Wetin na "Leaky Gut Syndrome"? Yu gut rili "leaky"?

Yu go don hie plenti pipul de tok abaut ‘Leaky Gut’ dis dez, no bi so? Sɔm pipul dɛn se na in de mek pipul dɛn gɛt difrɛn prɔblɛm dɛn na dɛn bɛlɛ ɛn ivin difrɛn sik dɛn. So wetin na dis "Leaky Gut Syndrome"? Yu gut kin rili bi "leaky"? Lɛ wi tɔk bɔt dis simpul wan, di we we yu go ɔndastand.

Wi gut rili "lik"? (Intestinal Pɛrmiabiliti) .

Fɔ tɔk am simpul wan, ɔlman in intestinal kin pas te to sɔm mak. Dat min se di insay wɔl na wi intestinal tan lɛk filta. Dɛn mek am fɔ tek wata ɛn tin dɛn we de insay di it we wi de it ɛn ad dɛn to di blɔd. Dis na nɔmal tin. Bɔt pan sɔm pipul dɛm, dis permeability, dat na di abiliti fɔ tin dɛm fɔ muv arawnd, na smɔl tumɔs. Dɔktɔ dɛn kɔl dis ``Intestinal Permeability`` ɔ ``Hypermeability``.

Imajin wetin go apin if di ol dɛn na dis filta na yu gut big smɔl? afta dat nכto כnli wata εn nyutriεnt dεm, bכt big patikyula dεm we nכmal wan nכ go go insay, εn i kin ivin tכxik tin dεm, go bigin fכ "lik" כ siep insay yu bכdi.

Di layn we de na wi insay nɔto jɔs wan mɛmbran. Na impɔtant pat pan wi imyun sistɛm . I de wok lɛk wɔl we de protɛkt pɔsin we de mek jem ɛn tin dɛn we de mek pɔsin sik, lɛk baktri, nɔ go insay di bɔdi.

So wetin na dis "Leaky Gut Syndrome" tin?

"Leaky Gut Syndrome" na wan tiori we de naw, wan haypothεsis . Frɔm dis tiori, di intestinal permeability we de go ɔp nɔto jɔs wan sayn fɔ wan dijestiv sistɛm sik (GI diseases), bɔt i kin bi di rut kɔz fɔ bɔku ɔda sik dɛn we de divɛlɔp fɔ dɛnsɛf .

Dis tiori se if dis protεktiv wכl na yu gכt wik, tכxin kin lik insay yu bכdi. Dɛn pɔyzin ya kin mek di bɔdi inflamɛns , we kin sho lɛk difrɛn sik dɛn.

Infakt, pan ɔl we dis tiori kin ɛp wi fɔ ɔndastand sɔm sik dɛn we wi stil nɔ no di rayt tin we kin mek dɛn gɛt am, dɛn nɔ dɔn pruv am gud gud wan yet na sayɛns . wi no se di intestinal permeability we de inkrεs, כ "leaky gut," na rial kכndishכn. Bɔt stil, nɔto inɔf klia pruf de fɔ no if na wan sik ɔ if i de mek ɔda sik dɛn. So, "Leaky Gut Syndrome" nɔto diagnosis we dɛn kin gri wit naw.

Us sik dεm dεn se dεn kכl "leaky gut"?

Apat frɔm sik dɛm we dɛn dɔn ɔlrɛdi si se gɛt fɔ du wit di intestinal permeability, sik dɛn de bak we dɛn tink se gɛt fɔ du wit dis, bɔt dɛn nɔ dɔn pruv am yet.

Sik dɛm wae rili gɛt fɔ du wit dis:

insay sכm inflammatory εn autoimyun sik dεm, spεshal wan dεm we de afekt di dijestiv sistεm, dεn fכnshכn se di intestinal permeability de inkrεs. Fɔ ɛgzampul:

• Inflammatory Bowel Disease (IBD) we pɔsin kin gɛt .
• Siliak Sik we pɔsin kin gɛt

Insay kes dɛm lɛk dis, sayɛnsman dɛn kin tek am se di intestinal permeability we de go ɔp na sayn fɔ di sik , pas fɔ tek am se na kɔz. Dis na bikɔs di sik kin mek di intestinal dɛn inflamɛns fɔ lɔng tɛm, we kin mek di layn we de protɛkt di intestines wik smɔl smɔl as tɛm de go.

Sɔntɛnde, ivin bifo dɛn no bɔt dɛn sik ya, dɛn dɔn si se dɛn kin gɛt mɔ intestinal permeability. Dis dɔn mek sɔm pipul dɛn biliv se dis permeability kin bi wan prɛ-ɛgzistin kɔndishɔn, ɔ ivin wan kɔz fɔ di sik. Bɔt sayɛnsman dɛn dɔn kam fɔ no se we di wata we de pas de go ɔp nɔmɔ nɔ go du fɔ mek i gɛt di sik pan dɛn kayn tin ya. I kin bi wan sayn fɔ di sik kwik kwik wan .

Sik dɛm wae dɛn kin tink se gɛt fɔ du wit dɛnsɛf, bɔt dɛn nɔr dɔn pruv fɔ tru:

Bɔrku ɔda sik dɛn de we dɛn kin tink se na "leaky gut syndrome." di aidia na se di tכxin dεm we de "lik" frכm di gכt de go insay di bכdi εn mek di bכdi inflameshn. Infakt, di inflamɛns we nɔ de te na di bɔdi kin gɛt fɔ du wit bɔku sik dɛn. Fɔ ɛgzampul:

• Mεtabolik dizכrd dεm lεk fכ fat εn dayabitis mεllitus
• Jɔyn pen (Atraytis) .
• Di sik we dɛn kɔl Chronic Fatigue Syndrome
• Asma we gɛt asma
• Fibromyalgia we pɔsin kin gɛt

Bɔt di rayt tin we mek dɛn gɛt dis padi biznɛs nɔ klia yet. pipul dεm we gεt gεstrointestinal (GI) dizכrd, we dεn no se kin mek intestinal permeability bכku, dεn fכnshכn se dεn gεt hכy lεvεl fכ gut baktri dεm na dεn blכd. Insay dɛn kayn tin ya, ɔda tin dɛn kin mek di bɔdi wam, bɔt dɛn bɔdi ya kin mek di bɔdi wam bak. Dɛn dɔn si dɛn bak pan pipul dɛn we gɛt liva sik. dis na biכs di liva na כgan we kכnekt dairekt to di gכt. dis baktri dεm kin travul tru wan big vein we de kכmכt na di gכt to di liva εn kin mek di liva sik. Bɔt nɔto fɔ se na in de mek pɔsin gɛt di sik.

Udat dɛn kin afɛkt mɔ pan di intestinal permeability?

fכ mek di intestinal permeability go כp, dat na fכ di protektiv layn fכ di intestinal fכ damej, i fכ damej sכmtεm εn kכntinyu . Dis nɔ kin izi. Yu intestinal layn gɛt bɔku layers we de protɛkt yu. Ɛn, ivin if i dɔn pwɛl fɔ sɔm tɛm, dɛn de mek am fayn ɛn mek am bak ɔltɛm. So, fɔ mek dis layn wik inof fɔ alaw am fɔ pas, i fɔ gɛt big impak. Dat kin min se:

• Sik we nɔ de mɛn
• Yuz sɔm mɛrɛsin dɛn fɔ lɔng tɛm ɔ fɔ drink rɔm
• I fɔ bi sɔntin lɛk redyushɔn tɛrapi .

di "Leaky Gut Syndrome" tiori na se enitin we de damej di layn na di gכt, if di damej kכntinyu, i kin mek di intestinal pεrmiabiliti. fכ dat, dis tiori se εvride tin dεm lεk f כ it εn strεs kin wik sכmtεm di layn na di gכt, we kin mek i ebul fכ pas. Bɔt sayɛnsman dɛn nɔ shɔ bɔt dis yet. Bɔt dɛn gri se dɛn tin ya we kin apin ɛvride kin mek di gut layn inflamɛns ɛn mek yu gɛt ``GI`` simptom dɛm we nɔ kin kɔmfyut.

aw "leaky gut" de afekt di bodi?

di damej pan di layn na di gכt εn di intestinal permiabiliti we de go כp na tu difrεn tin dεm. Bɔrku pipul dɛm wae tink se dɛn gɛt "leaky gut" kin gɛt kɔmɔn gastrointestinal (GI) simptom dɛm lɛk bɛlɛ pen, it sɛnsitiviti, blo, ɛn dijestiv prɔblɛm. Dɛn sayn ya kin bɔrku, ɛn dɛn kin gɛt bɔrku tin. Ɛn bɔku pan dɛn tin dɛn de kin pwɛl yu gut layn bak. So, yu nכ nid fכ gεt "leaky gut" fכ εkspiriεns di ifekt dεm.

Damej to di intestinal layn:

We yu gut layn de pwɛl ɔltɛm, i kin te i nɔ ebul fɔ protɛkt insɛf frɔm kemikal, rɔf, ɔ baktri dɛn we de na di gut. dis na wetin kin apin pan kכndishכn dεm lεk pεptik כlsa sik εn sכm intestinal baktriyal כvagrכw (SIBO ). we bad baktri dεm pas di gud baktri dεm we nכmal fכ kip dεm in chεk, di asid εn εnzym dεm na di gכt kin strכng pas di prכtektiv mכkus we nכmal fכ kip dεm in chεk.

If di layn na yu gut dɔn pwɛl, i kin afɛkt di we aw yu de digest, yu imyun sistɛm, ɛn aw yu de fil bɔt yu gut . Sɔntɛnde, i kin ivin mek di intestinal permeability go ɔp. Bɔt, i nɔ nid fɔ go so fa fɔ mek yu nɔ fil fayn. If yu gɛt `(GI)` simptom dɛm, bɔku tɛm dɛn kin gɛt fɔ du wit wan ɔndalayn kɔndishɔn we de pwɛl yu gut layn insay di fɔs ples. Bɔku `(GI)` sik dɛn kin gɛt di sem kayn sayn dɛm.

Intestinal Pɛrmiabiliti: .

Sɔm pipul dɛn kin rili gɛt gut we de lik. Bɔt di sayn dɛm fɔ dis lik gut kin at fɔ difrɛns frɔm di simptom dɛm fɔ wan ɔndalayn inflammatory kɔndishɔn. we yu gכt layn kכmprכmis, baktri dεm we de liv insay yu gכt kin pas dis prכtektiv barεri εn go insay yu bכdi. Bɔt wi nɔ no yet if dis kin mek ɛni big damej pas di fɔs injuri. Sɔm stɔdi dɔn sho se we baktri dɛm de muf frɔm yu gut to yu liva kin mek yu gɛt liva sik.

Wetin na di men tin dɛm we kin mek pɔsin gɛt "leaky gut"?

If yu gut barɛri dɔn kɔmprɔmis, i fɔ dɔn kɔmprɔmis bad bad wan, bɔku tɛm fɔ lɔng tɛm. sכm pan di dairekt kכz dεm fכ di gכt pεrmiabiliti inklud:

• Krכnik inflammatory stet dεm, fכ egzampl `(IBD)` εn `(Celiac Disease)`.
• Ɔda sik dɛm we de pwɛl di insay, fɔ ɛgzampul `HIV/AIDS` .
• Kimotɛrapi ɛn raytin tɛrapi we de pwɛl di intestinal mucosa.
• Fɔ yuz rɔm ɔ NSAID pasmak fɔ lɔng tɛm (e.g., pen kil lɛk aspirin ɛn ibuprofen) .
• Fɔd alɛji na di imyun sistɛm in rεspכns to sɔm it dεm.

Wetin na di simptom dɛm fɔ "leaky gut"?

nכ spεsifi k simptom dεm de we dεn kin atribyut dairekt to inkrεs intestinal permeability. Bɔt bikɔs di intestinal permeability kin apin afta di intestinal layn dɔn pwɛl, yu kin gɛt sɔm sayn dɛn we kin kɔmɔt frɔm da damej de. Fɔ ɛgzampul:

• Wan bɔn we pɔsin kin gɛt we i gɛt ɔlsa na in intestinal.
• Wan pen we de mek pɔsin nɔ ebul fɔ it di it we de mek di intestinal mucosa dɔn pwɛl.
• Rɔnbɛlɛ .
• gas εn blot bikoz fכ di baktri dεm we de fεmεnt pasmak na di intestכn dεm.
• Fɔ fil se yu nɔ gɛt bɔku ɛnaji bikɔs yu nɔ ebul fɔ tek ɛnaji frɔm it.
• Gastrointestinal mucositis we kin kam wit redyushɔn tɛrapi.

Aw yu kin mɛzhɔ di intestinal permeability?

Naw, nɔ standad tɛst nɔ de we go ebul fɔ mɛzhɔ di intestinal permeabiliti dairekt wan pan di sik pipul dɛn. Dis na wan rizin we mek dɛn nɔ de aksept intestinal permeability naw as mɛdikal diagnosis. Bɔt dɛn de du sɔm difrɛn tɛst dɛn na di klinik risach lɛvɛl fɔ fɛn pruf fɔ se intestinal permeability insay di pasɛnt dɛn. Dɛn tɛst ya na:

• Yurin tɛst: Dis kin min fɔ gi yu drink we gɛt miksɔp pan shuga dɛn we gɛt difrɛn saiz (sɔm pan dɛn nɔ kin tek di intestinal dɛn nɔmal wan). Dɔn, dɛn kin mɛzhɔ di shuga lɛvɛl na yu urine fɔ si us shuga dɛn dɔn pas na di intestinal wɔl.
• Blɔd tɛst: Dis min se yu fɔ tek wan sɛmpul pan yu blɔd ɛn luk fɔ sayn dɛn we de sho se yu gɛt baktri dɛn na yu intestinal. dis tεst de luk fכ bayomak dεm lεk spεsifi k antibodi dεm εn εndotoksin dεm.
• Tisu biopsy: Dis na tɛst we kɔmplikt smɔl. wan sεmpl fכ tisu frכm yu kכlon dεn de put am insay wan spεshal divays we dεn kכl ``Ussing chamber.'' Dis de yuz ilektrikal kכrant fכ mכsu di muvmεnt fכ ayכn dεm kכros di intestinal barεri. Dis we aw dɛn de mɛzhɔ di ayɔn muvmɛnt tan lɛk di we aw wata de muv.
• kכnfokal εndomaykroskכpi: dis na impruv vεshכn fכ εndoskopi.Dis kin mek sayɛnsman dɛn ebul fɔ si di layn we de na yu insay wit rili ay rɛsɔlɔshɔn ɛn magnifyeshɔn. wan spɛshal wata (kɔntrast fluid) de insay wan vein ɛn yu kin si am de lik insay yu intestinal if ol de na di layn.

Aw fɔ mɛn "leaky gut" kwik kwik wan?

di onli we fכ kכl "lik gut," כ inkrεs intestinal permeability, na fכ trit di כndalayn kכndyushכn we mek i . Fɔ ɛgzampul, dɛn dɔn sho se spɛshal tritmɛnt fɔ sik dɛn we gɛt fɔ du wit intestinal permeability, lɛk IBD ɛn Celiac Disease, kin mek di intestinal layn bak pan di wan dɛn we di sik afɛkt.

Bɔt, mɛmba se, dɛn nɔ dɔn pruv se tritmɛnt dɛn we de tɔch di intestinal layn nɔmɔ kin mɛn dɛn sik ya ɔ fɔ mek di intestinal permeability nɔ kam bak.

Aw a go tek kia ɔf mi gut wɛlbɔdi? (Tips fɔ kip wi gut wɛl)

Sayɛnsman dɛn de kɔntinyu fɔ du risach bɔt difrɛn tritmɛnt dɛn we go mek di jenɛral wɛlbɔdi ɛn trɛnk we di intestinal layn gɛt bɛtɛ. Dɛn tritmɛnt ya nɔ kin kɔntrol wan big sik ɔltogɛda. Bɔt dɛn kin ɛp fɔ ridyus di impak we tin dɛn we kin apin ɛvride lɛk it, strɛs, ɛn we baktri dɛn kin gro pasmak kin gɛt pan di intestinal layn. Dɛn kin ɛp bak fɔ pul yu jenɛral ``GI`` simptom dɛm. Sɔm pan dɛn kayn tritmɛnt ya na:

• Probiotics: dεn de stכdi sכm spεshal tכp dεm fכ di intestinal barεri fכ dεn ebul fכ mek di intestinal barεri wok bak. כltu, in jεnarכl, probayotiks kin εp fכ mεnten di hεlth fכ di intestinal layn bay we i de mek bad baktri dεm nכ gro pasmak na yu gכt, spεshal wan na di sכmכl intestinal.
• Prebiotics: Prebiotics na it fɔ di gud baktri dɛm we de na yu gut. Dɛn kin gi dɛn tin fɔ it ɛn ɛp dɛn fɔ fɛt di bad bad bɔdi. Dis na plant fayv - ɔda rizin we mek yu fɔ it yu frut ɛn vɛjitebul!
• Ridyus di fat ɛn shuga we yu de it: Dɛn tin ya de mek bad bad bɔdi na yu bɔdi gro. Dɛn kin pul bak harsh dijestiv sɔbstans dɛm (dietary emulsifiers) we kin mek yu gut vɛks.
• Nutrishכn: fכ bεlε fכ it we inklud כl di makronutriεnt dεm εn maykronutriεnt dεm (vitamin εn minral dεm) kin εp fכ mek yu gכt strכng. di vitamin D εn di amino asid L-glutamine kin εp spεshal fכ mek di layn na yu gכt rεpair.
• Di it we nɔ gɛt bɔku FODMAP:Dis na spɛshal it. I fayn fɔ di wan dɛn we gɛt IBS (Irritable Bowel Syndrome) ɛn di wan dɛn we kin fil fɔ it sɔm it dɛn. Dis na bikɔs smɔl smɔl i de pul bɔku tin dɛn we kin mek pɔsin it it. If yu fala dis fɔ sɔm tɛm, yu kin no us it dɛn yu kin fil fɔ it we yu de gi yu gut di rɛst we i nid fɔ mek insɛf fayn.

Fɔ dɔn, wetin fɔ mɛmba (Take-Home Message) .

Bɔrku pipul dɛn gɛt GI simptom dɛm wae dɛn nɔr ɛksplen. Sɔntɛnde, i kin rili mek wi at pwɛl fɔ fɛn di tin we mek i apin. So, we klia ansa nɔ de, "Leaky Gut Syndrome" dɔn bi pɔpul diagnosis fɔ kɔmɔn indigestion, ɛn sɔntɛm bɔku ɔda kɔndishɔn dɛn.

כltu, tru tru intestinal haypapermiabiliti na wan rili spεsifi k εn siriכs kכndyushכn. I nɔr go du fɔ ɛksplen de sayn dɛm fɔ bɔrku pipul dɛm.

כl di pipul dεm gεt jεnarכl gut inflameshn – di kכndishכn we de bifo di gut we de lik. I kin kam bikɔs ɔf wan patikyula sik, ɔr kin bi bikɔs ɔf wan kɔmbaynshɔn wae pɔrsin nɔr de it fayn, strɛs wae nɔr de dɔn, ɛn ɔda tin dɛm wae kin kɔmɔn.

Fɔs, tray fɔ pul dɛn tin ya we kin apin. If dat nɔ ɛp, mek shɔ se yu go to dɔktɔ . Wan kwalifay gastroenterologist kin ɛp yu fɔ pul di pɔsibul kɔz dɛm fɔ yu patikyula simptom dɛm.

` Lik gכt, lik gכt sεndrכm, lik gכt, intestinal pεrmiabiliti, dijestiv sistεm, bεlε we de at, gut hεlth, nyutrishכn