Yu kin fil sik bak wantɛm wantɛm? Wetin na dis sik we de kam pan fɔ natin? (Mast Sεl Aktivεshכn Sεndrכm) .

Sɔntɛnde, yu kin fil bad bad wan wantɛm wantɛm? I tan lɛk se yu gɛt siriɔs alɛji. Sɔntɛm yu ɔl bɔdi kin tɔn rɛd, it, swel, yu bɛlɛ kin kramp, yu kin vɔmit, ɔ yu kin gɛt prɔblɛm fɔ blo. Bɔt dɛn tin ya nɔ kin apin bikɔs yu it sɔntin ɔ tɔch sɔntin. if dεn tin ya apin fכ no rizin, i kin bi wan kכndyushכn we dεn kכl `Mast Cell Activation Syndrome (MCAS).` Lε wi tכk bכt dis mכr ditayli tide.

Wetin na ``Mast Sεl Aktivεshכn Sεndrכm (MCAS)''?

Fɔ tɔk am simpul wan, MCAS na wan kɔndishɔn we wan kayn sɛl na wi bɔdi we dɛn kɔl ``mast sɛl'' kin bi ɔva aktiv fɔ no rizin, we kin mek wi gɛt siriɔs simptom. Naw yu kin de tink se, "Na dat alɛji kin bi." Yes, alɛji kin involv bak di aktiveshɔn fɔ ``mast sɛl dɛm.'' Bɔt alɛji kin gɛt klia kɔz . Fɔ ɛgzampul, sɔm pipul dɛn kin gɛt alɛji fɔ shrimps, pinat, ɔ dɔst mit. Bɔt na MCAS, i nɔ kin izi fɔ fɛn wan patikyula kɔz. Dɛn sayn ya kin apin wantɛm wantɛm.

sכm tεm dεm, we dεn mast sεl dεm ya de aktibכt kin mek yu gεt wan alerjik riakshכn we rili siriכs, we de mek yu layf de pan denja we dεn kכl anafylaksis. Dis kin mek i nɔ izi fɔ blo ɛn i kin mek di blɔd prɛshɔn go dɔŋ we denja. If yu gɛt siriɔs anafilaksis, yu fɔ kɔl 911 ɔ go na di imejensi rum we de nia yu wantɛm wantɛm.

Mast sɛl dɛn tan lɛk sojaman dɛn na wi imyun sistɛm. Dɛn kin ɛp fɔ fɛt di infɛkshɔn dɛn. So, e nɔrmal fɔ fil frayd wae yu gɛt dis sik wae nɔr dɔn no bɔt. Bɔt i nɔmal fɔ mek di mast sɛl dɛn bigin fɔ wok. fכ egzampl, di mast sεl dεm de aktibכt insay kכndishכn dεm lεk alerjik raynayt, asma, anafylaksis to mεdikeshכn כ it dεm, εn mastocytosis. Dis na de tin wae kin mek wi gɛt dɛn kayn sik ya wae kin mek wi vɛks, sɔmtɛm kin denja.

כltu, ``Mast Cell Activation Syndrome (MCAS)`` na wan kכndyushכn we rili rεs . Dɔktɔ dɛn kin no se yu gɛt MCAS if dɛn tin ya de:

• If yu gɛt sɔm kayn sik wae de kam bak wae yu tink se kin bi anafylaksis fɔ no rizin.
• If dɛn sayn ya afɛkt mɔ pas wan pan yu bɔdi sistɛm dɛn di sem tɛm (fɔ ɛgzampul, ɔl tu di skin ɛn di intestinal dɛm).
• If tɛst sho pruf fɔ se di mast sɛl dɛn de aktiv.
• If yu simptom dεm dכn rεdכks bay mεdikal dεm wae de tכk bכt di mast sεl dεm.

Mast sɛl dɛn ɛn di wok we dɛn de du

Mast sɛl na sɛl dɛn na wi imyun sistɛm .Pat. Dɛn nɔmal wok na fɔ protɛkt wi bɔdi frɔm di patɔjɛns (e.g. parasayt, vayrɔs) ɔ ɔda bad bad tin dɛn we de kam insay wi bɔdi. Dɛn sɛl ya kin sidɔm na wi tisu dɛn, ɛn we dɛn si sɔntin we dɛn tink se go ambɔg wi, dɛn kin pul kemikal dɛn lɛk histamin, we kin mek di imyun sistɛm wok ɛn tray fɔ fɛt di pɔsin we kam insay wi.

Sɔntɛnde, dɛn kin riak to tin dɛn we dɛn nɔ fɔ riak to. Na da tɛm de wi kin gɛt alɛji . Bɔt alɛji kin mek yu gɛt smɔl smɔl tin dɛn lɛk we yu yay de it ɛn yu nos we de rɔn. Wetin kin apin na MCAS na dat, i kin gɛt mɔ siriɔs sik fɔ no rizin.

Aw siriɔs ``Mast Sɛl Aktivɛshɔn Sindrom (MCAS)''?

Di kayn we aw MCAS kin tranga kin dipen pan di sayn dɛm wae yu kin gɛt. Sɔm pipul dɛn kin gɛt sɔm kayn sik wae nɔr kin pasmak, ɛn na dɛn skin nɔmɔ kin gɛt sɔm kayn sik. Ɔda pipul dɛn kin gɛt mɔ bad bad tin dɛn lɛk anafilaksis. Anafylaksis kin kil pɔsin if dɛn nɔ trit am fayn. Bɔt di riakshɔn dɛn we kin mek pɔsin in layf de pan denja we i gɛt MCAS nɔ kin apin so ɔltɛm .

Wetin na di simptom dɛm fɔ `Mast Cell Activation Syndrome (MCAS)`?

MCAS kin mek yu gɛt siriɔs sik dɛn we kin kam bak na difrɛn pat dɛn na yu bɔdi. Dɛn sayn ya kin bi:

• Lɔw blɔd prɛshɔn.
• Skin de bi rɛd, pink, ɛn wam (`Flushing`).
• Skin we de it.
• Nasal kɔnjɛshɔn.
• Swel - spεshal wan na di fes, lip, yay, tכng כ trot (`Angioedema`).
• Kɔnstipɛshɔn ɔ dayarɛa (maybe i kin chenj bitwin di tu).
• Bɛlɛ de pen.
• I nɔ kin izi fɔ yu fɔ blo.
• Wiknɛs ɔ fɔdɔm.
• Memori lɔs ɔr i nɔ kin izi fɔ tink (bren fɔg).
• Fɔ mek pɔsin nɔ ebul fɔ du natin.
• Pen na di jɔyn dɛn.
• Anafylaksis (na wan bad bad alɛji riakshɔn wit wan ɔ mɔ pan di sayn dɛm we wi dɔn tɔk bɔt).

Fɔ saspek MCAS, dɛn simptom ya fɔ afɛkt at le tu pan yu bɔdi sistɛm dɛn. Dat na:

• Nεv sεstem (bren εn nεv dεm).
• di rεspiretכri sistεm (lכng dεm εn di aywe dεm).
• di kadiovaskular sistεm (at εn blכd vεsεl dεm).
• dijestiv sistεm (bεlε εn intestכn dεm).

Aw i kin fil we di mast sɛl dɛn kin wok wantɛm wantɛm?

If yu dɔn ɛva gɛt alɛji, yu go mɔs no aw i kin tan lɛk we di mast sɛl dɛn de wok. Bɔt fɔ pipul dɛn we gɛt MCAS, di sik kin tranga pas wan tipik alɛji, ɛn i kin afɛkt bɔku pat dɛn na di bɔdi. Yu skin kin swel, tɔn rɛd, bigin fɔ it, ɔ ivin blɔd. Yu kin gɛt dayarɛa ɛn vɔmit. If i bad, yu fes ɛn yu trot kin swel, ɛn yu blɔd prɛshɔn kin go dɔŋ. Mɛmba se if yu gɛt dɛn kayn bad bad sik ya, yu fɔ kɔl 911 ɔ go na di ɔspitul we de nia yu wantɛm wantɛm.

Wetin na di tin dɛm we kin mek pɔsin gɛt `Mast Cell Activation Syndrome (MCAS)`?

MCAS de kכz fכ yu mast sεl dεm we de riak we dεn nכ fכ riak. Di mast sɛl dɛn kin tink se sɔntin we bad dɔn kam insay di bɔdi ɛn dɛn nid fɔ protɛkt dɛn. Na da tɛm de dɛn kin pul di prɔtin dɛm we de mek di sik. Insay alɛji, wi kin no wetin de mek di bɔdi de riak pasmak. bכt insay MCAS, i at fכ fכn klia rizin fכ di mast sεl dεm fכ rilis dεn protin dεm ya.

Infakt, nɔbɔdi nɔ stil no di rayt tin we mek di mast sɛl dɛn kin rili fil fɔ du tin dɛn we dɛn nɔ want.

Wetin na di poshubul kכz dεm fכ mast sεl aktibכshכn?

pan ɔl we bɔku tin dɛn lɛk it ɛn pɔlin kin mek di mast sɛl dɛn wok ɛn pul histamin, i nɔ pɔsibul fɔ se di bad bad tin dɛn we kin apin to pɔsin we gɛt MCAS na wan patikyula alɛrjen kin mek am. Bɔt yu kin si se dɛn sayn ya kin tranga pasmak we chenj de na yu layf ɔr di say we yu de, fɔ ɛgzampul, di tɛm we yu strɛs pasmak ɔ we di wɛda kin chenj. If yu sik kin jɔs apin afta yu dɔn gɛt wan patikyula tin, tɛl yu dɔktɔ. If na so i bi, yu nɔ go gɛt MCAS, bɔt yu gɛt alɛji.

Aw dɛn kin no se pɔsin gɛt di sik we dɛn kɔl Mast Cell Activation Syndrome (MCAS)?

Dɔktɔ kin sɔprayz se yu gɛt MCAS afta i dɔn chɛk yu, tɔk bɔt yu sik, ɛn mɛdikal histri. Dɔktɔ dɛn go no se yu gɛt MCAS if dɛn mit dɛn kɔndishɔn ya:

• If yu gɛt simptom dɛm fɔ mast sɛl aktiveshɔn.
• If yu rεspכnd fayn to tritmεnt fכ mast sεl aktibכshכn.
• If tεst sho sayn dεm fכ mast sεl aktibכshכn.
• if yu gεt nכmal nכmba fכ mast sεl dεm na yu bכdi (we yu gεt bכku mast sεl dεm min se yu kin gεt כda mast sεl dizayd, lεk mastocytosis).

MCAS tɛst we dɛn de du

Fɔ chɛk fɔ MCAS, yu dɔktɔ kin du blɔd tɛst fɔ chɛk fɔ wan kemikal we dɛn kɔl ``tryptase'' na yu blɔd. ``tryptase'' na sכmtin we de inkrεs we ``mast sεl dεm'' de aktibכt. Dis tɛst go nid fɔ du bɔku tɛm – ɔl tu we yu wɛl ɛn we yu gɛt siriɔs sik. bכt mεmba se, ``tryptase'' kin εlevεt bak pan כda mεdikal kכndyushכn dεm. So di ``tryptase'' lεvεl dεm nכmכ nכ kin no if yu gεt MCAS. Sɔm pipul kin gɛt ay pas aw dɛn bin de ɛkspɛkt ``tryptase'' lɛvɛl ivin if dɛn nɔ gɛt ɛni simptom.

Yu dɔktɔ kin du bak alɛji skin tɛst ɔ alɛji blɔd tɛst fɔ chɛk fɔ ɔda tin dɛn we kin mek yu gɛt alɛji.

Impɔtant: Ivin if di histamin blɔd tɛst sho se di histamin lɛvɛl bɔku, di dɔktɔ dɛn nɔ kin se yu gɛt MCAS.

Aw dɛn kin trit di Mast Cell Activation Syndrome (MCAS)?

Dɔktɔ dɛn kin yuz tritmɛnt fɔ no if yu gɛt MCAS ɛn fɔ ridyus yu sik dɛn. If yu nɔr wɛl wit mɛrɛsin dɛm wae de tɔch mast sɛl dɛm, yu go mɔs nɔ gɛt MCAS.

Dipen pan yu sik, yu dɔktɔ kin gi yu mɛrɛsin lɛk dɛn wan ya:

• Histamine type 1 receptor blockers (Antihistamines) : Dis na mɛrɛsin wae dɛn kin yuse fɔ trit alɛji simptom dɛm. Ɛgzampul dɛn: Lɔratadin, Sɛtirizin, Fɛksofenadin.
• di histamin tayp 2 rεsεpכta blכk dεm (antihistamin dεm we de ridyus di bεlε asid) : dεn kin gi dεn tin ya fכ nכs εn bεlε pen. Ɛgzampul dɛn: Ranitidine ɔ Famotidine.
• Aspirin : Dɛn kin gi aspirin fɔ ridyus di flush.
• Leukotriene modifiers : Dɛn tin ya de ɛp fɔ mek i izi fɔ blo. Ɛgzampul dɛn: Mɔntelukast, Zafirlukast.
• Omalizumab (XOLAIR®) : Dis kin ridyus di risk fɔ gɛt anafilaksis.
• Epinephrine : Dɔktɔ dɛn kin yuz epinephrine fɔ stɔp anafilaksis. Yu kin kip wan epinephrine injector (EpiPen®, Auvi-Q®) nia yu if yu gɛt anafilaksis.
• Mast sel stεbyulayz : mεdikeshכn dεm lεk kromolin sכdiכm de mek di kεmikכl dεm we de kכmכt frכm di mast sεl dεm (degranulation).
• Kɔtikosterɔyd : Dɛn wan ya de ridyus di inflamɛns, opin di say dɛn we di briz de blo, ɛn ridyus di wata we de na di tisu dɛn. Bɔt bikɔs ɔf di risk fɔ sayd ɛfɛkt, dɔktɔ dɛn nɔ kin gi stɛroyd fɔ MCAS bɔku tɛm.

Yu tink se di Mast Cell Activation Syndrome (MCAS) go ɛva wɛl ɔltogɛda?

Nɔ, no mɛrɛsin nɔ de fɔ MCAS. If yu gɛt MCAS, yu go nid fɔ manej am wit mɛrɛsin.

Wetin na di layf we pɔsin we gɛt MCAS de liv?

Dɔktɔ dɛn kin tink se bɔku pipul dɛn we gɛt MCAS go liv lɔng lɛk pɔsin we nɔ gɛt am. Bɔt bikɔs dis na nyu sik we dɛn dɔn no, wi nɔ go ebul fɔ tɔk fɔ tru aw i go afɛkt di layf we pɔsin de liv.

Aw a kin kia fɔ misɛf?

Na sɔm we dɛm wae yu kin tek kia ɔf yusɛf wit MCAS:

• Kip wan dayari fɔ di sayn dɛm we yu gɛt. Rayt wetin bin de sho se yu gɛt dis sik, wetin yu bin it ɛn drink da tɛm de, ɛn ɛnitin we yu bin gɛt. Tink bɔt wetin bin difrɛn insay dɛn tɛm ya we yu kɔmpia am to we yu nɔ bin de gɛt di sik. If yu notis ɛni patɛn, tɛl yu dɔktɔ.
• Tɛl yu tayt padi dɛm, fambul dɛm, ɔr pipul dɛm wae yu kin hang ɔut wit bɔrku tɛm aw yu go riak pan dis kayn tin, ɛn usai yu epinephrine injector ɔr ɔda imejensi mɛrɛsin de.

Ustɛm a fɔ go na di Imejɛnsi Dipatmɛnt (ETU) ?

Pan ɔl we siriɔs riakshɔn to MCAS nɔ kin bɔku, if yu gɛt sayn dɛm fɔ siriɔs alɛji ɔ anafylaksis, yuz epinephrine injector if yu gɛt wan. Dɔn kɔl 911 ɔ go na di imejensi rum we de nia yu wantɛm wantɛm. Di sayn dɛm fɔ anafilaksis na:

• We yu fes, yu lip, yu tɔŋ, ɔ yu trot swel.
• I nɔ kin izi fɔ yu fɔ blo ɔ fɔ swɛla.
• Di at we de blo.
• Lɔw blɔd prɛshɔn.

Us kwɛstyɔn dɛn a fɔ aks mi dɔktɔ?

I go fayn fɔ aks yu dɔktɔ kwɛstyɔn dɛn lɛk dɛn wan ya:

• Wetin a fɔ du if dis kɔndishɔn wɔs/ɛskal fɔ mi wantɛm wantɛm?
• Aw a fɔ tek mi mɛrɛsin?
• Aw ɛn ustɛm a fɔ yuz mi epinephrine injector?
• Ustɛm a fɔ go na di imejensi rum?
• Ustɛm a fɔ kam si yu bak?

``Mast sel aktibכshכn'' na כtoimyun sik?

Nɔ, MCAS nɔto ɔtoimyun disɔda.

Imajin wan sayrin. Di sikyɔriti fɔs dɛn de kam. Yu ``mast sel`` dεn dכn dεtekt wan denja εn dεn de kol fכ εp. Bɔt... rili no denja nɔ de. Lɛk pesky klawn, yu ``mast cells`` de jɔs de sawnd di alam bɛl dɛn we nɔ gɛt ɛni urgency. Bifo dɛn protɛkt yu frɔm sik, na dɛn de mek yu sik.

pan ɔl we wi nɔ no bɛtɛ bɛtɛ wan wetin mek sɔm pipul dɛn mast sɛl dɛn kin riak pasmak, we dɛn de fɔ manej MCAS. No di sayn dɛm wae de sho aw pɔrsin de fil kwik kwik wan. If yu fil lɛk se yu sik de kɔmɔt na yu an, tɔk to yu dɔktɔ. Di tin we impɔtant pas ɔl na fɔ kɛr wan epinephrine injector ɔltɛm ɛn no aw ɛn ustɛm fɔ yuz am. Sɔntɛm yu nɔ go ɛva nid am, bɔt if yu rɛdi fɔ du sɔntin we yu nɔ bin de tink se go apin, dat kin mek yu gɛt kolat na yu maynd.

Tin dɛn we yu nid fɔ no (Take-Home Message) .

• Mast cell activation syndrome (MCAS) na wan sik we nɔ kin apin so ɔltɛm we kin mek pɔsin gɛt siriɔs alɛji we nɔ gɛt klia kɔz.
• Dis kin afɛkt sɔm bɔdi sistɛm dɛn wan tɛm.
• Kɔndishɔn dɛm we de mek yu layf de pan denja lɛk `Anaphylaxis` kin apin, so go to dɔktɔ wantɛm wantɛm if yu gɛt siriɔs sik.
• Pan ɔl we dɛn nɔ kin ebul fɔ mɛn MCAS ɔltogɛda, dɛn kin kɔntrol di sik dɛn wit mɛrɛsin.
• Yu fɔ no bɔt yu sik dɛn, kip wan epinephrine injector nia yu fɔ yuz am kwik kwik wan, ɛn tɛl yu famili bɔt am.
• If yu gɛt ɛni kwɛstyɔn bɔt MCAS, nɔ fred fɔ aks yu dɔktɔ.

` Mast sel dεm, MCAS, alerji, anafylaksis, histamin, triptaz, imyun sistεm