Yu dɔn ɛva wɔnda aw yu kin fil we yu ful-ɔp? We wi it, afta sɔm tɛm wi kin fil se "Okay, dat na inof." Wetin kin mek pɔsin fil dis kayn we? So wetin mek sɔm pipul dɛn nɔ kin ɛva fil ful ilɛksɛf dɛn it bɔku tin? Leptin na wan ki pleya bihayn ɔl dis. Dis na ɔmon we rili impɔtant fɔ mek wi bɔdi kɔntrol wi wet. Lɛ wi tɔk bɔt am simpul wan ɛn kɔrɛkt wan tide.
Wetin na Leptin, fɔ tɔk am simpul wan?
Fɔ tɔk am simpul wan, lɛptin na ɔmon we di fat sɛl dɛn na yu bɔdi (adipose tissue) de mek. dεn kכl am bak di "satiety hormone." I men wok na fɔ sɛn signal to yu bren we se, "Okay, yu dɔn gɛt inof ɛnaji, stɔp fɔ it." Dis na aw lɛptin de ɛp fɔ mek yu bɔdi gɛt stebul wet fɔ lɔng tɛm.
Sayɛnsman dɛn bin fɛn di lɛptin ɔmon insay 1994, we min se dɛn stil de du bɔku risach bɔt am. Naw dεn de invεstigat di kכnεkshכn we lεptin gεt nכto כnli weit mεnejmεnt, bכt bak to sik dεm lεk Alzaima sik, riprodaktiv hεlth, εn infεliti.
We yu yɛri di wɔd "weight control," yu kin tink se, "Oh... so wi kin kɔntrol lɛptin ɛn lɔs weit." Bɔt di tru tin na dat, fɔ kɔntrol dis ɔmon di we aw wi want nɔ izi lɛk aw wi kin tink.
Aw lɛptin de wok na wi bɔdi?
Di men wok we lɛptin de du na fɔ ɛp fɔ mek wi bɔdi kɔntinyu fɔ gɛt wet. Dat min se fɔ mek wi gɛt balans fɔ lɔng tɛm bitwin di it we wi de it ɛn di ɛnaji we wi bɔdi de spɛn. Leptin de stɔp wi fɔ fil angri we wi nɔ nid. i de εp fכ mek di bכdi nכ de signal angri we i nכ nid εnεji (kalori).
Leptin de wok mɔ bay we i de afɛkt wan pat na wi bren we dɛn kɔl di haypothalamus. כltu, rεsεpכta dεm de na כda pat dεm na di bכdi we de rεspכnd to lεptin.
Di tin we impɔtant pas ɔl na dat, lɛptin nɔ de kɔntrol wi angri frɔm wan it to di ɔda wan. Bifo dat, i de wok fɔ kɔntrol di it we pɔsin de it ɛn di ɛnaji we i de spɛn fɔ lɔng tɛm, we de mek di bɔdi wet nɔ chenj.
Imajin se yu de tray fɔ lɛf fɔ it bɔku bɔku it dɛn. As yu bɔdi fat de go dɔŋ, yu lɛptin lɛvɛl bak de go dɔŋ. Dis kin sɛn signal to yu bren se yu angri. Dis kin mek yu fil bad bad wan ɛn yu kin want fɔ du sɔntin. Dis kin mek yu it mɔ ɛn yu nɔ ivin no. Dis na wan pan de rizin wae mek e kin tranga fɔ lɛf fɔ it bɔku bɔku it.
Aw dɛn kin kɔntrol di lɛptin lɛvɛl?
di wayt adipos tisu na wi bכdi de mek lεptin εn kכmכt na di bכdi. So, di kayn lɛptin we de na yu blɔd gɛt sɔntin fɔ du wit di fat we de na yu bɔdi.
- If yu gɛt bɔku bɔku fat na yu bɔdi:di lεptin lεvεl dεm de hכy.
- If di bɔdi fat smɔl: di lɛptin lɛvɛl nɔ bɔku.
As tɛm de go, if yu bɔdi fat go ɔp, di lɛptin lɛvɛl go go ɔp, ɛn if yu bɔdi fat go dɔŋ, di lɛptin lɛvɛl go dɔŋ.
Wetin kin apin if di lɛptin lɛvɛl tumɔs? - Lɛptin Resistɛns
Pɔsin we fat kin gɛt bɔku fat na in bɔdi. Dis dɔn mek di lɛptin lɛvɛl na dɛn blɔd sɛf rili ay. Wi kin kɔl dis kɔndishɔn hyperleptinemia .
Naw yu kin de tink se, "If lɛptin bɔku, yu fɔ fil ful, so yu fɔ kɔntrol aw yu de it?" Bɔt di kɔmɔn tin na tru. we di lεptin lεvεl na di bכdi hכy fכ lכng tεm, di bren kin bigin fכ nכ de ansa da lεptin signal de. I tan lɛk se pɔsin de ala pan wi ɔltɛm ɛn wi kin numb to am afta sɔm tɛm. Dɛn kɔl dis lɛptin rɛsistɛns .
fכ simpul wan, lεptin rεsistεns min se pan כl we inof lεptin de na di bכdi, di bren nכ de gεt di "ful" signal.
Wetin kin apin bikɔs ɔf dis?
1. Nɔ fil ful: Pan ɔl we yu gɛt inof fat na yu bɔdi, yu bren de tink se yu stil angri. So yu de kɔntinyu fɔ it.
2. di bכdi de go insay "starvation mode": biכs di bren nכ de rεsכp di lεptin signal, di bren de tink se di bכdi nכ gεt inof enεji εn wi de angri. so, fכ kכnsyuv εnεji, di bכdi in basal mεtabolik rεt (BMR) de dכn. Dis min se di nɔmba fɔ di kalori dɛn we yu de bɔn we yu jɔs sidɔm stil de go dɔŋ.
dis we ya, di rεsistεns fכ lεptin, na wan say, de mek angri bכku εn i de mek di it we dεn de it bכku, εn na di כda say, di rεt we di bכdi de bכn kalori dεm de dכn. We dɛn tu tin ya kam togɛda, di tin we kin apin kin mek pɔsin gɛt mɔ wet mɔ ɛn mɔ.
| Men tin dɛn we de mek pɔsin gɛt Lɛptin Rɛsistɛns |
|---|
| Fɔ fil ɔltɛm fɔ angri bad bad wan (hyperphagia) pan ɔl we yu nɔ gɛt bɛtɛ fat na yu bɔdi ɔ yu nɔ gɛt ɛni fat na yu bɔdi. |
| I nɔ izi fɔ kɔntrol di it we yu de it ɛn di it we yu de it mɔ. |
Ɔda tin kin kam wit dɛn sik ya, so if yu de gɛt dɛn sik ya, i go fayn fɔ mek yu tɔk to yu dɔktɔ .
Wetin kin apin if di lɛptin lɛvɛl go dɔŋ?
We pɔsin nɔ gɛt lɛptin na wan tin we nɔ kin apin so ɔltɛm . I kin apin wit wan jenɛtik kɔndishɔn we dɛn kɔl kɔngenital lɛptin dɛfisiɛns . Pɔsin we gɛt dis sik kin gɛt wan sik we in fat sɛl dɛn nɔ kin ebul fɔ mek lɛptin.
We lɛptin nɔ de, di bɔdi kin tink se fat nɔ de na di bɔdi. Dis de sho se di bren de angri ɛn i nɔ ebul fɔ kɔntrol am. Dis kin mek yɔŋ pikin dɛn we gɛt dis sik kin want fɔ it tin dɛn we dɛn nɔ ebul fɔ kɔntrol. Dis kin mek dɛn fat pasmak (klas III fat) we dɛn rili yɔŋ ɛn dɛn kin delay fɔ bɔn pikin.
| Kɔndishɔn dɛn we kin gɛt fɔ du wit di ay lɛptin lɛvɛl (Hyperleptinemia) . | Kɔndishɔn dɛn we kin gɛt fɔ du wit di lɔw lɛptin lɛvɛl (Hypoleptinemia) . |
|---|---|
| Pwɛl at | Insulin lɛvɛl we ay (Hyperinsulinemia) . |
| Fɔ it adikshɔn | di bכdi fεt imbalans (Dyslipidemia), fכ egzampl. kכlestכl, triglisεrayd dεm |
| Nɔn-alcoholic fat liva sik | Fat liva sik |
| Nyurodijɛnɛraytiv dizayd dɛn | Baktri infekshɔn dɛn we kin kam bɔku tɛm |
Yu tink se dɛn kin mɛzhɔ di lɛptin lɛvɛl na blɔd?
Yɛs, wan simpul blɔd tɛst kin no di lɛptin lɛvɛl. Bɔt dis nɔto tɛst we dɔktɔ dɛn kin ɔda. Na spɛshal kes dɛn nɔmɔ dɛn kin du am. Fɔ ɛgzampul:
- If pikin we rili yɔŋ fat bad bad wan.
- If pɔsin we fat kɔntinyu fɔ gɛt angri we i nɔ ebul fɔ kɔntrol.
Tipikli, di hεlty lεptin lεvεl kin kכmכt frכm:
- Uman dɛn: 0.5 - 15.2 ng/mL (nanogram pan wan mililita)
- Man: 0,5 - 12,5 ng/mL
Dɛn valyu ya kin difrɛn smɔl frɔm wan lab to ɔda lab, so if yu gɛt ɛni dawt bɔt di valyu dɛn we de na yu ripɔt, aks yu dɔktɔ .
Aw wi kin ajɔst di lɛptin lɛvɛl?
No we nɔ de fɔ rili inkrisayz di lɛptin lɛvɛl fɔ mek yu nɔ angri, bikɔs di lɛptin lɛvɛl gɛt fɔ du wit di fat we de na yu bɔdi.
Bɔt sɔm tin dɛn de we kin ɛp fɔ mek lɛptin wok ɛn ɔda ɔmon dɛn balans:
1. Slip inof: Wan stɔdi dɔn sho se we pɔsin nɔ slip fayn, dat kin mek di ɔmon we dɛn kɔl ghrelin we de mek pɔsin angri bɔku ɛn i kin mek di ɔmon we dɛn kɔl lɛptin we de mek pɔsin satisfay nɔ bɔku. So, fɔ slip fayn ɛvride rili impɔtant fɔ mek di ɔmon balans.
2. It fayn it: Sɔm stɔdi dɛn dɔn sho se if yu gɛt bɔku triglisɛrɛyd, we na wan kayn fat we de na di blɔd, dat kin mek di lɛptin nɔ rich na di bren. Pan ɔl we difrɛn pipul dɛn stil de tink bɔt dis, i bɛtɛ ɔltɛm fɔ it tin dɛn we gɛt bɛlɛsin we gɛt vɛjitebul, frut, fayv, gud prɔtin, ɛn fayn fayn fat, ɛn yu nɔ go gɛt bɔku shuga, flawa, ɛn it dɛn we dɛn dɔn prosɛs .
3. Ɛksesaiz ɔltɛm: Risach dɔn sho se ɛksesaiz kin ɛp fɔ ridyus di lɛptin rɛsistɛns. Dat min se, ɛksesaiz kin mek di bren gɛt bɛtɛ lɛptin sɛnsitiviti.
Di impɔtant tin na dat, lɛptin nɔto sɔntin we dɛn kin si na it. Na ɔmon we wi bɔdi de mek insɛf. So no tin nɔ de we dɛn kɔl "it tumɔs lɛptin."
If yu de wɔri bɔt yu wet, ɔ nid fɔ gayd yu bɔt aw fɔ lɛf fɔ it bɔku bɔku it dɛn we go mek yu gɛt wɛlbɔdi, i go fayn fɔ mek yu tɔk to yu dɔktɔ . If nid de, i kin sɛn yu to dɔktɔ we de mɛn di sik we de mek yu bɔdi gɛt sik.
Mɛsej we dɛn kin kɛr go na os
- lεptin na di "fulness" כmon we wi bכdi in fεt sεl dεm de mek. I de sho di bren se wi dɔn gɛt inof it.
- As yu bɔdi fat de go ɔp, di lɛptin lɛvɛl bak de go ɔp.
- di men prכblεm we de pan fכ fat nכto we di lεptin nכ de, bכt na wan kכndyushכn we dεn kכl "lεptin rεsistεns," we di bren nכ de rεspכnd to lεptin.
- di lεptin rεsistεns de mek yu angri bכku εn i de ridyus di kalori we de bכn na di bכdi, we kin mek i gεt mכr weit.
- Fɔ slip fayn, it fayn it, ɛn ɛksesaiz kin ɛp fɔ mek di lɛptin wok fayn ɛn di ɔl di ɔmon dɛn balans.
- If yu gɛt ɛnitin we de mɔna yu bɔt yu wet ɔ aw yu de it, go to yu dɔktɔ ɔltɛm fɔ advays.
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