Yu ɔ pɔsin we yu sabi gɛt ɛmolaytik anemia we kin kam bikɔs ɔf wan ɛnzaym we dɛn kɔl pyruvate kinase dɛfisiɛns? Dis na tin we nɔ kin apin so ɔltɛm. If na so i bi, yu dɔktɔ go dɔn gi yu wan pil we dɛn kɔl Mitapivat. Yu kin fil kɔnfyus smɔl we yu yɛri dis nem. So, tide wi go tɔk simpul ɛn fayn bɔt dis mɛrɛsin we dɛn kɔl Mitapivat (brand nem PYRUKYND).
Fɔ tɔk am simpul wan, wetin na dis Mitapivat?
Mitapivat na spɛshal mɛrɛsin we dɛn kin gi fɔ trit ɛmolaytik anemia we kin kam wit wan kɔndishɔn we dɛn kɔl pyruvate kinase dɛfisiɛns. Naw yu kin de wɔnda, "Wetin na ɛmolaytik anemia?"
I rili simpul. Wi gɛt wan kayn blɔd sɛl we dɛn kɔl rɛd blɔd sɛl na wi bɔdi. Dɛn sɛl dɛn ya kin kɛr ɔksijɛn go ɔlsay na wi bɔdi. Nɔmal wan, dɛn rɛd blɔd sɛl ya kin liv fɔ lɛk 120 dez. Bɔt insay pɔsin in bɔdi we nɔ gɛt pyruvate kinase, dɛn rɛd blɔd sɛl ya kin brok ɛn pwɛl smɔl bifo tɛm, kwik kwik wan. Na dat dɛn kɔl ɛmolaytik anemia.
So, wetin Mitapivat de du na fɔ stɔp di rɛd blɔd sɛl dɛn we de brok kwik kwik wan. Fɔ tɔk di kɔrɛkt tin, i de gi dɛn sɛl dɛn de trɛnk ɛn i de mek dɛn liv lɔng . Wetin dis de du?
- Di nɔmba fɔ di rɛd blɔd sɛl dɛn na di bɔdi kin bɔku.
- Di sayn dɛm fɔ blɔd blɔd lɛk fɔ taya, fɔ taya ɔltɛm , ɛn fɔ shɔt briz kin ridyus.
- Di nid fɔ transfyushɔn blɔd ɔltɛm nɔ de igen.
Dat min se dis mɛrɛsin go ɛp fɔ mek yu layf bɛtɛ .
Tin dɛm wae yu fɔ tɛl yu dɔktɔ bifo yu tek dis mɛrɛsin
Bifo yu yuz ɛni mɛrɛsin, i rili impɔtant fɔ gi yu dɔktɔ kɔmplit diskripshɔn bɔt yu wɛlbɔdi prɔblɛm. Bifo yu bigin fɔ tek Mitapivat, mek shɔ se yu tɛl yu dɔktɔ if yu gɛt ɛni wan pan dɛn sik ya:
- Liva sik: If yu gɛt ɛni liva sik we bin dɔn de bifo, duya tɛl wi bɔt am.
- Alɛji dɛn : .If yu gɛt alɛji fɔ Mitapivat, ɛni ɔda mɛrɛsin, it, day, ɔ tin dɛn we de mek yu nɔ pwɛl, mek shɔ se yu tɛl wi.
- Bɛlɛ : If yu gɛt bɛlɛ ɔ yu de tray fɔ gɛt bɛlɛ kwik, tɔk to yu dɔktɔ bɔt am.
- If yu na mama we de gi pikin in bɛlɛ: If yu na mama we de gi pikin in bɛlɛ, yu fɔ tɛl di dɔktɔ bak.
Bay dis infɔmeshɔn, yu dɔktɔ go disayd if dis mɛrɛsin fayn fɔ yu ɔ if dɛn nid fɔ chenj di doz.
Aw fɔ yuz di mɛrɛsin kɔrɛkt wan?
Fɔ mek yu gɛt di bɛst pan di mɛrɛsin, i rili impɔtant fɔ yuz am di rayt we.
- Dis mɛrɛsin na pil we yu kin tek yu mɔt. Tray fɔ tek am di sem tɛm ɛvride , jɔs lɛk aw yu dɔktɔ dɔn tɛl yu.
- Swɛla di tablɛt ɔl wit wata. Nɔ ɛva brok, krɔs, ɔ chew di tablɛt.
- Kɔntinyu fɔ tek dis mɛrɛsin te yu dɔktɔ tɛl yu fɔ stɔp. Nɔ stɔp wantɛm wantɛm, ilɛksɛf yu fil fayn.
- Dɛn kin nid spɛshal kia if dɛn gi dis mɛrɛsin to pikin dɛn. So, du wetin di dɔktɔ tɛl yu fɔ du dat.
Wetin fɔ du if yu tek bɔku mɛrɛsin? (Ovadosage) .
Imajin se yu aksidɛntli tek mɔ pan dis mɛrɛsin pas di doz we dɛn tɛl yu fɔ tek. If dat apin, nɔ delay. Go na di ɔspitul we de nia yu Imejɛnsi Tritmɛnt Yunit (ETU) wantɛm wantɛm. Ɔda we de fɔ kɔl di Nashɔnal Pɔyzin Infɔmeshɔn Sɛnta na di Kɔlɔmbɔ Nashɔnal Ospital fɔ gɛt advays.
Dɛn dɔn gi yu dis mɛrɛsin fɔ yu nɔmɔ. Nɔ ɛva sheb am wit ɔda pɔsin, ilɛksɛf i gɛt di sem sayn dɛn we yu gɛt.
Wetin a go du if a mis wan doz fɔ tek mɛrɛsin?
Wit di bizi na layf, sɔmtɛm yu kin mis wan doz fɔ mɛrɛsin. If dat apin, na wetin fɔ du:
- Tek yu mɛrɛsin jɔs lɛk aw yu mɛmba.
- Bɔt if yu mis wan doz pas 4 awa, skip da doz de kpatakpata. Tek yu nɛks doz na di tɛm we dɛn dɔn sɛtul.
- Nɔ tek dabl doz fɔ mek di doz we yu mis fɔ ɛni rizin.
Ɔda mɛrɛsin dɛm wae kin miks wit dis mɛrɛsin
Sɔm mɛrɛsin dɛm wae yu de tek kin intarakt wit Mitapivat. Dis kin chenj aw Mitapivat de wok ɔ inkrisayz di sayd ɛfɛkt dɛm. So, mek shɔ se yu tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek (inklud vaytamɛn dɛn, ɛbul mɛrɛsin dɛn, ɛn mɛrɛsin dɛn we ɔda dɔktɔ dɛn dɔn gi yu).Tɛl yu dɔktɔ.
Dis dɔŋ ya na sɔm mɛrɛsin dɛm wae kin intarakt wit Mitapivat.
| Kategori fɔ drɔgs | Ɛgzampul dɛn |
|---|---|
| Sɔm mɛrɛsin fɔ fungal infɛkshɔn | Flukonazɔl, Itrakonazɔl, Kɛtokonazɔl |
| Efavirenz (na mɛrɛsin fɔ HIV) . | Efavirenz bin de du dat |
| Ɛstrojen ɛn prɔjɛstin ɔmon dɛn | Pils fɔ kɔntrol bɔn pikin, ɔmon tɛrapi |
| Midazolam we dɛn kɔl midazolam | Wan drɔg we dɛn kin yuz fɔ mek pɔsin in at kol ɔ fɔ mek pɔsin nɔ fil fayn |
| Rifampin bin de du am | Wan antibayɔtik we dɛn kin gi fɔ infɛkshɔn lɛk TB |
Impɔtant: Dis list nɔ de ɔlsay. Tɛl yu dɔktɔ if yu de smok, drink rɔm, ɔ yuz ɔda drɔgs.
Tin dɛn we yu fɔ tek tɛm wit we yu de tek mɛrɛsin
We yu de tek dis mɛrɛsin, yu dɔktɔ go de chɛk yu wɛlbɔdi ɔltɛm.
- Atɛnd di klinik apɔntinmɛnt dɛn we dɛn dɔn sɛtul fɔ. Dis na impɔtant tin fɔ si aw yu de du ɛn if di mɛrɛsin de wok.
- If yu sik nɔr de bɛtɛ, ɔr if i de wɔs, tɛl yu dɔktɔ.
- Dɛn kin aks yu fɔ mek dɛn du blɔd wok we yu de tek dis mɛrɛsin. Nɔ skip dɛn tɛst ya ɛn mek dɛn du dɛn ɔltɛm.
Wetin na di bad tin dɛn we kin apin to pɔsin?
Lɛk ɔl mɛrɛsin, Mitapivat kin mek yu gɛt sayd ɛfɛkt, pan ɔl we nɔto ɔlman kin gɛt am. Sɔm sayd ɛfɛkt kin bi siriɔs, so i impɔtant fɔ no bɔt dɛn.
| Sayd ɛfɛkt we pɔsin kin gɛt | Fɔ ɛksplen |
|---|---|
| Sayd ɛfɛkt dɛn we yu fɔ ripɔt to yu dɔktɔ wantɛm wantɛm | |
| Alɛji we pɔsin kin gɛt | Skin rash, it, swel na di fes, lip, tong ɔ trot, i nɔ izi fɔ blo. |
| Di wɔs we di ɛmolaytik anemia de mek | Fɔ fil taya/taya pas aw yu kin fil, diziz, ed we kin at, i nɔ kin izi fɔ blo, yu urine dak, yu skin ɔ yu yay kin yɔlɔ. |
| Di sayn dɛn we de sho se pɔsin in liva wund | Pen na di ɔp rayt say na di bɛlɛ, yu nɔ kin want fɔ it, yu nɔ kin fil fayn, yu kin gɛt stɔl we gɛt tar, yu kin gɛt dak yɔlɔ ɔ brawn urine, yu skin ɔ yu yay kin yɔlɔ, yu kin wik we nɔ kɔmɔn. |
| Tɛl yu dɔktɔ if i kɔntinyu fɔ de ɔ i de mɔna yu. | |
| Bak pen | |
| Pen na di jɔyn dɛn | |
Dis list nɔ de inklud ɔl di sayd ɛfɛkt dɛn we pɔsin kin gɛt. If yu gɛt ɛni ɔda sayn we nɔ kɔmɔn, tɔk to yu dɔktɔ bɔt am.
Aw fɔ kip mɛrɛsin fayn fayn wan?
- Kip am usay pikin ɛn animal dɛn we yu lɛk nɔ go ebul fɔ rich .
- Stɔr am na rum tɛmpracha (bitwin 20 ɛn 25 digri sɛlshiɔs).
- Kip di mɛrɛsin insay di ɔrijinal kɔntena we dɛn bin gɛt am insay.
- Nɔ ɛva yuz mɛrɛsin dɛn we dɔn pas . Trowe dɛn fayn fayn wan.
We yu de pul di mɛrɛsin dɛn we dɔn pas ɔ we yu nɔ want, i go fayn fɔ mek yu go to yu dɔktɔ. I go fayn fɔ mek yu trowe dɛn na dɔti. If na so, pul di pils dɛn na di bɔtul, miks dɛn wit sɔntin lɛk kɔfi grɔn we dɛn dɔn yuz, dɔti, ɔ pusi dɔti, ɛn put dɛn insay bag we dɛn tay tayt ɛn trowe dɛn na dɔti.
Mɛsej we dɛn kin kɛr go na os
- Mitapivat na spɛshal mɛrɛsin we de trit ɛmolaytik anemia we kin kam bikɔs ɔf di pyruvate kinase dɛfisiɛns.
- Ɔltɛm tek dis mɛrɛsin jɔs lɛk aw yu dɔktɔ tɛl yu fɔ tek, di rayt tɛm. Nɔ brok, krɔs, ɔ chew di tablɛt dɛn.
- Gi yu dɔktɔ kɔmplit diskripshɔn bɔt ɔl di ɔda mɛrɛsin dɛn, vaytamɛn dɛn, ɛn ɔda mɛrɛsin dɛn we yu de tek.
- Go to dɔktɔ wantɛm wantɛm if yu gɛt ɛni siriɔs sayd ɛfɛkt, lɛk alɛji ɔ sayn fɔ se yu liva dɔn pwɛl.
- Dɛn dɔn gi yu dis mɛrɛsin fɔ yu nɔmɔ. Nɔ ɛva sheb am wit ɔda pipul dɛn.
- If yu gɛt ɛnitin fɔ wɔri bɔt dis mɛrɛsin, tɔk to yu dɔktɔ.
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