɛt ɛn aw fɔ kɔntrol dɛn?
Lɛk ɛni mɛrɛsin, Ingrezza kin mek sɔm sayd ɛfɛkt, pan ɔl we nɔto ɔlman kin gɛt dɛn.
- Di sayd ɛfɛkt dɛm wae kin kam pan pipul dɛm wae gɛt tardive dyskinesia (TD) na:
- Di we aw pɔsin kin slip
- Di kɔmɔn sayd ɛfɛkt dɛn we kin apin to di wan dɛn we gɛt Chorea:
- Di we aw pɔsin kin slip
- Rash na di skin (Hives) .
- Skin rash we de kɔmɔt na di skin
- Trobul fɔ slip
Aw yu de dil wit dɛn tin ya?
- Fɔ slip: Nɔ du tin dɛn we nid fɔ de wach, lɛk fɔ drayv ɔ fɔ yuz mashin, te yu no gud gud wan aw dis mɛrɛsin de afɛkt yu.
- Skin rash ɔ ayv: Dɛn tin ya kin bi sayn fɔ se yu gɛt alɛji. If dis apin, kɔl yu dɔktɔ wantɛm wantɛm, ɔ go na di ɔspitul imejensi rum (ETU) we de nia yu.
- Inshɔmnia: Tin dɛn de we yu kin du fɔ yusɛf. If yu nɔ it bɔku tin dɛn we gɛt kafinɛ lɛk kɔfi, ti, ɛn kola, yu gɛt di abit fɔ go slip ɛn wek di sem tɛm ɛvride, fɔ mek yu bedrum dak, ɛn nɔ yuz fon ɛn tablɛt bifo yu go slip, dat kin ɛp.
Di Intarakshɔn wit Drug
If yu de tek Ingrezza, i rili impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di ɔda mɛrɛsin dɛn we yu de tek, ivin vaytamɛn dɛn, bikɔs sɔm mɛrɛsin dɛn kin miks wit Ingrezza.
- Monoamin oksidaz inhibito dεm (MAOIs):Dis na mɛrɛsin wae dɛn kin yuse fɔ trit pwɛl hat ɔr sik wae de kam pan pɔrsin wae gɛt dis sik. Dɛn MAOI mɛrɛsin ya strikt wan nɔ fɔ tek wit Ingrezza.
- Digoxin: Dis na mɛrɛsin we dɛn kin yuz fɔ trit at pwɛl ɛn at bit we nɔ de bit ɔltɛm. If yu tek Ingrezza wit Digoxin, i kin mek di lɛvɛl we di Digoxin de na yu blɔd go ɔp, ɛn dis kin mek yu gɛt sayd ɛfɛkt. Yu dɔktɔ go tɛst yu blɔd ɛn ridyus yu Digoxin doz if nid de.
- CYP3A4 εn CYP2D6 inhibito/inducer: Dis na sכm komplikεt mεdikal tεm. Dɛn kin aplay to difrɛn kayn mɛrɛsin dɛn. Di simpul ɛn sef tin we yu kin du na fɔ tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek. I go mek ɛni ajɔstmɛnt we i nid.
Mɛsej we dɛn kin kɛr go na os
- Ingrezza na wan mɛrɛsin wae de ɛp fɔ kɔntrol di bɔdi muvmɛnt dɛm wae nɔr kin kɔntrol wae kin apun pan kɔndishɔn wae dɛn kɔl tardive dyskinesia (TD) ɛn chorea wae kin kam wit Huntington’s disease.
- dis de kכntro di dopamin signal dεm na di bren.
- Ɔltɛm fala di doz ɛn instrɔkshɔn dɛn we yu dɔktɔ tɛl yu fɔ du di rayt tin. Nɔ ɛva chenj di doz yusɛf.
- Yu fɔ no bɔt di sayd ɛfɛkt dɛm lɛk fɔ slip ɛn alɛji na yu skin. If yu gɛt alɛji, go to dɔktɔ wantɛm wantɛm.
- I rili impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di ɔda mɛrɛsin dɛn, vaytamɛn dɛn, ɛn sɔpɔtmɛnt dɛn we yu de tek.
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